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PGSRLGVWSEAGKLRRVMVCAPGLAHQRLTPQNCNELLFDDVIWLQQARRDHFDFVAKMEDHGVEVLELG DLLAEVVATPQGREWVLDLKVTDDHVGLGLRHAIRTWLVELPADRLAEFLIGGVSYQDVPDEVGGNFLTA FRELDPTGFVLRPLPNTQFMRDNSSWIFGGVTLNPMYWPARRQETLLTTAVYKFHPAFAEEKFDVWLGGT EGAVSEHGSATLEGGDVMPLGRGIVVIGMGERSSHQAITQVARNLFAAGAAERVIIASLPKSRAAMHLDT VFTFCDHDLVTAYAPVVDGIVPFSLRPDDRTPSGLDIRREPKALIPTLGDALGVTFRVVTTAGDVYGVQR EQWDDGNNVVALEPGVVIGYDRNILTNTALRKAGVEVVTIDASELGRGRGGGRCMTCPILRDPLYT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1391 | - | - | 100% (417) | arginine deiminase |
| M. vanbaalenii PYR-1 | Mvan_4810 | - | 3e-72 | 39.95% (413) | arginine deiminase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1028 | arcA | 2e-73 | 39.28% (415) | arginine deiminase |
| M. gilvum PYR-GCK | Mflv_1923 | - | 4e-73 | 40.29% (417) | arginine deiminase |
| M. tuberculosis H37Rv | Rv1001 | arcA | 2e-73 | 39.28% (415) | arginine deiminase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1121 | - | 4e-76 | 40.68% (413) | arginine deiminase |
| M. marinum M | MMAR_4492 | arcA | 8e-72 | 38.20% (411) | arginine deiminase ArcA |
| M. avium 104 | MAV_1125 | arcA | 2e-74 | 39.90% (416) | arginine deiminase |
| M. smegmatis MC2 155 | MSMEG_1409 | arcA | 1e-131 | 55.29% (416) | arginine deiminase |
| M. thermoresistible (build 8) | TH_0930 | arcA | 3e-31 | 37.61% (226) | PROBABLE ARGININE DEIMINASE ARCA (ADI) (AD) (ARGININE |
| M. ulcerans Agy99 | MUL_4664 | arcA | 5e-71 | 37.96% (411) | arginine deiminase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1028|M.bovis_AF2122/97 ---MGVELGSNSEVGALRVVILHRPGAELRRLTPRNTDQLLFDGLPWVSR
Rv1001|M.tuberculosis_H37Rv ---MGVELGSNSEVGALRVVILHRPGAELRRLTPRNTDQLLFDGLPWVSR
MMAR_4492|M.marinum_M ---MVDELGSNSEVGTLKVVILHRPGTELRRLTPRNTDQLLFDGLPWVSR
MUL_4664|M.ulcerans_Agy99 ---MVDELGSNSEVGTLKVVILHRPGTELRRLTPRSSDQLLFDGLPWVSR
MAV_1125|M.avium_104 --MGVVELGTNSEVGALRVVILHRPGGELLRLNPRNVDQLLFDGLPWVAR
Mflv_1923|M.gilvum_PYR-GCK -MTDAP-LGCNSEVGTLRAVILHRPGAELQRLTPRNNDTLLFDGLPWVAR
MAB_1121|M.abscessus_ATCC_1997 -MTDVPVLGANSEVGRLRAVVLHRPGDELKRLTPRNNDQLLFDGLPWVAR
TH_0930|M.thermoresistible__bu -------LGLDSEVGRLRVIIVHRPGAELMRLTPQNSDALLFDGLPWVSK
Mvan_1391|M.vanbaalenii_PYR-1 --MPGSRLGVWSEAGKLRRVMVCAPGLAHQRLTPQNCNELLFDDVIWLQQ
MSMEG_1409|M.smegmatis_MC2_155 MSNPSDAYGVHSEVGKLRKVLVCSPGLAHERLTPTNCDDLLFDDVLWVQN
* **.* *: ::: ** **.* . : ****.: *: .
