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SEPDWAPLTGFRVAVTSARRADELSALLRRRGATVCSAAAIEMVPLPDDDELRQHTRSLIASPPDIVIAT TGIGFRGWVAAADGWGMATELTAALSNARIVSRGPKATGALRAAGLPEEWSPESESSRELLHYLVEGGIA GTRIAVQLHGATADWDPFPEFLDELRAAGAEVVPIRVYRWHPAPRNGEFDQLVAGIADEKFDAVSFTSAP AVASVLLRATEMGLEAEVLSALRTNVHAMCVGPVTARPLVRLGVPTSAPERMRLGALARHITDELPLLQT RTVRVAGHLLEIRGTCVLVDGTVKELSPSAMATIRALALRPGAVVSRVDLLRALPGSGTDTHAVETAVLR LRTALGDKKMVSTVVKRGYRLPVDEAFAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0301 | - | - | 100% (380) | bifunctional uroporphyrinogen-III synthetase/response regulator domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0846 | - | 9e-06 | 31.45% (124) | uroporphyrinogen III synthase HEM4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0266c | - | 1e-154 | 72.00% (375) | bifunctional uroporphyrinogen-III synthetase/response regulator |
| M. gilvum PYR-GCK | Mflv_0380 | - | 0.0 | 93.95% (380) | bifunctional uroporphyrinogen-III synthetase/response regulator |
| M. tuberculosis H37Rv | Rv0260c | - | 1e-154 | 72.00% (375) | bifunctional uroporphyrinogen-III synthetase/response regulator |
| M. leprae Br4923 | MLBr_02420 | hemD | 8e-06 | 30.65% (124) | putative uroporphyrin-III C-methyltransferase |
| M. abscessus ATCC 19977 | MAB_3520c | - | 1e-114 | 56.68% (367) | bifunctional uroporphyrinogen-III synthetase/response regulator |
| M. marinum M | MMAR_0520 | - | 1e-149 | 69.60% (375) | transcriptional regulatory protein |
| M. avium 104 | MAV_4900 | - | 1e-153 | 70.13% (375) | bifunctional uroporphyrinogen-III synthetase/response regulator |
| M. smegmatis MC2 155 | MSMEG_0432 | - | 0.0 | 85.90% (376) | bifunctional uroporphyrinogen-III synthetase/response regulator |
| M. thermoresistible (build 8) | TH_0582 | - | 1e-113 | 58.54% (369) | uroporphyrinogen-III synthetase |
| M. ulcerans Agy99 | MUL_1183 | - | 1e-148 | 69.07% (375) | bifunctional uroporphyrinogen-III synthetase/response regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0301|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0380|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0432|M.smegmatis_MC2_155 --------------------------------------------------
Mb0266c|M.bovis_AF2122/97 --------------------------------------------------
Rv0260c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0520|M.marinum_M --------------------------------------------------
MUL_1183|M.ulcerans_Agy99 --------------------------------------------------
