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MSIEITGTTEKRAAIFAALADPSRLAIVDHLLLADASPSELRAVLGIQSNLLAHHLGVLKTAGLVRQTRS EADRRRTYLQLDHQALESLVPATGRKATRVLFVCTQNSARSQLAAAIWNRRSELPAASAGTHPASGVHPG AVAAARRHKLHLRPHTPRYLGDVLGPGDLVIAVCDNAHEELPVELPRLHWSVPDPVRTAQAEAFDAAVDD LTDRIEHLVPHLKSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5093 | - | - | 100% (225) | protein tyrosine phosphatase |
| M. vanbaalenii PYR-1 | Mvan_2636 | - | 2e-07 | 43.24% (74) | regulatory protein, ArsR |
| M. vanbaalenii PYR-1 | Mvan_3220 | - | 7e-07 | 27.82% (133) | protein tyrosine phosphatase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2676 | arsC | 2e-10 | 33.86% (127) | arsenic-transport integral membrane protein ArsC |
| M. gilvum PYR-GCK | Mflv_1660 | - | 4e-96 | 76.89% (225) | protein tyrosine phosphatase |
| M. tuberculosis H37Rv | Rv2643 | arsC | 3e-10 | 33.86% (127) | arsenic-transport integral membrane protein ArsC |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4844c | - | 2e-60 | 55.66% (212) | ArsR family regulatory protein |
| M. marinum M | MMAR_2055 | arsC | 2e-08 | 33.59% (128) | arsenic-transport integral membrane protein ArsC |
| M. avium 104 | MAV_1496 | - | 2e-05 | 25.20% (127) | low molecular weight phosphotyrosine protein phosphatase |
| M. smegmatis MC2 155 | MSMEG_1171 | - | 4e-07 | 31.50% (127) | low molecular weight phosphotyrosine protein phosphatase |
| M. thermoresistible (build 8) | TH_1049 | arsC | 9e-08 | 30.37% (135) | PROBABLE ARSENIC-TRANSPORT INTEGRAL MEMBRANE PROTEIN ARSC |
| M. ulcerans Agy99 | MUL_3611 | - | 0.0001 | 36.14% (83) | ArsR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5093|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1660|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4844c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2676|M.bovis_AF2122/97 MTETVTRTAAPAVVGKLSTLDRFLPVWIGSAMAAGLLLGRWIPGLHTALE
Rv2643|M.tuberculosis_H37Rv MTETVTRTAAPAVVGKLSTLDRFLPVWIGSAMAAGLLLGRWIPGLHTALE
MMAR_2055|M.marinum_M MTGTVDHQPAPAVVGKLSTLDRFLPVWIGLAMAAGLLLGRWIPGLNTALE
TH_1049|M.thermoresistible__bu --------------------------------------------------
MAV_1496|M.avium_104 --------------------------------------------------
MSMEG_1171|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3611|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5093|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1660|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4844c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2676|M.bovis_AF2122/97 GVQLDGISLPIALGLLIMMYPVLAKVRYDRLDTVTGDRKLLLSSLLLNWV
Rv2643|M.tuberculosis_H37Rv GVQLDGISLPIALGLLIMMYPVLAKVRYDRLDTVTGDRKLLLSSLLLNWV
MMAR_2055|M.marinum_M KVQVDGISLPIALGLLIMMYPVLAKVRYDRLDSVTGDRKLLISSLLLNWV
TH_1049|M.thermoresistible__bu --------------------------------------------------
MAV_1496|M.avium_104 --------------------------------------------------
MSMEG_1171|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3611|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5093|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1660|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4844c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2676|M.bovis_AF2122/97 LGPALMFALAWLLLADLPEYRTGLIIVGLARCIAMVIIWNDLACGDREAA
Rv2643|M.tuberculosis_H37Rv LGPALMFALAWLLLADLPEYRTGLIIVGLARCIAMVIIWNDLACGDREAA
MMAR_2055|M.marinum_M AGPALMFALAWLLLPDLPEYRTGLIIVGLARCIAMVIIWNDLARGDREAA
TH_1049|M.thermoresistible__bu --------------------------------------------------
MAV_1496|M.avium_104 --------------------------------------------------
MSMEG_1171|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3611|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5093|M.vanbaalenii_PYR-1 ------------------------------------MSIEITGTTE----
Mflv_1660|M.gilvum_PYR-GCK ------------------------------------MFTDSTGDSG----
MAB_4844c|M.abscessus_ATCC_199 ------------------------------------MATEGVEEGTPPDQ
Mb2676|M.bovis_AF2122/97 AVLVALNSIFQVAMFAALGWFYLSVLPGWLGLEQTTIATSPWQIAKSVLI
Rv2643|M.tuberculosis_H37Rv AVLVALNSIFQVAMFAALGWFYLSVLPGWLGLEQTTIATSPWQIAKSVLI
MMAR_2055|M.marinum_M AVLVALNSIFQVAMFAVLGWFYLSVLPGWLHLTQTTISTSPWQIAKSVLI
TH_1049|M.thermoresistible__bu --------------------------------------------------
MAV_1496|M.avium_104 ------------------------------------MTDSPASLAAHVRR
MSMEG_1171|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3611|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5093|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1660|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4844c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2676|M.bovis_AF2122/97 FLGIPLLAGYLSRRIGEKTKGRNWYESRFLPKVGPWALYGLLFTIVILFA
Rv2643|M.tuberculosis_H37Rv FLGIPLLAGYLSRRIGEKTKGRNWYESRFLPKVGPWALYGLLFTIVILFA
MMAR_2055|M.marinum_M FLGIPLLAGYLSRRLGERAKGRGWYESRFLPKVGPWALYGLLFTIVILFA
TH_1049|M.thermoresistible__bu --------------------------------------------------
MAV_1496|M.avium_104 DISI----------------------------------------------
MSMEG_1171|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3611|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5093|M.vanbaalenii_PYR-1 ---KRAAIFAALADPSRLAIVDHLLLADASPSELRAVLGIQS-NLLAHHL
Mflv_1660|M.gilvum_PYR-GCK ---RRAAVFAALADPVRLAIVDHLLLADAAPSELGAVLDVRS-NLLAHHL
MAB_4844c|M.abscessus_ATCC_199 GLLARVAVHAALADPTRLAIVEALSIGDASPTELQARLSIPSSNLLAHHL
Mb2676|M.bovis_AF2122/97 LQGDQITGRPLDVARIALPLLAYFAIMWVGGYLLGAALRLGYRRTTTLAF
Rv2643|M.tuberculosis_H37Rv LQGDQITGRPLDVARIALPLLAYFAIMWVGGYLLGAALRLGYRRTTTLAF
MMAR_2055|M.marinum_M LQGDQITNRPQDVARIALPLLVYFAVMWGGGYLLGAALHLGYQRTTTMAF
TH_1049|M.thermoresistible__bu --------------------------------------------------
MAV_1496|M.avium_104 ---DQQLALRTASTRLHDDFAEHFGVETIERFLHSSYDQFAGRATVPNFL
MSMEG_1171|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3611|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5093|M.vanbaalenii_PYR-1 GVLKTAGLVRQTRSEADRRRT------------------------YLQLD
Mflv_1660|M.gilvum_PYR-GCK NQLKKSGLVRQSRSEADGRRS------------------------YLSLN
MAB_4844c|M.abscessus_ATCC_199 GVLQSAGVVHKRRSEGDRRRW------------------------YLRLI
Mb2676|M.bovis_AF2122/97 TAASNNFELAIAVAIATYGATSGQALAGVVGPLIEVPVLVGLVYVSLALR
Rv2643|M.tuberculosis_H37Rv TAASNNFELAIAVAIATYGATSGQALAGVVGPLIEVPVLVGLVYVSLALR
MMAR_2055|M.marinum_M TAAGNNFELAIAVAIATYGATSGQALAGVVGPLIEVPVLVGLVYVSLALR
TH_1049|M.thermoresistible__bu --------------MTSDSAT-----------------------------
MAV_1496|M.avium_104 PLLAERWARQRLTALARVEGK-----------------------------
MSMEG_1171|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3611|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5093|M.vanbaalenii_PYR-1 HQALESLVPATGRKATRVLFVCTQNSARSQLAAAIWNRRS--ELPAASAG
Mflv_1660|M.gilvum_PYR-GCK REVLETLVPRLESQAQRVVFVCTQNSARSQLAAAIWNRRS--ELPATSAG
MAB_4844c|M.abscessus_ATCC_199 PQVLDSMCTTSPTSVSRVVFVCTQNSARSQLAAAAWRAQS--PIPAESAG
Mb2676|M.bovis_AF2122/97 NRLAGPN-ATHDADKPSVLFVCVHNAGRSQMAAGLLTHLAGDRIEVRSAG
Rv2643|M.tuberculosis_H37Rv NRLAGPN-ATHDADKPSVLFVCVHNAGRSQMAAGLLTHLAGDRIEVRSAG
MMAR_2055|M.marinum_M NRYYGPHRRKHDMIKPSVLFVCVHNAGRSQMAAGWLRHLAGDRIEVRSAG
TH_1049|M.thermoresistible__bu -----------DNPTPSVLFVCVHNAGRSQMAAGFLTALAGGRIEVRSAG
MAV_1496|M.avium_104 ----------VTDTKPTVLFLCTHNAGRSQMALGYFNHLAGDQGVAWSGG
MSMEG_1171|M.smegmatis_MC2_155 ------------MTGPTVLFLCTHNAGRSQMALGYFTHLAGDGAVAWSGG
MUL_3611|M.ulcerans_Agy99 ----------MATSPSPSTAAHDDFVSRHEHDVGDFAEHPAFPAPPPREI
. .* : . .
Mvan_5093|M.vanbaalenii_PYR-1 THPASGVHPGAVAAARRHKLHLRPHTPRYLG-DVLGPGDLVIAVCDNAHE
Mflv_1660|M.gilvum_PYR-GCK THPAARVHPGAVAAAQRHKLHLRPHTPRYLG-DVLAAGDLVIAVCDSAHE
MAB_4844c|M.abscessus_ATCC_199 TRPARRIHPEAIETARRHGLELAAAAPRRLD-DVLQASDYLIVVCDNAHE
Mb2676|M.bovis_AF2122/97 TEPAGQVNPTAVAAMAEMGIDITANAPTLLTGGQVQSSDVVITMGCGDAC
Rv2643|M.tuberculosis_H37Rv TEPAGQVNPTAVAAMAEMGIDITANAPTLLTGGQVQSSDVVITMGCGDAC
MMAR_2055|M.marinum_M TEPADRINPVAVAAMAELGIDITANTPEVLTGAWVQTSDVVITMGCGDAC
TH_1049|M.thermoresistible__bu SAPADQLNPAAVEAMAEVGIDISTHQPKVLTTDAVQASDVVITMGCGDTC
MAV_1496|M.avium_104 SEPGNEINPAAVQAMAEVGIDITREFPKPWTDEIVQASDVVVTMGCGDAC
MSMEG_1171|M.smegmatis_MC2_155 SEPAAEINPVAVAAMAEVGIDITGEYPKPWTDEIVRVADVVITMGCGDTC
MUL_3611|M.ulcerans_Agy99 LEGAGELLR-ALAAPVRIAIVLQLREAQRCVHELVDALGVPQPLVSQHLK
. : *: : . : : . : . :
Mvan_5093|M.vanbaalenii_PYR-1 ELPVELPRLHWSVPDPVRTAQAEAFDAAVDDLTDRIEHLVPHLK-----S
Mflv_1660|M.gilvum_PYR-GCK ELPIELARLHWSVADPARTARAEAFDAAVGELTERINHLVPNLK-----S
MAB_4844c|M.abscessus_ATCC_199 ELPAIITRSHWAIQDPVPDGGTAVFDEVMTDIDSRIGRLAPRLI-----P
Mb2676|M.bovis_AF2122/97 PYFPGASYRNWKLPDPAG-QPLDVVRMIRDDIADRVQALIAEL-----LA
Rv2643|M.tuberculosis_H37Rv PYFPGVSYRNWKLPDPAG-QPLDVVRMIRDDIADRVQALIAEL-----LA
MMAR_2055|M.marinum_M PYFPGVSYRDWTLADPAG-QPLDVVRPIRDDIGERVRALIAEL-----LN
TH_1049|M.thermoresistible__bu PIFPGRSYRDWVLDDPAG-KDLDDVRRIRDDIKARVEDLIAELDPPPDLN
MAV_1496|M.avium_104 PFFPGKRYENWDLTDPAG-QGVDVVRPIRDEIESRVRRLLAELH----IT
MSMEG_1171|M.smegmatis_MC2_155 PVYPGKRYENWELPDPAG-QALDAVRPIRDDIEHRVRRLLADLG----VA
MUL_3611|M.ulcerans_Agy99 ILKAAG------VVTGERSGREVLYRLVDQHLAHIVVDAVAHAG-----E
: .: : .
Mvan_5093|M.vanbaalenii_PYR-1 A---------------
Mflv_1660|M.gilvum_PYR-GCK A---------------
MAB_4844c|M.abscessus_ATCC_199 AQAS------------
Mb2676|M.bovis_AF2122/97 TAKTR-----------
Rv2643|M.tuberculosis_H37Rv TAKTR-----------
MMAR_2055|M.marinum_M EHPDTAQICRG-----
TH_1049|M.thermoresistible__bu ARDRPVPATRAGTTTR
MAV_1496|M.avium_104 PVS-------------
MSMEG_1171|M.smegmatis_MC2_155 TIR-------------
MUL_3611|M.ulcerans_Agy99 DSA-------------