Mb1028|M.bovis_AF2122/97 AQDEHDEFAELLASRGAEVLLLSDLLTEALHHSGAARMQGIAAAVDAPRL
Rv1001|M.tuberculosis_H37Rv AQDEHDEFAELLASRGAEVLLLSDLLTEALHHSGAARMQGIAAAVDAPRL
MMAR_4492|M.marinum_M AQEEHDQFAELLRSRGVEVLLLSELLTEALH-SGAARMQGVAAAVDSRRL
MUL_4664|M.ulcerans_Agy99 AQEEHDQFAELLRSRGVEVLLLSELLTEALH-SGAARMQGVAAAVDSRRL
MAV_1125|M.avium_104 AQEEHDQFAELLRSRGVEVLLLSDLLTEALTHSGAARMQGVAAAVDARRL
Mflv_1923|M.gilvum_PYR-GCK AQQEHDAFADLLRSRGVEVLLLGDLLTEALDKSGAARMQGISAAVDARRL
MAB_1121|M.abscessus_ATCC_1997 AQEEHDAFAEVLRSRGVEVLLLSDLLREALA-SGAARVQGIAAAVNARRL
TH_0930|M.thermoresistible__bu AQEEHDEFTALLRSRGVEVLLLADLLTEALGHSGAARMHGIGAAVDPRRL
Mvan_1391|M.vanbaalenii_PYR-1 ARRDHFDFVAKMEDHGVEVLELGDLLAEVVA-TPQGREWVLDLKVTDDHV
MSMEG_1409|M.smegmatis_MC2_155 ARRDHFDFMDKMRDRDVEVVELHELLSETMD-IPEAKDWLLDRKITPNEV
*: :* * : .:..**: * :** *.: .: : : .:
Mb1028|M.bovis_AF2122/97 GLPLAQELSAYLRSLDPGRLAHVLTAGMTFNELPSDTR-TDVSLVLRMHH
Rv1001|M.tuberculosis_H37Rv GLPLAQELSAYLRSLDPGRLAHVLTAGMTFNELPSDTR-TDVSLVLRMHH
MMAR_4492|M.marinum_M GIPLAQELSAYLRGLDPVRLSHVLTAGMTFNELPADAR-TDVSLVVRMHH
MUL_4664|M.ulcerans_Agy99 GIPLAQELSAYLRGLDPVRLSHVLTAGMTFNELPADAR-TDVSLVVRMHH
MAV_1125|M.avium_104 GVPLAQELSAYLRGLEPARLAQVLMAGMTFNELPADTR-TDVSLVLRMHH
Mflv_1923|M.gilvum_PYR-GCK GAPLAQELSAYLRTLEAAPLARILMAGMTFDELPFGE--NELSLVRRMHH
MAB_1121|M.abscessus_ATCC_1997 GYALAQDLSAYLRSLDAADLAYVLMCGMTFDELPLGGGVAQPSLVRTMHH
TH_0930|M.thermoresistible__bu GIPLSQELSSYLRTLEPAELAHVLIAGMTFDELPFGPG--ELSLVRRMHH
Mvan_1391|M.vanbaalenii_PYR-1 GLGLRHAIRTWLVELPADRLAEFLIGGVSYQDVPDEVGGNFLTAFRELD-
MSMEG_1409|M.smegmatis_MC2_155 GLGLVDDTRGFLNSLTSRRLTELLIGGMSISDLPPEMKSGYRALAREANG
* * . :* * . *: .* *:: .::* : .