MAV_4900|M.avium_104 --------------------------------------------------
MAB_3520c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0582|M.thermoresistible__bu --------------------------------------------------
MLBr_02420|M.leprae_Br4923 MVGATMTTRGRKLRPGRITFVGAGPGAPGLLTAQAVAVLANAALVFIDPD
Mvan_0301|M.vanbaalenii_PYR-1 -----------MSEPDWAPLTGFRVAVTSARRADELSALLRRRGATVCSA
Mflv_0380|M.gilvum_PYR-GCK -----------MTDPDWAPLTGFRVAVTSARRADELAALLRRRGATVTSA
MSMEG_0432|M.smegmatis_MC2_155 -----------MREPDWAPLTGFRVAVTSARRADELCALLRRRGATVTSA
Mb0266c|M.bovis_AF2122/97 -----------MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSA
Rv0260c|M.tuberculosis_H37Rv -----------MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSA
MMAR_0520|M.marinum_M -----------MAQQKSEPLRGYRIAVTSSRRAEELCALLRRHGADVCSA
MUL_1183|M.ulcerans_Agy99 -----------MAQQKSEPLRGYRIAVTSSRRAEELCALLRRHGADVCSA
MAV_4900|M.avium_104 -------MAPQLAPPDSAPLTGYRIAVTSANRAEELCALLRRNGAEVTSA
MAB_3520c|M.abscessus_ATCC_199 ----------MPRNEPERRLDGFTIGVTAARRSEELIALLERRGAAVVHA
TH_0582|M.thermoresistible__bu -------------------LAGFTVGVTAARRAEELITLLERRGANVVHA
MLBr_02420|M.leprae_Br4923 VPEPVLALIGKDLPPVSGPAPAGPAAVTAGRAADGTLEGDHYQAAPMVMS
. .**:.. :: . ..* : :
Mvan_0301|M.vanbaalenii_PYR-1 AAIEMVPLP-DDDELRQHTRSLIASPPDIVIATTG-----IGFRGWVAAA
Mflv_0380|M.gilvum_PYR-GCK AAIEMVPLP-DDDELRQRTQSLIDAPPDIVIATTG-----IGFRGWVAAA
MSMEG_0432|M.smegmatis_MC2_155 PAITMVPLP-DDDELRAHTESLITDPPDIVVATTG-----IGLRGWIAAA
Mb0266c|M.bovis_AF2122/97 PAIKMIALP-DDDELQNNTEALIADPPDILVAHTG-----IGFRGWLAAA
Rv0260c|M.tuberculosis_H37Rv PAIKMIALP-DDDELQNNTEALIADPPDILVAHTG-----IGFRGWLAAA
MMAR_0520|M.marinum_M PAINMIALP-EDDELQGNTEALIANPPDILVAHTG-----IGFRGWVAAA
MUL_1183|M.ulcerans_Agy99 PAINMIALP-EDDELQGNTEALIANPPDILVAHTG-----IGFRGWVAAA
MAV_4900|M.avium_104 AAINIIALP-EDQELHRHTEAVITQPPDILVAHTG-----IGFRGWVAAA
MAB_3520c|M.abscessus_ATCC_199 AAIRIIPLA-DDAELRDATELVIANPPDLTVATTG-----IGFRGWIEAA
TH_0582|M.thermoresistible__bu PAIRIVPLV-DDDELRRVTAGLIEAPPDLVLVTTG-----IGFRGWVEAA
MLBr_02420|M.leprae_Br4923 GGADIRPALGDPTEVAKTLTAEARSGVDVVRLVAGDPLTVDAVIAEVNAV
. : . : *: *: :* .. . : *.
Mvan_0301|M.vanbaalenii_PYR-1 DGWGMATELTAALSNARIVS----------------RGPKATGALRAAGL
Mflv_0380|M.gilvum_PYR-GCK DGWGMAADLTTALSTARIVS----------------RGPKATGALRAAGL
MSMEG_0432|M.smegmatis_MC2_155 DGWGLAGELTEALGKARIVS----------------RGPKATGALRAAGL
Mb0266c|M.bovis_AF2122/97 EGWGLANELLESLSSARIIS----------------RGPKATGALRAAGL
Rv0260c|M.tuberculosis_H37Rv EGWGLANELLESLSSARIIS----------------RGPKATGALRAAGL
MMAR_0520|M.marinum_M EGWGLAGELVDALSVGRTIS----------------RGPKATGELRAAGL
MUL_1183|M.ulcerans_Agy99 EGWGLAGELVDALSVGRTIS----------------RGPKATGELRAAGL
MAV_4900|M.avium_104 DGWGLAPQLLSALSQARIVA----------------RGPKATGALRAAGL
MAB_3520c|M.abscessus_ATCC_199 DEWGVADGLKSALESGRLVA----------------RGPKATGAIRQAGL
TH_0582|M.thermoresistible__bu HGWDVSDELTAALASTRILA----------------RGPKARGAVRQAGL
MLBr_02420|M.leprae_Br4923 ARTNLQIEIVPGLVTSSVVPTYAGLPLGSSHTVADVRGDVDWEALAAAPG
.: : .* :. ** : *
Mvan_0301|M.vanbaalenii_PYR-1 PEEWSPESESSRELLHYLVEGGIAGTR---------------IAVQLHGA
Mflv_0380|M.gilvum_PYR-GCK PEEWSPESESSRELLHYLVEGGIAGTR---------------IAVQLHGA
MSMEG_0432|M.smegmatis_MC2_155 PEEWSPDSESSREVVRYLVEHGVDGRR---------------IAVQLHGA
Mb0266c|M.bovis_AF2122/97 REEWSPDSESSHEVLEYLLESGVSRTR---------------IAVQLHGA
Rv0260c|M.tuberculosis_H37Rv REEWSPDSESSHEVLEYLLESGVSRTR---------------IAVQLHGA
MMAR_0520|M.marinum_M REEWSPESESSQEVLEYLLESGVAGQR---------------IAIQLHGA
MUL_1183|M.ulcerans_Agy99 REEWSPESESSQEVLEYLLESGVAGQR---------------IAIQLHGA
MAV_4900|M.avium_104 HEEWSPKSESSREVLRYLLDSGVAGKR---------------IAVQLHGA
MAB_3520c|M.abscessus_ATCC_199 REEWSPASESSAEVLDRLLEEGVEGRR---------------IAVQLHGA
TH_0582|M.thermoresistible__bu CEEWSPGSESSAEVLQRLLADGVDGLR---------------IAVQLHGA
MLBr_02420|M.leprae_Br4923 PLILQATASHLADAAHILIDHGLDDATPCVVTAQGTTCQQRSVETTLEGL
.. :. : *: *: : *.*
Mvan_0301|M.vanbaalenii_PYR-1 TA------------------------------------------------
Mflv_0380|M.gilvum_PYR-GCK TA------------------------------------------------
MSMEG_0432|M.smegmatis_MC2_155 TD------------------------------------------------
Mb0266c|M.bovis_AF2122/97 AD------------------------------------------------
Rv0260c|M.tuberculosis_H37Rv AD------------------------------------------------
MMAR_0520|M.marinum_M AD------------------------------------------------
MUL_1183|M.ulcerans_Agy99 AD------------------------------------------------
MAV_4900|M.avium_104 AD------------------------------------------------
MAB_3520c|M.abscessus_ATCC_199 AT------------------------------------------------
TH_0582|M.thermoresistible__bu AS------------------------------------------------
MLBr_02420|M.leprae_Br4923 ADSAVLVGTDTAGPLTGPLVVTIGKTVTSRARLNWWESRALYGWTVLVPR
:
Mvan_0301|M.vanbaalenii_PYR-1 DWDPFPEFLDELRAAGAEVVPIRVYRWHPAPRNGEFDQLVAGIADEKFDA
Mflv_0380|M.gilvum_PYR-GCK EWDPFPEFLDELRAAGAEVVPIRVYRWHPAPRNGDFDQLVAGIAEEKFDA
MSMEG_0432|M.smegmatis_MC2_155 DWDPFPEFLDELRVAGAEVVPIRVYRWHPAPPGGEFDQLVAGIAERRFDA
Mb0266c|M.bovis_AF2122/97 SWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLGGVFDHLVTGIARRQFDA
Rv0260c|M.tuberculosis_H37Rv SWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLGGVFDHLVTGIARRQFDA
MMAR_0520|M.marinum_M GWDPFPEFVGGLRAAGAEVVPIRVYRWKPTPLGGAFDQLVTEIARRQFDA
MUL_1183|M.ulcerans_Agy99 GWDPFPEFVGGLRAAGAEVVPIRVSRWKPTPLGGAFDQLVTEIARRQFDA
MAV_4900|M.avium_104 GWDPFPEFINGLRSAGAQVMPIHVYRWKPTPAGGEFDQLVASVARRQFDA
MAB_3520c|M.abscessus_ATCC_199 EWEPIADLCEALTIAGAQVIRVPVYRWEPPEDQRPMDRLISMAINAELDG
TH_0582|M.thermoresistible__bu EWEPGTDICEALARAGAQVIKVPVYRWQPAQDCRRGEQLITAILDADLDA
MLBr_02420|M.leprae_Br4923 TKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW
: :: * ** : : . .*. :: : ::
Mvan_0301|M.vanbaalenii_PYR-1 VSFTSAPAVASVLLRATEMGLEAEVLSALRTNVHAMCVGPVTARPLVRLG
Mflv_0380|M.gilvum_PYR-GCK VSFTSAPAVASVLLRATEMGLEAEVLSALRNGVHAMCVGPVTARPLVRLG
MSMEG_0432|M.smegmatis_MC2_155 VSFTSAPAVASVLMRATELGLTEQVVSALRTDVHAMCVGPVTARPLVRLG
Mb0266c|M.bovis_AF2122/97 VTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTSRPLIRKG
Rv0260c|M.tuberculosis_H37Rv VTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTSRPLIRKG
MMAR_0520|M.marinum_M VSFTSAPAAAAVLERGRELDIEEELLEALRNDVHAMCVGPVTSRPLIRKG
MUL_1183|M.ulcerans_Agy99 VSFTSAPAAAAVLERGRELDIEEELLEALRNDVHAMCVGPVTSRPLIRKG
MAV_4900|M.avium_104 VTFTSAPAGAALLERSRELGIEDQLLQALRSDVHAMCVGPVTAQPLIRAG
MAB_3520c|M.abscessus_ATCC_199 ISFTSAPAVASMLGRAKATGRLDELLAALRARVAPLCVGPVTAAPLEVLG
TH_0582|M.thermoresistible__bu VSFTSAPAVAAVLQRAKTLGVLDDLIAALRTEVAVFCVGPVTATPLRRIG
MLBr_02420|M.leprae_Br4923 VVFTSTNAVRAVWEKFGEFGLDARAFSGVK----IACVGEATADRVRAFG
: ***: * :: : . . .:: *** .*: : *
Mvan_0301|M.vanbaalenii_PYR-1 VP---TSAPERMRLGALARH----------------ITDELPLLQTRTVR
Mflv_0380|M.gilvum_PYR-GCK VP---TSAPERMRLGALARH----------------ITDELPLLQARTVR
MSMEG_0432|M.smegmatis_MC2_155 IP---TSAPERMRLGALARH----------------ITDELPLLQSRTLR
Mb0266c|M.bovis_AF2122/97 VP---TSAPERMRLGALARH----------------IAEELPLLGSCTFK
Rv0260c|M.tuberculosis_H37Rv VP---TSAPERMRLGALARH----------------IAEELPLLGSCTFK
MMAR_0520|M.marinum_M VP---TSSPERMRLGALARH----------------IAEELPLLGSCTVN
MUL_1183|M.ulcerans_Agy99 VP---TSSPERLRLGALARH----------------IAEELPLLGSCTVN
MAV_4900|M.avium_104 VP---TSSPERMRLGALARH----------------IAQELPPLRSCTLR
MAB_3520c|M.abscessus_ATCC_199 VP---TTQPERARLGALARH----------------IADELTRR-APRFH
TH_0582|M.thermoresistible__bu VD---ARHPQRYRLGALARL----------------ITDELPGL-ARQYR
MLBr_02420|M.leprae_Br4923 ISPELVPAGEQSSLGLLDEFPPYDSVFDPVNRVLLPRADIATETLAEGLR
: . :: ** * . :: . : .
Mvan_0301|M.vanbaalenii_PYR-1 VAGHLLEIRGTC--------------VLVDGTVKELSPSAMATIRALALR
Mflv_0380|M.gilvum_PYR-GCK VAGHLLEIRGTC--------------VLVDGTVKALSPAAMATIRALALK
MSMEG_0432|M.smegmatis_MC2_155 VAGHLLEIRGTC--------------VLVDGVVKSLSPAGMATIRALAHR
Mb0266c|M.bovis_AF2122/97 AAGHVIEIRGTS--------------VLVDDSVKPLSPSGMAILRALVHR
Rv0260c|M.tuberculosis_H37Rv AAGHVIEIRGTS--------------VLVDDSVKPLSPSGMAILRALVHR
MMAR_0520|M.marinum_M AAGHVVDIRGTC--------------VLVDGSIKTLSGSGMAILRALTKR
MUL_1183|M.ulcerans_Agy99 AAGHVVDIRGTC--------------VLVDGSIKTLSGSGMAILRALTKR
MAV_4900|M.avium_104 AAGHQIEIRGTC--------------VLVDGAVKSLSGSAMATLRALAAR
MAB_3520c|M.abscessus_ATCC_199 AGGHIVSVRSCG--------------IAVDGETRQISPAGMALMKRLMVR
TH_0582|M.thermoresistible__bu AGGHHLSVRNGS--------------VEVDGELKVLPPAAMALLRRLLAT
MLBr_02420|M.leprae_Br4923 GCGWEIEDVTAYRTVRAAPPPAATREMIKTGGFDAVCFTSSSTVRNLVGI
* :. : . : :. : :: *
Mvan_0301|M.vanbaalenii_PYR-1 PGAVVSRVDLLRALPGSGTDTHAVETAVLRLRTALGDKKMVSTVVKRGYR
Mflv_0380|M.gilvum_PYR-GCK PGAVVSRTDLLRALPGSGTDTHAVETAVLRLRAALGDKKMVSTVVKRGYR
MSMEG_0432|M.smegmatis_MC2_155 PGAVVSRFDLLGALPGSGTDTHAVETAVLRLRTALGDKSIVSTVVKRGYR
Mb0266c|M.bovis_AF2122/97 PGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVKRGYR
Rv0260c|M.tuberculosis_H37Rv PGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVKRGYR
MMAR_0520|M.marinum_M PGDVVARSELLNVLPGNGDDTHAVDTAVLRLRTALGDKNIIATVVKRGYR
MUL_1183|M.ulcerans_Agy99 PGDVVARSELLNVLPGNGDDTHAVDTAVLRLRTALGDKNIIATVVKRGYR
MAV_4900|M.avium_104 PGDVVARNDLLRVLPGNSNDPHAVDTAVLRLRTALGDKNIIATVVKRGYR
MAB_3520c|M.abscessus_ATCC_199 PGQVVSREDLLAALPGGGDDTHAVETAMTRLRAALGAPKVIQTVVKRGYR
TH_0582|M.thermoresistible__bu PGMVVSREELLAELPGGGDETHAVETAMARLRSALSAPQVVQTVVKRGYR
MLBr_02420|M.leprae_Br4923 AGKPHARTVIACIGPKTAETASEFGLRVDVQPETAAVGPLVDALAEHVAR
.* :* : * . . . : : . :: ::.:: *
Mvan_0301|M.vanbaalenii_PYR-1 LPVDEAFAS--------
Mflv_0380|M.gilvum_PYR-GCK LPVDEAFAS--------
MSMEG_0432|M.smegmatis_MC2_155 LAVDDTDTEMARAL---
Mb0266c|M.bovis_AF2122/97 LAVDSRHDDV-------
Rv0260c|M.tuberculosis_H37Rv LAVDSRHDDV-------
MMAR_0520|M.marinum_M LALDTQDDTACT-----
MUL_1183|M.ulcerans_Agy99 LALDTQDDTACT-----
MAV_4900|M.avium_104 LAIDTPDGSAWH-----
MAB_3520c|M.abscessus_ATCC_199 LAIDPTTIGECHG----
TH_0582|M.thermoresistible__bu LAVDPAAT---------
MLBr_02420|M.leprae_Br4923 LRAEGALPPPRKKSRRR
* :