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MGTLINIDNGGTLTDICVWDGNAFTFTKTLTTPHDLSECLFTGIEKASDALYGEADITRLLHATEHIRYS TTQGTNALVERRGPMIGILTTIGGLDAGMKRGAAEKKLFTGLVGDRFLTVDPEADLEFDAVQKINRLTTL GAARVVVAAATPEEERQLRHVLLRKFPRHLLGSVPLIYSWELAGDRDDARRAWSCVVNAFLHPTMERFLY SAERRLQAYKVVNPLLVYRNDGASSRVAKSVALKTYSSGPRGGLEGTAALARVYGLPHALMMDIGGTTTD VGVVEGGAVAVADRGGIEGVHISYPMSDVTSSGVGGSSVIQVVDSEITVGPQSVGAAPGPACFGFGGKQA TITDVNLLLGVLDPDTYLDGTFTLDPSRSQAVITETIARPLGISLEEALIRMEHAYFQALSASFAPLVTE DTTLLAFGGAGPMSATGAARLAGVKQVLVPRTAAVFSAFGISFSDIGKTYEVIVAEPTTEAATETHDALL VRAERDMFQEGYALADCETSWQLLVENLEDGSVSRLPYQPGDEVDYPGSVVSLQLNAAAPLSHPDLTADA VVTATAAPAAGTRQVRSAADHVDDVPVHVLDDLSPGDGGEGPAIIEGPFFTARVLPGWSFRLTAAGDLLL NDKS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4896 | - | - | 100% (634) | hydantoinase/oxoprolinase |
| M. vanbaalenii PYR-1 | Mvan_4898 | - | 3e-68 | 29.56% (707) | 5-oxoprolinase (ATP-hydrolyzing) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0272c | oplA | 1e-35 | 25.85% (677) | 5-oxoprolinase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0266c | oplA | 1e-35 | 25.85% (677) | 5-oxoprolinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0272c|M.bovis_AF2122/97 MVGAGWHFWVDRGGTFTDVVARRPDGRLLTHKLLS--DNPARYRDAAVAG
Rv0266c|M.tuberculosis_H37Rv MVGAGWHFWVDRGGTFTDVVARRPDGRLLTHKLLS--DNPARYRDAAVAG
Mvan_4896|M.vanbaalenii_PYR-1 ---MGTLINIDNGGTLTDICVWDGNAFTFTKTLTTPHDLSECLFTGIEKA
* : :*.***:**: . :. :*:.* : * . . .
Mb0272c|M.bovis_AF2122/97 IRALLANGEAG---TRVDAVRMGTTVATNALLERTGERTLLVITRGFGDA
Rv0266c|M.tuberculosis_H37Rv IRALLANGEAG---TRVDAVRMGTTVATNALLERTGERTLLVITRGFGDA
Mvan_4896|M.vanbaalenii_PYR-1 SDALYGEADITRLLHATEHIRYSTTQGTNALVERRGPMIGILTTIGGLDA
** .:.: .: :* .** .****:** * :: * * **
Mb0272c|M.bovis_AF2122/97 LRIAYQNRPRIFDRRIVLPEMLYERVVEVDERVTADGRVLRAPDLEALGE
Rv0266c|M.tuberculosis_H37Rv LRIAYQNRPRIFDRRIVLPEMLYERVVEVDERVTADGRVLRAPDLEALGE
Mvan_4896|M.vanbaalenii_PYR-1 GMKRGAAEKKLFTG--LVGDRFLTVDPEADLEFDAVQKINRLTTLGAARV
. ::* :: : : *.* .. * :: * . * *
Mb0272c|M.bovis_AF2122/97 KMRQAHADGIRAVAVVCLHSYLYPGHEREIGTLAQRIGFAQISLSSEVSP
Rv0266c|M.tuberculosis_H37Rv KMRQAHADGIRAVAVVCLHSYLYPGHEREIGTLAQRIGFAQISLSSEVSP
Mvan_4896|M.vanbaalenii_PYR-1 VVAAATPEEERQLRHVLLRKFPR-----------HLLGSVPLIYSWELAG
: * .: * : * *:.: : :* . : * *::
Mb0272c|M.bovis_AF2122/97 LMKLVPRGDTTVVDAYLSPVLRRYINQVADQMRGVR----LMFMQSNGGL
Rv0266c|M.tuberculosis_H37Rv LMKLVPRGDTTVVDAYLSPVLRRYINQVADQMRGVR----LMFMQSNGGL
Mvan_4896|M.vanbaalenii_PYR-1 DRDDARRAWSCVVNAFLHPTMERFLYSAERRLQAYKVVNPLLVYRNDGAS
. . *. : **:*:* *.:.*:: .. :::. : *:. :.:*.
