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EHPAYGLLRPVTDTASVLLCENPGLMTLDGTNTWVLRGPGSDEMVVVDPGPDDRDEHIERLAALGPIPLV LISHRHADHTGGIDRIVDLTGAVVRSVGSGFQRGLGGTLTDGEVIDAAGLKITVMATPGHTADSMSFLVG DAVLTADTILGRGTTVIDSEDGDLGDYLESLRRLHGLGHRRVLPGHGPELDDVVVVSQDYLTHREERLEQ VRAALRELGEDATARQVVEHVYTDVDEKLWDAAESSVQAQLDHLRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5436 | - | - | 100% (257) | beta-lactamase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1228 | - | 4e-09 | 28.50% (193) | beta-lactamase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2589 | - | 2e-07 | 26.24% (202) | beta-lactamase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3701c | - | 1e-106 | 74.22% (256) | putative hydrolase |
| M. gilvum PYR-GCK | Mflv_1370 | - | 1e-130 | 88.72% (257) | beta-lactamase domain-containing protein |
| M. tuberculosis H37Rv | Rv3677c | - | 1e-106 | 74.22% (256) | hydrolase |
| M. leprae Br4923 | MLBr_02303 | - | 1e-104 | 73.15% (257) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0414 | - | 1e-100 | 69.38% (258) | beta-lactamase-like hydrolase |
| M. marinum M | MMAR_5165 | - | 1e-104 | 71.60% (257) | hypothetical protein MMAR_5165 |
| M. avium 104 | MAV_0452 | - | 1e-113 | 77.56% (254) | metallo-beta-lactamase family protein |
| M. smegmatis MC2 155 | MSMEG_6190 | - | 1e-116 | 80.08% (261) | metallo-beta-lactamase family protein |
| M. thermoresistible (build 8) | TH_2128 | - | 1e-123 | 84.77% (256) | POSSIBLE HYDROLASE |
| M. ulcerans Agy99 | MUL_4251 | - | 1e-104 | 71.60% (257) | hypothetical protein MUL_4251 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5436|M.vanbaalenii_PYR-1 -------MEHPAYGLLRPVTDTASVLLCENPGLMTLDGTNTWVLRGPGSD
Mflv_1370|M.gilvum_PYR-GCK -------MEHPAYNVLRPVTDTASVLLCENPGLMTLDGTNTWVLRGPGSD
MSMEG_6190|M.smegmatis_MC2_155 ----MSDLQHPAYGLLRPVTGSASVLLCNNPGLMTLEGTNTWVLRAPRSD
TH_2128|M.thermoresistible__bu ----VSDLEHPAYGLLRPVTETASVLLADNPGLMTLDGTNTWVLRGPGSD
MMAR_5165|M.marinum_M MSETAGSLTHPAYGRLRPVTDLASVLVADNPGLLTLEGTNTWVLRGPRSD
MUL_4251|M.ulcerans_Agy99 MSETAGSLTHPAYGRLRPVTDLASVLVADNPGLLTLEGTNTWVLRGPRSD
MAV_0452|M.avium_104 MTEVAESPTHPAYGRLRAVTDTASVLLADNPGLLTLEGTNTWVLRGPGSD
Mb3701c|M.bovis_AF2122/97 MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSD
Rv3677c|M.tuberculosis_H37Rv MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSD
MLBr_02303|M.leprae_Br4923 MAEVVKWLAHPAYGRLRAVTDTASVLLADNPGLLTLEGTNTWVLRGPGSG
MAB_0414|M.abscessus_ATCC_1997 --------MHPAYGQLRPVTETASVLLANNPGMMTLEGTNTWVLRAPGSD
****. **.** ****:.:***::**:********.* *.
Mvan_5436|M.vanbaalenii_PYR-1 EMVVVDPGP----DDRDEHIERLAALGPIPLVLISHRHADHTGGIDRIVD
Mflv_1370|M.gilvum_PYR-GCK EMVVVDPGP----DDKDEHIERLAALGRISLVLISHRHGDHTGGIDRLVD
MSMEG_6190|M.smegmatis_MC2_155 EIVVVDPGP----DD-DEHIARVAELGTISLVLISHKHEDHTGGIDKIVE
TH_2128|M.thermoresistible__bu EMVVVDPGP----DD-ADHIARLAELGPIPLVLISHKHEDHTGGIDKIVD
MMAR_5165|M.marinum_M ELVVVDPGP----AD-DEHIARIAALGRIALVLISHRHGDHTDGIDKLFE
MUL_4251|M.ulcerans_Agy99 ELVVVDPGP----AD-DEHIARIAALGRIALVLISHRHGDHTDGIDKLFE
MAV_0452|M.avium_104 ELVIVDPGP----DD-DEHIARIAALGRIALVLISHRHGDHTDGIDKLVE
Mb3701c|M.bovis_AF2122/97 ELVVVDPGP----DD-DEHLARVAALGRIALVLISHRHGDHTSGIDKLVA
Rv3677c|M.tuberculosis_H37Rv ELVVVDPGP----DD-DEHLARVAALGRIALVLISHRHGDHTSGIDKLVA
MLBr_02303|M.leprae_Br4923 ELVIVDPGP----GD--EHIVQVATLGRIALVLISHRHPDHTDGIDKLVE
MAB_0414|M.abscessus_ATCC_1997 EIVIVDPGPGVATGDPDVHVEQLAKIGKVALVLVSHRHFDHTGGVDRLVE
*:*:***** * *: ::* :* :.***:**:* ***.*:*::.
Mvan_5436|M.vanbaalenii_PYR-1 LTGAVVRSVGSGFQRGLGGTLTDGEVIDAAGLKITVMATPGHTADSMSFL
Mflv_1370|M.gilvum_PYR-GCK MTGAVVRSVGSGFQRGLGGTLTDGEVIDAAGLAITVMATPGHTADSVSFL
MSMEG_6190|M.smegmatis_MC2_155 RTGAVVRSVGSGFLRGLGGPLTDGEVIDAAGLRITVMATPGHTADSLSFV
TH_2128|M.thermoresistible__bu ATGAVVRSVGSGFLRGLGGPLTDGEVIEAAGLRITVLATPGHTVDSLSFV
MMAR_5165|M.marinum_M RTGAPVRAADPQFLRGDPVALSDGEVIDAGGLKITVLATPGHTADSLSFV
MUL_4251|M.ulcerans_Agy99 RTGAPVRAADPQFLRGDPVALSDGEVIDAGGLKITVLATPGHTADSLSFV
MAV_0452|M.avium_104 RTGATVRSAGSGFLRGLGGELTDGEVIDAAGLRIKVMATPGHTADSLCFL
Mb3701c|M.bovis_AF2122/97 LTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTITVLATPGHTADSLSFV
Rv3677c|M.tuberculosis_H37Rv LTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTITVLATPGHTADSLSFV
MLBr_02303|M.leprae_Br4923 LTGAPVCAADPQFLRGDGVTLTDREVIDAGGLTITVLATPGHTADSMSFV
MAB_0414|M.abscessus_ATCC_1997 LTGAPARAVDPAWLRGDSVALTDGERIDVAGLSISVLATPGHSDDSVSFV
*** . :... : * *:* * *:..** *.*:*****: **:.*:
Mvan_5436|M.vanbaalenii_PYR-1 VGD-----AVLTADTILGRGTTVIDSEDGDLGDYLESLRRLHGLGHRRVL
Mflv_1370|M.gilvum_PYR-GCK VDD-----AVLTADTVLGRGTTVIDSEDGDLGDYLESLRRLRGLGHLTVL
MSMEG_6190|M.smegmatis_MC2_155 LDDGDGPGAVLTADTVLGRGTTVIDTEDGSLRDYLDSLHRLKGLGERVVL
TH_2128|M.thermoresistible__bu LDD-----AVLTADTVLGRGTTVIDDEDGSLAAYLESLRRLRGLGRRVVL
MMAR_5165|M.marinum_M LED-----AVLTADSVLGRGTTVLDKQDGSLSEYLESLHRLRGLGPRMVL
MUL_4251|M.ulcerans_Agy99 LED-----AVLTADSVLGRGTTVLDKQDGSLSEYLESLHRLRGLGPRMVL
MAV_0452|M.avium_104 LDD-----AVLTADTVLGRGTTVLDKEDGSLTDYLESLRRLRGLGRRAVL
Mb3701c|M.bovis_AF2122/97 LDD-----AVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGRRTVL
Rv3677c|M.tuberculosis_H37Rv LDD-----AVLTADTVLGCGTTVIDKEDGSLADYLESLHRLRGLGRRTVL
MLBr_02303|M.leprae_Br4923 LAD-----AVLTADSVLGHGTTVIDPDDGSLADYLESLHRLSGLGRRTVL
MAB_0414|M.abscessus_ATCC_1997 LDD-----AVLTADTILGRGTTVIAQDGGGLGDYLESLKRLEGLGKRTVL
: * ******::** ****: :.*.* **:**:** *** **
Mvan_5436|M.vanbaalenii_PYR-1 PGHGPELDDVVVVSQDYLTHREERLEQVRAALRELGEDATARQVVEHVYT
Mflv_1370|M.gilvum_PYR-GCK PGHGPELDDMAAVSEFYLAHREERLAQVRGALGALGEDATARQVVEHVYT
MSMEG_6190|M.smegmatis_MC2_155 PGHGPELGDLSGVAQMYLAHREERLEQVREALRELGDDATARQVVEHVYT
TH_2128|M.thermoresistible__bu PGHGPELPDLAAVSDMYLAHREERLEQVRAALRELGEDATARQVVEHVYT
MMAR_5165|M.marinum_M PGHGPDLADIRIVAQGYLAHRQERLEQVRSALRELGEQASARQIVEHVYV
MUL_4251|M.ulcerans_Agy99 PGHGPDLADIRIVAQGYLAHRQERLEQVRSALRELGEQASARQIVEHVYV
MAV_0452|M.avium_104 PGHGPDLTDLESVAQGYLEHRRERLDQVRSAVRELGEDVSARRIVEHVYV
Mb3701c|M.bovis_AF2122/97 PGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL
Rv3677c|M.tuberculosis_H37Rv PGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL
MLBr_02303|M.leprae_Br4923 PGHGPDLANLESVASGYLVHRQERLEQVRAALRELGDDATARQVVEHVYV
MAB_0414|M.abscessus_ATCC_1997 PGHGPELSDLSAASAEYLAHREQRLDQVRAALAALGEDASARQVVEFVYT
*****:* :: : ** **.:** *:* *: **::.:.*.:**.**
Mvan_5436|M.vanbaalenii_PYR-1 DVDEKLWDAAESSVQAQLDHLRR------
Mflv_1370|M.gilvum_PYR-GCK DVDEKLWDAAEWSVQAQLNYLRR------
MSMEG_6190|M.smegmatis_MC2_155 DVDEKLWDAAEKSVQAQLDYLRH------
TH_2128|M.thermoresistible__bu DVDEKLWDAAESSVRAQLDYLRFRRGHDR
MMAR_5165|M.marinum_M DVDEKLWDAAEWSVQVQLNHLHQAGSPS-
MUL_4251|M.ulcerans_Agy99 DVDEKLWDAAEWSVQVQLNHLHQAGSQS-
MAV_0452|M.avium_104 DVDEKLWDAAEWSVQVQLNHLRSEPST--
Mb3701c|M.bovis_AF2122/97 DVDEKLWNAAEWSVQAQLDYLRTR-----
Rv3677c|M.tuberculosis_H37Rv DVDEKLWNAAEWSVQAQLDYLRTR-----
MLBr_02303|M.leprae_Br4923 DVDEKFWDAAEWSVQAQLDYLRR------
MAB_0414|M.abscessus_ATCC_1997 DVDPSLWGAAEWSVQAQLDYLRTV-----
*** .:*.*** **:.**::*: