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GVVNVTDDSFSDGGLFLDRDRAVIHGVELVRQGAAIVDVGGESTRPGATRIDPAVESSRILPVVKELAQL GITVSIDTMHAAVARVALEHGAQIVNDVSGGRADPDMARVVADAGVPWVLMHWRSVGSDRPHEVPPYGDV VTAVRDELMAGVDAAVDAGVDPAKLIIDPGLGFAKTAQHNWALLHALPEFVTTGIPVLVGASRKRFLGEL LASPDGELRPPAGRETATAVVSALAGWHHVWGVRVHDVRASVDALAVVAAWQAGRDD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5370 | - | - | 100% (268) | dihydropteroate synthase |
| M. vanbaalenii PYR-1 | Mvan_4509 | - | 1e-28 | 36.26% (273) | dihydropteroate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3638c | folP1 | 1e-108 | 72.52% (262) | dihydropteroate synthase |
| M. gilvum PYR-GCK | Mflv_1418 | - | 1e-132 | 87.17% (265) | dihydropteroate synthase |
| M. tuberculosis H37Rv | Rv3608c | folP1 | 1e-108 | 72.52% (262) | dihydropteroate synthase |
| M. leprae Br4923 | MLBr_00224 | folP | 1e-107 | 72.90% (262) | dihydropteroate synthase |
| M. abscessus ATCC 19977 | MAB_0535 | - | 3e-89 | 60.38% (265) | dihydropteroate synthase |
| M. marinum M | MMAR_5111 | folP1 | 1e-108 | 72.62% (263) | dihydropteroate synthase 1 FolP1 |
| M. avium 104 | MAV_0544 | folP | 1e-109 | 74.90% (259) | dihydropteroate synthase |
| M. smegmatis MC2 155 | MSMEG_6103 | folP | 1e-111 | 73.58% (265) | dihydropteroate synthase |
| M. thermoresistible (build 8) | TH_0989 | folP | 1e-119 | 78.36% (268) | DIHYDROPTEROATE SYNTHASE 1 FOLP (DHPS 1) (DIHYDROPTEROATE |
| M. ulcerans Agy99 | MUL_4190 | folP1 | 1e-107 | 70.85% (271) | dihydropteroate synthase 1 FolP1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3638c|M.bovis_AF2122/97 ----------MSPAPVQVMGVLNVTDDSFSDGGCYLDLDDAVKHGLAMAA
Rv3608c|M.tuberculosis_H37Rv ----------MSPAPVQVMGVLNVTDDSFSDGGCYLDLDDAVKHGLAMAA
MLBr_00224|M.leprae_Br4923 ----------MSLAPVQVIGVLNVTDNSFSDGGRYLDPDDAVQHGLAMVA
MAV_0544|M.avium_104 ---------------------MNVTDDSFSDGGRYLDPDKAVAHGLALVA
MMAR_5111|M.marinum_M ----------MSSRPVQVMGVLNVTNDSFSDGGRYCDEAKAIEHGLALAA
MUL_4190|M.ulcerans_Agy99 ------------------MGVLNVTNDSFSDGGRYCDEAKAIEHGLALAA
Mvan_5370|M.vanbaalenii_PYR-1 ------------------MGVVNVTDDSFSDGGLFLDRDRAVIHGVELVR
Mflv_1418|M.gilvum_PYR-GCK ---------------MQVMGVVNVTDDSFSDGGLFLDRDRAVAHGVELVA
TH_0989|M.thermoresistible__bu VTPLPVLPQTSTTGSTVVMGVVNVTDDSFSDGGLFLDRDRAVAHGLALTE
MSMEG_6103|M.smegmatis_MC2_155 MNPPSLTAQPGTP--VQVMGVVNVTQDSFSDGGKFIDTDRAVEHGLALVA
MAB_0535|M.abscessus_ATCC_1997 ----MIAGVTETPALTHILGVVNVTDDSFSDGGRFVRQSDAVAHGLALAS
:***::****** : *: **: :.
Mb3638c|M.bovis_AF2122/97 AGAGIVDVGGESSRPGATRVDPAVETSRVIPVVKELAAQGITVSIDTMRA
Rv3608c|M.tuberculosis_H37Rv AGAGIVDVGGESSRPGATRVDPAVETSRVIPVVKELAAQGITVSIDTMRA
MLBr_00224|M.leprae_Br4923 EGAAIVDVGGESTRPGAIRTDPRVELSRIVPVVKELAAQGITVSIDTTRA
MAV_0544|M.avium_104 EGAGIVDVGGESTRPGATRIDPRVETSRVVPVVKALAAEGVTVSIDTMHA
MMAR_5111|M.marinum_M EGADIIDVGGESTRPGAARVDPAVEASRVLPVIKELAARGIKVSIDTTRA
MUL_4190|M.ulcerans_Agy99 EGADIIDVGGESTRPGAARVDPAVEASRVLPVIKELAARGIKVSIDTTRA
Mvan_5370|M.vanbaalenii_PYR-1 QGAAIVDVGGESTRPGATRIDPAVESSRILPVVKELAQLGITVSIDTMHA
Mflv_1418|M.gilvum_PYR-GCK QGAAIVDVGGESTRPGATRVDPEVEISRILPVVKELAQQGITVSIDTMHA
TH_0989|M.thermoresistible__bu QGAAVIDVGGESTRPGATRIDPAVEAARVVPVITDLVAQGVTVSIDTMHA
MSMEG_6103|M.smegmatis_MC2_155 AGAQIIDVGGESTRPGATRIDPGVEAARVTPVIRELAAQGITISIDTMHA
MAB_0535|M.abscessus_ATCC_1997 AGADIIDVGGQSTRPGAAPIRQKIEMQRVIPVIKELASHGINISVDTMRA
** ::****:*:**** :* *: **: *. *:.:*:** :*
Mb3638c|M.bovis_AF2122/97 DVARAALQNGAQMVNDVSGGRADPAMGPLLAEADVPWVLMHWRAVSADTP
Rv3608c|M.tuberculosis_H37Rv DVARAALQNGAQMVNDVSGGRADPAMGPLLAEADVPWVLMHWRAVSADTP
MLBr_00224|M.leprae_Br4923 DVARAALQSGARIVNDVSGGRADPAMAPLVAEAGVAWVLMHWRLMSAERP
MAV_0544|M.avium_104 DVARAALGSGARIVNDVSGGRADPAMAPLLAEAKVPWVLMHWRSVSAERP
MMAR_5111|M.marinum_M AVACEALHNGAQIVNDVSGGRADPAMAPLVAEAGVPWVLMHWRPVSDDNP
MUL_4190|M.ulcerans_Agy99 AVACEALHNGAQIVNDVSGGRADPAMAPLVAEASVPWVLMHWRPVSDDNP
Mvan_5370|M.vanbaalenii_PYR-1 AVARVALEHGAQIVNDVSGGRADPDMARVVADAGVPWVLMHWRSVGSDRP
Mflv_1418|M.gilvum_PYR-GCK AVAHAALDNGAKIVNDVSGGRADPDMVRVVADAGVPWILMHWRSVDGDNP
TH_0989|M.thermoresistible__bu DVASAALEHGAHIVNDVSGGRADPNMAKLVAEARVPWVLMHWRSVGATHP
MSMEG_6103|M.smegmatis_MC2_155 DVARAALEAGAHIVNDVSGGRADPGMAGVLAEAKVPWILMHWRSVDADHP
MAB_0535|M.abscessus_ATCC_1997 EVAAAAIDAGANMVNDVSGGRSDPEMAQLIAQRGVPWILMHWRSKDFIHT
** *: **.:********:** * ::*: *.*:***** . .
Mb3638c|M.bovis_AF2122/97 HVPVRYGNVVAEVRADLLASVADAVAAGVDPARLVLDPGLGFAKTAQHNW
Rv3608c|M.tuberculosis_H37Rv HVPVRYGNVVAEVRADLLASVADAVAAGVDPARLVLDPGLGFAKTAQHNW
MLBr_00224|M.leprae_Br4923 YEAPNYRDVVAEVRADLLAGVDQAVAAGVDPGSLVIDPGLGFAKTGQHNW
MAV_0544|M.avium_104 HAAPQYRDVVAEVRAELLASVDAAVAAGVDSARLMIDPGLGFAKTGQHNW
MMAR_5111|M.marinum_M HQVPNYRDVVAEVRAELLTAVDDAIAAGVGPSNLMIDPGLGFAKAGQHNW
MUL_4190|M.ulcerans_Agy99 HQVPNYRDVVAEVRAELLTAVDDAIAAGVGPSNLMIDPGLGFAKAGQHNW
Mvan_5370|M.vanbaalenii_PYR-1 HEVPPYGDVVTAVRDELMAGVDAAVDAGVDPAKLIIDPGLGFAKTAQHNW
Mflv_1418|M.gilvum_PYR-GCK HEVPAYGDVVAEVRDELLSGVDAAVAAGVHPDKLIIDPGLGFAKTGQHNW
TH_0989|M.thermoresistible__bu HRPPRYRDVVAEVRAELLESVDAATSAGVDPANLIIDPGLGFAKTAEHNW
MSMEG_6103|M.smegmatis_MC2_155 HRVPGYRDVVAEVRTELLAAVDAAVTAGVEPERLVIDPGLGFAKTAEHNW
MAB_0535|M.abscessus_ATCC_1997 PATRNYRDVVADVSRELMESVAVAVNAGVSPDKLILDPGLGFAKTAHHNW
* :**: * :*: .* * *** . *::********:..***
Mb3638c|M.bovis_AF2122/97 AILHALPELVATGIPVLVGASRKRFLGALLAGPDGVMRPTDGRDTATAVI
Rv3608c|M.tuberculosis_H37Rv AILHALPELVATGIPVLVGASRKRFLGALLAGPDGVMRPTDGRDTATAVI
MLBr_00224|M.leprae_Br4923 ALLNALPELVATGVPILLGASRKRFLGRLLAGADGAVRPPDGRETATAVI
MAV_0544|M.avium_104 ALLHALPQLVATGIPVLLGASRKRFLGTLLAGPDGAPRPPDGRETATAVI
MMAR_5111|M.marinum_M TLLHALPELVATGIPVLVGASRKRFLGSLLAGPDGAVRPPDGRETATAVI
MUL_4190|M.ulcerans_Agy99 TLLHALPELVATGIPVLVGASRKRFLGSLLAGPDGAVRPPDGRETATAVI
Mvan_5370|M.vanbaalenii_PYR-1 ALLHALPEFVTTGIPVLVGASRKRFLGELLASPDGELRPPAGRETATAVV
Mflv_1418|M.gilvum_PYR-GCK ALLHALPDFVSTGIPVLVGASRKRFLGTLLAAPDGEPRPPAGRETATAVI
TH_0989|M.thermoresistible__bu ALLHALPEFVGTGIPVLVGASRKRFLGALLAGPDGEPRPPDGRETATAVI
MSMEG_6103|M.smegmatis_MC2_155 ALLHALPDLVATGVPVLVGASRKRFLGTLLAAADGTPRPPDGRETATAVI
MAB_0535|M.abscessus_ATCC_1997 LLLQAIPDLQELGYPILIGASRKRFLGSLLTDLKGVERPPDGRETATAVI
:*:*:*:: * *:*:********* **: .* **. **:*****:
Mb3638c|M.bovis_AF2122/97 SALAALHGAWGVRVHDVRASVDAIKVVEAWMGA----ERIERDG------
Rv3608c|M.tuberculosis_H37Rv SALAALHGAWGVRVHDVRASVDAIKVVEAWMGA----ERIERDG------
MLBr_00224|M.leprae_Br4923 SALAALHGAWGVRVHDVRASVDALKVVGAWLHAGPQIEKVRCDG------
MAV_0544|M.avium_104 SALAALHGAWGVRVHDVRATVDALKVLGAWMGD---------DG------
MMAR_5111|M.marinum_M SALAALHGAWGVRVHDVRASVDALKVVDAWQRA----ERTGHDG------
MUL_4190|M.ulcerans_Agy99 SALGALHGAWGVRVHDVRASVDALKVVDAWQRA----ERTGRDG------
Mvan_5370|M.vanbaalenii_PYR-1 SALAGWHHVWGVRVHDVRASVDALAVVAAWQAG-------RDD-------
Mflv_1418|M.gilvum_PYR-GCK SALAGWHDVWGVRVHDVRASVDALAVVAAWRGG-------AS--------
TH_0989|M.thermoresistible__bu SALAGLAGVWGVRVHDVRASVDALRVMRAWQAG-------SADG------
MSMEG_6103|M.smegmatis_MC2_155 SVLAAMHGAWGVRVHDVQASVDALKVLGAWTSG-------GQIG------
MAB_0535|M.abscessus_ATCC_1997 TALGALHEVWGVRVHDVTASMDALKVVRAWETGGAETVEEGEEEAQEAAA
:.*.. .******** *::**: *: **
Mb3638c|M.bovis_AF2122/97 --------------------------------------------------
Rv3608c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00224|M.leprae_Br4923 --------------------------------------------------
MAV_0544|M.avium_104 --------------------------------------------------
MMAR_5111|M.marinum_M --------------------------------------------------
MUL_4190|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5370|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1418|M.gilvum_PYR-GCK --------------------------------------------------
TH_0989|M.thermoresistible__bu --------------------------------------------------
MSMEG_6103|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0535|M.abscessus_ATCC_1997 PEPPPAPESPPVTIAQDEVTTEVTVRTARPEPSKTAGGRWRREVAQRGAK
Mb3638c|M.bovis_AF2122/97 ----
Rv3608c|M.tuberculosis_H37Rv ----
MLBr_00224|M.leprae_Br4923 ----
MAV_0544|M.avium_104 ----
MMAR_5111|M.marinum_M ----
MUL_4190|M.ulcerans_Agy99 ----
Mvan_5370|M.vanbaalenii_PYR-1 ----
Mflv_1418|M.gilvum_PYR-GCK ----
TH_0989|M.thermoresistible__bu ----
MSMEG_6103|M.smegmatis_MC2_155 ----
MAB_0535|M.abscessus_ATCC_1997 GEPK