Mb0272c|M.bovis_AF2122/97 AQAGHFRGKDAILSGPAGGIVGMVRMSALAGFDHVIGFDMGGTSTDVSHY
Rv0266c|M.tuberculosis_H37Rv AQAGHFRGKDAILSGPAGGIVGMVRMSALAGFDHVIGFDMGGTSTDVSHY
Mvan_4896|M.vanbaalenii_PYR-1 SRVAKSVALKTYSSGPRGGLEGTAALARVYGLPHALMMDIGGTTTDVGVV
::..: . .: *** **: * . :: : *: *.: :*:***:***.
Mb0272c|M.bovis_AF2122/97 AG-EYERVFTTQVAGVRLRAPMLDIHTVAAGGGSILHFDGSRYRVGPDSA
Rv0266c|M.tuberculosis_H37Rv AG-EYERVFTTQVAGVRLRAPMLDIHTVAAGGGSILHFDGSRYRVGPDSA
Mvan_4896|M.vanbaalenii_PYR-1 EGGAVAVADRGGIEGVHISYPMSDVTSSGVGGSSVIQVVDSEITVGPQSV
* . : **:: ** *: : ..**.*:::. .*. ***:*.
Mb0272c|M.bovis_AF2122/97 GADPGPACYRGGG-PLCVTDANVMLGRIQPTHFPSVFGPSGDQPLDAGTV
Rv0266c|M.tuberculosis_H37Rv GADPGPACYRGGG-PLCVTDANVMLGRIQPTHFPSVFGPSGDQPLDAGTV
Mvan_4896|M.vanbaalenii_PYR-1 GAAPGPACFGFGGKQATITDVNLLLGVLDPDTY-----LDGTFTLDP---
** *****: ** :**.*::** ::* : .* .**.
Mb0272c|M.bovis_AF2122/97 RRGFTDLAADIAARTGDDRSPEQVAEGYLRIAVANMANAVKKISVQKGHD
Rv0266c|M.tuberculosis_H37Rv RRGFTDLAADIAARTGDDRSPEQVAEGYLRIAVANMANAVKKISVQKGHD
Mvan_4896|M.vanbaalenii_PYR-1 SRSQAVITETIARPLG-----ISLEEALIRMEHAYFQALSASFAPLVTED
*. : :: ** * .: *. :*: * : .:: .*
Mb0272c|M.bovis_AF2122/97 VTRYALTTFGGAGGQHACAVADALGIRTVLIPPMAGVLSALGIGLADTTA
Rv0266c|M.tuberculosis_H37Rv VTRYALTTFGGAGGQHACAVADALGIRTVLIPPMAGVLSALGIGLADTTA
Mvan_4896|M.vanbaalenii_PYR-1 TT---LLAFGGAGPMSATGAARLAGVKQVLVPRTAAVFSAFGISFSDIGK
.* * :***** * ..* *:: **:* *.*:**:**.::*
Mb0272c|M.bovis_AF2122/97 MREQSVEIPLGPAAPQRLASVAESLERAARAELLDEGVPGERIRVVRRVH
Rv0266c|M.tuberculosis_H37Rv MREQSVEIPLGPAAPQRLASVAESLERAARAELLDEGVPGERIRVVRRVH
Mvan_4896|M.vanbaalenii_PYR-1 TYEVIVAEPTTEAATETHDALLVRAER----DMFQEGYALADCETSWQLL
* * * **.: :: ** ::::** . .. ::
Mb0272c|M.bovis_AF2122/97 LR--YEGTDTAIPVQLAEIETMATAFESSHRALYTFLLDRPLIAEAISVE
Rv0266c|M.tuberculosis_H37Rv LR--YEGTDTAIPVQLAEIETMATAFESSHRALYTFLLDRPLIAEAISVE
Mvan_4896|M.vanbaalenii_PYR-1 VENLEDGSVSRLPYQPGD------------------EVDYPGSVVSLQLN
:. :*: : :* * .: :* * . ::.::
Mb0272c|M.bovis_AF2122/97 ATGLTDQPDLSQLGDQANDTTGSSETVRIYSNG-LWRDAPLRRREAMRPG
Rv0266c|M.tuberculosis_H37Rv ATGLTDQPDLSQLGDQANDTTGSSETVRIYSNG-LWRDAPLRRREAMRPG
Mvan_4896|M.vanbaalenii_PYR-1 AAAPLSHPDLTADAVVTATAAPAAGTRQVRSAADHVDDVPVHVLDDLSPG
*:. .:***: . : :: :: * :: * . *.*:: : : **
Mb0272c|M.bovis_AF2122/97 DVLTGPAIIAEANATTVVDDGWQATMTETGHLLAQRVVTPPRPDAATRAG
