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AGDRALIMAIVNRTPDSFYDRGATFTDDAAKEAAHRVVEDGADIIDVGGVKAGPGAIVDVDEEIARVVPF IEWLRATFPDRVISVDTWRAEVAKQACAAGADLINDTWGGADPDLAGVAAEFGAGLVCSHTGGAVPRTRP FRVNYGLSERGVVDDVIAEVTSAAERAVALGVRRDGILIDPTHDFGKNTYHGLSLLRHVKDLVNTGWPVL MALSNKDFVGETLGVGLTERLEGTLAATALAAADGAAMFRVHEVGPTRRVLEMVASIQGARPPKHTVRGL A*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4509 | - | - | 100% (282) | dihydropteroate synthase |
| M. vanbaalenii PYR-1 | Mvan_5370 | - | 1e-28 | 36.26% (273) | dihydropteroate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1239 | folP2 | 1e-130 | 80.50% (282) | dihydropteroate synthase 2 FolP2 |
| M. gilvum PYR-GCK | Mflv_2186 | - | 1e-151 | 93.26% (282) | dihydropteroate synthase |
| M. tuberculosis H37Rv | Rv1207 | folP2 | 1e-130 | 80.50% (282) | dihydropteroate synthase 2 FolP2 |
| M. leprae Br4923 | MLBr_01063 | folP2 | 1e-130 | 80.14% (282) | dihydropteroate synthase |
| M. abscessus ATCC 19977 | MAB_1345 | - | 1e-129 | 79.43% (282) | dihydropteroate synthase |
| M. marinum M | MMAR_4231 | folP2 | 1e-129 | 79.79% (282) | dihydropteroate synthase 2 FolP2 |
| M. avium 104 | MAV_1352 | folP | 1e-133 | 82.98% (282) | dihydropteroate synthase |
| M. smegmatis MC2 155 | MSMEG_5085 | folP | 1e-144 | 89.01% (282) | dihydropteroate synthase |
| M. thermoresistible (build 8) | TH_0657 | folP2 | 1e-110 | 85.78% (225) | PROBABLE DIHYDROPTEROATE SYNTHASE 2 FOLP2 (DHPS 2) |
| M. ulcerans Agy99 | MUL_0958 | folP2 | 1e-129 | 79.43% (282) | dihydropteroate synthase 2 FolP2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4509|M.vanbaalenii_PYR-1 ------------------------------------MAGDRALIMAIVNR
Mflv_2186|M.gilvum_PYR-GCK ---------------------------MQSTFLGRPVAGDRALIMAIVNR
MSMEG_5085|M.smegmatis_MC2_155 ---------------------------MFSTFCGRPVAHDRALIMAIVNR
TH_0657|M.thermoresistible__bu --------------------------------------------------
Mb1239|M.bovis_AF2122/97 MRSTPPASAGRSTPPALAGHSTPPALAGHSTLCGRPVAGDRALIMAIVNR
Rv1207|M.tuberculosis_H37Rv MRSTPPASAGRSTPPALAGHSTPPALAGHSTLCGRPVAGDRALIMAIVNR
MMAR_4231|M.marinum_M ---------------------------MQATLCGRPVAGDRPLIMAIVNR
MUL_0958|M.ulcerans_Agy99 ---------------------------MQATLCGRPVAGDRPLIMAIVNR
MLBr_01063|M.leprae_Br4923 ---------------------------MQSMLCGRPVAADRQLIMAIVNR
MAV_1352|M.avium_104 ---------------------------MQSTFCGRPVAGDRALIMAIINR
MAB_1345|M.abscessus_ATCC_1997 ----------------MARRAALHNEDVRETFCGRPVRTDRALIMAIVNR
Mvan_4509|M.vanbaalenii_PYR-1 TPDSFYDRGATFTDDAAKEAAHRVVEDGADIIDVGGVKAGPGAIVDVDEE
Mflv_2186|M.gilvum_PYR-GCK TPDSFYDRGATFSDDAAKEAAHRVIADGADIVDVGGVKAGPGTTVDVDEE
MSMEG_5085|M.smegmatis_MC2_155 TPDSFYDRGATFTDEAAKAAAHRVIDEGADVIDVGGVKAGPGSNVDAEEE
TH_0657|M.thermoresistible__bu -------------------------------------------VVDAEEE
Mb1239|M.bovis_AF2122/97 TPDSFYDKGATFSDAAARDAVHRAVADGADVIDVGGVKAGPGERVDVDTE
Rv1207|M.tuberculosis_H37Rv TPDSFYDKGATFSDAAARDAVHRAVADGADVIDVGGVKAGPGERVDVDTE
MMAR_4231|M.marinum_M TPDSFYDKGATFSDAAARDAVHRAVAEGADVIDVGGVKAGPGEDVDPDTE
MUL_0958|M.ulcerans_Agy99 TPDSFYDKGATFSDAAARDAVHRAVAEGADVIDVGGVKAGPGQDVDPDTE
MLBr_01063|M.leprae_Br4923 TPDSFYDRGATFSDEAARAAAHRAVAEGADVIDVGGVKAGPGQGVDVDTE
MAV_1352|M.avium_104 TPDSFYDRGATFSDDAARAAVHRAVAEGADVIDVGGVKAGPGQDVDADTE
MAB_1345|M.abscessus_ATCC_1997 TPDSFYDRGATFTDEAAQAAVHQAVADGADVVDIGGVKAGPGENVDADAE
** : *
Mvan_4509|M.vanbaalenii_PYR-1 IARVVPFIEWLRATFPDRVISVDTWRAEVAKQACAAGADLINDTWGGADP
Mflv_2186|M.gilvum_PYR-GCK IARVVPFIEWLRGTFPDQVISVDTWRAAVAKQACAAGADLINDTWGGTDP
MSMEG_5085|M.smegmatis_MC2_155 ITRVVPFIEWLRSTFPDRLISIDTWRAAVAKQACAAGADIINDTWAGADP
TH_0657|M.thermoresistible__bu IARVVPFIEWLRDTYPDQLISVDTWRASVAKQACAAGADLINDTWAGHDP
Mb1239|M.bovis_AF2122/97 ITRLVPFIEWLRGAYPDQLISVDTWRAQVAKAACAAGADLINDTWGGVDP
Rv1207|M.tuberculosis_H37Rv ITRLVPFIEWLRGAYPDQLISVDTWRAQVAKAACAAGADLINDTWGGVDP
MMAR_4231|M.marinum_M IGRLVPFVEWLRDAYPEQVISVDTWRSEVARRACAAGADLINDTWAGVDP
MUL_0958|M.ulcerans_Agy99 IGRLVPFVEWLRDAYPEQVISVDTWRSEVARRACAAGADLINDTWAGVDP
MLBr_01063|M.leprae_Br4923 IARLVPFIEWLRSAYTDLLISVDTWRAEVARLACTAGADLINDSWGGADP
MAV_1352|M.avium_104 IARLVPFIEWLRDAYPDQLISADTWRAEVAKVACAAGADLINDTWGGVDP
MAB_1345|M.abscessus_ATCC_1997 IARVVPFIEWVRGAHPDLLISVDTWRAEVAAKACAAGADLINDTWAGADP
* *:***:**:* :..: :** ****: ** **:****:***:*.* **
Mvan_4509|M.vanbaalenii_PYR-1 DLAGVAAEFGAGLVCSHTGGAVPRTRPFRVNYGLSERGVVDDVIAEVTSA
Mflv_2186|M.gilvum_PYR-GCK DLAGVAAEFDAGLVCSHTGGAVPRTRPFRVNYGLSERGVVDDVLAEVTAA
MSMEG_5085|M.smegmatis_MC2_155 GLAEVAAEFGAGLVCSHTGGATPRTRPFRVNYGISERGVVDDVIAEVTAA
TH_0657|M.thermoresistible__bu ELPAVAAEFNAGLVCSHTGGAAPRTRPFRVNYGITERAVVDDVIAEVTAA
Mb1239|M.bovis_AF2122/97 AMPEVAAEFGAGLVCAHTGGALPRTRPFRVSYGTTTRGVVDAVISQVTAA
Rv1207|M.tuberculosis_H37Rv AMPEVAAEFGAGLVCAHTGGALPRTRPFRVSYGTTTRGVVDAVISQVTAA
MMAR_4231|M.marinum_M AIVEVAAEFGAGLVCAHTGGARPRTRPFRVSYGTTTRGVVDDVIREVTAA
MUL_0958|M.ulcerans_Agy99 AIVEVAAEFGAGLVCAHTGGARPRTRPFRVSYGTTTRGVVDDVIREVTAA
MLBr_01063|M.leprae_Br4923 AMHEVAAELGAGLVCSHTGGALPRTRPFRVSYGTTTRGVVDDVIRQVTAA
MAV_1352|M.avium_104 ALPEVAAEFGAGLVCSHTGNALPRTRPFRVSYGTSTRGVVDDVIAQVTAA
MAB_1345|M.abscessus_ATCC_1997 ELPAVAAAYGAGLVCSHTGGAVPRTRPYRVHYGTEVDGVVRAVLDEVTAS
: *** .*****:***.* *****:** ** .** *: :**::
Mvan_4509|M.vanbaalenii_PYR-1 AERAVALGVRRDGILIDPTHDFGKNTYHGLSLLRHVKDLVNTGWPVLMAL
Mflv_2186|M.gilvum_PYR-GCK AERAVSLGVSRDRILIDPTHDFGKNTYHGLSLLRHVKELVNTGWPVLMAL
MSMEG_5085|M.smegmatis_MC2_155 AERAVATGVQRDRILIDPTHDFGKNTYHGLSLLRHVKDLVNTGWPVLMAL
TH_0657|M.thermoresistible__bu AERAVAAGVPRDAILIDPTHDFGKNTHHGLTLLRHVEDLVNTGWPVLMAL
Mb1239|M.bovis_AF2122/97 AERAVAAGVAREKVLIDPAHDFGKNTFHGLLLLRHVADLVMTGWPVLMAL
Rv1207|M.tuberculosis_H37Rv AERAVAAGVAREKVLIDPAHDFGKNTFHGLLLLRHVADLVMTGWPVLMAL
MMAR_4231|M.marinum_M AERAVAAGVARDRVLIDPAHDFGKNTWHGLLLLRHVADLVKTGWPVLMAL
MUL_0958|M.ulcerans_Agy99 AERAVAAGVARDRVLIDPAHDFGKNTWHGLLLLRHVADLVKTGWPVLMAL
MLBr_01063|M.leprae_Br4923 AERAVAAGVTRDSVLVDPTHDFGKNTFHGLLLLRHVDELVKTGWPVLMSL
MAV_1352|M.avium_104 AERAVGCGVAPDRVLIDPTHDFGKNTFHGLLLLRHVGDLVNTGWPVLMAL
MAB_1345|M.abscessus_ATCC_1997 AERALALGVSKDAILIDPTHDFGKNTFHGLALLRHVNDLVNTGWPVLMAL
****:. ** : :*:**:******* *** ***** :** *******:*
Mvan_4509|M.vanbaalenii_PYR-1 SNKDFVGETLGVGLTERLEGTLAATALAAADGAAMFRVHEVGPTRRVLEM
Mflv_2186|M.gilvum_PYR-GCK SNKDFVGETLGVGLTERLEGTLAATALAAADGAAVFRVHEVGPTRRVLEM
MSMEG_5085|M.smegmatis_MC2_155 SNKDFVGETLGVDLTERLEGTLAATALAAADGAAMFRVHEVGPTRRVLEM
TH_0657|M.thermoresistible__bu SNKDFVGETLGVVLTDRLEGTLAATALAAAAGAAMFRVHEVAPTRRVLEM
Mb1239|M.bovis_AF2122/97 SNKDVVGETLGVDLTERLEGTLAATALAAAAGARMFRVHEVAATRRVLEM
Rv1207|M.tuberculosis_H37Rv SNKDVVGETLGVDLTERLEGTLAATALAAAAGARMFRVHEVAATRRVLEM
MMAR_4231|M.marinum_M SNKDFVGETLGVDLTERLEGTLAATALAAAAGARMFRVHEVAATRRVLEM
MUL_0958|M.ulcerans_Agy99 SNKDFVGETLGVDLTERLEGTLAATALAAAAGARMFRVHEIAATRRVLEM
MLBr_01063|M.leprae_Br4923 SNKDFVGETLGVGLTERLEGTLAATALAAAAGVRMFRVHEVVATRRVLEM
MAV_1352|M.avium_104 SNKDFVGETLGVELTERLEGTLAATALAAAAGARMFRVHEVAPTRRVLEM
MAB_1345|M.abscessus_ATCC_1997 SNKDFIGETLGVGLTERLEGTLAATALAAAAGARMFRVHEVGPTRRTLEM
****.:****** **:************** *. :*****: .***.***
Mvan_4509|M.vanbaalenii_PYR-1 VASIQGARPPKHTVRGLA
Mflv_2186|M.gilvum_PYR-GCK VASIQGARPPKRTVRGLA
MSMEG_5085|M.smegmatis_MC2_155 VASIQGVRKPARTVRGLA
TH_0657|M.thermoresistible__bu VASIQGVRPPTRTVRGLA
Mb1239|M.bovis_AF2122/97 VASIQGVRPPTRTVRGLA
Rv1207|M.tuberculosis_H37Rv VASIQGVRPPTRTVRGLA
MMAR_4231|M.marinum_M VASIQGTRPPTRTVRGLA
MUL_0958|M.ulcerans_Agy99 VASIQGTRPPTRTVRGLA
MLBr_01063|M.leprae_Br4923 VASIQGTRPPTRTVRGLA
MAV_1352|M.avium_104 VASIQGTRPPTRTVRGLA
MAB_1345|M.abscessus_ATCC_1997 VGSIVGTRPPARTVRGLA
*.** *.* * :******