Mb1028|M.bovis_AF2122/97 GGDFVIEPLPNLVFTRDSSIWIGPRVVIPSLALRARVREASLTDLIYAHH
Rv1001|M.tuberculosis_H37Rv GGDFVIEPLPNLVFTRDSSIWIGPRVVIPSLALRARVREASLTDLIYAHH
MMAR_4492|M.marinum_M DADFVIEPLPNLLFTRDSSIWIGPRFVIPSLAMRARVREASLTDIIYAHH
MUL_4664|M.ulcerans_Agy99 DADFVIEPLPNLLFTRDSSIWIGPRFVIPSLAMRARVREASLTDIIYAHH
MAV_1125|M.avium_104 GGDFVIDPLPNLVFTRDSSIWIGPRVVIPTLALRARVREASLTDLIYAHH
Mflv_1923|M.gilvum_PYR-GCK GGDFVIDPLPNLLFTRDSSFWIGPRVAITSLSMHARVRETSLTDLIYAHH
MAB_1121|M.abscessus_ATCC_1997 GSDFVIEPLPNLLFTRDSSFWIGRKFAITTLALPARVRETSLTDLIYAHH
TH_0930|M.thermoresistible__bu GGDFVIEPLPNLVFTRDSSFWIGPRVAITSLALPARSRETSLTDVIYAHH
Mvan_1391|M.vanbaalenii_PYR-1 PTGFVLRPLPNTQFMRDNSSWIFGGVTLNPMYWPARRQETLLTTAVYKFH
MSMEG_1409|M.smegmatis_MC2_155 VTEYLMPPLPNTLYTRDTTCWIYGGLTLNPLFWPARHDETLLMKAIYEFH
::: **** : **.: ** ..: .: ** *: * :* .*
Mb1028|M.bovis_AF2122/97 PRFTGVR----------RAYESRTAPVEGGDVLLLAPGVVAVGVGERTTP
Rv1001|M.tuberculosis_H37Rv PRFTGVR----------RAYESRTAPVEGGDVLLLAPGVVAVGVGERTTP
MMAR_4492|M.marinum_M PRFTGIR----------RAYESRTAPVEGGDVLLLAPGVVAVGVGERTTP
MUL_4664|M.ulcerans_Agy99 PRFTGIR----------RAYESRTAPVEGGDVLLLAPGVVAVGVGERTTP
MAV_1125|M.avium_104 PRFTGVR----------RAYESRTAPVEGGDVLLLAPGVVAVGVGERTTP
Mflv_1923|M.gilvum_PYR-GCK PRFLRVR----------RAYESRSAPIEGGDVLLLAPGVVAVGVGERTTP
MAB_1121|M.abscessus_ATCC_1997 PRFLGVR----------RAYESHSAPVEGGDVLLLGPGVVAVGVGERTTP
TH_0930|M.thermoresistible__bu PRFLGVR----------RAYESRSAPVEGGDVLLXX---HMWADGAEWQC
Mvan_1391|M.vanbaalenii_PYR-1 PAFAEEKFDVWLGGTEGAVSEHGSATLEGGDVMPLGRGIVVIGMGERSSH
MSMEG_1409|M.smegmatis_MC2_155 PDYVDSR--VWWGDPE---ANWGLATFEGGDVLVPGNGVVLIGMSERTSR
* : : : *..*****: . . .
Mb1028|M.bovis_AF2122/97 AGAEALARSLFDDDLAHTVLAVPIAQQRAQMHLDTVCTMVDTDTMVMYAN
Rv1001|M.tuberculosis_H37Rv AGAEALARSLFDDDLAHTVLAVPIAQQRAQMHLDTVCTMVDTDTMVMYAN
MMAR_4492|M.marinum_M AGAEALARSLFDDDLAHTVLAVPIAQRRAQMHLDTVCTMVDVDKVVMYAN
MUL_4664|M.ulcerans_Agy99 AGAEALARSLFDDDLAHTVLAVPIAQRRAQMHLDTVCTMVDVDKVVMYAN
MAV_1125|M.avium_104 AGAEALARSLFDDDLAHTVLAVPIAQRRAQMHLDTVCTMVDTDTVVMYAN
Mflv_1923|M.gilvum_PYR-GCK AGAEALARSLFDDDLAHTVLAVPIAQERAQMHLDTVCTMVDTDAVVMYPN
MAB_1121|M.abscessus_ATCC_1997 AGAEALARSLFDDGLAHTVLAVPIAQERASMHLDTVCTMVDTDAVVMYPA
TH_0930|M.thermoresistible__bu GGCTWFTSQFTRLEFLDNYDARFVVVTNGPIDEALAYREKVGNRMAWYSS
Mvan_1391|M.vanbaalenii_PYR-1 QAITQVARNLFAAGAAERVIIASLPKSRAAMHLDTVFTFCDHDLVTAYAP
MSMEG_1409|M.smegmatis_MC2_155 QAITQVAAELFDEGAAEKVIVAGMPKLRSAMHLDTVFTFADRDVVTIYPE
. .: .: . : .. :. . : :. *.
Mb1028|M.bovis_AF2122/97 VVDTLEAFTIQ---RTPDGVTIGDAA-PFAEAAAKAMGIDKLRVIHTGMD
Rv1001|M.tuberculosis_H37Rv VVDTLEAFTIQ---RTPDGVTIGDAA-PFAEAAAKAMGIDKLRVIHTGMD
MMAR_4492|M.marinum_M VVDELTAFTIE---RQPDGVTISDAA-PFVEAAARAMGIEKLQVIGTGID
MUL_4664|M.ulcerans_Agy99 VVDELTAFTIE---RQPDGVTISDAA-PFVEAAVRAMGIEKLQVIGTGID
MAV_1125|M.avium_104 VVDALSAFTIQ---RTPSGVEIS-EA-PFLEAAATAMGIDKLRVIDTGLD
Mflv_1923|M.gilvum_PYR-GCK IQDSLTAFPIR---RKSGGVTIDRAA-PFVDAAADAMGIGKLRVIDTGLD
MAB_1121|M.abscessus_ATCC_1997 IQDSLSAFTIR---RTDSGVSISGAE-PFVEAAADAMGIGKLRVIDTGLD
TH_0930|M.thermoresistible__bu ADSPFGADVDA---PPGGGFAVN----VFLRATA-----------ADGTD
Mvan_1391|M.vanbaalenii_PYR-1 VVDGIVPFSLRPDDRTPSGLDIRREPKALIPTLGDALG-VTFRVVTTAGD
MSMEG_1409|M.smegmatis_MC2_155 IVDSIQTFVLHPCDRDP-GVEVEEATKPFVEVVADALGLAELRVVETGGT
. : . *. : : . .
Mb1028|M.bovis_AF2122/97 PVVAEREQWDDGNNTLALAPGVVVAYERNVQTNARLQDAGIEVLTIAGSE
Rv1001|M.tuberculosis_H37Rv PVVAEREQWDDGNNTLALAPGVVVAYERNVQTNARLQDAGIEVLTIAGSE
MMAR_4492|M.marinum_M PVVAEREQWDDGNNTLALAPGVVVAYERNAQTNARLEAAGIEVLTIGGSE
MUL_4664|M.ulcerans_Agy99 PVVAEREQWDDGNNTLALAPGVVVAYERNAQTNARLEAAGIEVLTIGGSE
MAV_1125|M.avium_104 PVIAEREQWDDGNNTLALSPGVVVAYERNAQTNMRLQEAGIEVLTIAGSE
Mflv_1923|M.gilvum_PYR-GCK PVTAEREQWDDGNNTLALAPGVVVAYERNTETNARLADSGIEVLPIAASE
MAB_1121|M.abscessus_ATCC_1997 PVTAEREQWDDGNNTLALAPGVVVAYERNVETNARLEDSGIEVLAISASE
TH_0930|M.thermoresistible__bu AVFRTWHTDGRGTEQLSHVFALLDILPWGRQEEWQDSPDGWPRWPTYSG-
Mvan_1391|M.vanbaalenii_PYR-1 VYGVQREQWDDGNNVVALEPGVVIGYDRNILTNTALRKAGVEVVTIDASE
MSMEG_1409|M.smegmatis_MC2_155 RYDSERQQWDSGNNLVAVEPGVVLAYDRNTHTNSLLRKAGIEVITIVGAE
. . *.: :: .:: . : * . ..
Mb1028|M.bovis_AF2122/97 LGTGRGGPRCMSCPAARDPL------------
Rv1001|M.tuberculosis_H37Rv LGTGRGGPRCMSCPAARDPL------------
MMAR_4492|M.marinum_M LGTGRGGPRCMSCPVARDPLP-----------
MUL_4664|M.ulcerans_Agy99 LGTGRGGPRCMSCPVARDPLP-----------
MAV_1125|M.avium_104 LGTGRGGPRCMSCPVARDPL------------
Mflv_1923|M.gilvum_PYR-GCK LGTGRGGPRCMSCPAGRDPL------------
MAB_1121|M.abscessus_ATCC_1997 LGTGRGGPRCMSCPVSRDLL------------
TH_0930|M.thermoresistible__bu -WPDSPDIARWYGPAPR---------------
Mvan_1391|M.vanbaalenii_PYR-1 LGRGRGGGRCMTCPILRDPLYT----------
MSMEG_1409|M.smegmatis_MC2_155 LGRGRGGGHCMTCPIIRDPLDWEVLEHVLVSL
. . * *