Rv0266c|M.tuberculosis_H37Rv DVLTGPAIIAEANATTVVDDGWQATMTETGHLLAQRVVTPPRPDAATRAG
Mvan_4896|M.vanbaalenii_PYR-1 DGGEGPAIIEGPFFTARVLPGWSFRLTAAGDLLLNDKS------------
* ***** . *: * **. :* :*.** :
Mb0272c|M.bovis_AF2122/97 FEAGFEADPVLLEIFNNLFMSIAEQMGFRLEATAQSVNIRERLDFSCALF
Rv0266c|M.tuberculosis_H37Rv FEAGFEADPVLLEIFNNLFMSIAEQMGFRLEATAQSVNIRERLDFSCALF
Mvan_4896|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 DPDGNLVANAPHIPVHLGSMGTTVKEVIRRRLSGMKPGDVYAVNDPYHGG
Rv0266c|M.tuberculosis_H37Rv DPDGNLVANAPHIPVHLGSMGTTVKEVIRRRLSGMKPGDVYAVNDPYHGG
Mvan_4896|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 THLPDITVITPVFNTGGEDVLFFVASRGHHAEIGGITPGSMPADSREIHE
Rv0266c|M.tuberculosis_H37Rv THLPDITVITPVFNTGGEDVLFFVASRGHHAEIGGITPGSMPADSREIHE
Mvan_4896|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 EGVLFDNWLLAENGRFREAETRRLLTEAPFGSRNPDTNLADLRAQIAANQ
Rv0266c|M.tuberculosis_H37Rv EGVLFDNWLLAENGRFREAETRRLLTEAPFGSRNPDTNLADLRAQIAANQ
Mvan_4896|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 KGVDEVGKMIDHFGRDVVAAYMRHVQDNAEEAVRRVIDRLDNGAYRYRMD
Rv0266c|M.tuberculosis_H37Rv KGVDEVGKMIDHFGRDVVAAYMRHVQDNAEEAVRRVIDRLDNGAYRYRMD
Mvan_4896|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 SGATIAVRITVDRAARSATIDFTGTSAQLDTNFNAPTSVVNAAVLYVFRT
Rv0266c|M.tuberculosis_H37Rv SGATIAVRITVDRAARSATIDFTGTSAQLDTNFNAPTSVVNAAVLYVFRT
Mvan_4896|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 LVADDIPLNDGCLRPLRIVVPEGSMLAPTHPAAVVAGNVETSQAITGALF
Rv0266c|M.tuberculosis_H37Rv LVADDIPLNDGCLRPLRIVVPEGSMLAPTHPAAVVAGNVETSQAITGALF
Mvan_4896|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 AALGVQAEGSGTMNNVTFGNERHQYYETVGSGSGAGDGYHGASVVQTHMT
Rv0266c|M.tuberculosis_H37Rv AALGVQAEGSGTMNNVTFGNERHQYYETVGSGSGAGDGYHGASVVQTHMT
Mvan_4896|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 NSRLTDPEVLEWRYPVLLREFAVRQGSGGAGRWRGGDGAVRRLEFTEPMT
Rv0266c|M.tuberculosis_H37Rv NSRLTDPEVLEWRYPVLLREFAVRQGSGGAGRWRGGDGAVRRLEFTEPMT
Mvan_4896|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 VSTLSGHRRVRPYGMAGGSPGELGRNRVERADGSTVELAGCGSTHVEPGD
Rv0266c|M.tuberculosis_H37Rv VSTLSGHRRVRPYGMAGGSPGELGRNRVERADGSTVELAGCGSTHVEPGD
Mvan_4896|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 TLVIETPGGGGYGPASTSARRRR
Rv0266c|M.tuberculosis_H37Rv TLVIETPGGGGYGPASTSARRRR
Mvan_4896|M.vanbaalenii_PYR-1 -----------------------