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TDATLGCNSEVGRLRVVILHRPGPELQRLTPRNNDTLLFDGLPWVARAQQEHDAFAELLRSRGVEVLLLG VLLTEALSNSGAARMHGISAAVDSRRLGVPLAQELSAYLRTLDAAALARILMAGMTFDELPFGENELSLV RRMHHGADFVIDPLPNLLFTRDSSFWIGPRVAITSLSMHARVRETSLTDLIYAHHPRFLGVRRAYESRSA PIEGGDVLLLAPGVVAVGVGERTTPAGAEALARSLFDDDLAHTVLAVPIAQERAQMHLDTVCTMVDTDAV VMYPNIQDSLTAFTIRRESGGVKIDRAAPFVDAAADAMGIAKLRVIDTGLDPVTAEREQWDDGNNTLAVA PGVVVAYERNTETNARLADSGIEVLPISASELGTGRGGPRCMSCPAGRDPL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4810 | - | - | 100% (402) | arginine deiminase |
| M. vanbaalenii PYR-1 | Mvan_1391 | - | 3e-72 | 39.95% (413) | arginine deiminase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1028 | arcA | 1e-180 | 79.90% (398) | arginine deiminase |
| M. gilvum PYR-GCK | Mflv_1923 | - | 0.0 | 94.78% (402) | arginine deiminase |
| M. tuberculosis H37Rv | Rv1001 | arcA | 1e-180 | 79.90% (398) | arginine deiminase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1121 | - | 0.0 | 83.46% (399) | arginine deiminase |
| M. marinum M | MMAR_4492 | arcA | 1e-179 | 79.65% (398) | arginine deiminase ArcA |
| M. avium 104 | MAV_1125 | arcA | 0.0 | 80.40% (398) | arginine deiminase |
| M. smegmatis MC2 155 | MSMEG_5448 | arcA | 0.0 | 85.82% (402) | arginine deiminase |
| M. thermoresistible (build 8) | TH_0930 | arcA | 6e-99 | 80.93% (215) | PROBABLE ARGININE DEIMINASE ARCA (ADI) (AD) (ARGININE |
| M. ulcerans Agy99 | MUL_4664 | arcA | 1e-178 | 79.15% (398) | arginine deiminase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4810|M.vanbaalenii_PYR-1 MTDAT-LGCNSEVGRLRVVILHRPGPELQRLTPRNNDTLLFDGLPWVARA
Mflv_1923|M.gilvum_PYR-GCK MTDAP-LGCNSEVGTLRAVILHRPGAELQRLTPRNNDTLLFDGLPWVARA
MAB_1121|M.abscessus_ATCC_1997 MTDVPVLGANSEVGRLRAVVLHRPGDELKRLTPRNNDQLLFDGLPWVARA
MSMEG_5448|M.smegmatis_MC2_155 MTDVV-LGVDSEVGTLRVAILHRPGPELKRLTPRNNDALLFDGLPWVSKA
Mb1028|M.bovis_AF2122/97 --MGVELGSNSEVGALRVVILHRPGAELRRLTPRNTDQLLFDGLPWVSRA
Rv1001|M.tuberculosis_H37Rv --MGVELGSNSEVGALRVVILHRPGAELRRLTPRNTDQLLFDGLPWVSRA
