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TTVRSDSDVSLADADFSGDTRADETFGAAVRGYLQRVRGGDMGSLPAVLGLVVLFVVFGLANDRFLSALN LANLITQAGSICVLAMGLVFVLLLGDIDLSAGVAGGVSACAMALIVVNLSWPWWAALLVGIACGALIGLA IGLLRAKLGIPSFVVTLAFFLGLQGVTLKLIGEGGSVRVDDPVIRGLTISNLPVAAGWAIAGVVVLGFAG LELHQHRRKIALRLSHSPLGVVVARVGAVAAVVLGVTYVMSVNRSVSAVADIRGIPYVLPLMLVLLIAMT VVLRRTSYGRHIYAVGGNAEAARRAGISVDRIRVSVFVVCSSLAALSGIIAASYAGKVSASSGAGNTLLY AVGAAVIGGTSLFGGKGRAIDAVIGGVVVATIANGLGLLNQSSYINFLVTGGVLLLAASVDAISRRRRSS TGLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5291 | - | - | 100% (425) | inner-membrane translocator |
| M. vanbaalenii PYR-1 | Mvan_4010 | - | 1e-18 | 25.45% (385) | inner-membrane translocator |
| M. vanbaalenii PYR-1 | Mvan_2595 | - | 2e-07 | 25.27% (281) | inner-membrane translocator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0162 | pntB | 2e-05 | 24.01% (279) | NAD(P) transhydrogenase subunit beta |
| M. gilvum PYR-GCK | Mflv_2606 | - | 2e-25 | 26.76% (340) | inner-membrane translocator |
| M. tuberculosis H37Rv | Rv0157 | pntB | 2e-05 | 24.01% (279) | NAD(P) transhydrogenase subunit beta |
| M. leprae Br4923 | MLBr_00397 | - | 5e-20 | 26.26% (297) | putative transporter protein |
| M. abscessus ATCC 19977 | MAB_2625c | - | 5e-06 | 27.35% (117) | branched chain amino acid ABC transporter |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_6018 | - | 0.0 | 87.99% (408) | xylose transport system permease protein XylH |
| M. thermoresistible (build 8) | TH_2329 | - | 1e-07 | 32.12% (137) | branched-chain amino acid ABC-type transport system, permease |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5291|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6018|M.smegmatis_MC2_155 --------------------------------------------------
Mb0162|M.bovis_AF2122/97 --------------------------------------------------
Rv0157|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2606|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_00397|M.leprae_Br4923 MDHTTKCDAEQYFQAIVTSMADGVIVVDIDGRIESINPAATRILGLRAHD
TH_2329|M.thermoresistible__bu --------------------------------------------------
MAB_2625c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_5291|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6018|M.smegmatis_MC2_155 --------------------------------------------------
Mb0162|M.bovis_AF2122/97 --------------------------------------------------
Rv0157|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2606|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_00397|M.leprae_Br4923 VVDMKHGHPFCFYDTDNQRVDLEREVMRVVRREVTTVSKVVGIDQHSGQR
TH_2329|M.thermoresistible__bu --------------------------------------------------
MAB_2625c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_5291|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6018|M.smegmatis_MC2_155 --------------------------------------------------
Mb0162|M.bovis_AF2122/97 ----------------------------------MNLHYLVEILYIISFS
Rv0157|M.tuberculosis_H37Rv ----------------------------------MNLHYLVEILYIISFS
Mflv_2606|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_00397|M.leprae_Br4923 LWLSVNVSLLAYKAPPHSALVVSFSDISAHHLSIERLTYEATHDCLTGLA
TH_2329|M.thermoresistible__bu --------------------------------------------------
MAB_2625c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_5291|M.vanbaalenii_PYR-1 --------MTTVRSDSDVSLADAD-------------FSGDTRADETFGA
MSMEG_6018|M.smegmatis_MC2_155 ------MNTDTNSKDREMSIQAPSEKPTASEQPDAGGFAGDTRSDQTFGD
Mb0162|M.bovis_AF2122/97 LFIYGLMGLTGPKTAVRGNLIAAAG-MTIAVAATLVMIRHTSQWPLIIAG
Rv0157|M.tuberculosis_H37Rv LFIYGLMGLTGPKTAVRGNLIAAAG-MTIAVAATLVMIRHTSQWPLIIAG
Mflv_2606|M.gilvum_PYR-GCK -------------MSTKEALDVGG---------------HKVVRDERVKE
MLBr_00397|M.leprae_Br4923 NRRFAEDQITKSLQHDERSRLAAVLLLDLDDFKVINDSLGHDVGDAVLQT
TH_2329|M.thermoresistible__bu --------------------------------------------------
MAB_2625c|M.abscessus_ATCC_199 ----------------------------------MISGWMAQTGVQASTI
Mvan_5291|M.vanbaalenii_PYR-1 AVRGYLQRVRGGDMGSLPAVLGLVVLFVVFG------LANDRFLSALNLA
MSMEG_6018|M.smegmatis_MC2_155 AVRSYAQRVRGGDMGSLPAVLGLVVLFVVFG------LANDRFLSALNLA
Mb0162|M.bovis_AF2122/97 LVVGVVLGVPPARLTKMTAMPQLVAFFNGVGGGTVALIALSEFIDTTGFS
Rv0157|M.tuberculosis_H37Rv LVVGVVLGVPPARLTKMTAMPQLVAFFNGVGGGTVALIALSEFIDTTGFS
Mflv_2606|M.gilvum_PYR-GCK RNRLQRLLIRP-EMGAGIGAIGIFVFFLVVAP---------PFREASSLA
MLBr_00397|M.leprae_Br4923 VAQRLRSAVRPDDVVARLGGDEFIVLLRGPLSDMN--ANDVAKRLHTTLS
TH_2329|M.thermoresistible__bu ------MDILIGQLATGLS-LGSILLLAALG-------------------
MAB_2625c|M.abscessus_ATCC_199 SFDLHGLWSSIGQLTIDGLAWGAIYALVAVG----------YTLVFGVLR
: . :
Mvan_5291|M.vanbaalenii_PYR-1 NLITQAGSICVLAMGLVFVLLLGDIDLSAGVAG-GVSACAMALIVVNLSW
MSMEG_6018|M.smegmatis_MC2_155 NLITQAGSICVLAMGLVFVLLLGDIDLSAGVAG-GVAACAMALAVVNLGW
Mb0162|M.bovis_AF2122/97 AFQHGESPTVHIVVASLFAAIIGSISFWGSIVAFGKLQEIISGRPIGLGK
Rv0157|M.tuberculosis_H37Rv AFQHGESPTVHIVVASLFAAIIGSISFWGSIVAFGKLQEIISGRPIGLGK
Mflv_2606|M.gilvum_PYR-GCK TVLYASSTIGIMACGVAVLMIGGEFDLSAGVAV-TFSSLAASMLAYNLHL
MLBr_00397|M.leprae_Br4923 ESLVVDQLTVPIGASVGILEVRPDDRRRAADILRDADSAMYAAKNKKQCA
TH_2329|M.thermoresistible__bu -LALTFGQMGVINMAHGEFIMVG-------CYTAYVVQQIVSDAGVSLLV
MAB_2625c|M.abscessus_ATCC_199 LINFAHSEVFMLGMFGAYFALDVVLGFS---PGGNAYNKGVSLTVLYLGV
: : :
Mvan_5291|M.vanbaalenii_PYR-1 PWWAALLVGIACGALIGLAIGLLRAKLG---IPSFVVTLAFFLGLQGVTL
MSMEG_6018|M.smegmatis_MC2_155 PWWAAVLVAIACGAVIGLIIGVLRAKLG---IPSFVVTLAFFLGLQGVTL
Mb0162|M.bovis_AF2122/97 AQQPINLLLLAVAVAAAVVIGLHAHPGSGGVALWWMIGLLVAAGVLGLMV
Rv0157|M.tuberculosis_H37Rv AQQPINLLLLAVAVAAAVVIGLHAHPGSGGVALWWMIGLLVAAGVLGLMV
Mflv_2606|M.gilvum_PYR-GCK NLWVGALLALVLALTVGFFNGFLVMKTK---IPSFLITLSTFFMLAGINL
MLBr_00397|M.leprae_Br4923 VTPQQLVPFVALIALFVFFTAAAGAKFYAPSNLLVILQQTVVLAIVGYGM
TH_2329|M.thermoresistible__bu SLFVGFLVGGAMGALLEVTLIRRMYHRP---LDTLLVTFGVGLILQQVAR
MAB_2625c|M.abscessus_ATCC_199 AMLVAMAVSATTALGLEAVAYRPLRRRGARPLTFLITAIGMSFVIQEFVH
. : :
Mvan_5291|M.vanbaalenii_PYR-1 KLIGEGGS--VRVDDPVIRGLT-ISNLPVAAGWAIAGVVVLGFAGLELHQ
MSMEG_6018|M.smegmatis_MC2_155 KLIGEGGS--VRVDNPVIRGLT-IANLPVAVGWTIALVVVLAFAGLEIYN
Mb0162|M.bovis_AF2122/97 VLPIGGAD--MPVVISMLNAMTGLSAAAAGLALNNTAMIVAGMIVGASGS
Rv0157|M.tuberculosis_H37Rv VLPIGGAD--MPVVISMLNAMTGLSAAAAGLALNNTAMIVAGMIVGASGS
Mflv_2606|M.gilvum_PYR-GCK AVT------------KLVAGQVATQSVSDMQGWDSAQKVFASSFTLFG--
MLBr_00397|M.leprae_Br4923 TFVIMAGS--VDLSVGSIVALTGVTAALVAAQNQFAAIVTALLVGLAAGM
TH_2329|M.thermoresistible__bu DIFG-------------APAVNVLAPAWLGGGVEIFGAVVP---------
MAB_2625c|M.abscessus_ATCC_199 WVLPKIAKGYGGSNAQQPLMLVTPRPVWTFGPFDVSGHHIPFQATITN--
.
Mvan_5291|M.vanbaalenii_PYR-1 HRRKIALRLSHSPLGVVVARVGAVAAVVLGVTYVMSVNRSVSAVA-DIRG
MSMEG_6018|M.smegmatis_MC2_155 YRRKKALQLTHSPLGVVVARAIAVAVVVLGVTFVLSVNRSVNPRV-EIRG
Mb0162|M.bovis_AF2122/97 ILTNLMAKAMNRSIPAIVAGGFGGGGVAPSGGGDDKHVKATSAAD-AAIQ
Rv0157|M.tuberculosis_H37Rv ILTNLMAKAMNRSIPAIVAGGFGGGGVAPSGGGDDKHVKATSAAD-AAIQ
Mflv_2606|M.gilvum_PYR-GCK ------------------------------------------------VG
MLBr_00397|M.leprae_Br4923 VNGIVFAYGKIPSFVSTLGMLQVCRGITLMISDSSAKPMPFHGILGAMGA
TH_2329|M.thermoresistible__bu ------------------------------------------------KT
MAB_2625c|M.abscessus_ATCC_199 -------------------------------------------------V
Mvan_5291|M.vanbaalenii_PYR-1 IPYVLPLMLVLLIAMTVVLRRTSYG--------RHIYAVGGNAEAARRAG
MSMEG_6018|M.smegmatis_MC2_155 IPYVLPLILLLLIGMTVLLRRTAYG--------RHIYAVGGNAEAARRAG
Mb0162|M.bovis_AF2122/97 MAYANQVIVVPGYGLAVAQAQHAVKDLATLLEDRGVPVKYAIHPVAGRMP
Rv0157|M.tuberculosis_H37Rv MAYANQVIVVPGYGLAVAQAQHAVKDLATLLEDRGVPVKYAIHPVAGRMP
Mflv_2606|M.gilvum_PYR-GCK IRITVVWWLVFTAVATWVLFKTKVG--------NWIFAVGGDADSARAVG
MLBr_00397|M.leprae_Br4923 MPWILIVCLFVTILAGILFQFTMFG--------RWVKAIGGNERVATLAG
TH_2329|M.thermoresistible__bu RLFILVLAVVCVAALAAVLKYSPAG--------RRIRAVVQNRDLAETSG
MAB_2625c|M.abscessus_ATCC_199 TVVVVAAALVLAFVTDIAINHTKFG--------RGIRAVAQDSTTATLMG
:. . : . *
Mvan_5291|M.vanbaalenii_PYR-1 ISVDRIRVSVFVVCSSLAALSGIIAASYAGKVSASSGAGNTLLYAVGAAV
MSMEG_6018|M.smegmatis_MC2_155 ISVDRIRVTAFIACSSLAALSGIIAASYAGKVSASSGAGNTLLYAVGAAV
Mb0162|M.bovis_AF2122/97 GHMNVLLAEAEVDYDAMKDMDDINDEFARTDVTIVIGANDVTNPAARNET
Rv0157|M.tuberculosis_H37Rv GHMNVLLAEAEVDYDAMKDMDDINDEFARTDVTIVIGANDVTNPAARNET
Mflv_2606|M.gilvum_PYR-GCK VPVTKVKIGLFMFVGFCAWFVGMHLLFAFNTVQSGQGIGNEFFYII-AAV
MLBr_00397|M.leprae_Br4923 VPTRGIKVAIFAICGLTAGLGGIVLASRLGAGTPTAATG-FEIDVIAAVV
TH_2329|M.thermoresistible__bu ISSRTTDVTTFFIGSGLAAVAGVALTLIG---STSPTIGQSYLIDAFLVV
MAB_2625c|M.abscessus_ATCC_199 VSRERIIMATFVIGGLLAGAAALLYTLKVPQGIIYSGGFLLGIKAFSAAV
. : .
Mvan_5291|M.vanbaalenii_PYR-1 IGGTSLFGGKGRAIDAVIGGVVVATIANGLGLLNQSSYINFLVTGGVLLL
MSMEG_6018|M.smegmatis_MC2_155 IGGTSLFGGKGRALDAVIGGVVVATIANGLGLLNQSSYINFLVTGGVLLL
Mb0162|M.bovis_AF2122/97 S--SPIYGMPILNVDKSRSVIVLKRSMNSG--FAGIDNPLFYADGTTMLF
Rv0157|M.tuberculosis_H37Rv S--SPIYGMPILNVDKSRSVIVLKRSMNSG--FAGIDNPLFYADGTTMLF
Mflv_2606|M.gilvum_PYR-GCK IGGCLLTGGYGTAIGAAIGALIFGMTNQGIVYAGWDPDWFKFFLGAMLLF
MLBr_00397|M.leprae_Br4923 IGGTPLTGGLGRLSGTLIGAIIISMLSNGMVFMGVGNAASQIIKGIMLAA
TH_2329|M.thermoresistible__bu V-----VGGLGQIKGTVIAALGLGFLNSFIEYSTTASLAKVIVFALIVIF
MAB_2625c|M.abscessus_ATCC_199 L------GGIGNLRGALLGGLILGVMENYGQAVFGTQWRDVVAFVLLVLV
* . . : . . :
Mvan_5291|M.vanbaalenii_PYR-1 AASVDAISRRRRSSTGLG
MSMEG_6018|M.smegmatis_MC2_155 AAGVDAISRRRRSATGL-
Mb0162|M.bovis_AF2122/97 GDAKKSVTEVSEELKAL-
Rv0157|M.tuberculosis_H37Rv GDAKKSVTEVSEELKAL-
Mflv_2606|M.gilvum_PYR-GCK AVIANNAFRSYAARK---
MLBr_00397|M.leprae_Br4923 AVFVFLQRRKIGIIK---
TH_2329|M.thermoresistible__bu LQVRPQGLFTVRTRSLA-
MAB_2625c|M.abscessus_ATCC_199 LMFRPTGILGESLGRAKA