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VESEPEDQGTDSSESPELTFDEHLHPARPRSLRFRPRVRAPFTRRSLARDGSPTGDNPAYVSWLISQSML ADANEISQQFSGQGSMWQNPYATPSPRGAVETASVWFTAYPLSLITRSNESFLKAMADVEMWKAFAEIGI EAVHTGPVKRAGGISGWELTPSVDGHFDRISTEIDPAFGTEDEFRQMCGTANWYGGTIIDDIVPGHTGKG ADFRLAEMKYADYPGIYHMVEVDPRDWEHLPDVPPGADSVNIDPATEQWLDKAGYIIGKLQRVIFYAEGI KETNWSVTRPVVGIDGVERRWVYLHYFKDGQPSINWLDPSFAGMRLVIGDALHSLTDLGTGGLRLDANGF LGAEKTAAEDSAAWSEGHPLSEAANHLIASMVRKVGGFTFQELNLTIDDIREIGEAGADLSYDFITRPAA HHALATADTEFLRLTLRTTLELGVDPASLVHALQNHDELTYELVHWSTGHRDDVYTYKGEEITGEVLGET IRSDLSEKLTGENAPYNLVFTTNGIACTTATVIAATLGIAALDDIVDDEQIDRIRRAHLLLAMFNALQPG VFALSGWDVCGMLTLPPSQITELLHGGDTRWIHRAAHDLMGVNPTATRSPAGMPRGRSLYGSIPDQLAED TSFLRQLQAILKVRSHYGIATSRQIDIPEVSHRGMLVLVHQLHEEGRYQLTVLNFANEDVAGTVRSLKLP PGSEVSDMFSGRPLATVDDLHSFGVELTAHQGLSLLVEAPVPDAGTEGDHVQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5178 | - | - | 100% (752) | trehalose synthase |
| M. vanbaalenii PYR-1 | Mvan_2546 | - | 9e-08 | 25.44% (228) | alpha amylase, catalytic region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0131 | treS | 7e-07 | 26.75% (329) | trehalose synthase TRES |
| M. gilvum PYR-GCK | Mflv_1577 | - | 0.0 | 91.03% (747) | trehalose synthase |
| M. tuberculosis H37Rv | Rv0126 | treS | 7e-07 | 26.75% (329) | trehalose synthase TRES |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0325 | treS | 4e-07 | 27.66% (329) | trehalose synthase TreS |
| M. avium 104 | MAV_5186 | treS | 4e-06 | 25.53% (329) | trehalose synthase |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4797 | treS | 2e-07 | 27.66% (329) | trehalose synthase TreS |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0131|M.bovis_AF2122/97 ---MNEAEHSVEHPPVQGSHVEGGVVEHPDAKDFG---------SAAALP
Rv0126|M.tuberculosis_H37Rv ---MNEAEHSVEHPPVQGSHVEGGVVEHPDAKDFG---------SAAALP
MMAR_0325|M.marinum_M --MMNEATNTIEHNPAEGSHVEGGVVEHPDAKDFG---------NAAALP
MUL_4797|M.ulcerans_Agy99 MELMNEATNTIEHNPAEGSHVEGGMVEHPDAKDFG---------NAAPLP
MAV_5186|M.avium_104 ---MNDAREAVEHHPEEGSHVQDGVVEHPEAEDFD---------NAAALP
Mvan_5178|M.vanbaalenii_PYR-1 MESEPEDQGTDSSESPELTFDEHLHPARPRSLRFRPRVRAPFTRRSLARD
Mflv_1577|M.gilvum_PYR-GCK MESDPEDQGN---EPPEINFDEHLHPARPRSLRFRPRVRTPFTRRSLSRD
: . : .. : :* : * : .
Mb0131|M.bovis_AF2122/97 ADPTWFKHAVFYEVLVRAFFDASADGSGDLRG------------------
Rv0126|M.tuberculosis_H37Rv ADPTWFKHAVFYEVLVRAFFDASADGSGDLRG------------------
MMAR_0325|M.marinum_M ADPTWFKHAVFYEVLVRAFYDGTADGSGDLRG------------------
MUL_4797|M.ulcerans_Agy99 ADPTWFKHAVFYEVLVRAFYDGTADGSGDLRG------------------
MAV_5186|M.avium_104 TDPTWFKHAVFYEVLVRAFFDANADGAGDLRG------------------
Mvan_5178|M.vanbaalenii_PYR-1 GSPTGDNPAYVSWLISQSMLADANEISQQFSGQGSMWQNPYATPSPRGAV
Mflv_1577|M.gilvum_PYR-GCK GSPTGDNPAYVSWLISQSMLADANEISQQFSGQGSMWQNPYATPSARGAV
.** : * . :: ::: : : :: *
Mb0131|M.bovis_AF2122/97 ----------------------LIDRLDYLQWLGIDCIWLPPFYDSPLRD
Rv0126|M.tuberculosis_H37Rv ----------------------LIDRLDYLQWLGIDCIWLPPFYDSPLRD
MMAR_0325|M.marinum_M ----------------------LMQRLDYLQWLGIDCIWLPPFYDSPLRD
MUL_4797|M.ulcerans_Agy99 ----------------------LMQRLDYLQWLGIDCIWLPPFYDSPLRD
MAV_5186|M.avium_104 ----------------------LLAQLDYLQWLGIDCIWLPPFYDSPLRD
Mvan_5178|M.vanbaalenii_PYR-1 ETASVWFTAYPLSLITRSNESFLKAMADVEMWKAFAEIGIEAVHTGPVKR
Mflv_1577|M.gilvum_PYR-GCK ETASVWFTAYPLSLITRSNESFLKAMADADMWKAFAEIGIEAVHTGPVKR
* * * .: * : ..: .*::
Mb0131|M.bovis_AF2122/97 GG-------------YDIRDFYKVLPEFGTVDDFVALVDAAHRRGIRIIT
Rv0126|M.tuberculosis_H37Rv GG-------------YDIRDFYKVLPEFGTVDDFVALVDAAHRRGIRIIT
MMAR_0325|M.marinum_M GG-------------YDIRDFYKVLPEFGTVGDFVALVDAAHRRGIRVIT
MUL_4797|M.ulcerans_Agy99 GG-------------YDIRDFYKVLPEFGTVGDFVALVDAAHRRGIRVIT
MAV_5186|M.avium_104 GG-------------YDIRDFYKVLPEFGTVEDFVALLNAAHERGIRVIT
Mvan_5178|M.vanbaalenii_PYR-1 AGGISGWELTPSVDGHFDRISTEIDPAFGTEDEFRQMCGTANWYGGTIID
Mflv_1577|M.gilvum_PYR-GCK AGGISGWELTPSVDGHFDRISTQIDPAFGTEDEFRQMCGTANWYGGTIID
.* : * :: * *** :* : .:*: * :*
Mb0131|M.bovis_AF2122/97 DLVMNHTSESHPWFQESRRDPDGP------YGDYYVWSDTSERYTDARII
Rv0126|M.tuberculosis_H37Rv DLVMNHTSESHPWFQESRRDPDGP------YGDYYVWSDTSERYTDARII
MMAR_0325|M.marinum_M DLVMNHTSESHPWFQESRHDPDGP------YGDYYVWSDSSEKYTDARII
MUL_4797|M.ulcerans_Agy99 DLVMNHTSESHPWFQESRHDPDGP------YGDYYVWSDSSEKYTDARII
MAV_5186|M.avium_104 DLVMNHTSESHPWFQESRHDPDGP------YGDFYVWSDTSDRYADARII
Mvan_5178|M.vanbaalenii_PYR-1 DIVPGHTGKGADFRLAEMKYADYPGIYHMVEVDPRDWEHLPDVPPGADSV
Mflv_1577|M.gilvum_PYR-GCK DIVPGHTGKGADFRLAEMKYADYPGIYHMVEVDPRDWEHLPEVPAGADSV
*:* .**.:. : . : .* * * *.. .: ..* :
Mb0131|M.bovis_AF2122/97 FVDTE--------------------------ESNWSFDP--------VRR
Rv0126|M.tuberculosis_H37Rv FVDTE--------------------------ESNWSFDP--------VRR
MMAR_0325|M.marinum_M FVDTE--------------------------ESNWTFDP--------VRR
MUL_4797|M.ulcerans_Agy99 FVDTE--------------------------ESNWTFDP--------VRR
MAV_5186|M.avium_104 FVDTE--------------------------ESNWTFDP--------VRR
Mvan_5178|M.vanbaalenii_PYR-1 NIDPATEQWLDKAGYIIGKLQRVIFYAEGIKETNWSVTRPVVGIDGVERR
Mflv_1577|M.gilvum_PYR-GCK NIDSDTEDWLDKAGYIIGKLQRVIFYAEGIKETNWSVTRPVVGIDGVERR
:*. *:**:. **
Mb0131|M.bovis_AF2122/97 QFYWHRFFSHQPDLNYDNP---AVQEAMIDVIRFWLGLGIDGFRLDAVPY
Rv0126|M.tuberculosis_H37Rv QFYWHRFFSHQPDLNYDNP---AVQEAMIDVIRFWLGLGIDGFRLDAVPY
MMAR_0325|M.marinum_M QFYWHRFFSHQPDLNYDNP---AVQEAMIDVLRFWLGLGIDGFRLDAVPY
MUL_4797|M.ulcerans_Agy99 QFYWHRFFSHQPDLNYDNP---AVQEAMIDVLRFWLGLGIDGFRLDAVPY
MAV_5186|M.avium_104 QFYWHRFFSHQPDLNYDNP---AVQEAMIDVIRFWLGLGIDGFRLDAVPY
Mvan_5178|M.vanbaalenii_PYR-1 WVYLHYFKDGQPSINWLDPSFAGMRLVIGDALHSLTDLGTGGLRLDANGF
Mflv_1577|M.gilvum_PYR-GCK WVYLHYFKDGQPSINWLDPSFAGMRLVIGDALHSLTDLGTGGLRLDANGF
.* * * . **.:*: :* .:: .: *.:: .** .*:**** :
Mb0131|M.bovis_AF2122/97 LFEREGTNCENLPETHAFLKRVRKVVDDEFPGRVLLAEANQWPGDVVEYF
Rv0126|M.tuberculosis_H37Rv LFEREGTNCENLPETHAFLKRVRKVVDDEFPGRVLLAEANQWPGDVVEYF
MMAR_0325|M.marinum_M LFEREGTNCENLPETHAFLKRVRKVVDDEFPGRVLLAEANQWPADVVEYF
MUL_4797|M.ulcerans_Agy99 LFEREGTNCENLPETHAFLKRVRKVVDDEFPGRLLLAEANQWPADVVEYF
MAV_5186|M.avium_104 LFEREGTNCENLPETHAFLKRVRKVVDDEFPGRVLLAEANQWPADVVEYF
Mvan_5178|M.vanbaalenii_PYR-1 LGAEKTAAEDSAAWSEG--HPLSEAANHLIASMVRKVGGFTFQELNLTID
Mflv_1577|M.gilvum_PYR-GCK LGAEKTAAEDSAAWSEG--HPLSEAANHLIASMVRKVGGFTFQELNLTID
* .: : :. . :.. : : :..:. :.. : . . : :
Mb0131|M.bovis_AF2122/97 GDPNTGGDECHMAFHFPLMPRIFMAVR-RESRFPISEIIAQTPPIPDMAQ
Rv0126|M.tuberculosis_H37Rv GDPNTGGDECHMAFHFPLMPRIFMAVR-RESRFPISEIIAQTPPIPDMAQ
MMAR_0325|M.marinum_M GEASTGGDECHMAFHFPLMPRIFMAVR-RESRFPISEILAKTPPIPDMAQ
MUL_4797|M.ulcerans_Agy99 GEASTGGDECHMAFHFPLMPRIFMAVR-RESRFPISEILAKTPPIPDMAQ
MAV_5186|M.avium_104 GDPSTGGDECHMAFHFPLMPRIFMAVR-RESRFPISEILAQTPQIPEMAQ
Mvan_5178|M.vanbaalenii_PYR-1 DIREIGEAGADLSYDFITRPAAHHALATADTEFLRLTLRTTLELGVDPAS
Mflv_1577|M.gilvum_PYR-GCK DIREIGEAGADLSYDFITRPGVQHALATADTEFLRLTLRTTLELGVDPAS
. . * ..:::.* * *: ::.* : : : *.
Mb0131|M.bovis_AF2122/97 WGIFLRNHDELTLEMVTDEE--RDYMYAEYAKDPRMKAN-VGIRRRLAPL
Rv0126|M.tuberculosis_H37Rv WGIFLRNHDELTLEMVTDEE--RDYMYAEYAKDPRMKAN-VGIRRRLAPL
MMAR_0325|M.marinum_M WGIFLRNHDELTLEMVTDEE--RDYMYAEYAKDPRMKAN-VGIRRRLAPL
MUL_4797|M.ulcerans_Agy99 WGIFLRNHDELTLEMVTDEE--RDYMYAEYAKDPRMKAN-VGIRRRLAPL
MAV_5186|M.avium_104 WGIFLRNHDELTLEMVTDEE--RDYMYAEYAKDPRMKAN-VGIRRRLAPL
Mvan_5178|M.vanbaalenii_PYR-1 LVHALQNHDELTYELVHWSTGHRDDVYTYKGEEITGEVLGETIRSDLSEK
Mflv_1577|M.gilvum_PYR-GCK LVHALQNHDELTYELVHWSNGHRDDLFPYKGEEVTGEVLGDIVRTDLREK
*:****** *:* . ** ::. .:: :. :* *
Mb0131|M.bovis_AF2122/97 LDNDRNQIELFTALLLSLPGSPVLYYGDEIGMGDVIWLGDRDGVRIPMQW
Rv0126|M.tuberculosis_H37Rv LDNDRNQIELFTALLLSLPGSPVLYYGDEIGMGDVIWLGDRDGVRIPMQW
MMAR_0325|M.marinum_M LENDRNQIQLFNALLLSLPGSPVLYYGDEIGMGDVIWLGDRDGVRTPMQW
MUL_4797|M.ulcerans_Agy99 LENDRNQIQLFNALLLSLPGSPVLYYGDEIGMGDVIWLGDRDGVRTPMQW
MAV_5186|M.avium_104 LDNDRNQIELFTALLLSLPGSPVLYYGDEIGMGDVIWLGDRDGVRTPMQW
Mvan_5178|M.vanbaalenii_PYR-1 LTGENAPYNLVFTTNG-IACTTATVIAATLGIAALDDIVDDEQIDR-IRR
Mflv_1577|M.gilvum_PYR-GCK LSGDNAPYNLVFTTNG-IACTSATIIAATLGITSLDDITEPEQIDR-IRR
* .:. :*. : :. :.. . :*: : : : : : ::
Mb0131|M.bovis_AF2122/97 TPDRNAGFSTANP-----------GRLYLPPS--------------QDPV
Rv0126|M.tuberculosis_H37Rv TPDRNAGFSTANP-----------GRLYLPPS--------------QDPV
MMAR_0325|M.marinum_M TPDRNAGFSTANP-----------GRLYLPPS--------------QDSV
MUL_4797|M.ulcerans_Agy99 TPDRNAGFSTANP-----------GRLYLPPS--------------QDSV
MAV_5186|M.avium_104 TPDRNAGFSKANP-----------GRLYLPPS--------------QDPV
Mvan_5178|M.vanbaalenii_PYR-1 AHLLLAMFNALQPGVFALSGWDVCGMLTLPPSQITELLHGGDTRWIHRAA
Mflv_1577|M.gilvum_PYR-GCK AHLLLAMFNALQPGVFALSGWDVCGMLTLPSSTIPELLREGDTRWIHRAA
: * *. :* * * **.* : ..
Mb0131|M.bovis_AF2122/97 YGYQAVNVEAQRDTS-------------------TSLLNFTRTMLAVRRR
Rv0126|M.tuberculosis_H37Rv YGYQAVNVEAQRDTS-------------------TSLLNFTRTMLAVRRR
MMAR_0325|M.marinum_M YGYQAVNVEAQRDTS-------------------TSLLNWTRTMLAVRRR
MUL_4797|M.ulcerans_Agy99 YGYQAVNVEAQRDTS-------------------TSLLNWTRTMLAVRRR
MAV_5186|M.avium_104 YGYQAVNVEAQRDTS-------------------TSLLNFTRTMLAVRRR
Mvan_5178|M.vanbaalenii_PYR-1 HDLMGVNPTATRSPAGMPRGRSLYGSIPDQLAEDTSFLRQLQAILKVRSH
Mflv_1577|M.gilvum_PYR-GCK HDLMGVNPEATQSPAGMPRGRSLYGSIPEQLADDTSFLRQLQAILKVRSH
:. .** * :..: **:*. :::* ** :
Mb0131|M.bovis_AF2122/97 HPAFAVGAFQELGGSNPSVLAYVRQVAG---DDGDTVLCVNNLS--RFPQ
Rv0126|M.tuberculosis_H37Rv HPAFAVGAFQELGGSNPSVLAYVRQVAG---DDGDTVLCVNNLS--RFPQ
MMAR_0325|M.marinum_M HNAFAVGTFQELGGSNPSILAYVREAPGPAGEDGDVVLCVNNLS--RFPQ
MUL_4797|M.ulcerans_Agy99 HNAFAVGTFQELGGSNPSILAYVREAPGPAGEDGDVVLCVNNLS--RFPQ
MAV_5186|M.avium_104 HEAFAIGTFEELGGSNPSVLAFVRQVSN----DGDTVLCVNNLS--RFPQ
Mvan_5178|M.vanbaalenii_PYR-1 YGIATSRQIDIPEVSHRGMLVLVHQLHE----EGRYQLTVLNFANEDVAG
Mflv_1577|M.gilvum_PYR-GCK YGIATSRQIDIPEVSQRGMLVLVHHLDT----DNQYQLTVLNFANEDVTG
: : :: *: .:*. *:. :. * * *:: ..
Mb0131|M.bovis_AF2122/97 PIELDLQQWTNYTPVELTGHVEFPRIGQVPYLLTLPGHGFYWFQLTTHEV
Rv0126|M.tuberculosis_H37Rv PIELDLQQWTNYTPVELTGHVEFPRIGQVPYLLTLPGHGFYWFQLTTHEV
MMAR_0325|M.marinum_M PIELNLQQWNSYTPVELTGQVEFPKIGHLPYLLTLPGHGFYWFQLSASEE
MUL_4797|M.ulcerans_Agy99 PIELNLQQWNSYTPVELTGQVEFRKIGHLPYLLTLPGHGFYWFQLSASEE
MAV_5186|M.avium_104 PIELNLQHWSGCIPVELTGHVEFPRIGHLPYLLTLPGHGFYWFQLTACEE
Mvan_5178|M.vanbaalenii_PYR-1 TVRSLKLPPGSEVSDMFSGRPLATVDDLHSFGVELTAHQGLSLLVEAPVP
Mflv_1577|M.gilvum_PYR-GCK TVRSKKLPPGSEVSDMFSGRHLATVDDLHSFSVELTAHQGLSLLVEAPAE
.:. . . ::*: . .: : *..* : : :
Mb0131|M.bovis_AF2122/97 GAPPTCGGERRL
Rv0126|M.tuberculosis_H37Rv GAPPTCGGERRL
MMAR_0325|M.marinum_M --------ER--
MUL_4797|M.ulcerans_Agy99 --------ER--
MAV_5186|M.avium_104 DT----------
Mvan_5178|M.vanbaalenii_PYR-1 DAGTEGDHVQ--
Mflv_1577|M.gilvum_PYR-GCK DTDAD-------