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VTNPGQKFSLLGSALYRFPVSYETLEETGLLPNGLTVEAARAEAARAYELDRAHVFHSWSAQAEISPMTL VAADGCHVWDGQGNKLLDFSSMLVNTNIGHQHPKVVAAIAQQAAKLCTVAPQHANAARSEAARLIAERTP GELNRIFFTNGGADAVEHAVRMARLHTGRSKVLSRYRSYHGGTDTAINLTGDPRRWPNDHGTAGIVHFFG PFLYRSQFHAGTEAEESERALAHLHDTIRMEGPNTIAAIILESIPGTAGIMVPPPGYMAGVRALCDEYGI VFIADEVMAGFGRSGKWFSINHFDVVPDLLTFAKGVNSGYVPLGGVAISPAIAETFAHRAYPGGLTYSGH PLATAAAVATINTMAEDGIVENAARVGAEVIGPGLRELAARHRSVGEVRGAGVFWAVELVADQTTREPLA PYGSSSAAMNSVIAECKKLGLLPFANYNRIHVVPPCTITDEQAREGLAILDKALDVADAATENA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5776 | - | - | 100% (484) | hypothetical protein Mvan_5776 |
| M. vanbaalenii PYR-1 | Mvan_1823 | - | 0.0 | 78.35% (448) | hypothetical protein Mvan_1823 |
| M. vanbaalenii PYR-1 | Mvan_1570 | - | 4e-55 | 34.31% (376) | hypothetical protein Mvan_1570 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3362 | - | 5e-53 | 34.15% (369) | hypothetical protein Mb3362 |
| M. gilvum PYR-GCK | Mflv_1055 | - | 0.0 | 91.27% (458) | hypothetical protein Mflv_1055 |
| M. tuberculosis H37Rv | Rv3329 | - | 4e-53 | 34.15% (369) | hypothetical protein Rv3329 |
| M. leprae Br4923 | MLBr_00485 | gabT | 1e-47 | 32.54% (418) | 4-aminobutyrate aminotransferase |
| M. abscessus ATCC 19977 | MAB_4345c | - | 0.0 | 75.94% (453) | hypothetical protein MAB_4345c |
| M. marinum M | MMAR_3558 | - | 6e-56 | 35.07% (365) | aminotransferase (adenosylmethionine-8-amino-7- oxononanoate) |
| M. avium 104 | MAV_4304 | - | 7e-54 | 34.42% (369) | hypothetical protein MAV_4304 |
| M. smegmatis MC2 155 | MSMEG_2450 | - | 0.0 | 84.25% (457) | hypothetical protein MSMEG_2450 |
| M. thermoresistible (build 8) | TH_1978 | - | 1e-58 | 35.37% (393) | PROBABLE AMINOTRANSFERASE |
| M. ulcerans Agy99 | MUL_2791 | - | 9e-56 | 34.79% (365) | hypothetical protein MUL_2791 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3362|M.bovis_AF2122/97 --------------------------------------------------
Rv3329|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4304|M.avium_104 -------------------------------------------------M
MMAR_3558|M.marinum_M ------------------------------------------MTELSAKA
MUL_2791|M.ulcerans_Agy99 ------------------------------------------MTELSAKA
TH_1978|M.thermoresistible__bu -----------------------------------------MSTDRAAQA
Mvan_5776|M.vanbaalenii_PYR-1 MTNPGQKFSLLGSALYRFPVSYETLEETGLLPNGLTVEAARAEAARAYEL
Mflv_1055|M.gilvum_PYR-GCK MLN-------------------ETLDD--LLPNGLTVEAARAEAARTYEL
MSMEG_2450|M.smegmatis_MC2_155 ---------------------MTAIQESTLLPNGLTVDTAKAEAARAYEL
MAB_4345c|M.abscessus_ATCC_199 MKD----------------ETMTLTQETETLPNGLSAADAFQEASRAYTL
MLBr_00485|M.leprae_Br4923 ----------------------------MTSVEQSRQLVTEIPGPVSLEL
Mb3362|M.bovis_AF2122/97 -----MHFARHGAGIQHPVIVRGDGVTIFDDRGKSYLDALSGLFVVQVGY
Rv3329|M.tuberculosis_H37Rv -----MHFARHGAGIQHPVIVRGDGVTIFDDRGKSYLDALSGLFVVQVGY
MAV_4304|M.avium_104 TDHLWLHFARHGPGITPPIITRGHGVTIYDDRGNSYLDGLSGLFTVQVGH
MMAR_3558|M.marinum_M NRHLWGHFARHGAGITPPIITRGEGVTIWDDRGNSYLDGLSGLFVVQAGH
MUL_2791|M.ulcerans_Agy99 NRHLWGHFARHGAGITPPIITRGEGVTIWDDRGNSYLDGLSGLFVVQAGH
TH_1978|M.thermoresistible__bu DRHLWGHFARHGPGVTPPIIVRGDGVTIWDDHGRRYLDGLSGLFVVQAGH
Mvan_5776|M.vanbaalenii_PYR-1 DRAHVFHSWSAQAEISPMTLVAADGCHVWDGQGNKLLDFSSMLVNTNIGH
Mflv_1055|M.gilvum_PYR-GCK DRAHVFHSWSAQAEISPMTITASQGCHVWDGDGNKLLDFSSMLVNTNIGH
MSMEG_2450|M.smegmatis_MC2_155 DRAHVFHSWSAQEEISPMTVTAAQGSYLWDGDGNRLLDFSSQLVNTNIGH
MAB_4345c|M.abscessus_ATCC_199 DRAHVFHSWSAQSQIKPMTIVASAGSYVWDGGGRRLLDFSSQLVNTNIGH
MLBr_00485|M.leprae_Br4923 AKRLNAAVPRGVGVTLPVFVTRAAGGVIEDVDGNRLIDLGSGIAVTTIGN
:. . * : * *. :* * : . *
Mb3362|M.bovis_AF2122/97 GRAELAEAAARQAGTLGYFPLWGYATPPAIELAERLARYAPG-DLNRVFF
Rv3329|M.tuberculosis_H37Rv GRAELAEAAARQAGTLGYFPLWGYATPPAIELAERLARYAPG-DLNRVFF
MAV_4304|M.avium_104 GRAELAEAAARQAGTLAFFPLWGYATPPAIELAERLAGYAPG-DLNRVFF
MMAR_3558|M.marinum_M GRTELAEAAAKQAETLAFFPLWSYATPTAIELAERVAHYAPG-DLNRVFF
MUL_2791|M.ulcerans_Agy99 GRTELAEAAAKQAETLAFFPLWSYATPTAIELAERVAHYAPG-DLNRVFF
TH_1978|M.thermoresistible__bu GRAELAEAAARQAGQLAYFPLWSYATPPAIELAERIAHYAPG-DLNRVFF
Mvan_5776|M.vanbaalenii_PYR-1 QHPKVVAAIAQQAAKLCTVAPQ-HANAARSEAARLIAERTPG-ELNRIFF
Mflv_1055|M.gilvum_PYR-GCK QHPKVIAAIAEQAAKLCTVAPQ-YANDARSEAARLIAERTPG-ELNRIFF
MSMEG_2450|M.smegmatis_MC2_155 QHPKVVAAIAEQAAKLCTVAPQ-HANAARSEAARLIAERTPG-ELNKIFF
MAB_4345c|M.abscessus_ATCC_199 QHPKVVAAIQRQAAKLCTVAPQ-YANDARSEAARLIAERTPG-DLDKIFF
MLBr_00485|M.leprae_Br4923 SSPRVVDAVRAQVADFTHTCFIITPYEEYVAVTEQLNRITPGSGEKRSVL
..: * *. : . :. : :** .: .:
Mb3362|M.bovis_AF2122/97 TSGGTEAVETAWKVAKQYFKLTGKPGKHKVISRSIAYHGTTQGALAITGL
Rv3329|M.tuberculosis_H37Rv TSGGTEAVETAWKVAKQYFKLTGKPGKQKVISRSIAYHGTTQGALAITGL
MAV_4304|M.avium_104 TTGGTEAVETAWKLAKQYFKLTGKPGKHKVISRAVAYHGTTQGALAITGL
MMAR_3558|M.marinum_M TTGGGEAVESAWKLAKQYFKETGKPGKYKAISRSTAYHGTPHGALAITGL
MUL_2791|M.ulcerans_Agy99 TTGGGEAVESAWKLAKQYFKETGKPGKYKAISRSTAYHGTPHGALAITGL
TH_1978|M.thermoresistible__bu TTGGGEAVESAWKLAKQYFKLTGKPGKHKVVSRAVAYHGTPQGALAITGL
Mvan_5776|M.vanbaalenii_PYR-1 TNGGADAVEHAVRMARLHT------GRSKVLSRYRSYHGGTDTAINLTGD
Mflv_1055|M.gilvum_PYR-GCK TNAGADAVEHAVRMARLHT------GRYKVLARYRSYHGGTETAINLTGD
MSMEG_2450|M.smegmatis_MC2_155 TNGGADAVEHAVRMARLHT------GRYKVLSRYRAYHGGTDTAINLTGD
MAB_4345c|M.abscessus_ATCC_199 TNGGADANEHAVRMARLHT------GRYKVLARYRSYHGGTDTAINLTGD
MLBr_00485|M.leprae_Br4923 FNSGAEAVENSIKVARSYTR------KPAVVAFDHAYHGRTNLTMALTAK
..* :* * : ::*: : : .:: :*** .. :: :*.
Mb3362|M.bovis_AF2122/97 PLF-KAPFEPLTPGGFRVPNTNFYRAP--LHTDLKEFGRWAADRIAEAIE
Rv3329|M.tuberculosis_H37Rv PLF-KAPFEPLTPGGFRVPNTNFYRAP--LHTDLKEFGRWAADRIAEAIE
MAV_4304|M.avium_104 PRY-KAPFEPVTPGGFRVPNTNFYRAPEAFANDPKGFGLWAADRIAEAIE
MMAR_3558|M.marinum_M PAF-KAPFEPLTPGGVRIPNTNFYRAPAPYADDSKEFGLWAANRIAEAIE
MUL_2791|M.ulcerans_Agy99 PAF-KAPFEPLTPGGVRIPNTNFYRAPAPYADDSKDFGLWAANRIAEAIE
TH_1978|M.thermoresistible__bu PMF-KAPFEPLTPGGFRVPNTNFYRAPAPYRDDEKAFGRYCADRIAETIE
Mvan_5776|M.vanbaalenii_PYR-1 PR--RWPNDHGTAGIVHFFGPFLYRSQFHAGTEAEES-ERALAHLHDTIR
Mflv_1055|M.gilvum_PYR-GCK PR--RWPNDHGNAGVVHFFGPFLYRSQFHATTEAEES-ERALRHLHDTIR
MSMEG_2450|M.smegmatis_MC2_155 PR--RWPNDRGNSGIVHFNGPFLYRSSFYAETEEQES-QRALEYLEKLIQ
MAB_4345c|M.abscessus_ATCC_199 PR--RWPNDYGNSGVVHFHGPFLYRSVFNSANEEQET-ERALAHLEQTIR
MLBr_00485|M.leprae_Br4923 SMPYKSGFGPFAPEIYRAPLSYPYRDGLLNKDLATDGKLAGARAINVIEK
. : . : . ** : .
Mb3362|M.bovis_AF2122/97 FEGPDTVAAVFLEPVQNAGGCIPAPPGYFERVREICDRYDVLLVSDEVIC
Rv3329|M.tuberculosis_H37Rv FEGPDTVAAVFLEPVQNAGGCIPAPPGYFERVREICDRYDVLLVSDEVIC
MAV_4304|M.avium_104 FEGPDTVAAVFVEPVQNAGGSIPPPPGYFERVREICDRYDVLLVSDEVIC
MMAR_3558|M.marinum_M FEGPDTVAAVFLEPVQNAGGCFPPPPGYFERVREICDEYDVLLVSDEVIC
MUL_2791|M.ulcerans_Agy99 FEGPDTVAAVFLEPVQNAGGCFPPPPGYFERVREICDEYDVLLVSDEVIC
TH_1978|M.thermoresistible__bu FEGPDTVAAVVLEPVQNAGGCIPPPPGYFERVREICDTYDVLLISDEVIC
Mvan_5776|M.vanbaalenii_PYR-1 MEGPNTIAAIILESIPGTAGIMVPPPGYMAGVRALCDEYGIVFIADEVMA
Mflv_1055|M.gilvum_PYR-GCK MEGPNTIAAIILESIPGTAGIMVPPPGYIAGVREICDEYGIVFIADEVMA
MSMEG_2450|M.smegmatis_MC2_155 MEGPSTIAAIILESIPGTAGIMVPPPGYLAGVRELCTRYGIVFIADEVMA
MAB_4345c|M.abscessus_ATCC_199 LEGPSTIAAIVLESIPGTAGVMVPPPGYMAGVRELCDQFGIVFIADEVMA
MLBr_00485|M.leprae_Br4923 QVGADDLAAVIIEPIQGEGGFIVPAEGFLATLLDWCRKNNVMFIADEVQT
*.. :**:.:*.: . .* : .. *:: : * .:::::***
Mb3362|M.bovis_AF2122/97 AFGRIGSMFACEDLGYVPDMITCAKGLTSGYSPLGAMIASDRLFEPFNDG
Rv3329|M.tuberculosis_H37Rv AFGRIGSMFACEDLGYVPDMITCAKGLTSGYSPLGAMIASDRLFEPFNDG
MAV_4304|M.avium_104 AFGRIGSMFACADFGYVPDMITCAKGMTSGYSPIGAMIASERLFEPFADG
MMAR_3558|M.marinum_M AFGRIGSMFACNDFGYVPDIITCAKGMTSGYSPIGAMVASDRLFEPFNDG
MUL_2791|M.ulcerans_Agy99 AFGRIGSMFACNDFGYVPDIITCAKGMTSGYSPIGAMVASDRLFEPFNDG
TH_1978|M.thermoresistible__bu AFGRIGSMFACDDFGYQPDIITCAKGLTSGYAPLGAMIATDRLFEPFADG
Mvan_5776|M.vanbaalenii_PYR-1 GFGRSGKWFSINHFDVVPDLLTFAKGVNSGYVPLGGVAISPAIAETFAHR
Mflv_1055|M.gilvum_PYR-GCK GFGRSGKWFSINHFDVVPDLLTFAKGVNSGYVPLGGVAINPAISETFAHR
MSMEG_2450|M.smegmatis_MC2_155 GFGRSGKWFSINHFDVVPDLMTFAKGVNSGYVPLGGVAISPEIYETFAHR
MAB_4345c|M.abscessus_ATCC_199 GFGRTGEWFAINHFNVVPDLLTFAKGVNSGYVPLGGVAINGAIAETFSER
MLBr_00485|M.leprae_Br4923 GFARTGAMFACEHDGIVPDLICTAKGIADGLPLAAVTGRAEIMNAPHVSG
.*.* * *: . . **:: ***: .* . : ..
Mb3362|M.bovis_AF2122/97 ETMFAHGYTFGGHPVSAAVGLANLDIFEREGLSDHVKRN-SPALRATLEK
Rv3329|M.tuberculosis_H37Rv ETMFAHGYTFGGHPVSAAVGLANLDIFEREGLSDHVKRN-SPALRATLEK
MAV_4304|M.avium_104 DTMFPHGYTFGGHPVSAAVGLVNLDIFEREGLNDRVRTL-APTFRATLEK
MMAR_3558|M.marinum_M KTTFAHGYTFGGHPVSSAVALANLDIFEREGLNDHVKQN-APAFRTTLEK
MUL_2791|M.ulcerans_Agy99 KTTFAHGYTFGGHPVSSAVALANLDIFEREGLNDHVKQN-APAFRTTLEK
TH_1978|M.thermoresistible__bu KTVFPHGYTFGGHPVSAAVALANLDIFEREGLNDRVRTL-SPLLRATLER
Mvan_5776|M.vanbaalenii_PYR-1 --AYPGGLTYSGHPLATAAAVATINTMAEDGIVENAARVGAEVIGPGLRE
Mflv_1055|M.gilvum_PYR-GCK --AYPGGLTYSGHPLATAAAVATINAMADEGIVENAATIGAEVIGPGLTE
MSMEG_2450|M.smegmatis_MC2_155 --AYPGGLTYSGHPLACAAAVATINAMEDEGMVENAAKVGAEVIGPGLAE
MAB_4345c|M.abscessus_ATCC_199 --AYPGGLTYSGHPLATAAAVATIEAMDEEGMIGNARRIGRDVLGPQLQR
MLBr_00485|M.leprae_Br4923 -----LGGTFGGNPVACAAALATITTIENDGLIQRAQQI-ERLITDRLLR
* *:.*:*:: *..:..: : :*: .. : * .
Mb3362|M.bovis_AF2122/97 LYDLP-IVGDIRGEGYFFGIELVKDQATKQTFTDDERARLL-GQVSAALF
Rv3329|M.tuberculosis_H37Rv LYDLP-IVGDIRGEGYFFGIELVKDQATKQTFTDDERARLL-GQVSAALF
MAV_4304|M.avium_104 LYDLP-IVGDVRGEGFFYGVELVKDRATKQTFTDSERRALL-GRVGAALF
MMAR_3558|M.marinum_M LLDLP-IVGDVRGEGFFYGIELVKDKDTKATFSDEESERLLRGFLSSALL
MUL_2791|M.ulcerans_Agy99 LLDLP-IVGDVRGEGFFYGIELVKDKDTKATFSDEESERLLRGFLSSALL
TH_1978|M.thermoresistible__bu LYELP-IVGDVRGEGYFFAVELVQDKAGRQPFSAEESARLV-AHLNRALL
Mvan_5776|M.vanbaalenii_PYR-1 LAARHRSVGEVRGAGVFWAVELVADQTTREPLAPYGSSSAAMNSVIAECK
Mflv_1055|M.gilvum_PYR-GCK IAAKHRSVGEVRGAGVFWAVELVADQATREPLAPYGSSSAAMNSVIAECK
MSMEG_2450|M.smegmatis_MC2_155 LAAKHRSVGEVRGLGVFWAVELVKDQKTREPLAPYGSSSPAMNAVIAACK
MAB_4345c|M.abscessus_ATCC_199 LKERHRSIGEIRGLGVFWAIELVANPESREPLSPYGTSNAAINSVVAECK
MLBr_00485|M.leprae_Br4923 LQDADDRIGDVRGRGAMIAVELVKSGTAEPDPELTEKVATAAHATGVIIL
: :*::** * : .:*** . .
Mb3362|M.bovis_AF2122/97 EAGLYCRTDDRGDPVVQVAPPLISGQPEFDTIETILRSVLTDTGRKYLHL
Rv3329|M.tuberculosis_H37Rv EAGLYCRTDDRGDPVVQVAPPLISGQPEFDTIETILRSVLTDTGRKYLHL
MAV_4304|M.avium_104 EAGLYCRTDDRGDSVIQLAPPLISGQAEFDTIEAALRGVLSDECRRL---
MMAR_3558|M.marinum_M EAGLYCRADDRGDPVVQLAPPLISGQQEFDKMEQILRGVLSEAWSRL---
MUL_2791|M.ulcerans_Agy99 EAGLYCRADDRGDPVVQLAPPLISGQQEFDKMEQILRGVLSEAWSRL---
TH_1978|M.thermoresistible__bu DAGLYCRADNRGDTVVQVAPPLISGPAEFDAMHDILRTVLKDAPNHV---
Mvan_5776|M.vanbaalenii_PYR-1 KLGLLPFANYN---RIHVVPPCTITDEQAREGLAILDKALDVADAATENA
Mflv_1055|M.gilvum_PYR-GCK KLGLLPFANYN---RIHVVPPCTITADLAREGLAILDRALDVADAAVAGS
MSMEG_2450|M.smegmatis_MC2_155 SGGLLPFANFN---RIHVVPPCNVSADEAREGLAILDSALDVADEHTV--
MAB_4345c|M.abscessus_ATCC_199 ATGLLPFANFN---RIHAVPPCSVTDLEVQEGIKSLDTALAIADEYVVP-
MLBr_00485|M.leprae_Br4923 TCGMFGN-------IIRLLPPLTISDELLAEGLDILSRILGDF-------
*: :: ** * *