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VNFEIDEQQRDFAASIDAALGAADVPAAVRAWGEGDTAPGRKVWSQLADLGVTALMVPEKFDGIEAHPVD LVVALERLGRWNVPGPVAESVAVAPVLLADDDRSAALAAGELIATVAAPPLVPRAVNADTAGLILLAEDG SVSNASAGAEHESVDPSRKLFEVSAYGDRKAADVARAFEFGALATSALLVGAAQAMLDASVEYAKQRSQF GTVIGTYQAIKHKLADVLIAVELARPLVYGAALSLADGSTDTGRDVSAAKVAAADAALLAARSSLQTHGA IGFTQEHDLSLLLLRVQALRPAWGDPTWHRRRVLEALTK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5288 | - | - | 100% (319) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0393 | - | 9e-33 | 33.53% (337) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0226 | - | 2e-30 | 31.56% (339) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3593 | fadE32 | 1e-121 | 72.45% (323) | acyl-CoA dehydrogenase FADE32 |
| M. gilvum PYR-GCK | Mflv_1478 | - | 1e-160 | 89.34% (319) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3563 | fadE32 | 1e-120 | 72.14% (323) | acyl-CoA dehydrogenase FADE32 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-15 | 38.28% (128) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0594c | - | 1e-115 | 66.98% (321) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_5052 | fadE32 | 1e-129 | 75.71% (317) | acyl-CoA dehydrogenase FadE32 |
| M. avium 104 | MAV_0598 | - | 1e-130 | 75.62% (320) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6015 | - | 1e-149 | 83.65% (318) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2067 | fadE32 | 1e-139 | 79.75% (326) | PROBABLE ACYL-CoA DEHYDROGENASE FADE32 |
| M. ulcerans Agy99 | MUL_4128 | fadE32 | 1e-127 | 74.76% (317) | acyl-CoA dehydrogenase FadE32 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5288|M.vanbaalenii_PYR-1 ----------MNFEIDEQQRDFAASIDAALGAADVPAAVRAWGEGDTAPG
Mflv_1478|M.gilvum_PYR-GCK ----------MNFEIDDQQRDFAASIDAALGAADLPAAVRAWGEGDTAPG
MSMEG_6015|M.smegmatis_MC2_155 ----------MNFETDEQQRDFAASIDAALGASDVPAAVRAWGEGDTAPG
TH_2067|M.thermoresistible__bu ----------VNFELDEQQRDFAASIDAALSAADVPAAVRAWAEGDASPG
Mb3593|M.bovis_AF2122/97 --------MTMEFALNEQQRDFAASIDAALGAADLPGVVRAWAAGDVAPG
Rv3563|M.tuberculosis_H37Rv --------MTMEFALNEQQRDFAASIDAALGAADLPGVVRAWAAGDVAPG
MMAR_5052|M.marinum_M ----------MEFALDEQQRDFAASIDAALAAADLPAAVRAWSAGDVAPG
MUL_4128|M.ulcerans_Agy99 ----------MEFALDEQQRDFAASIDAALAAADLPAAVRAWSAGDVAPG
MAV_0598|M.avium_104 ----------MKFALDEQQRDFAASIDAALGAADLPAAVRAWAVGDTAPG
MAB_0594c|M.abscessus_ATCC_199 ----------MKFDLDTQQRDFAASIDAALSVADVPAAARAWAAGNHGPG
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFP--
* ::.:: *:* * * .. . .
Mvan_5288|M.vanbaalenii_PYR-1 RKVWSQLADLGVTALMVPEKFDGIEAHPVDLVVALERLGRWNVPG---PV
Mflv_1478|M.gilvum_PYR-GCK RKVWSQLTDLGVTALMVPEKFDGIEAHPVDLVVALERLGRWNVPG---PV
MSMEG_6015|M.smegmatis_MC2_155 RKVWAQLTDLGVTALLVPEKFDGIEAHPTDLVVALERLGYWGVPG---PV
TH_2067|M.thermoresistible__bu RKIWFQLGELGVTALMVPERFDGIEAHPVDLVVALERLGRWCVPG---PV
Mb3593|M.bovis_AF2122/97 RKVWQQLANLGVTALGVAEKFDGLGASPVDLVVALERLGRWCVPG---PV
Rv3563|M.tuberculosis_H37Rv RKVWQQLANLGVTALGVAEKFDGLGASPVDLVVALERLGRWCVPG---PV
MMAR_5052|M.marinum_M HKVWEQLANLGVTALTVSEKFDGLGAHPIDLVVALERLGRWCVPG---PV
MUL_4128|M.ulcerans_Agy99 HKVWEQLANLGVTALTVSEKFDGLGAHPIDLVVALERLGRWCVPG---PV
MAV_0598|M.avium_104 RKVWEQLANLGVTALAVPEKFDGIEAEPIDLVVAIERLGRWCVPG---PV
MAB_0594c|M.abscessus_ATCC_199 LAVWSTLAELGVTALAVSEKYDGIGAHPVDLVVALEGLGKWAVPG---PV
MLBr_00737|M.leprae_Br4923 EEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPA
* *..*: *.*.:.* * . :.:* :. ... *.
Mvan_5288|M.vanbaalenii_PYR-1 AESVAVAPVLLA----DDDRSAALAAGELIATVAAPPLVPRAVNADTAGL
Mflv_1478|M.gilvum_PYR-GCK TESIAVAPILLG----DDDRVGALASGELIATVAAPPLVSRAVDADTAGL
MSMEG_6015|M.smegmatis_MC2_155 TESIAVAPILLA----DDERCGALASGELIATVALPPQVPRAVDADTAGL
TH_2067|M.thermoresistible__bu TESIAVAPVLLAGSAQEADRYPALAAGELIATVAAPPHTPRAVDADTAGL
Mb3593|M.bovis_AF2122/97 TESIAVAPILLA-HDDRAERSHGLASGELIATVAMPPRVPRAVDADTAGL
Rv3563|M.tuberculosis_H37Rv TESIAVAPILLA-HDDQAERSHGLASGELIATVAMPPRVPRAVDADTAGL
MMAR_5052|M.marinum_M AESIAVAPVLLA-DDD---RSAGLACGELIATVALPPHAPRAVDADTAGL
MUL_4128|M.ulcerans_Agy99 AESIAVAPVLLA-DDD---RSAGLACGELIATVALPPHAPRAVDADTAGL
MAV_0598|M.avium_104 VESIAVAPVLLA-GDEHAERCAALASGELIATVALPPQVPRAVDAEEAGL
MAB_0594c|M.abscessus_ATCC_199 VESVAVAPVLLSSHEDGAEPSTRLASGELIATVAAPPIAPRALDADIAGL
MLBr_00737|M.leprae_Br4923 VNKLGTMGLILR--GSEELKKQVLPSLAAEGAMASYALSEREAGSDAASM
.:.:.. ::* *.. .::* . * .:: *.:
Mvan_5288|M.vanbaalenii_PYR-1 ILLAEDGS-------------------------VSNASAGA---------
Mflv_1478|M.gilvum_PYR-GCK ILLATEGA-------------------------VADAEMGT---------
MSMEG_6015|M.smegmatis_MC2_155 ILLAQDGQ-------------------------VHDGSAGA---------
TH_2067|M.thermoresistible__bu ILLAADGQ-------------------------VQDATAGA---------
Mb3593|M.bovis_AF2122/97 VLLAGDGS-------------------------VTEGTPGD---------
Rv3563|M.tuberculosis_H37Rv VLLAGDGS-------------------------VTEGTPGD---------
MMAR_5052|M.marinum_M VLVAGESG-------------------------VSEAAVAN---------
MUL_4128|M.ulcerans_Agy99 VLVAGESG-------------------------VCEAAVAD---------
MAV_0598|M.avium_104 VLLADQDG-------------------------VAEAAAGR---------
MAB_0594c|M.abscessus_ATCC_199 VLIADDIG-------------------------IREAQAGA---------
MLBr_00737|M.leprae_Br4923 RTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVH
* : : .
Mvan_5288|M.vanbaalenii_PYR-1 ---EHESVDPSRKLFEVSAY-------------GDRKAAD-------VAR
Mflv_1478|M.gilvum_PYR-GCK ---QHESVDPARKLFEVTAS-------------GEARAAD-------VER
MSMEG_6015|M.smegmatis_MC2_155 ---SHESVDPTRKLFDVAAS-------------GDARTAD-------TAT
TH_2067|M.thermoresistible__bu ---AHESVDPSRKLFDVNGT-------------GVTHSAD-------TGR
Mb3593|M.bovis_AF2122/97 ---CHRSVDPSRRLYEVAAS-------------GQAWRAPKDV----VAR
Rv3563|M.tuberculosis_H37Rv ---CHRSVDPSRRLYEVAAS-------------GQAWRAPKDV----VAR
MMAR_5052|M.marinum_M ---CHESIDPSRRSYDVTAT-------------GATWQAD-------VKR
MUL_4128|M.ulcerans_Agy99 ---CHESIDPSRRSYDVTAT-------------GAAWQAD-------VKR
MAV_0598|M.avium_104 ---QHASVDPSRRLYDVEPT-------------GDRWQAD-------VGR
MAB_0594c|M.abscessus_ATCC_199 ---QHESIDATRRVFDVQPK-------------EAGISLD-------TSR
MLBr_00737|M.leprae_Br4923 KDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALA
*:.. .: : .
Mvan_5288|M.vanbaalenii_PYR-1 AFEFGALATSALLVGAAQAMLDASVEYAKQRSQFGTVIGTYQAIKHKLAD
Mflv_1478|M.gilvum_PYR-GCK AFEFGALATAAQLVGAAQAMLDASVEYAKQRSQFGTIIGTYQAIKHKLAD
MSMEG_6015|M.smegmatis_MC2_155 AYEFGVLATAAQLVGAGQAMLDQAVEYAKQRTQFGRVIGSYQAIKHKLAD
TH_2067|M.thermoresistible__bu AFEFGALGTAAQLIGAAQAMLDMSVDYAKQRSQFGNVIGSYQAIKHKLAD
Mb3593|M.bovis_AF2122/97 AYEFGALATAAQLVGAGQALLEAAVNYAKQRTQFGRAIGSYQAIKHKLAD
Rv3563|M.tuberculosis_H37Rv AYEFGALATAAQLVGAGQALLEAAVNYAKQRTQFGRAIGSYQAIKHKLAD
MMAR_5052|M.marinum_M AYEFGALATAAQLIGAAEALLDATVDYAKQRTQFGRVIGSYQAIKHKLAD
MUL_4128|M.ulcerans_Agy99 AYEFGALATAAQLIGAAEALLDATVDYAKQRTQFGRVIGSYQAIKHKLAD
MAV_0598|M.avium_104 GYEFGALATAAQLVGAAEALRDAAVDYAKQRTQFGRVIGSYQAIKHKLAD
MAB_0594c|M.abscessus_ATCC_199 AIDFGVLAISAQLIGAGQALLDRAVAYAKQRSQFGRPIGSYQAVKHKLAD
MLBr_00737|M.leprae_Br4923 TLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLAD
:. .* :* .:. : :: *:*:*.*** *.::*:::. ***
Mvan_5288|M.vanbaalenii_PYR-1 VLIAVELARPLVYGAALSLAD----GSTDTGRDVSAAKVAAADAALLAAR
Mflv_1478|M.gilvum_PYR-GCK VLIAVELARPLVYGAALSLAD----GSQDTARDVSAAKVAAADAALLAAR
MSMEG_6015|M.smegmatis_MC2_155 VHIAVELARPLVYGAALSLAD----GSSDTARDVSAAKVAAADAALLAAR
TH_2067|M.thermoresistible__bu VHIAVELARPLVYGAALSLAGRKEEASPDTARDVSAAKVAAGEAALLAAR
Mb3593|M.bovis_AF2122/97 VHIAIELACPLVYGAAVSLEP----------RDVSAAKAAASEAALLAAR
Rv3563|M.tuberculosis_H37Rv VHIAIELACPLVYGAAVSLEP----------RDVSAAKAAASEAALLAAR
MMAR_5052|M.marinum_M VHIAIELARPLVHGAALSLQP----------RDVSAAKVAAGDAALLAAR
MUL_4128|M.ulcerans_Agy99 VHIAIELARPLVHGAALSLQP----------RDVSAAKVAAGGAARLAAR
MAV_0598|M.avium_104 VHIAIELARPLVYGAALTLQP----------RDVSAAKAAASDAALLAAR
MAB_0594c|M.abscessus_ATCC_199 VHIALELARPLVYGAALSLAD----QSPTAARDASAAKVAAAKAAYLAAR
MLBr_00737|M.leprae_Br4923 MAMKVEAARLIVYAAAARAER----GEPDLGFISAASKCFASDIAMEVTT
: : :* * :*:.** :*:* *. * .:
Mvan_5288|M.vanbaalenii_PYR-1 SSLQTHGAIGFTQEHDLSLLLLRVQALRPAWGDPTWHRRRVLEALTK
Mflv_1478|M.gilvum_PYR-GCK SSLQTHGAIGFTQEHDLSLLLLRVQALRPAWGDPTWHRHRVLEALTK
MSMEG_6015|M.smegmatis_MC2_155 SALQTHGAIGFTQEHDLSLLLLRVQALRPAWGDPALHRRRVLEGLS-
TH_2067|M.thermoresistible__bu SSLQTHGAIGFTAEHDLSLWLLRVQALRTAWGDPTTHRRRVLEGIS-
Mb3593|M.bovis_AF2122/97 SALQTHGAIGFTCEHDLSLWLLRVQALHSAWGTPQEHRRRVLEAL--
Rv3563|M.tuberculosis_H37Rv WALQTHGAIGFTCEHDLSLWLLRVQALHSAWGTPQEHRRRVLEAL--
MMAR_5052|M.marinum_M SALQTHGAIGFTQEHDLSLWLLRVQALRSAWGTPEVHRRRVLEAL--
MUL_4128|M.ulcerans_Agy99 SALQTHGAIGFTQEHDLSLWLLRVQALRSAWGTPEVHRRRVLEAL--
MAV_0598|M.avium_104 SALQTHGAIGFTQEHDLSLLLLRVQAVRSAWGPPQVHRRRVLEAL--
MAB_0594c|M.abscessus_ATCC_199 SALQTHGAIGFTAEYDLSLWILKVRALTSAWGTSEWHRARVLEAL--
MLBr_00737|M.leprae_Br4923 DAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR
::* .*. *:* :. :. : .: * :* : ..: