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MQDSIFNLLTEEQLRGRNTLKWNYFGPDVVPLWLAEMDFPTAPAVLDGVRACVDNEEFGYPPLGEDSLPR ATADWCRQRYGWCPRPDWVRVVPDVLKGMEVVVEFLTRPESPVALPVPAYMPFFDVLHVTGRQRVEVPMV QQDSGRYLLDLDALQAAFVRGAGSVIICNPNNPLGTAFTEAELRAIVDIAARHGARVIADEIWAPVVYGS RHVAAASVSEAAAEVVVTLVSASKGWNLPGLMCAQVILSNRRDAHDWDRINMLHRMGASTVGIRANIAAY HHGESWLDELLPYLRANRDHLARALPELAPGVEVNAPDGTYLSWVDFRALALPSEPAEYLLSKAKVALSP GIPFGAAVGSGFARLNFATTRAILDRAIEAIAAALRDIID
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0075 | - | - | 100% (390) | PROBABLE AMINOTRANSFERASE |
| M. tuberculosis H37Rv | Rv2294 | - | 3e-59 | 38.29% (410) | aminotransferase |
| M. tuberculosis H37Rv | Rv0858c | - | 3e-20 | 29.17% (360) | aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0077 | - | 0.0 | 100.00% (390) | aminotransferase |
| M. gilvum PYR-GCK | Mflv_1680 | - | 2e-22 | 30.17% (295) | aminotransferase |
| M. leprae Br4923 | MLBr_01794 | - | 5e-61 | 38.75% (400) | aminotransferase |
| M. abscessus ATCC 19977 | MAB_0847c | - | 3e-23 | 28.41% (352) | aminotransferase |
| M. marinum M | MMAR_3453 | - | 2e-57 | 37.00% (400) | aminotransferase |
| M. avium 104 | MAV_2132 | - | 1e-62 | 38.90% (401) | transferase |
| M. smegmatis MC2 155 | MSMEG_5725 | - | 1e-23 | 29.81% (359) | aminotransferase |
| M. thermoresistible (build 8) | TH_1406 | - | 6e-60 | 39.13% (391) | Probable aminotransferase |
| M. ulcerans Agy99 | MUL_2727 | - | 3e-56 | 36.75% (400) | aminotransferase |
| M. vanbaalenii PYR-1 | Mvan_5070 | - | 5e-22 | 28.89% (360) | aminotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0075|M.tuberculosis_H37Rv MQD-----SIFNLLTEEQLRGRNTLKWNYFGPDVVPLWLAEMDFPTAPAV
Mb0077|M.bovis_AF2122/97 MQD-----SIFNLLTEEQLRGRNTLKWNYFGPDVVPLWLAEMDFPTAPAV
MMAR_3453|M.marinum_M MNP-----NPLEQLTLEQLRTRTSMKWRAHPADVLPLWVAEMDVNLAPTV
MUL_2727|M.ulcerans_Agy99 MNP-----NPLEQLTLEQLRTRTSMKWRAHPADVLPLWVAEMDVNLAPTV
MLBr_01794|M.leprae_Br4923 MTS-----NPLEQLTIEQLQCRTSMKWRAHPEDVLPLWVAEMDVLLAPTV
MAV_2132|M.avium_104 MTF-----NPFEELTLDQLRLRTSMKWRAHPADVLPLWVAEMDVKLAPTV
TH_1406|M.thermoresistible__bu MAPSAPVANPLEQLTLEQLRLRTSMKWRVHPPDVLPLWVAEMDVPLADPI
Mflv_1680|M.gilvum_PYR-GCK --------MTVQRLRPYAVTIFAETSALAARVGAVNLGQGFPDEDGPPAM
Mvan_5070|M.vanbaalenii_PYR-1 --------MTVRRLQPYAVTIFAEMSALAARVGAVNLGQGFPDEDGPPAM
MSMEG_5725|M.smegmatis_MC2_155 --------MTVRRLQPFAVTIFAEMSALATRLGAVNLGQGFPDEDGPVEM
MAB_0847c|M.abscessus_ATCC_199 MNQ-----RTVERLRPFGATIFAEMSALAVRHDAINLGQGFPDEDGPASM
.. * . ..: * . * . :
Rv0075|M.tuberculosis_H37Rv LDGVRACVDNEEFGYPP-LGEDSLPRATADWCRQRYGWCP-RPDWVRVVP
Mb0077|M.bovis_AF2122/97 LDGVRACVDNEEFGYPP-LGEDSLPRATADWCRQRYGWCP-RPDWVRVVP
MMAR_3453|M.marinum_M AAALHRAVDNGDTGYP--YGT-AYAEALAEFAALRWQWHDLEVGRTAIVP
MUL_2727|M.ulcerans_Agy99 AAALHRAVDNGDTGYP--YGT-AYAEALAEFAALRWQWHDLEVGRTAIVP
MLBr_01794|M.leprae_Br4923 AEAVHRAVDNGDTGYP--YGT-TFAEAISEFASQRWQWHDLDVSRTAIVP
MAV_2132|M.avium_104 AQALRTAIDHGDTGYP--CGT-AFAEAVSEFAARRWQWHDLDVSRTALVP
TH_1406|M.thermoresistible__bu AEALTTAVARGDTGYA--AGARRYAEAFAGFAARRWGWSGPAAEHTAIVP
Mflv_1680|M.gilvum_PYR-GCK LKAAENAIAEGVNQYPPGLGFAPLRQAIADQRRRRYGTVYDPDTEVLVTV
Mvan_5070|M.vanbaalenii_PYR-1 LKAAENAIAEGVNQYPPGLGIAPLRQAIADQRRRRYGSEYDPDTEVLVTV
MSMEG_5725|M.smegmatis_MC2_155 LKVAQNAIADGINQYPPGLGVPELRQAIAAQRKRVHGVQYDPDTEVLVTV
MAB_0847c|M.abscessus_ATCC_199 LDAAQQAIRSGLNQYPPGLGIPELRRAITADRLARYGEELDPDTQVLVTV
.: *. * .* : . :.
Rv0075|M.tuberculosis_H37Rv DVLKGMEVVVEFLTRPESPVALPVPAYMPFFDVLHVTGRQRVEVPMVQQD
Mb0077|M.bovis_AF2122/97 DVLKGMEVVVEFLTRPESPVALPVPAYMPFFDVLHVTGRQRVEVPMVQQD
MMAR_3453|M.marinum_M DVMMGIVEMLRLVTDRGDTVIVNSPVYAPFYAFVSHDGRRVVEAPLG--T
MUL_2727|M.ulcerans_Agy99 DVMMGIVEMLRLVTDRGDTVIVNSPVYAPFYAFVSHDGRRVVEAPLG--T
MLBr_01794|M.leprae_Br4923 DVMLGVVEMLRLITDRGDGVIVSPPVYPPFYAFVTHDGRRVLEAPLG--R
MAV_2132|M.avium_104 DVMLGAVEVLRLVTDPGDAVVVNPPVYAPFYAFVSHDGRRVVEAPLD--D
TH_1406|M.thermoresistible__bu DVMLGIVEVLKLITDPGDAVVVNAPVYPPFYAFVTHAGRCVVEARLG--A
Mflv_1680|M.gilvum_PYR-GCK GATEAIASSVLGLVEPGSEVLLIEPFYDSYSPVIAMAGCHRRAVPLRQ-N
Mvan_5070|M.vanbaalenii_PYR-1 GATEAIAAAILGLVEPDSEVLLIEPFYDSYSPVIAMAGCHRRAVPMVR-D
MSMEG_5725|M.smegmatis_MC2_155 GATEAIAASVIGLVEPGSEVLVIEPFYDSYSPVIAMAGCERRAVPLVP-S
MAB_0847c|M.abscessus_ATCC_199 GATEAIAGALLGLVEPGSEVILIEPYYDSYAAVVAMAGAVRVPVPLVP-D
.. . : :. . * : * * .: .: * . :
Rv0075|M.tuberculosis_H37Rv SGRYLLDLDALQAAFVRG---AG-----SVIICNPNNPLGTAFTEAELRA
Mb0077|M.bovis_AF2122/97 SGRYLLDLDALQAAFVRG---AG-----SVIICNPNNPLGTAFTEAELRA
MMAR_3453|M.marinum_M DGR--IDLDALEEAFAHARRAGG---NVAYLLCNPHNPTGAVHSYDELRG
MUL_2727|M.ulcerans_Agy99 DGR--INLDALEEAFAHARRAGG---NVPYLLCNPHNPTGAAHSCDELRG
MLBr_01794|M.leprae_Br4923 DGR--LDLAALQDAFSRARRSSGPNGKVAYLLCNPHNPTGSVHTVAELHG
MAV_2132|M.avium_104 GGR--IDLGALEEAFAHARAGNT--AKVAYLLCNPHNPTGSVHTAAELRG
TH_1406|M.thermoresistible__bu DGR--IDPASLEAAFGTAAGIGD---RAAYLLCSPHNPTGAVHTADELAH
Mflv_1680|M.gilvum_PYR-GCK GRGFAIDIEALRAAVGPRTR--------ALIVNTPHNPTGMIASDEELRG
Mvan_5070|M.vanbaalenii_PYR-1 GRGFAIDVEGLRRAVTPKTR--------ALILNSPHNPTGSVASDDELRA
MSMEG_5725|M.smegmatis_MC2_155 GRGFAIDVDALRAAVTPQTK--------ALILNSPHNPTGAVASDAELRA
MAB_0847c|M.abscessus_ATCC_199 GAGFALDTDALAAAITPRTA--------ALVINSPHNPTGKVFTDTELAR
. :: .* *. . :: .*:** * : **
Rv0075|M.tuberculosis_H37Rv IVDIAARHGARVIADEIWAPVVYGSRHVAAASVSEAAAEVVVTLVSASKG
Mb0077|M.bovis_AF2122/97 IVDIAARHGARVIADEIWAPVVYGSRHVAAASVSEAAAEVVVTLVSASKG
MMAR_3453|M.marinum_M VAERARRYDVRVVSDEIHAPLVFSGARFTP-YLTVPGSENALSLTSATKA
MUL_2727|M.ulcerans_Agy99 VAERARRYDVRVVSDEIHAPLVFSGARFTP-YLTVPGSENALSLTSATKA
MLBr_01794|M.leprae_Br4923 VAELARRFGVRVISDEIHAPLVLSGARFTP-YLSIPGAENAFALMSATKG
MAV_2132|M.avium_104 VAELARRFGVRVVSDEIHAPVILPGSRFTP-FLTVAGAENAFALTSASKA
TH_1406|M.thermoresistible__bu VAALASRYGVRVISDEIHAPLVLPGASFTP-YLSVPGAEDAFAVTSASKA
Mflv_1680|M.gilvum_PYR-GCK LAELAVAHDLLVITDEVYEHLVFDGRQHRPLAGYPGMAERTVTISSAGKM
Mvan_5070|M.vanbaalenii_PYR-1 VAELAISADLLVITDEVYEHLVFDGRRHRPLADYPGMAGRTITISSAGKM
MSMEG_5725|M.smegmatis_MC2_155 VAALAVEHDLLVITDEVYEALVFDGHRHLTLASYPGMRDRTVTISSAAKM
MAB_0847c|M.abscessus_ATCC_199 IAELAVEHDLLVVSDEVYERLLFDGRTQTPMASLPGMADRTVTISSAAKT
:. * . *::**: :: . . ..:: ** *
Rv0075|M.tuberculosis_H37Rv WNLPGLMCAQVILSNRRDAHDWDRINMLHRMGASTVGIRANIAAYHHGES
Mb0077|M.bovis_AF2122/97 WNLPGLMCAQVILSNRRDAHDWDRINMLHRMGASTVGIRANIAAYHHGES
MMAR_3453|M.marinum_M WNLGGVKAALAVAG-PEAAADLRRMPEEVSHGPSHLGIIAHTEAFRTGGD
MUL_2727|M.ulcerans_Agy99 WNLGGVKAALAVAG-PEAAADLRRMPEEVSHGPSHLGIIAHTEAFRTGGD
MLBr_01794|M.leprae_Br4923 WNLCGLKAAIAIAG-REAAADLRRIPKEVSHGPSHLGIIAHTAAFRTGSS
MAV_2132|M.avium_104 WNLSGLKAALAIAG-PEAAADLNRMPEEVSHGPSHLGVIAHTEAFRSGDG
TH_1406|M.thermoresistible__bu WNLAGLKAGLVIAG-PDAAADLDRMPEEVSHGPSHLGVIAHTVSFAEGEP
Mflv_1680|M.gilvum_PYR-GCK FNVTGWKIGWACGP-SDLIAGVRAAKQYLSYVAGAPFQPAVAQALNNEDA
Mvan_5070|M.vanbaalenii_PYR-1 FNVTGWKIGWACGP-SDLIAGVRAAKQYLSYVGGAPFQPAVAHALATEDA
MSMEG_5725|M.smegmatis_MC2_155 FNATGWKIGWACGA-PELIAGVRAAKQYLTYVGGAPFQPAVAHALNHEDG
MAB_0847c|M.abscessus_ATCC_199 FNCTGWKIGWACGT-PELVAGVRAAKQFLSYVGGGPFQPAVAVALDTEQS
:* * . . . . * :
Rv0075|M.tuberculosis_H37Rv WLDELLPYLRANRDHLARALPELAPGVEVNAPDGTYLSWVDFRALAL---
Mb0077|M.bovis_AF2122/97 WLDELLPYLRANRDHLARALPELAPGVEVNAPDGTYLSWVDFRALAL---
MMAR_3453|M.marinum_M WLDALLAGLDANRTLLSDLVDAQLPGVRLRWPEGTYLAWLDCRDLGISEQ
MUL_2727|M.ulcerans_Agy99 WLDALLAGLDANRTLSSDLVDAQLPGVRLRWPQGTYLAWLDCRDLGISEQ
MLBr_01794|M.leprae_Br4923 WLDALLQGLEANRALLRDLVTKHLPGVRYQRPQGTYLTWLDCRHLGFDEQ
MAV_2132|M.avium_104 WLDATLQGLDQNRALLGELVAEHLPGVKYQWPQGTYLAWLDCRELGFAED
TH_1406|M.thermoresistible__bu WLDALLAGLAANRDLLGRLLAERLPLVGYTPPQGTYLAWLDCRRLGLDEA
Mflv_1680|M.gilvum_PYR-GCK WVDALCASFQARRDRLSSALSDIG--FDVFDSFGTYFLTVDPRPLGYDDS
Mvan_5070|M.vanbaalenii_PYR-1 WVDALCASFQSRRDRLGSALSDIG--FEVHESFGTYFLCVDPRPLGFTDS
MSMEG_5725|M.smegmatis_MC2_155 WVADLRDSFQSKRDRLGSALAEIG--FEVHDSRGTYFLCADPRPLGYDDS
MAB_0847c|M.abscessus_ATCC_199 WVKTLRESLQRRRDRLSAALTGLG--FEVHSSDGGYFVCADPRPLGFSDS
*: : .* : . . * *: * * *.
Rv0075|M.tuberculosis_H37Rv -----------PSEPAEYLLSKAKVALSPGIPFGAAVGSGFARLNFATTR
Mb0077|M.bovis_AF2122/97 -----------PSEPAEYLLSKAKVALSPGIPFGAAVGSGFARLNFATTR
MMAR_3453|M.marinum_M D-ASGLAVVSDLSGPASWFLDHARVALSSGHVFGTG-GDGHVRMNFATSQ
MUL_2727|M.ulcerans_Agy99 D-ASGLAVVSDLSGPASWFLDHARVALSSGHVFGTG-GDGHVRMNFATSQ
MLBr_01794|M.leprae_Br4923 I-NEGLAAISDLSGPARWFLDHSRVALTSGHAFGTG-GVGHVRVNFATSQ
MAV_2132|M.avium_104 A-AQGLAVVADLSGPARWFLEHARVALSSGHVFGTG-GAGHLRLNFATSR
TH_1406|M.thermoresistible__bu GGGDGPGIVSELAGPARVFLDQARVALSSGHVFGSG-GAGHVRLNFATSQ
Mflv_1680|M.gilvum_PYR-GCK T------SFCAQLPEQVGVAAIPMSAFCDPDAAHAGEWKHLVRFAFCKRD
Mvan_5070|M.vanbaalenii_PYR-1 A------AFCAELPERVGVAAIPMSAFCDPAAGHAEEWKHLVRFAFCKRE
MSMEG_5725|M.smegmatis_MC2_155 T------AFCAELPTRAGVAAIPMSAFCDPDAPHADVWNHLVRFAFCKRD
MAB_0847c|M.abscessus_ATCC_199 A------ELCRRLPETVGVAAVPVSAFCD---RYADQWNHLVRFTFAKRD
. . *: : *. *..
Rv0075|M.tuberculosis_H37Rv AILDRAIEAIAAALRDIID
Mb0077|M.bovis_AF2122/97 AILDRAIEAIAAALRDIID
MMAR_3453|M.marinum_M AILTEAVTRMGKALGELR-
MUL_2727|M.ulcerans_Agy99 AILTEAVTRMGKALGELR-
MLBr_01794|M.leprae_Br4923 AILIEALSRMGRALVNFR-
MAV_2132|M.avium_104 AILTEALSRMGRALAARSG
TH_1406|M.thermoresistible__bu AILTEAITRMSTVRAARCE
Mflv_1680|M.gilvum_PYR-GCK ETLDEAIRRLQALRSTG--
Mvan_5070|M.vanbaalenii_PYR-1 DTLDEAIRRLRALPRSR--
MSMEG_5725|M.smegmatis_MC2_155 DTLDEAIRRLQALRRC---
MAB_0847c|M.abscessus_ATCC_199 VVIDEAITRLARLGA----
: .*: :