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VTHRRAVAGGALVTVASCVAAWALAYPAGSLTSAVPRAVADGAAVVTLGLAVVPALDGPRYRDELVRRAT APLVSASAVWVVAELVRLALAGAEAAGTTVTGLGLREAWEFAAYTAPGRAGLLTVLAAAAVCAVTSVAPR SGPACIAGAGLACIGVIGHPLTGHLSGSVLGGVSIAVHALAAALWCGTLAGLVLTVDHRGQWARVLPRFS QLSLGCVAALLAGGIAAGVTVLESPAALYATGYGRVLSLKIALTLVLIALAWRNRELWLPAARTHRSTAA VSRTRAYTELTLMAATVAAAAVLSVTG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5680 | - | - | 100% (307) | copper resistance D domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3692 | - | 5e-14 | 26.77% (325) | copper resistance D domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4073 | - | 1e-12 | 24.76% (307) | copper resistance D domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0231c | - | 4e-05 | 26.42% (246) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_1126 | - | 1e-114 | 69.93% (296) | copper resistance D domain-containing protein |
| M. tuberculosis H37Rv | Rv0226c | - | 4e-05 | 26.42% (246) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1557 | - | 1e-13 | 28.48% (309) | copper resistance D precursor |
| M. marinum M | MMAR_0475 | - | 6e-05 | 26.80% (306) | transmembrane protein |
| M. avium 104 | MAV_1692 | - | 2e-19 | 32.48% (311) | ABC-type transporter, permease components |
| M. smegmatis MC2 155 | MSMEG_6437 | - | 3e-87 | 55.02% (309) | copper resistance protein D |
| M. thermoresistible (build 8) | TH_1178 | - | 2e-42 | 66.67% (126) | copper resistance protein D |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5680|M.vanbaalenii_PYR-1 ------------------------------MTHRRAVAGGALVTVASCVA
Mflv_1126|M.gilvum_PYR-GCK ----------------------------------------MLVTVAACVM
MSMEG_6437|M.smegmatis_MC2_155 ------------------------------------MAGGVLVIAASAVT
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 MTTAPTAR--------KTDSPIWTIVVGLAVLAGLVAATIGALSLAEALL
MAV_1692|M.avium_104 MTVAPPAGTASTEAVPQHRTQVWPVLAGVAVLAGCTAAGIGTLSLASALT
Mb0231c|M.bovis_AF2122/97 ----------------MR------------------WFRPGYALVLVLLL
Rv0226c|M.tuberculosis_H37Rv ----------------MR------------------WFRPGYALVLVLLL
MMAR_0475|M.marinum_M ----------------MRAKMARGEGAGWASPRCACWWRPGYALVLALLV
Mvan_5680|M.vanbaalenii_PYR-1 AWALAYP--AGSLTSAVPRAVADGAAVVTLGLAVVPALDGPRYRDELVR-
Mflv_1126|M.gilvum_PYR-GCK AWGLAYP--ASPLGPAVVRAVADAAAVATLGLVVVPLLDGPRYRAELSR-
MSMEG_6437|M.smegmatis_MC2_155 AWALAFP--HTPIIGAAVRALADAAAVATLGLATVPMLDQARHRADVAR-
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 ATGLPNPGPVTSYGLPFVRAAAEIAAVVAVGAFLLAAFFVPPQTSGVLDV
MAV_1692|M.avium_104 ATGLPDPGPVTTLGLPFLRAAGEIAAVLAVGSFLFAAFLVPPQPSGVLDA
Mb0231c|M.bovis_AF2122/97 AAPLLRPG--YLLLRDAVSTPRSYVSANALGLTSAPRATPQDFAVALAS-
Rv0226c|M.tuberculosis_H37Rv AAPLLRPG--YLLLRDAVSTPRSYVSANALGLTSAPRATPQDFAVALAS-
MMAR_0475|M.marinum_M VGPVLGPG--YLLLRDAVSTPRSYLSDSALGLMAAPRATPQDFAIALAS-
Mvan_5680|M.vanbaalenii_PYR-1 ---RATAPLVSASAVWVVAELVRLALAGAEAAGTTVTGLGLREAWEFAAY
Mflv_1126|M.gilvum_PYR-GCK ---RAWLPLVVASATWVVAEVVRLTITAAGAAGTGATSLGLRTAVEFATR
MSMEG_6437|M.smegmatis_MC2_155 ---VAATPLAVTAAVWALAELVRLVTDAALAAGLSVRHIGVRTVADFGWY
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 DGYRALRLGTAAATVLAVLSAVMVPLSVSDVSGQPLSDFGPGELWTLASE
MAV_1692|M.avium_104 DGYRALRLGTVASGVWAVCAALLVPLTLSDVSGHPVADLRPAQMWSLAGL
Mb0231c|M.bovis_AF2122/97 ---------HLVDGGVVVKALLLLGLWLAGWGAARLVATALPAAGAAGQF
Rv0226c|M.tuberculosis_H37Rv ---------HLVDGGVVVKALLLLGLWLAGWGAARLVATALPAAGAAGQF
MMAR_0475|M.marinum_M ---------QVIDGGILVKALLVLGLWLAGWGAAVLVARALPAAGAGGQF
Mvan_5680|M.vanbaalenii_PYR-1 TAPGRAGLLTVLAAAAVCAVTSVAPRSG--------PACIAGAGLACIGV
Mflv_1126|M.gilvum_PYR-GCK TAPGRAGLLTILAAALVCALAVLRIGSV--------PTAVASAGAAAVGI
MSMEG_6437|M.smegmatis_MC2_155 TTVGRSGLVSIVAAVAVCGVASATQRPARFSVVSGPSAMLATVGISAAGM
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 IETVNAWRWMAFIAAGVAITSRVVLRWS------WTPLLVLGSVATLMPL
MAV_1692|M.avium_104 ITTASAWRWTAILAAAITLASLPVLRWS------WAPVLVAASLTTLIPL
Mb0231c|M.bovis_AF2122/97 VAITLAIWNPYVAERLLQGHWSLLVGYG----------CLPWVATAMLTM
Rv0226c|M.tuberculosis_H37Rv VAITLAIWNPYVAERLLQGHWSLLVGYG----------CLPWVATAMLTM
MMAR_0475|M.marinum_M VAITLAIWNPYVAERLLQGHWSLLLGYG----------CLPWVAATMLGL
Mvan_5680|M.vanbaalenii_PYR-1 IGHPLTGHLSGSVLGGVSIAVHALAAALWCGTLAGLVLTVDHRG----QW
Mflv_1126|M.gilvum_PYR-GCK VGHPLTGHLADSPFGGVAIAVHALAAAVWCGALAAVVLTVDHRG----QW
MSMEG_6437|M.smegmatis_MC2_155 AARTLAGHLSESPLGGLAVAVHALAAALWCGLLAALVVTVTHRG----QW
TH_1178|M.thermoresistible__bu -----VDRLXXX-------------AALWCGVLAALVLTVAHRG----RW
MAB_1557|M.abscessus_ATCC_1997 ALVGHSATGGAHDLGTNSLIIHLVSAALWAGGLVSLLIHALRGG---GHL
MAV_1692|M.avium_104 GLTGHSSAGGSHDLATNGLLIHLVAAALWSGGLLALLAYALRGGQGGGHL
Mb0231c|M.bovis_AF2122/97 RTTVGAGWFGLFGLAFWVALAGLTPSGLLLAATVAVVCVAMPGA-GRPRW
Rv0226c|M.tuberculosis_H37Rv RTTVGAGWFGLFGLAFWVALAGLTPSGLLLAATVAVVCVAMPGA-GRPRW
MMAR_0475|M.marinum_M RASEAS-QTGFFGLAFWIALAGLTPTGLLLAATVALTCVAAPGG-GKPRW
:.: . .: . . :
Mvan_5680|M.vanbaalenii_PYR-1 ARVLPRFSQLSLGCVAALLAGGIAAGVTVLESPAALYATGYGRVLSLKIA
Mflv_1126|M.gilvum_PYR-GCK ARILPRFSRLSFGCVAALLAGGVVGGVAMLASAADLYATGYGRVLTAKIA
MSMEG_6437|M.smegmatis_MC2_155 ARVLPRFSQLSLGCVAVLLVAGVVGALVRLQSPADLVVTGYGRLLSAKML
TH_1178|M.thermoresistible__bu ARVLPRFSQVSLWCVIVLLVCGVAGAAVTLASPAALFDTGYGRVLSGKIA
MAB_1557|M.abscessus_ATCC_1997 DVAARRFSMLALWCYVAIGLSGIINALIRVQ-LSDLFTTRYGWLLMGKAT
MAV_1692|M.avium_104 GLATRRFSAIALWCWVAMALSGLVNAAVRVQ-PSDLLATGYGRLVLAKAA
Mb0231c|M.bovis_AF2122/97 QCGVAALGSALVGALPWLTASALGSSLTSHTAANQLGVTAFAPRAEPGLG
Rv0226c|M.tuberculosis_H37Rv QCGVAALGSALVGALPWLTASALGSSLTSHTAANQLGVTAFAPRAEPGLG
MMAR_0475|M.marinum_M LCATAALTAALVGALPWLTASALGSSLTTHTAANGLGVAAFAPRAEPGLG
: . . : .: . * : :.
Mvan_5680|M.vanbaalenii_PYR-1 LTLVLIALAWRNRELWLPAARTHRSTAAVSR---TRAYTELTLMA--ATV
Mflv_1126|M.gilvum_PYR-GCK LTVVLVVLAWRNRRIWVPAARTHRSSAVLSR---SRAHVEVALMA--AAL
MSMEG_6437|M.smegmatis_MC2_155 VTAGLLVLAWRNRSGWLPAARAHRSSAGLSQ---RRSLVELGAMG--VVV
TH_1178|M.thermoresistible__bu VTVALIGLAWRNRTGWVPAARAHRTTAEVST---ARSLTELALMT--VAL
MAB_1557|M.abscessus_ATCC_1997 ALLLLGVLGYLQRRSAITALDED---PENRQPLIRLAGVEAIIFA--VTF
MAV_1692|M.avium_104 ALCLLGGVGWRQRRVNVAALQAVSTLARARRALLRLTLIEAALFG--LTF
Mb0231c|M.bovis_AF2122/97 TLGSLASLGGIWNGEAVPSSRTTLFAVASAVVLLAMVAIGLPTVARRPVA
Rv0226c|M.tuberculosis_H37Rv TLGSLASLGGIWNGEAVPSSRTTLFAVASAVVLLAMVAIGLPTVARRPVA
MMAR_0475|M.marinum_M TLLSLASLGGIWNGDAVPGSRTTLFAVASAAVLLVVVAVGLPTVARRPAL
* :. . :.. . .
Mvan_5680|M.vanbaalenii_PYR-1 AAAAVLSVTG----------------------------------------
Mflv_1126|M.gilvum_PYR-GCK AAAATLSVTG----------------------------------------
MSMEG_6437|M.smegmatis_MC2_155 TFAAALAVTG----------------------------------------
TH_1178|M.thermoresistible__bu TFAAVLTVTG----------------------------------------
MAB_1557|M.abscessus_ATCC_1997 GIAVGLGRTPPPPPVNLNPSPVEVAIGYNLDGPPTPGRLMFDWRFDLIFG
MAV_1692|M.avium_104 GIAVGLGRTAPPPPPARLPSIAEAEIGYDFDGPPTLTRILFDWRFDLIFG
Mb0231c|M.bovis_AF2122/97 VPLLTLAAVSVMVPAVLATGPGLHALRVVVDAAPGLGVLRDGQKWVALAV
Rv0226c|M.tuberculosis_H37Rv VPLLTLAAVSVMVPAVLATGPGLHALRVVVDAAPGLGVLRDGQKWVALAV
MMAR_0475|M.marinum_M VPLLVLAAVSVLVPAALATGPGLHILAAAVDAAPGLGVLRDGQKWVALAM
* .
Mvan_5680|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1126|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6437|M.smegmatis_MC2_155 --------------------------------------------------
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 TAAIVFAIAYVVGVRRLKQRGDEWPIGRTISWLFGCGFLLIATSSGVGRY
MAV_1692|M.avium_104 TAAIVLAGLYVAGVVRLRRRGDRWQPGCTSSWLLGCLVLLFVTSSGVGRY
Mb0231c|M.bovis_AF2122/97 PGYTLSGAGTVLTLRRWLRPAT----------------------AAVVCC
Rv0226c|M.tuberculosis_H37Rv PGYTLSGAGTVLTLRRWLRPAT----------------------AAVVCC
MMAR_0475|M.marinum_M PGYAVSAAAAVSTLSRCKTAATPLKS----------------TLAASACC
Mvan_5680|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1126|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6437|M.smegmatis_MC2_155 --------------------------------------------------
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 MPAMFSMHMVAHMMLSMLVPVLLVLGGPVTLLLRVLPAAGKSDPPGLREW
MAV_1692|M.avium_104 MPAMFSMHMVVHMCLSMLVPILLALGAPVTLALRALPAAGRGDPPGPREW
Mb0231c|M.bovis_AF2122/97 LALVLTLPDLAWGVWGKVAPVHYPSG-------WAAVAAAINADPRTVAV
Rv0226c|M.tuberculosis_H37Rv LALVLTLPDLAWGVWGKVAPVHYPSG-------WAAVAAAINADPRTVAV
MMAR_0475|M.marinum_M LALVLALPDLAWGVLGRVAPVHYPPG-------WTAVATAINHQPGTVAV
Mvan_5680|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1126|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6437|M.smegmatis_MC2_155 --------------------------------------------------
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 VQLALHSKFSRFLTHPLVATSLFIGGFYGLYLSGLYDAAVDVHAAHLAMN
MAV_1692|M.avium_104 LLAALHSRFSRLLTNPVVATVLFVAGFYGLYLSNLFDTTASSHAGHLLMN
Mb0231c|M.bovis_AF2122/97 LPAGTMRRFSWSGSAPVLDP-------LPRWVRADVLTTGDLVISGVTVP
Rv0226c|M.tuberculosis_H37Rv LPAGTMRRFSWSGSAPVLDP-------LPRWVRADVLTTGDLVISGVTVP
MMAR_0475|M.marinum_M LPIGTMRRFSWAGRAPVLDP-------LPRWVRPDVLSSGDLVISGVLVP
Mvan_5680|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1126|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6437|M.smegmatis_MC2_155 --------------------------------------------------
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 LHFLLSGYLFYWVVIGIDPSPRRLPPVAKLGIVLVSLPLHAFFGVILMGT
MAV_1692|M.avium_104 LHFLLSGYLFYWVVIGVDPTPRPIPPLAKLAVVFASLPLHAFFGVVLMGT
Mb0231c|M.bovis_AF2122/97 GEDAHARAVQELLLTGPHPSTLAAAGVGWLVVESDSAGDMGAAARTLGRL
Rv0226c|M.tuberculosis_H37Rv GEDAHARAVQELLLTGPHPSTLAAAGVGWLVVESDSAGDMGAAARTLGRL
MMAR_0475|M.marinum_M GDGVRARTVQKLLLAGADPAALAQAGVGWLVVEVHGGGEVGEAGRTLDRL
Mvan_5680|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1126|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6437|M.smegmatis_MC2_155 --------------------------------------------------
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 KSILGEKFYSNLALPWRIDLAADQHMGGAITWATGELPLMVVMIALVVQW
MAV_1692|M.avium_104 RKVLGADYYRSLGFSWHTDLLGDQRLGGGIAWSAGEFPLVIVMLALLVQW
Mb0231c|M.bovis_AF2122/97 AAAHRDDELALYRVGGQTSGASSARLK-ATMLAHWAWLSMLLVGGAGAAG
Rv0226c|M.tuberculosis_H37Rv AAAHRDDELALYRVGGQTSGASSARLK-ATMLAHWAWLSMLLVGGAGAAG
MMAR_0475|M.marinum_M TPTYRDDELALYRIGGRSAGVPAGDRR-AMMLAHWAWLSMLLAGGAGMAA
Mvan_5680|M.vanbaalenii_PYR-1 ------------------------------------------------
Mflv_1126|M.gilvum_PYR-GCK ------------------------------------------------
MSMEG_6437|M.smegmatis_MC2_155 ------------------------------------------------
TH_1178|M.thermoresistible__bu ------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 SRSDERLARRQDRAADRDDDADLAAYNAMLAKMAQHNEKTRG------
MAV_1692|M.avium_104 ARSDRRTAKRLDRAADRDDDAELAAYNAMLAQLAGRDKPGEGSATGQA
Mb0231c|M.bovis_AF2122/97 YWVRRHLHHCEDTPASRAQD----------------------------
Rv0226c|M.tuberculosis_H37Rv YWVRRHLHHCEDTPASRAQD----------------------------
MMAR_0475|M.marinum_M GRVRRHLSGREESPTDLAAD----------------------------