MMAR_4492|M.marinum_M --MVDELGSNSEVGTLKVVILHRPGTELRRLTPRNTDQLLFDGLPWVSRA
MUL_4664|M.ulcerans_Agy99 --MVDELGSNSEVGTLKVVILHRPGTELRRLTPRSSDQLLFDGLPWVSRA
MAV_1125|M.avium_104 -MGVVELGTNSEVGALRVVILHRPGGELLRLNPRNVDQLLFDGLPWVARA
TH_0930|M.thermoresistible__bu ------LGLDSEVGRLRVIIVHRPGAELMRLTPQNSDALLFDGLPWVSKA
** :**** *:. ::**** ** **.*:. * *********::*
Mvan_4810|M.vanbaalenii_PYR-1 QQEHDAFAELLRSRGVEVLLLGVLLTEALSNSGAARMHGISAAVDSRRLG
Mflv_1923|M.gilvum_PYR-GCK QQEHDAFADLLRSRGVEVLLLGDLLTEALDKSGAARMQGISAAVDARRLG
MAB_1121|M.abscessus_ATCC_1997 QEEHDAFAEVLRSRGVEVLLLSDLLREALA-SGAARVQGIAAAVNARRLG
MSMEG_5448|M.smegmatis_MC2_155 QEEHDQFAEMLRSRGVEVLLVADLLTEALAHSGAARMHGISAAVDARRLG
Mb1028|M.bovis_AF2122/97 QDEHDEFAELLASRGAEVLLLSDLLTEALHHSGAARMQGIAAAVDAPRLG
Rv1001|M.tuberculosis_H37Rv QDEHDEFAELLASRGAEVLLLSDLLTEALHHSGAARMQGIAAAVDAPRLG
MMAR_4492|M.marinum_M QEEHDQFAELLRSRGVEVLLLSELLTEALH-SGAARMQGVAAAVDSRRLG
MUL_4664|M.ulcerans_Agy99 QEEHDQFAELLRSRGVEVLLLSELLTEALH-SGAARMQGVAAAVDSRRLG
MAV_1125|M.avium_104 QEEHDQFAELLRSRGVEVLLLSDLLTEALTHSGAARMQGVAAAVDARRLG
TH_0930|M.thermoresistible__bu QEEHDEFTALLRSRGVEVLLLADLLTEALGHSGAARMHGIGAAVDPRRLG
*:*** *: :* ***.****:. ** *** *****::*:.***:. ***
Mvan_4810|M.vanbaalenii_PYR-1 VPLAQELSAYLRTLDAAALARILMAGMTFDELPFGE--NELSLVRRMHHG
Mflv_1923|M.gilvum_PYR-GCK APLAQELSAYLRTLEAAPLARILMAGMTFDELPFGE--NELSLVRRMHHG
MAB_1121|M.abscessus_ATCC_1997 YALAQDLSAYLRSLDAADLAYVLMCGMTFDELPLGGGVAQPSLVRTMHHG
MSMEG_5448|M.smegmatis_MC2_155 VPLAQELSAHLRTLEPAALAHVLIAGMTFNELPFSG--KELSLVRRMHHG
Mb1028|M.bovis_AF2122/97 LPLAQELSAYLRSLDPGRLAHVLTAGMTFNELPSDTR-TDVSLVLRMHHG
Rv1001|M.tuberculosis_H37Rv LPLAQELSAYLRSLDPGRLAHVLTAGMTFNELPSDTR-TDVSLVLRMHHG
MMAR_4492|M.marinum_M IPLAQELSAYLRGLDPVRLSHVLTAGMTFNELPADAR-TDVSLVVRMHHD
MUL_4664|M.ulcerans_Agy99 IPLAQELSAYLRGLDPVRLSHVLTAGMTFNELPADAR-TDVSLVVRMHHD
MAV_1125|M.avium_104 VPLAQELSAYLRGLEPARLAQVLMAGMTFNELPADTR-TDVSLVLRMHHG
TH_0930|M.thermoresistible__bu IPLSQELSSYLRTLEPAELAHVLIAGMTFDELPFGPG--ELSLVRRMHHG
.*:*:**::** *:. *: :* .****:*** . : *** ***.
Mvan_4810|M.vanbaalenii_PYR-1 ADFVIDPLPNLLFTRDSSFWIGPRVAITSLSMHARVRETSLTDLIYAHHP
Mflv_1923|M.gilvum_PYR-GCK GDFVIDPLPNLLFTRDSSFWIGPRVAITSLSMHARVRETSLTDLIYAHHP
MAB_1121|M.abscessus_ATCC_1997 SDFVIEPLPNLLFTRDSSFWIGRKFAITTLALPARVRETSLTDLIYAHHP
MSMEG_5448|M.smegmatis_MC2_155 GDFVIDPLPNLLFTRDSSFWIGPRVAITSLALPARHRETSLTDVIYAHHP
Mb1028|M.bovis_AF2122/97 GDFVIEPLPNLVFTRDSSIWIGPRVVIPSLALRARVREASLTDLIYAHHP
Rv1001|M.tuberculosis_H37Rv GDFVIEPLPNLVFTRDSSIWIGPRVVIPSLALRARVREASLTDLIYAHHP
MMAR_4492|M.marinum_M ADFVIEPLPNLLFTRDSSIWIGPRFVIPSLAMRARVREASLTDIIYAHHP
MUL_4664|M.ulcerans_Agy99 ADFVIEPLPNLLFTRDSSIWIGPRFVIPSLAMRARVREASLTDIIYAHHP
MAV_1125|M.avium_104 GDFVIDPLPNLVFTRDSSIWIGPRVVIPTLALRARVREASLTDLIYAHHP
TH_0930|M.thermoresistible__bu GDFVIEPLPNLVFTRDSSFWIGPRVAITSLALPARSRETSLTDVIYAHHP
.****:*****:******:*** :..*.:*:: ** **:****:******
Mvan_4810|M.vanbaalenii_PYR-1 RFLGVRRAYESRSAPIEGGDVLLLAPGVVAVGVGERTTPAGAEALARSLF
Mflv_1923|M.gilvum_PYR-GCK RFLRVRRAYESRSAPIEGGDVLLLAPGVVAVGVGERTTPAGAEALARSLF
MAB_1121|M.abscessus_ATCC_1997 RFLGVRRAYESHSAPVEGGDVLLLGPGVVAVGVGERTTPAGAEALARSLF
MSMEG_5448|M.smegmatis_MC2_155 RFLGVRRAYESRSAPVEGGDVLLLAPGVVAVGVGERTTPAGAEALARSLF
Mb1028|M.bovis_AF2122/97 RFTGVRRAYESRTAPVEGGDVLLLAPGVVAVGVGERTTPAGAEALARSLF
Rv1001|M.tuberculosis_H37Rv RFTGVRRAYESRTAPVEGGDVLLLAPGVVAVGVGERTTPAGAEALARSLF
MMAR_4492|M.marinum_M RFTGIRRAYESRTAPVEGGDVLLLAPGVVAVGVGERTTPAGAEALARSLF
MUL_4664|M.ulcerans_Agy99 RFTGIRRAYESRTAPVEGGDVLLLAPGVVAVGVGERTTPAGAEALARSLF
MAV_1125|M.avium_104 RFTGVRRAYESRTAPVEGGDVLLLAPGVVAVGVGERTTPAGAEALARSLF
TH_0930|M.thermoresistible__bu RFLGVRRAYESRSAPVEGGDVLLXX--------HMWADGAEWQCGGCTWF
** :******::**:******* : * :. . : *
Mvan_4810|M.vanbaalenii_PYR-1 DDDLAHTVLAVPIAQERAQMHLDTVCTMVDTDAVVMYPNIQDSLTAFTIR
Mflv_1923|M.gilvum_PYR-GCK DDDLAHTVLAVPIAQERAQMHLDTVCTMVDTDAVVMYPNIQDSLTAFPIR
MAB_1121|M.abscessus_ATCC_1997 DDGLAHTVLAVPIAQERASMHLDTVCTMVDTDAVVMYPAIQDSLSAFTIR
MSMEG_5448|M.smegmatis_MC2_155 DDALAHTVLAVPIAQERAQMHLDTVCTMVDVDAVVMYPNIVDSLSAFTIR
Mb1028|M.bovis_AF2122/97 DDDLAHTVLAVPIAQQRAQMHLDTVCTMVDTDTMVMYANVVDTLEAFTIQ
Rv1001|M.tuberculosis_H37Rv DDDLAHTVLAVPIAQQRAQMHLDTVCTMVDTDTMVMYANVVDTLEAFTIQ
MMAR_4492|M.marinum_M DDDLAHTVLAVPIAQRRAQMHLDTVCTMVDVDKVVMYANVVDELTAFTIE
MUL_4664|M.ulcerans_Agy99 DDDLAHTVLAVPIAQRRAQMHLDTVCTMVDVDKVVMYANVVDELTAFTIE
MAV_1125|M.avium_104 DDDLAHTVLAVPIAQRRAQMHLDTVCTMVDTDTVVMYANVVDALSAFTIQ
TH_0930|M.thermoresistible__bu TSQFTRLEFLDNYDAR------FVVVTNGPIDEALAYREKVGNRMAWYSS
. ::: : . .* * * : * . *:
Mvan_4810|M.vanbaalenii_PYR-1 RESGGVKIDRAAPFVDAAADAMGIAKLRVIDTGLDPVTAEREQWDDGNNT
Mflv_1923|M.gilvum_PYR-GCK RKSGGVTIDRAAPFVDAAADAMGIGKLRVIDTGLDPVTAEREQWDDGNNT
MAB_1121|M.abscessus_ATCC_1997 RTDSGVSISGAEPFVEAAADAMGIGKLRVIDTGLDPVTAEREQWDDGNNT
MSMEG_5448|M.smegmatis_MC2_155 HDAGGVHISDAQRFVDAAAEAMGIDKLRVIDTGLDPVTAEREQWDDGNNT
Mb1028|M.bovis_AF2122/97 RTPDGVTIGDAAPFAEAAAKAMGIDKLRVIHTGMDPVVAEREQWDDGNNT
Rv1001|M.tuberculosis_H37Rv RTPDGVTIGDAAPFAEAAAKAMGIDKLRVIHTGMDPVVAEREQWDDGNNT
MMAR_4492|M.marinum_M RQPDGVTISDAAPFVEAAARAMGIEKLQVIGTGIDPVVAEREQWDDGNNT
MUL_4664|M.ulcerans_Agy99 RQPDGVTISDAAPFVEAAVRAMGIEKLQVIGTGIDPVVAEREQWDDGNNT
MAV_1125|M.avium_104 RTPSGVEIS-EAPFLEAAATAMGIDKLRVIDTGLDPVIAEREQWDDGNNT
TH_0930|M.thermoresistible__bu ADS---PFGADVDAPPGGGFAVNVFLRATAADGTDAVFRTWHTDGRGTEQ
:. .. *:.: . * *.* . . *.:
Mvan_4810|M.vanbaalenii_PYR-1 LAVAPGVVVAYERNTETNARLADSGIEVLPISASELGTGRGGPRCMSCPA
Mflv_1923|M.gilvum_PYR-GCK LALAPGVVVAYERNTETNARLADSGIEVLPIAASELGTGRGGPRCMSCPA
MAB_1121|M.abscessus_ATCC_1997 LALAPGVVVAYERNVETNARLEDSGIEVLAISASELGTGRGGPRCMSCPV
MSMEG_5448|M.smegmatis_MC2_155 LALAPGVVVAYERNSVTNARLQDSGIEVLAIPASELGTGRGGPRCMSCPA
Mb1028|M.bovis_AF2122/97 LALAPGVVVAYERNVQTNARLQDAGIEVLTIAGSELGTGRGGPRCMSCPA
Rv1001|M.tuberculosis_H37Rv LALAPGVVVAYERNVQTNARLQDAGIEVLTIAGSELGTGRGGPRCMSCPA
MMAR_4492|M.marinum_M LALAPGVVVAYERNAQTNARLEAAGIEVLTIGGSELGTGRGGPRCMSCPV
MUL_4664|M.ulcerans_Agy99 LALAPGVVVAYERNAQTNARLEAAGIEVLTIGGSELGTGRGGPRCMSCPV
MAV_1125|M.avium_104 LALSPGVVVAYERNAQTNMRLQEAGIEVLTIAGSELGTGRGGPRCMSCPV
TH_0930|M.thermoresistible__bu LSHVFALLDILPWGRQEEWQDSPDGWPRWPTYSG--WPDSPDIARWYGPA
*: .:: . : : * . .. .. . *.
Mvan_4810|M.vanbaalenii_PYR-1 GRDPL-
Mflv_1923|M.gilvum_PYR-GCK GRDPL-
MAB_1121|M.abscessus_ATCC_1997 SRDLL-
MSMEG_5448|M.smegmatis_MC2_155 ARDPL-
Mb1028|M.bovis_AF2122/97 ARDPL-
Rv1001|M.tuberculosis_H37Rv ARDPL-
MMAR_4492|M.marinum_M ARDPLP
MUL_4664|M.ulcerans_Agy99 ARDPLP
MAV_1125|M.avium_104 ARDPL-
TH_0930|M.thermoresistible__bu PR----
*