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PELPEVEALADHLRRHAVGLTVGRVDVAALSVLKTFDPPISALYGQEVTGANRWGKYLGLQAGELHLITH LSRAGWLRWSDKLAAAPLKPGKGPIALRVHLGPPGESPGPNVAAGAAPGFDLTEAGTQKRLAVWLVTDPM AVPQIASLGPDALSLTGQALAEVLGGQSGRIKTVITDQKVIAGIGNAYSDEILHVAKLSPFATANKLTPS QLVTLHDAMISVLTDAVTRSVGQQAATLKGEKRSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQ TGGKVLADRRMSRLLK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4883 | - | - | 100% (297) | DNA-formamidopyrimidine glycosylase |
| M. vanbaalenii PYR-1 | Mvan_2172 | - | 5e-22 | 30.16% (315) | formamidopyrimidine-DNA glycosylase |
| M. vanbaalenii PYR-1 | Mvan_4051 | - | 4e-14 | 26.60% (297) | formamidopyrimidine-DNA glycolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0969 | - | 2e-67 | 81.82% (154) | formamidopyrimidine-DNA glycosylase |
| M. gilvum PYR-GCK | Mflv_1852 | - | 1e-146 | 87.54% (297) | DNA-formamidopyrimidine glycosylase |
| M. tuberculosis H37Rv | Rv0944 | - | 2e-67 | 81.82% (154) | formamidopyrimidine-DNA glycosylase |
| M. leprae Br4923 | MLBr_01658 | fpg | 3e-18 | 28.62% (311) | formamidopyrimidine-DNA glycosylase |
| M. abscessus ATCC 19977 | MAB_1038 | - | 1e-138 | 80.47% (297) | putative formamidopyrimidine-DNA glycosylase |
| M. marinum M | MMAR_4559 | - | 1e-137 | 82.49% (297) | formamidopyrimidine-DNA glycosylase |
| M. avium 104 | MAV_1066 | - | 1e-137 | 81.82% (297) | formamidopyrimidine-DNA glycosylase |
| M. smegmatis MC2 155 | MSMEG_5545 | - | 1e-135 | 81.40% (301) | formamidopyrimidine-DNA glycosylase |
| M. thermoresistible (build 8) | TH_2321 | - | 1e-130 | 76.09% (297) | POSSIBLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (FAPY-DNA |
| M. ulcerans Agy99 | MUL_4418 | - | 1e-132 | 80.13% (297) | formamidopyrimidine-DNA glycosylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0969|M.bovis_AF2122/97 --------------------------------------------------
Rv0944|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1066|M.avium_104 MPELPEIEALADHLRRHAVGLPIGRVDVAALSVLKTFDP----PISALHG
MMAR_4559|M.marinum_M MPELPEIEALVDHLRRHAVGTTIGRVDVAALSVLKTFDP----PINALHG
MUL_4418|M.ulcerans_Agy99 MPELPEIGALVDHLRRPAVGTTIGRVDVAALSVLKTFDS----PINALHG
Mvan_4883|M.vanbaalenii_PYR-1 MPELPEVEALADHLRRHAVGLTVGRVDVAALSVLKTFDP----PISALYG
Mflv_1852|M.gilvum_PYR-GCK MPELPEVEALADHLRRHAVGLTVGRVDVASLSVLKTFDP----PVSALVG
MAB_1038|M.abscessus_ATCC_1997 MPELPEVEALADHLRRHATGATIGRIDISALSVLKTFDP----PITALHG
MSMEG_5545|M.smegmatis_MC2_155 MPELPEVEALADHLRRHAVGRVVSRVDVSALSVLKTFDP----PVAALHG
TH_2321|M.thermoresistible__bu MPELPEVEALADHLRRHAVGQRILRIDVAALSALKTFDP----PVTALHG
