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MRTIETGDLWWKNAVVYCADIETFYDWNGDGCGDIRGMTERIEYLADLGITCLWLMPFYPTARKDDGYDI TDFFGVDERLGNLGDFVELIRTAGSHGIRVIVDFVMNHTSDAHPWFKSARRGTDDPYRDYYVWTATEPPD TSEDVVFPDQEDSLWELDPKTGQWYLHHFYKHQPDLNIANPQVQEEISRTLGFWLQLGVAGFRVDAVPFL FARDGAPGDPGVFDPFQYLGDVRNFVTRRVGDAVLLGEVNVPYKDQKAFFGGSDGDGLNMQFDFIGMQSM YLSLARGDARPLAKALRSRPSLDVTSQWANFARNHDELTLDKLSDSERQEVFDAFGPDPDMQLYDRGLRR RLPSMLGADQRRMRMVYSLAFSLPGTPVLFYGEEIGMAENLDVPGRFAVRTPMQWTSGTNGGFSTAPKRR LPRPLPEGLFGPDRVNVADQRRDHRSFWWFVRDLIYTYRQQPEIGWSTVEILKQPHTAVLAHVCRESSGW AMVGLHNFGADGCLVPLTLGDLPEGSRLVDLLDGRAEFPVDARGGIELSLEGYGYRWLRLLRPDDPPII
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3723 | - | - | 100% (559) | alpha amylase, catalytic region |
| M. gilvum PYR-GCK | Mflv_3849 | - | 9e-49 | 30.98% (468) | alpha amylase, catalytic region |
| M. gilvum PYR-GCK | Mflv_3333 | - | 6e-10 | 25.76% (198) | alpha amylase, catalytic region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0131 | treS | 1e-106 | 38.76% (547) | trehalose synthase TRES |
| M. tuberculosis H37Rv | Rv0126 | treS | 1e-106 | 38.76% (547) | trehalose synthase TRES |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1565c | - | 7e-37 | 27.39% (555) | Alpha-amylase family protein |
| M. marinum M | MMAR_0325 | treS | 1e-108 | 39.57% (556) | trehalose synthase TreS |
| M. avium 104 | MAV_5186 | treS | 1e-105 | 38.74% (555) | trehalose synthase |
| M. smegmatis MC2 155 | MSMEG_6515 | treS | 1e-107 | 38.49% (569) | trehalose synthase |
| M. thermoresistible (build 8) | TH_1780 | treS | 1e-106 | 38.82% (559) | trehalose synthase |
| M. ulcerans Agy99 | MUL_4797 | treS | 1e-107 | 39.39% (556) | trehalose synthase TreS |
| M. vanbaalenii PYR-1 | Mvan_2546 | - | 7e-48 | 31.09% (460) | alpha amylase, catalytic region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0131|M.bovis_AF2122/97 ---MNEAEHSVEHPPVQGSHVEGG----VVEHPDAKDFGSAAALPADPTW
Rv0126|M.tuberculosis_H37Rv ---MNEAEHSVEHPPVQGSHVEGG----VVEHPDAKDFGSAAALPADPTW
MMAR_0325|M.marinum_M --MMNEATNTIEHNPAEGSHVEGG----VVEHPDAKDFGNAAALPADPTW
MUL_4797|M.ulcerans_Agy99 MELMNEATNTIEHNPAEGSHVEGG----MVEHPDAKDFGNAAPLPADPTW
MAV_5186|M.avium_104 ---MNDAREAVEHHPEEGSHVQDG----VVEHPEAEDFDNAAALPTDPTW
MSMEG_6515|M.smegmatis_MC2_155 ----------MEEH-TQGSHVEAG----IVEHPNAEDFGHARTLPTDTNW
TH_1780|M.thermoresistible__bu MESTSEPDRRTEHHRSEGSHVEHGPAGSVVEHPTADDFGQARVLPEDPTW
Mflv_3723|M.gilvum_PYR-GCK ----------------------------------------MRTIETGDLW
MAB_1565c|M.abscessus_ATCC_199 -------------------------------------MTAAYLGQHDDPW
Mvan_2546|M.vanbaalenii_PYR-1 -----------------------------MRKRLRTVWRSSPVAPEESPW
*
Mb0131|M.bovis_AF2122/97 FKHAVFYEVLVRAFFDASADGSGDLRGLIDRLDYLQWLGIDCIWLPPFYD
Rv0126|M.tuberculosis_H37Rv FKHAVFYEVLVRAFFDASADGSGDLRGLIDRLDYLQWLGIDCIWLPPFYD
MMAR_0325|M.marinum_M FKHAVFYEVLVRAFYDGTADGSGDLRGLMQRLDYLQWLGIDCIWLPPFYD
MUL_4797|M.ulcerans_Agy99 FKHAVFYEVLVRAFYDGTADGSGDLRGLMQRLDYLQWLGIDCIWLPPFYD
MAV_5186|M.avium_104 FKHAVFYEVLVRAFFDANADGAGDLRGLLAQLDYLQWLGIDCIWLPPFYD
MSMEG_6515|M.smegmatis_MC2_155 FKHAVFYEVLVRAFYDSNADGIGDLRGLTEKLDYIKWLGVDCLWLPPFYD
TH_1780|M.thermoresistible__bu YKHAVFYEVLVRAFYDSNADGIGDLRGLTEQLDYLKWLGVDCLWLPPFYD
Mflv_3723|M.gilvum_PYR-GCK WKNAVVYCADIETFYDWNGDGCGDIRGMTERIEYLADLGITCLWLMPFYP
MAB_1565c|M.abscessus_ATCC_199 WSRAVFYQIYPRSFGDSDGDGVGDIDGISAKLGYLDLLGVEGIWLNPVTR
Mvan_2546|M.vanbaalenii_PYR-1 WQTAVVYQVYIRSFADGNGDGVGDIAGLRARLPYLARLGVDAMWINPWYP
:. **.* .:* * .** **: *: :: *: **: :*: *
Mb0131|M.bovis_AF2122/97 SPLRDGGYDIRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMNHTS
Rv0126|M.tuberculosis_H37Rv SPLRDGGYDIRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMNHTS
MMAR_0325|M.marinum_M SPLRDGGYDIRDFYKVLPEFGTVGDFVALVDAAHRRGIRVITDLVMNHTS
MUL_4797|M.ulcerans_Agy99 SPLRDGGYDIRDFYKVLPEFGTVGDFVALVDAAHRRGIRVITDLVMNHTS
MAV_5186|M.avium_104 SPLRDGGYDIRDFYKVLPEFGTVEDFVALLNAAHERGIRVITDLVMNHTS
MSMEG_6515|M.smegmatis_MC2_155 SPLRDGGYDIRDFYKVLPEFGTVDDFVTLLDAAHRRGIRIITDLVMNHTS
TH_1780|M.thermoresistible__bu SPLRDGGYDIRDFYKVLPEFGTVDDFVNLLDAAHRRGIRIITDLVMNHTS
Mflv_3723|M.gilvum_PYR-GCK TARKDDGYDITDFFGVDERLGNLGDFVELIRTAGSHGIRVIVDFVMNHTS
MAB_1565c|M.abscessus_ATCC_199 SPMADHGYDVSNPREIDPLFGGSIAMHRLIASAHRHNIKVIMDLVPNHTS
Mvan_2546|M.vanbaalenii_PYR-1 SPMADAGYDVADYRDIEPAYGTLEDARALIAEAHALGIRVILDIVPNHTS
:. * ***: : : * *: * .*::* *:* ****
Mb0131|M.bovis_AF2122/97 ESHPWFQESRRDPDGP-YGDYYVWSDTSERY-----TDARIIFVDTEESN
Rv0126|M.tuberculosis_H37Rv ESHPWFQESRRDPDGP-YGDYYVWSDTSERY-----TDARIIFVDTEESN
MMAR_0325|M.marinum_M ESHPWFQESRHDPDGP-YGDYYVWSDSSEKY-----TDARIIFVDTEESN
MUL_4797|M.ulcerans_Agy99 ESHPWFQESRHDPDGP-YGDYYVWSDSSEKY-----TDARIIFVDTEESN
MAV_5186|M.avium_104 ESHPWFQESRHDPDGP-YGDFYVWSDTSDRY-----ADARIIFVDTEESN
MSMEG_6515|M.smegmatis_MC2_155 DQHEWFQESRHNPDGP-YGDFYVWSDTSDRY-----PDARIIFVDTEESN
TH_1780|M.thermoresistible__bu DTHPWFEESRRDPDGP-YGDFYVWSDTAEKY-----SQARIIFVDTEESN
Mflv_3723|M.gilvum_PYR-GCK DAHPWFKSARRGTDDP-YRDYYVWTATEPPD-----TSEDVVFPDQEDSL
MAB_1565c|M.abscessus_ATCC_199 SEHPWFLEALQSPPGSDARERYIFRDGKGAHGELPPNNWPSVFGGPAWTR
Mvan_2546|M.vanbaalenii_PYR-1 DQHAWFRAALAGESG--ARRRYHFLAGRGADGELPPNDWQSVFGGPAWTR
. * ** : . . * : . :* . :
Mb0131|M.bovis_AF2122/97 WSFDP-VRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVIRFWLGLGIDGFR
Rv0126|M.tuberculosis_H37Rv WSFDP-VRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVIRFWLGLGIDGFR
MMAR_0325|M.marinum_M WTFDP-VRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVLRFWLGLGIDGFR
MUL_4797|M.ulcerans_Agy99 WTFDP-VRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVLRFWLGLGIDGFR
MAV_5186|M.avium_104 WTFDP-VRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVIRFWLGLGIDGFR
MSMEG_6515|M.smegmatis_MC2_155 WTFDP-VRRQFYWHRFFSHQPDLNYDNPAVQEAMLDVLRFWLDLGIDGFR
TH_1780|M.thermoresistible__bu WTFDP-VRRQFYWHRFFSHQPDLNYDNPAVQEAMLDVLRFWLDLGIDGFR
Mflv_3723|M.gilvum_PYR-GCK WELDP-KTGQWYLHHFYKHQPDLNIANPQVQEEISRTLGFWLQLGVAGFR
MAB_1565c|M.abscessus_ATCC_199 VTEADGTPGQWYLHLFAPEQPDVNWDNPEVFDDFADTLRFWLDRGIDGFR
Mvan_2546|M.vanbaalenii_PYR-1 VDRGP-LEGQWYLHLFAPGQPDLNWENDEVRAEFEDILAFWFDRGVDGFR
*:* * * ***:* * * : : **: *: ***
Mb0131|M.bovis_AF2122/97 LDAVP-------------------YLFEREGTNCEN-LPETHAFLKRVRK
Rv0126|M.tuberculosis_H37Rv LDAVP-------------------YLFEREGTNCEN-LPETHAFLKRVRK
MMAR_0325|M.marinum_M LDAVP-------------------YLFEREGTNCEN-LPETHAFLKRVRK
MUL_4797|M.ulcerans_Agy99 LDAVP-------------------YLFEREGTNCEN-LPETHAFLKRVRK
MAV_5186|M.avium_104 LDAVP-------------------YLFEREGTNCEN-LPETHAFLKRVRK
MSMEG_6515|M.smegmatis_MC2_155 LDAVP-------------------YLFEREGTNCEN-LPETHAFLKRCRK
TH_1780|M.thermoresistible__bu LDAVP-------------------YLFEREGTNCEN-LPETHAFLKRCRK
Mflv_3723|M.gilvum_PYR-GCK VDAVP-------------------FLFARDGAPGDPGVFDPFQYLGDVRN
MAB_1565c|M.abscessus_ATCC_199 LDVAHGMAKPPGLPD---IEDTETSMLHIADEDPRFNNEGVHEYHRKIRK
Mvan_2546|M.vanbaalenii_PYR-1 IDVAHGLVKAAGLPDGAGVDAEPHTLLQVQGRHPAWDQDGVHDIYRGWRA
:*.. :: . . *
Mb0131|M.bovis_AF2122/97 VVDDEFPGRVLLAEANQWPGDVVEYFGDPNTGGDECHMAFHFPLMPRIFM
Rv0126|M.tuberculosis_H37Rv VVDDEFPGRVLLAEANQWPGDVVEYFGDPNTGGDECHMAFHFPLMPRIFM
MMAR_0325|M.marinum_M VVDDEFPGRVLLAEANQWPADVVEYFGEASTGGDECHMAFHFPLMPRIFM
MUL_4797|M.ulcerans_Agy99 VVDDEFPGRLLLAEANQWPADVVEYFGEASTGGDECHMAFHFPLMPRIFM
MAV_5186|M.avium_104 VVDDEFPGRVLLAEANQWPADVVEYFGDPSTGGDECHMAFHFPLMPRIFM
MSMEG_6515|M.smegmatis_MC2_155 AIDDEYPGRVLLAEANQWPADVVAYFGDPDTGGDECHMAFHFPLMPRIFM
TH_1780|M.thermoresistible__bu VVDDEYPGRVLLAEANQWPADVVAYFGDPAVGGDECHMAFHFPLMPRIFM
Mflv_3723|M.gilvum_PYR-GCK FVTRRVGDAVLLGEVNVPYKDQKAFFG--GSDGDGLNMQFDFIGMQSMYL
MAB_1565c|M.abscessus_ATCC_199 VLDQYR-DVVAVGEIWVNDNTRFAEYVR----PDELHLGFNFKLVEADFD
Mvan_2546|M.vanbaalenii_PYR-1 VADRYAPERIFIAEAWVSSNARLARYLR----PDELHTAFQFDFLRTPWR
: :.* : * : *.* : :
Mb0131|M.bovis_AF2122/97 AVRRESRFPISEIIAQTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMY
Rv0126|M.tuberculosis_H37Rv AVRRESRFPISEIIAQTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMY
MMAR_0325|M.marinum_M AVRRESRFPISEILAKTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMY
MUL_4797|M.ulcerans_Agy99 AVRRESRFPISEILAKTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMY
MAV_5186|M.avium_104 AVRRESRFPISEILAQTPQIPEMAQWGIFLRNHDELTLEMVTDEERDYMY
MSMEG_6515|M.smegmatis_MC2_155 AVRRESRFPISEILAQTPPIPDTAQWGIFLRNHDELTLEMVTDEERDYMY
TH_1780|M.thermoresistible__bu AVRRESRFPISEILAQTPDIPETAQWGIFLRNHDELTLEMVTDEERDYMY
Mflv_3723|M.gilvum_PYR-GCK SLARGDARPLAKALRSRPSLDVTSQWANFARNHDELTLDKLSDSERQEVF
MAB_1565c|M.abscessus_ATCC_199 ADQIR--AAIQNSLAAVDSVGATPTWTLSNHDVEREVTRYGDGQ------
Mvan_2546|M.vanbaalenii_PYR-1 AQMLR--EVIDDAIDSAASVGAPPTWVLSNHDVTRTVTRFSRSQPAHLIE
: : . : : . * :: . . ..
Mb0131|M.bovis_AF2122/97 AEYAKDPRMKAN-VGIRRRLAPLLDNDRNQIELFTALLLSLPGSPVLYYG
Rv0126|M.tuberculosis_H37Rv AEYAKDPRMKAN-VGIRRRLAPLLDNDRNQIELFTALLLSLPGSPVLYYG
MMAR_0325|M.marinum_M AEYAKDPRMKAN-VGIRRRLAPLLENDRNQIQLFNALLLSLPGSPVLYYG
MUL_4797|M.ulcerans_Agy99 AEYAKDPRMKAN-VGIRRRLAPLLENDRNQIQLFNALLLSLPGSPVLYYG
MAV_5186|M.avium_104 AEYAKDPRMKAN-VGIRRRLAPLLDNDRNQIELFTALLLSLPGSPVLYYG
MSMEG_6515|M.smegmatis_MC2_155 AEYAKDPRMKAN-VGIRRRLAPLLENDRNQIELFTALLLSLPGSPVLYYG
TH_1780|M.thermoresistible__bu AEYAKDPRMKAN-VGIRRRLAPLLENDRNQIELFTALLLSLPGSPVIYYG
Mflv_3723|M.gilvum_PYR-GCK DAFGPDPDMQLYDRGLRRRLPSMLGADQRRMRMVYSLAFSLPGTPVLFYG
MAB_1565c|M.abscessus_ATCC_199 -------------------------IGQWRARAMALVMLALPGTVFIYNG
Mvan_2546|M.vanbaalenii_PYR-1 TDWERGRWEDER---------PDHALGRRRARAAALVQLALPGTAYVYQG
.: : . : ::***: :: *
Mb0131|M.bovis_AF2122/97 DEIGMGDVIWLGDRDGVRIPMQWTPDRNAGFSTANPGRLYLPPSQDPVYG
Rv0126|M.tuberculosis_H37Rv DEIGMGDVIWLGDRDGVRIPMQWTPDRNAGFSTANPGRLYLPPSQDPVYG
MMAR_0325|M.marinum_M DEIGMGDVIWLGDRDGVRTPMQWTPDRNAGFSTANPGRLYLPPSQDSVYG
MUL_4797|M.ulcerans_Agy99 DEIGMGDVIWLGDRDGVRTPMQWTPDRNAGFSTANPGRLYLPPSQDSVYG
MAV_5186|M.avium_104 DEIGMGDVIWLGDRDGVRTPMQWTPDRNAGFSKANPGRLYLPPSQDPVYG
MSMEG_6515|M.smegmatis_MC2_155 DEIGMGDIIWLGDRDSVRTPMQWTPDRNAGFSKATPGRLYLPPNQDAVYG
TH_1780|M.thermoresistible__bu DEIGMGDIIWLGDRDAVRTPMQWTPDRNAGFSKANPGRLYLPVNQDPIYG
Mflv_3723|M.gilvum_PYR-GCK EEIGMAENLDVPGRFAVRTPMQWTSGTNGGFSTAPKRRLPRPLPEG-LFG
MAB_1565c|M.abscessus_ATCC_199 SELGLPNVE-LPDEALQDPVWERS-----GHTERGRDGCRVPIPWEGTDP
Mvan_2546|M.vanbaalenii_PYR-1 EELGLEEVEDLPDEARQDPTWVQS-----GFTDVGRDGCRIPLPWTETSV
.*:*: : : .. : *.: *
Mb0131|M.bovis_AF2122/97 YQAVNVEAQRDTSTSLLNFTRTMLAVRRRHPAFAVGAFQELGGSNPSVLA
Rv0126|M.tuberculosis_H37Rv YQAVNVEAQRDTSTSLLNFTRTMLAVRRRHPAFAVGAFQELGGSNPSVLA
MMAR_0325|M.marinum_M YQAVNVEAQRDTSTSLLNWTRTMLAVRRRHNAFAVGTFQELGGSNPSILA
MUL_4797|M.ulcerans_Agy99 YQAVNVEAQRDTSTSLLNWTRTMLAVRRRHNAFAVGTFQELGGSNPSILA
MAV_5186|M.avium_104 YQAVNVEAQRDTSTSLLNFTRTMLAVRRRHEAFAIGTFEELGGSNPSVLA
MSMEG_6515|M.smegmatis_MC2_155 YHSVNVEAQLDSSSSLLNWTRNMLAVRSRHDAFAVGTFRELGGSNPSVLA
TH_1780|M.thermoresistible__bu YQSVNVEAQRDSSTSLLNWTRKMLAVRRRHRAFAVGDFRELGGSNPSVLA
Mflv_3723|M.gilvum_PYR-GCK PDRVNVADQRRDHRSFWWFVRDLIYTYRQQPEIGWSTVEILKQPHTAVLA
MAB_1565c|M.abscessus_ATCC_199 PYGFSSN-----AQTWLPMPHGWAEYTVERQLEHTDSMLSLYRRAIELRK
Mvan_2546|M.vanbaalenii_PYR-1 PYGFAAHP---AAVTWLPQPEHWAEHSVEAQERDPGSTLNLYRSALELRP
. : . . . * :
Mb0131|M.bovis_AF2122/97 YVRQVAG------DDGDTVLCVNNLSRFPQPIELDLQQWT-NYTPVELT-
Rv0126|M.tuberculosis_H37Rv YVRQVAG------DDGDTVLCVNNLSRFPQPIELDLQQWT-NYTPVELT-
MMAR_0325|M.marinum_M YVREAPGP---AGEDGDVVLCVNNLSRFPQPIELNLQQWN-SYTPVELT-
MUL_4797|M.ulcerans_Agy99 YVREAPGP---AGEDGDVVLCVNNLSRFPQPIELNLQQWN-SYTPVELT-
MAV_5186|M.avium_104 FVRQVSN-------DGDTVLCVNNLSRFPQPIELNLQHWS-GCIPVELT-
MSMEG_6515|M.smegmatis_MC2_155 YIREVTRQQGDGGAKTDAVLCVNNLSRFPQPIELNLQQWA-GYIPVEMT-
TH_1780|M.thermoresistible__bu FIRELEE---DG--QKDTVLCVNNLSRFPQPIELQLQNWS-GYTPVEMT-
Mflv_3723|M.gilvum_PYR-GCK HVCRESS--------GWAMVGLHNFGADGCLVPLTLGDLPEGSRLVDLLD
MAB_1565c|M.abscessus_ATCC_199 SRKEFTGT------SLEWYGSPPGALAFRVKGGGLTCALNVSSDLVDLP-
Mvan_2546|M.vanbaalenii_PYR-1 TMWRDTG-------DVKWLEVASDIAAFER--GGAQCWVNTGDAGVPLP-
. . . * :
Mb0131|M.bovis_AF2122/97 GHVEFPRIGQVPYLLTLPGHGFYWFQLTTHEVGAPPTCGGERRL
Rv0126|M.tuberculosis_H37Rv GHVEFPRIGQVPYLLTLPGHGFYWFQLTTHEVGAPPTCGGERRL
MMAR_0325|M.marinum_M GQVEFPKIGHLPYLLTLPGHGFYWFQLSASEE--------ER--
MUL_4797|M.ulcerans_Agy99 GQVEFRKIGHLPYLLTLPGHGFYWFQLSASEE--------ER--
MAV_5186|M.avium_104 GHVEFPRIGHLPYLLTLPGHGFYWFQLTACEEDT----------
MSMEG_6515|M.smegmatis_MC2_155 GYVEFPSIGQLPYLLTLPGHGFYWFQLREPDPEP-----GAQQ-
TH_1780|M.thermoresistible__bu GYVEFPRIGQLPYLLTLPGHGFYWFQLREPEPEV-----GEQP-
Mflv_3723|M.gilvum_PYR-GCK GRAEFPVDARGGIELSLEGYGYRWLRLLRPDDPPII--------
MAB_1565c|M.abscessus_ATCC_199 EGE-VILTSGPLVNGKLPRNTAAWIV------------------
Mvan_2546|M.vanbaalenii_PYR-1 AGAAVVLASEPGVDGMLPPDTAVWLR------------------
. . * *: