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M. tuberculosis H37Rv Rv0230c (php)

annotation: PROBABLE PHOSPHOTRIESTERASE PHP (PARATHION HYDROLASE) (PTE) (ARYLDIALKYLPHOSPHATASE) (PARAOXONASE) (A-ESTERASE) (ARYLTRIPHOSPHATASE) (PARAOXON HYDROLASE)
coordinates: 274983 - 275963
length: 326

PELNTARGPIDTADLGVTLMHEHVFIMTTEIAQNYPEAWGDEDKRVAGAIARLGELKARGVDTIVDLTVI
GLGRYIPRIARVAAATELNIVVATGLYTYNDVPFYFHYLGPGAQLDGPEIMTDMFVRDIEHGIADTGIKA
GILKCATDEPGLTPGVERVLRAVAQAHKRTGAPISTHTHAGLRRGLDQQRIFAEEGVDLSRVVIGHCGDS
TDVGYLEELIAAGSYLGMDRFGVDVISPFQDRVNIVARMCERGHADKMVLSHDACCYFDALPEELVPVAM
PNWHYLHIHNDVIPALKQHGVTDEQLHTMLVDNPRRIFERQGGYQ*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv0230c php - 100% (326) PROBABLE PHOSPHOTRIESTERASE PHP (PARATHION HYDROLASE) (PTE) (ARYLDIALKYLPHOSPHATASE) (PARAOXONASE) (A-ESTERASE) (ARYLTRIPHOSPHATASE) (PARAOXON HYDROLASE)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0235c php 0.0 99.69% (326) phosphotriesterase
M. gilvum PYR-GCK - - - - -
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 - - - - -
M. marinum M MMAR_0487 php 1e-172 88.65% (326) phosphotriesterase PHP
M. avium 104 MAV_4940 - 1e-166 92.79% (305) phosphotriesterase-like protein
M. smegmatis MC2 155 MSMEG_0320 - 1e-153 79.08% (325) putative phosphotriesterase
M. thermoresistible (build 8) TH_1316 - 1e-152 79.19% (322) PROBABLE PHOSPHOTRIESTERASE PHP (PARATHION HYDROLASE) (PTE)
M. ulcerans Agy99 MUL_1150 php 1e-172 88.96% (326) phosphotriesterase PHP
M. vanbaalenii PYR-1 - - - - -

CLUSTAL 2.0.9 multiple sequence alignment


Rv0230c|M.tuberculosis_H37Rv        --MPELNTARGPIDTADLGVTLMHEHVFIMTTEIAQNYPEAWGDEDKRVA
Mb0235c|M.bovis_AF2122/97           --MPELNTARGPIDTADLGVTLMHEHVFIMTTEIAQNYPEAWGDEDKRVA
MAV_4940|M.avium_104                ----------------------MHEHVFIMTTEIAQNYPEAWGDEEQRVA
MMAR_0487|M.marinum_M               --MSALNTARGPIDTADLGVTLMHEHVFIMTTEVAQNYPEAWGDEEKRVA
MUL_1150|M.ulcerans_Agy99           --MSALNTARGPIDTADLGVTLMHEHVFIMTTEIAQNYPEAWGDEEKRVA
MSMEG_0320|M.smegmatis_MC2_155      --MPTVNTAAGAIDTADLGVTLMHEHVFIMTTEVMLNHPESWGDEHRREA
TH_1316|M.thermoresistible__bu      MGRRTVNTAGGSIDTADLGVTLMHEHVFVLTTEIAVNYPERWGDGARREA
                                                          ******::***:  *:** ***  :* *

Rv0230c|M.tuberculosis_H37Rv        GAIARLGELKARGVDTIVDLTVIGLGRYIPRIARVAAATELNIVVATGLY
Mb0235c|M.bovis_AF2122/97           GAIARLGELKARGVDTIVDLTVIGLGRYIPRIARVAAATELNIVVATGLY
MAV_4940|M.avium_104                DAIDRLNELKARGVDTIVDLTVIGLGRYIPRIARVAAATELNIVVATGLY
MMAR_0487|M.marinum_M               DAITRLNELKSRGVDTIVDLTVIGLGRYIPRIARIAAATDLNIVVATGLY
MUL_1150|M.ulcerans_Agy99           DAITRLNELKSRGVDTIVDLTVIGLGRYIPRIARIAAATDLNIVVATGLY
MSMEG_0320|M.smegmatis_MC2_155      DAIVRLGELKARGVDTIVDLTVIGLGRYIPRIARIAEATELNIVVATGLY
TH_1316|M.thermoresistible__bu      DAVARLDELKSRGVDTIVDLTVIGLGRDLPRIVRIAEQTDLNIVVATGLY
                                    .*: **.***:**************** :***.*:*  *:**********

Rv0230c|M.tuberculosis_H37Rv        TYNDVPFYFHYLGPGAQLDGPEIMTDMFVRDIEHGIADTGIKAGILKCAT
Mb0235c|M.bovis_AF2122/97           TYNDVPFYFHYLGPGAQLDGPEIMTDMFVRDIEHGIADTGIKAGILKCAT
MAV_4940|M.avium_104                TYNDVPFYFHYLGPGAELGGPEIMTDMFVRDIEQGIADTGIKAGILKCAT
MMAR_0487|M.marinum_M               TYNDVPYRFHYQGPGGMLDGPEIMTDMFVRDIEQGIADTGVKAGILKCAT
MUL_1150|M.ulcerans_Agy99           TYNDVPYRFHYQGPGGMLDGPEIMTDMFVRDIEQGIADTGVKAGILKCAT
MSMEG_0320|M.smegmatis_MC2_155      TYNDIPMTFHFRGPGTALDGDEPMAEMFVRDIEKGIADTGIKAAILKCAT
TH_1316|M.thermoresistible__bu      TYNDVPFCFSLQGPGTELDGPESMTDMFVRDIEHGIADTGVKAAVLKCAT
                                    ****:*  *   ***  *.* * *::*******:******:**.:*****

Rv0230c|M.tuberculosis_H37Rv        DEPGLTPGVERVLRAVAQAHKRTGAPISTHTHAGLRRGLDQQRIFAEEGV
Mb0235c|M.bovis_AF2122/97           DEPGLTPGVERVLRAVAQAHKRTGAPISTHTHAGLRRGLDQQRIFAEEGV
MAV_4940|M.avium_104                DAPGVTPGVERVLRAVAQAHKRTGVPISTHTHAGLRRGLDQQRIFEEEGV
MMAR_0487|M.marinum_M               DEPGITPGVERVLRAVAQTHKRTGVPISTHTHAGLRRGLEQQRIFEEEGV
MUL_1150|M.ulcerans_Agy99           DEPGITPGVERVLRAVAQTHKRTGVPISTHTHAGLRRGLEQQRIFEEEGV
MSMEG_0320|M.smegmatis_MC2_155      DEPGVTPGVERVLRAVAAAHRQTGVPISTHTHAATRRGLEQQRVFAEEGV
TH_1316|M.thermoresistible__bu      DKPGVTAGVDRVLRAVAQAHRRTGVPISTHTHAASRRGLDQQRVFAEEGV
                                    * **:*.**:******* :*::**.********. ****:***:* ****

Rv0230c|M.tuberculosis_H37Rv        DLSRVVIGHCGDSTDVGYLEELIAAGSYLGMDRFGVDVISPFQDRVNIVA
Mb0235c|M.bovis_AF2122/97           ELSRVVIGHCGDSTDVGYLEELIAAGSYLGMDRFGVDVISPFQDRVNIVA
MAV_4940|M.avium_104                DLSRVVIGHSGDSTDVGYLEELIAAGSYLGMDRFGIDAISPFEDRVNIVA
MMAR_0487|M.marinum_M               DLSRVIIGHSGDSTDVGYLEELIAAGSYLGMDRFGIDLILPFEDRVSIVA
MUL_1150|M.ulcerans_Agy99           DLSRVIIGHSGDSTDVGYLEELIAAGSYLGMDRFGIDLILPFEDRVNIVA
MSMEG_0320|M.smegmatis_MC2_155      DLTRVIIGHCGDTTDIGYLEELIANGSYIGMDRFGVDVFLPFEQRVATVA
TH_1316|M.thermoresistible__bu      DLSRVVIGHCGDTTDIGYLEQLIANGSYIGMDRFGVDTFLSFEDRVNTVA
                                    :*:**:***.**:**:****:*** ***:******:* : .*::**  **

Rv0230c|M.tuberculosis_H37Rv        RMCERGHADKMVLSHDACCYFDALPEELVPVAMPNWHYLHIHNDVIPALK
Mb0235c|M.bovis_AF2122/97           RMCERGHADKMVLSHDACCYFDALPEELVPVAMPNWHYLHIHNDVIPALK
MAV_4940|M.avium_104                QMCERGHADKMVLSHDANCYFDALPEELVPQVMPNWHYLHIHNDVIPALK
MMAR_0487|M.marinum_M               TMCERGHADKMVLSHDANCYFDALPEELTAVATPNWHYLHIHNDVIPALK
MUL_1150|M.ulcerans_Agy99           TMCERGHADKMVLSHDANCYFDALPEELTAVATPNWHYLHIHNDVIPALK
MSMEG_0320|M.smegmatis_MC2_155      TMCERGHAERMVLSHDTWCYFDALPDELTTAALPNSHYLHIHNDVIPALR
TH_1316|M.thermoresistible__bu      KMCELGYADRMVLSHDAHCYFDWLPEQLVAAGLPNWHYLHIHDDVIPALK
                                     *** *:*::******: **** **::*..   ** ******:******:

Rv0230c|M.tuberculosis_H37Rv        QHGVTDEQLHTMLVDNPRRIFERQGGYQ
Mb0235c|M.bovis_AF2122/97           QHGVTDEQLHTMLVDNPRRIFERQGGYQ
MAV_4940|M.avium_104                QRGVTDEQLHTMLVDNPRRIFERQGPYG
MMAR_0487|M.marinum_M               ERGVTDEQVHTMLVDNPRRIFERQGGYQ
MUL_1150|M.ulcerans_Agy99           ERGVTHEQVHTMLVDNPRRIFERQGGYQ
MSMEG_0320|M.smegmatis_MC2_155      QRGVTDEQITTMLVDNPRRIFEHKGGY-
TH_1316|M.thermoresistible__bu      QRGVTDEQLTTMLVDNPRRIFETQGGY-
                                    ::***.**: ************ :* *

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv0230c	php	-	100% (326)	PROBABLE PHOSPHOTRIESTERASE PHP (PARATHION HYDROLASE) (PTE) (ARYLDIALKYLPHOSPHATASE) (PARAOXONASE) (A-ESTERASE) (ARYLTRIPHOSPHATASE) (PARAOXON HYDROLASE)