MLBr_01658|M.leprae_Br4923 MPELPEVEVVRRGLQDYIVGKTITAVRVHHPRAVRRHVAGPTDLTNRLLG
Mb0969|M.bovis_AF2122/97 --------------------------------------------------
Rv0944|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1066|M.avium_104 QTVVGAERWGKYLGLRTE----GLFLIAHLSRAGWLRWSDRLTAAPLRPG
MMAR_4559|M.marinum_M QTVTGAGRWGKYLGVQAG----PLWLIAHLSRAGWLRWSDKLAAAPLRPG
MUL_4418|M.ulcerans_Agy99 QTVTGAGRWGKYLGVQAG----PLWLIAHLSRAGWLRWSDKLAAAPLPPG
Mvan_4883|M.vanbaalenii_PYR-1 QEVTGANRWGKYLGLQAG----ELHLITHLSRAGWLRWSDKLAAAPLKPG
Mflv_1852|M.gilvum_PYR-GCK REVTAANRWGKYLGLQAG----DLHLITHLSRAGWLRWSDKLAAAPLKPG
MAB_1038|M.abscessus_ATCC_1997 QPVTGATRWGKYLGLQAG----DLYLVTHLSRAGWLRWSDKLAAAPLKPG
MSMEG_5545|M.smegmatis_MC2_155 STVTAAHRWGKYLGMEVESGGAPLHLITHLSRAGWLRWSDKLAPTPLKPG
TH_2321|M.thermoresistible__bu RTVTDVHRWGKYLGVRCA----ELHLVTHLSRAGWLRWSDKLSTTPLRPG
MLBr_01658|M.leprae_Br4923 TRINGIDRRGKYLWFLLDT---DIALVVHLGMSGQMLLGTVPRVDHVR--
Mb0969|M.bovis_AF2122/97 --------------------------------MAGTPQ------------
Rv0944|M.tuberculosis_H37Rv --------------------------------MAGTPQ------------
MAV_1066|M.avium_104 KGPIALRVHLGSPGAAPG----------FDLTEAGTQKRLAVWLVDDPAR
MMAR_4559|M.marinum_M KGPIALRVHLGTPGVAPG----------FDLTEAGTQKRLAVWLVEDPRQ
MUL_4418|M.ulcerans_Agy99 KGPIALRVHLGTLGVAPG----------FDLTEAGTQKRLAVWLVEDPRQ
Mvan_4883|M.vanbaalenii_PYR-1 KGPIALRVHLGPPGESPGPNVAAGAAPGFDLTEAGTQKRLAVWLVTDPMA
Mflv_1852|M.gilvum_PYR-GCK KGPIALRVHLGTPGEAPG----------YDLTEAGTQKRLAVWLVTDPLA
MAB_1038|M.abscessus_ATCC_1997 KGPIALRVHLGTPGDAPG----------FDLTEAGTQKRLAVWVVRDPAA
MSMEG_5545|M.smegmatis_MC2_155 KGPIALRVHLG---DSQG----------FDLTEAGTQKRLAVWVVRDPMD
TH_2321|M.thermoresistible__bu KGPIALRVHVGDGAEPAG--------IGFDLTEAGTQKRLAVWVVDDPAQ
MLBr_01658|M.leprae_Br4923 ---ISALFDDGTVLNFTD------------QRTLGGWLLADLMTVDGSVL
*
Mb0969|M.bovis_AF2122/97 -P--RALGPDALD--VSTDDLAGLLAGNTGRIKTVITDQKVIAGIGNAYS
Rv0944|M.tuberculosis_H37Rv -P--RALGPDALD--VSTDDLAGLLAGNTGRIKTVITDQKVIAGIGNAYS
MAV_1066|M.avium_104 VPGIAALGPDALD--LDVDALADLLAGNTGRIKTVITDQKVIAGIGNAYS
MMAR_4559|M.marinum_M VPGIATLGPDALE--LGPEELAGVLGPHTGRIKTVITDQKVIAGIGNAYS
MUL_4418|M.ulcerans_Agy99 VPGIATLGPDALE--LGPEELAGVLGPHTGRIKTVMTDQKVIAGIGNAYS
Mvan_4883|M.vanbaalenii_PYR-1 VPQIASLGPDALS--LTGQALAEVLGGQSGRIKTVITDQKVIAGIGNAYS
Mflv_1852|M.gilvum_PYR-GCK VPQIASLGPDALS--LTLPAFTEMLSGESGRIKTVITDQKVISGIGNAYS
MAB_1038|M.abscessus_ATCC_1997 VPQIASLGPDALS--LTADGLADILAGTTARLKNVITDQRVISGIGNAYS
MSMEG_5545|M.smegmatis_MC2_155 VPQIASLGPDALS--LDSTALAGVLAGNSGRIKTVITDQKVMAGIGNAYS
TH_2321|M.thermoresistible__bu VPGIAALGPDALD--VDRDTLAELLGRSTGRIKTVLTDQKVIAGIGNAYS
MLBr_01658|M.leprae_Br4923 PVPVAHLARDPFDPRFDVEAVVKVLRCKHSELKRQLLDQQTVSGIGNIYA
*. *.:. . .. :* ..:* : **:.::**** *:
Mb0969|M.bovis_AF2122/97 DEILHVAKISPFATAGKLSGAQLTCLHEAMASVLSDAVRR---SVGQGAA
Rv0944|M.tuberculosis_H37Rv DEILHVAKISPFATAGKLSGAQLTCLHEAMASVLSDAVRR---SVGQGAA
MAV_1066|M.avium_104 DEILHVAKISPFATAGKLSDKQLATLHDAMVTVLTDAVSR---SVGQGAA
MMAR_4559|M.marinum_M DEILHVAKISPFATAAKLSEEQLAALHDAVVSVLTDAVSR---SVGQGAA
MUL_4418|M.ulcerans_Agy99 DEILHVAKISPFATAAKLSEEQLAALHDAVVSVLTDAVSR---SVGQGAA
Mvan_4883|M.vanbaalenii_PYR-1 DEILHVAKLSPFATANKLTPSQLVTLHDAMISVLTDAVTR---SVGQQAA
Mflv_1852|M.gilvum_PYR-GCK DEILHVARLSPFATANKLTEAQRADLYDAMITVLTDAVTR---SVGQQAA
MAB_1038|M.abscessus_ATCC_1997 DEILHVAKLSPFASGKTLSEGQLTALYEAMQSVLTDAVER---SVGQQAA
MSMEG_5545|M.smegmatis_MC2_155 DEILHVAKLSPFTTAGKLTDAQLGALHDAMITVLTDAVSR---SVGQQAA
TH_2321|M.thermoresistible__bu DEILHTARLSPFATANRLTAPQLDALHEAMIGVLTDAVQR---SVGQQAA
MLBr_01658|M.leprae_Br4923 DEALWRAEVHGARIAATLTRRQLAAVLDAAADVMRDSLAKGGTSFDSLYV
** * *.: . *: * : :* *: *:: : *... .
Mb0969|M.bovis_AF2122/97 MLKGEK---RSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGG
Rv0944|M.tuberculosis_H37Rv MLKGEK---RSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGG
MAV_1066|M.avium_104 MLKGEK---RSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGG
MMAR_4559|M.marinum_M TLKGEK---RSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCATCQTGG
MUL_4418|M.ulcerans_Agy99 TLKGEK---RSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCATCQTGG
Mvan_4883|M.vanbaalenii_PYR-1 TLKGEK---RSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGG
Mflv_1852|M.gilvum_PYR-GCK TLKGEK---RSGLRVHARTGLPCPVCVDTVREVSFADKSFQYCATCQTGG
MAB_1038|M.abscessus_ATCC_1997 TLKGEK---RSGLRVHARAGMPCPVCGDVVREVSFADKSFQYCPTCQTGG
MSMEG_5545|M.smegmatis_MC2_155 TLKGEK---RSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGG
TH_2321|M.thermoresistible__bu TLKGEK---RAGLRVHGRTGLPCPVCGDSVREVSFADKSFQYCPTCQTGG
MLBr_01658|M.leprae_Br4923 NVNGESGYFDRSLDAYGREGEGCRRCGAVMHREKFMNRSSFYCPRCQPRP
::**. .* .:.* * * * ::. .* ::* **. **.
Mb0969|M.bovis_AF2122/97 KALADRRMSRLLK
Rv0944|M.tuberculosis_H37Rv KALADRRMSRLLK
MAV_1066|M.avium_104 KILADRRMSRLLK
MMAR_4559|M.marinum_M KVLADRRMSRLLK
MUL_4418|M.ulcerans_Agy99 KVLPHRRMSRLLK
Mvan_4883|M.vanbaalenii_PYR-1 KVLADRRMSRLLK
Mflv_1852|M.gilvum_PYR-GCK KVLADRRMSRLLK
MAB_1038|M.abscessus_ATCC_1997 KVLADRRLSRLLK
MSMEG_5545|M.smegmatis_MC2_155 KVLADRRMSRLLK
TH_2321|M.thermoresistible__bu RILADRRMSKLLK
MLBr_01658|M.leprae_Br4923 RR-----------
: