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SSSSKSGFTVGRAVDWKLAATLGGKLARPEPPATDYTRKQAFEQLAEAARASELPVREVTGLIEGGEIPE ARIVNRPEWIHAAAQSMRAMTGGGHADDVKPRAVTGRIAGAQTGAVLAFVSSGILGQYDPFAVGGGELLL VYPNVIAVERQLRVAPKDFRMWVCLHEVTHRVQFRANPWLADHMSKALAVLTEDAGEDLPQVVGRLVDYV RDREVVVKNSEPAMNSTGVLGLLRAVQSEPQREALDRLLVLGTLLEGHAEHVMDAVGPAVVPSVASIRHR FDQRRQRRQPPLQRLLRALLGVDAKMSQYTRGKAFVDHVVAEVGMQRFNAIWTDAETLPKPAEIDEPQRW IDRVL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5379 | - | - | 100% (356) | hypothetical protein Mvan_5379 |
| M. vanbaalenii PYR-1 | Mvan_1812 | - | 1e-09 | 21.07% (280) | hypothetical protein Mvan_1812 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3650c | - | 1e-133 | 67.90% (352) | hypothetical protein Mb3650c |
| M. gilvum PYR-GCK | Mflv_1410 | - | 1e-173 | 84.23% (355) | hypothetical protein Mflv_1410 |
| M. tuberculosis H37Rv | Rv3626c | - | 1e-133 | 67.90% (352) | hypothetical protein Rv3626c |
| M. leprae Br4923 | MLBr_00642 | - | 1e-10 | 20.24% (252) | hypothetical protein MLBr_00642 |
| M. abscessus ATCC 19977 | MAB_0520 | - | 1e-132 | 67.53% (348) | hypothetical protein MAB_0520 |
| M. marinum M | MMAR_5126 | - | 1e-135 | 67.60% (358) | hypothetical protein MMAR_5126 |
| M. avium 104 | MAV_0530 | - | 1e-136 | 68.82% (356) | hypothetical protein MAV_0530 |
| M. smegmatis MC2 155 | MSMEG_6112 | - | 1e-154 | 73.95% (357) | hypothetical protein MSMEG_6112 |
| M. thermoresistible (build 8) | TH_1411 | - | 1e-144 | 68.42% (380) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4202 | - | 1e-135 | 67.32% (358) | hypothetical protein MUL_4202 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3650c|M.bovis_AF2122/97 ----------------------------------------------MTGA
Rv3626c|M.tuberculosis_H37Rv ----------------------------------------------MTGA
MMAR_5126|M.marinum_M ----------------------------------------------MTAA
MUL_4202|M.ulcerans_Agy99 ----------------------------------------------MTAA
MAV_0530|M.avium_104 ----------------------------------------------MTPA
Mvan_5379|M.vanbaalenii_PYR-1 --------------------------------------------MSSSSK
Mflv_1410|M.gilvum_PYR-GCK ------------------------------------MPLMTPKTKSDSGT
MSMEG_6112|M.smegmatis_MC2_155 -----------------------------------------------MSR
TH_1411|M.thermoresistible__bu -------------------------------------------VPDMTSE
MAB_0520|M.abscessus_ATCC_1997 ---------------------------------MAESGRVVQSGGVGTKS
MLBr_00642|M.leprae_Br4923 MAHSGSPVSTVDGVANPPFGFSSGNDSPNDESGRDKHGKNGPDSGSSGSD
Mb3650c|M.bovis_AF2122/97 SELTLGNTVDWEFAAS------VGERLARP----------APPSTEYTRR
Rv3626c|M.tuberculosis_H37Rv SELTLGNTVDWEFAAS------VGERLARP----------APPSTEYTRR
MMAR_5126|M.marinum_M SDVTLGNTVDWQFAAT------VGERLARP----------GPPSSDYTRR
MUL_4202|M.ulcerans_Agy99 SDVTLGNTVDWQFAAT------VGERLARP----------GPPSSDYTRR
MAV_0530|M.avium_104 PDLTLGTAVDWRFAAT------VGRRLARP----------GPPSTDYTRR
Mvan_5379|M.vanbaalenii_PYR-1 SGFTVGRAVDWKLAAT------LGGKLARP----------EPPATDYTRK
Mflv_1410|M.gilvum_PYR-GCK SRFSVGHAVDWNLAAT------VGGKLARQ----------EPKATDYTRR
MSMEG_6112|M.smegmatis_MC2_155 PTMTAGRAVDWDFAAS------VGAKLARP----------EPPSTDYTRR
TH_1411|M.thermoresistible__bu RRLTVGRAVDWEFAAD------VGARLARP----------GPTTTDYTRR
MAB_0520|M.abscessus_ATCC_1997 PELTVGRMVNWEFAAT------VGVKLARP----------APPTTEYTRR
MLBr_00642|M.leprae_Br4923 PLASFGMSGDFGMSDLGQIFTHLGQMFTNAGTAMTADKQLGPVNYELARR
: * :: :: :* ::. * : :*:
Mb3650c|M.bovis_AF2122/97 QVIDELTVAAEK---AEPPVRDVTGLIAD-----GVVPPARVVDR----P
Rv3626c|M.tuberculosis_H37Rv QVIDELTVAAEK---AEPPVRDVTGLIAD-----GVVPPARVVDR----P
MMAR_5126|M.marinum_M QAVDELMRAAEQ---AEPPVRDVTGLITT-----GDVPAARVVDR----P
MUL_4202|M.ulcerans_Agy99 QAVDELMRAAEQ---AEPPVRDVTGLITT-----GDVPAGRVVDR----P
MAV_0530|M.avium_104 QVIDELAGAATK---AEPLVRQVTGLLTDGAD-DGRVPAARIVDR----P
Mvan_5379|M.vanbaalenii_PYR-1 QAFEQLAEAARA---SELPVREVTGLIEG-----GEIPEARIVNR----P
Mflv_1410|M.gilvum_PYR-GCK QAIEQLAQSARD---SEIPVREVTGLIEG-----GEIPEARIVNR----P
MSMEG_6112|M.smegmatis_MC2_155 QAIDQLSESARA---AELPVREVTGLNEG-----AEVPEARVVDR----P
TH_1411|M.thermoresistible__bu QAIEQLAELSRT---AEVPVREVTGLIEG-----DEIPEARIVDR----P
MAB_0520|M.abscessus_ATCC_1997 QAIAELSDAARR---AETPVREVTGLADG-----LLVPEARVIDR----P
MLBr_00642|M.leprae_Br4923 VASSSIGFVAPIPATTSSAIGDAVHLAETWLDGVTALPAGTTKAEGWTPD
. .: : :. : :.. * :* . .
Mb3650c|M.bovis_AF2122/97 AWIRSAAESMRAMTH-------------GSAKPRG----------FLTGR
Rv3626c|M.tuberculosis_H37Rv AWIRSAAESMRAMTH-------------GSAKPRG----------FLTGR
MMAR_5126|M.marinum_M EWIRAAAESMRAMTN-------------GAEKPRG----------LLTGR
MUL_4202|M.ulcerans_Agy99 EWIRAAAESMRAMTN-------------GAEKPRG----------LLTGR
MAV_0530|M.avium_104 EWIAAAAESMRVMMN-------------GTERPRG----------FLTGR
Mvan_5379|M.vanbaalenii_PYR-1 EWIHAAAQSMRAMTG-------------GGHADDV-------KPRAVTGR
Mflv_1410|M.gilvum_PYR-GCK DWIRAAAQSMRAMTG-------------GAHDGDV-------KPRMITGR
MSMEG_6112|M.smegmatis_MC2_155 AWIRAATRSMRVMTT-------------GGDTGDS--DANGDKPGFITGR
TH_1411|M.thermoresistible__bu QWIRAASASMRVMTG-------------GATSADTNGEKSGAAAGFIAGK
MAB_0520|M.abscessus_ATCC_1997 GWISAAAQSMRLMAG-------------GGEGATG----------FLSGR
MLBr_00642|M.leprae_Br4923 DWVNNTLETWKRLCDPMAQQISTVWAASLPEEAKSMASPLLSMMSQMGGM
*: : : : : : *
Mb3650c|M.bovis_AF2122/97 ITGAQTGAVLAFVASGILGQYDPFGAA-------------------GEGC
Rv3626c|M.tuberculosis_H37Rv ITGAQTGAVLAFVASGILGQYDPFGAA-------------------GEGC
MMAR_5126|M.marinum_M ITGAQTGAVLAFVASGILGQYDPFAAADAA----------------GMGG
MUL_4202|M.ulcerans_Agy99 ITGAQTGAVLAFVASGILGQYDPFAAADGA----------------GMGG
MAV_0530|M.avium_104 VTGAQTGAVLAYVSSGILGQYDPFATDRGA----------------GAGC
Mvan_5379|M.vanbaalenii_PYR-1 IAGAQTGAVLAFVSSGILGQYDPFAV--------------------GGGE
Mflv_1410|M.gilvum_PYR-GCK VAGAQTGAVLAFVSSGILGQYDPFS---------------------GDGE
MSMEG_6112|M.smegmatis_MC2_155 VTGAQTGAVLAFISSGILGQYDPFGP--------------------DGGE
TH_1411|M.thermoresistible__bu LTGAQTGAVLAFISSGILGQYDPFAPRGRERGADGGRAGDDPGGPRSGGE
MAB_0520|M.abscessus_ATCC_1997 VTGAQTGAVLAFVSSGILGQYDPFTAD-------------------GAGA
MLBr_00642|M.leprae_Br4923 AFGSQLGQAFGQLSREVLTSTDIGLPLG------------------PRGV
*:* * .:. :: :* . * *
Mb3650c|M.bovis_AF2122/97 LLLVYPNVIAVERQLRVEPSDFRLWVCLHEVTHRVQFTANPWLSGYMSQA
Rv3626c|M.tuberculosis_H37Rv LLLVYPNVIAVERQLRVEPSDFRLWVCLHEVTHRVQFTANPWLSGYMSQA
MMAR_5126|M.marinum_M LLLVYPNVIAVERQLRVDPSDFRLWVCLHEVAHRVQFTANPWLAGYMQQA
MUL_4202|M.ulcerans_Agy99 LLLVYPNVIAVERQLRVDPSDFRLWVCLHEVAHRVQFTANPWLAGYMQQA
MAV_0530|M.avium_104 LLLVYPNVIAVERQLRIEPSDFRLWVCLHEVTHRVQFTANPWLPGYMSQA
Mvan_5379|M.vanbaalenii_PYR-1 LLLVYPNVIAVERQLRVAPKDFRMWVCLHEVTHRVQFRANPWLADHMSKA
Mflv_1410|M.gilvum_PYR-GCK LLLVYPNVIAVERQLRVVPEDFRMWVCLHEVTHRVQFRANPWLAEHMSGA
MSMEG_6112|M.smegmatis_MC2_155 LLLVYPNVISVERQLRVAPADFRLWVCLHEVTHRVQFRANPWLADHMSQA
TH_1411|M.thermoresistible__bu LLLVYPNVIAVERQLRVVPADFRLWVCLHEVTHRVQFRANPWLAEHMSRA
MAB_0520|M.abscessus_ATCC_1997 LLLVYPNVIAVERQLRVVPSDFRMWVCLHEVTHRVQFSANPWLADYMSGT
MLBr_00642|M.leprae_Br4923 AAIMPQAVESFADGLEQPRCEILTFLATREAAHHRLFSHVPWLASQLLGA
:: * :. *. :: ::. :*.:*: * ***. : :
Mb3650c|M.bovis_AF2122/97 LNLLTFEPVDDIGRVVSRLADFIRSRGHG--TDDSEVNPSGILGLVRAVQ
Rv3626c|M.tuberculosis_H37Rv LNLLTFEPVDDIGRVVSRLADFIRSRGHG--TDDSEVNPSGILGLVRAVQ
MMAR_5126|M.marinum_M LGLLTTEPADDIGQVVSRLANFVRNRDDP--GDDS-GNVTGILGVVRAVQ
MUL_4202|M.ulcerans_Agy99 LGLLTTEPADDIGQVVSRLANFVRNRDDP--GDDS-GNVTGILGVVRAVQ
MAV_0530|M.avium_104 LALLTRDTGDDLGQVLSRLADYARNRGNT--ASQADANSTGILGLVRAVQ
Mvan_5379|M.vanbaalenii_PYR-1 LAVLTEDAGEDLPQVVGRLVDYVRDREVVVKNSEPAMNSTGVLGLLRAVQ
Mflv_1410|M.gilvum_PYR-GCK LAVLTEDGGEDLTAMVGRLADYVRDHQVVVKNGEPELNSTGIIGLLRAVQ
MSMEG_6112|M.smegmatis_MC2_155 LAVLTQDAGDDVAALAGRLAQYVRDQRGT-NGSAPEPNSTGILGLMRAVQ
TH_1411|M.thermoresistible__bu LAVLTQDVTEEATAVIARLAEFLRNRR---TYVETEPNSTGVLGLVRAVQ
MAB_0520|M.abscessus_ATCC_1997 LATLAHEQEEDVAGMLGRLADFVRSSRSQ--------GHNGIVELLRAMQ
MLBr_00642|M.leprae_Br4923 VEAYAAGMKIDMNGIEELARDFNPASLSD----PTAIEELLGQGVFEPQA
: : : : :: :...
Mb3650c|M.bovis_AF2122/97 SEPQRKALDQLLVLGTLLEGHAEHVMDAVGPMVVPSVATIRRRFDDRRHH
Rv3626c|M.tuberculosis_H37Rv SEPQRKALDQLLVLGTLLEGHAEHVMDAVGPMVVPSVATIRRRFDDRRHH
MMAR_5126|M.marinum_M SEPQRQALDQLLALGTLLEGHAEHVMDAVGPMVVPSVAVIRRRFDERRQR
MUL_4202|M.ulcerans_Agy99 SEPQRQALDQLLALGTLLEGHAEHVMDAVGPMVVPSVAVIRRRFDERRQR
MAV_0530|M.avium_104 SEPQRQALDQLLVLGTLLEGHADHVMDAVGPMAVPSVATIRRRFDERRHR
Mvan_5379|M.vanbaalenii_PYR-1 SEPQREALDRLLVLGTLLEGHAEHVMDAVGPAVVPSVASIRHRFDQRRQR
Mflv_1410|M.gilvum_PYR-GCK SEPQRQALDRLLVLGTLLEGHAEHVMDAVGPAVVPSVATIRQRFDQRRQR
MSMEG_6112|M.smegmatis_MC2_155 AEPQRRALDQLLVLGTLLEGHADHVMDAVGPAVVPTVGTIRRRFDERRQR
TH_1411|M.thermoresistible__bu AEPQRRALDQLLVLGTLLEGHAEHVMDAVGPAVVPTVSVIRRRFDERRQR
MAB_0520|M.abscessus_ATCC_1997 SDSGRDALDRLLVLGTLLEGHADHVMDAVGPAVVPSVASIRSRFEARRSR
MLBr_00642|M.leprae_Br4923 TPAQTQALERLEALLALIEGWVQVVVTAALGDRIPGAAALGETLRRRRAS
: . **::* .* :*:** .: *: *. :* .. : : **
Mb3650c|M.bovis_AF2122/97 KQPPLQRLVRALLGFDAKLSQYTRGKAFVDHVVDRAGMKLFNTIWSGPET
Rv3626c|M.tuberculosis_H37Rv KQPPLQRLVRALLGFDAKLSQYTRGKAFVDHVVDRAGMKLFNTIWSGPET
MMAR_5126|M.marinum_M KQPPLQRLLRALLGFDAKLNQYTRGKAFVDDVVARVGMKRFNTIWTSPQT
MUL_4202|M.ulcerans_Agy99 KQPPLQRLLRALLGFDAKLNQYTRGKAFVDDVVARVGMKRFNTIWTSPQT
MAV_0530|M.avium_104 KQPPLQRLLRALLGLDAKLSQYTRGKAFVDQVVGRVGMARFNAVWTGPET
Mvan_5379|M.vanbaalenii_PYR-1 RQPPLQRLLRALLGVDAKMSQYTRGKAFVDHVVAEVGMQRFNAIWTDAET
Mflv_1410|M.gilvum_PYR-GCK KQPPLQRLLRILLGVDAKMSQYTKGKAFVDEVVGTVGMERFNAIWTDADT
MSMEG_6112|M.smegmatis_MC2_155 KQPPVQRIVRALLGFDAKLSQYTRGKAFVDHVVSAVGMQRFNTVWTNAET
TH_1411|M.thermoresistible__bu RQPPLQRLVRALLGVDAKISQYTRGKAFVDHVVAKVGMDRFNRVWESPET
MAB_0520|M.abscessus_ATCC_1997 KQPPLQRIIRALIGMDAKMRQYTRGKKFVDHVVGKVGMERFNTIWRDPQT
MLBr_00642|M.leprae_Br4923 GGP-AEQTFATLVGLELRPRKLREAAVLWERLTQAAGVDARDAVWQHPDL
* :: . *:*.: : : .. : : :. .*: : :* .:
Mb3650c|M.bovis_AF2122/97 LPLPAEIENPQRWIDRVL--------------------------------
Rv3626c|M.tuberculosis_H37Rv LPLPAEIENPQRWIDRVL--------------------------------
MMAR_5126|M.marinum_M LPLPAELENPRRWIDRVL--------------------------------
MUL_4202|M.ulcerans_Agy99 LPLPAELENPRRWIDRVL--------------------------------
MAV_0530|M.avium_104 LPLPVEIEEPQRWIDRVL--------------------------------
Mvan_5379|M.vanbaalenii_PYR-1 LPKPAEIDEPQRWIDRVL--------------------------------
Mflv_1410|M.gilvum_PYR-GCK LPQPQEIDEPQRWIDRVL--------------------------------
MSMEG_6112|M.smegmatis_MC2_155 LPLPTEIDEPQRWIDRVL--------------------------------
TH_1411|M.thermoresistible__bu LPLPAEIEEPHRWIDRVL--------------------------------
MAB_0520|M.abscessus_ATCC_1997 LPQPAEIEDPDQWIDRVL--------------------------------
MLBr_00642|M.leprae_Br4923 LPSGKDLDDPASFIDRIIGGDTSGIDEAIAKLDLDRGNSDGRTPGSGGPV
** ::::* :***::
Mb3650c|M.bovis_AF2122/97 --
Rv3626c|M.tuberculosis_H37Rv --
MMAR_5126|M.marinum_M --
MUL_4202|M.ulcerans_Agy99 --
MAV_0530|M.avium_104 --
Mvan_5379|M.vanbaalenii_PYR-1 --
Mflv_1410|M.gilvum_PYR-GCK --
MSMEG_6112|M.smegmatis_MC2_155 --
TH_1411|M.thermoresistible__bu --
MAB_0520|M.abscessus_ATCC_1997 --
MLBr_00642|M.leprae_Br4923 DN