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IVDLIPRRLKEPMYRLYELRLRQGLTASRSELPRHIAVLCDGNRRWARESGHDDVSYGYRAGARKIAEML RWCQEAGIEMATVYLLSTENLQRDTEELSALIEIITEVVEEICAPANQWSVRTVGDLELIGEESARRLRD AVSSTDGNGGTFHVNVAVGYGGRQEIVDAVRALLSKELANGLTGEQLIESVTAEAISENLYTSGQPDPDL VIRTSGEQRLSGFLLWQSAYSEMWFTEAYWPEFRRVDFLRALRDYSARHRRYGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4662 | - | - | 100% (265) | undecaprenyl diphosphate synthase |
| M. vanbaalenii PYR-1 | Mvan_3822 | - | 1e-33 | 37.02% (235) | undecaprenyl diphosphate synthase |
| M. vanbaalenii PYR-1 | Mvan_1705 | - | 2e-16 | 31.40% (207) | di-trans-poly-cis-decaprenylcistransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1115 | - | 1e-127 | 84.41% (263) | short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP |
| M. gilvum PYR-GCK | Mflv_2055 | - | 1e-143 | 93.16% (263) | undecaprenyl diphosphate synthase |
| M. tuberculosis H37Rv | Rv1086 | - | 1e-127 | 84.03% (263) | short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP |
| M. leprae Br4923 | MLBr_02467 | - | 1e-125 | 82.89% (263) | putative undecaprenyl pyrophosphate synthetase |
| M. abscessus ATCC 19977 | MAB_1209 | - | 1e-114 | 74.14% (263) | short-chain Z-isoprenyl diphosphate synthetase |
| M. marinum M | MMAR_4380 | uppS | 1e-128 | 84.03% (263) | short (C15) chain Z-isoprenyl diphosphate synthase, UppS |
| M. avium 104 | MAV_1211 | - | 1e-125 | 81.13% (265) | short-chain Z-isoprenyl diphosphate synthetase |
| M. smegmatis MC2 155 | MSMEG_5256 | uppS | 1e-126 | 81.75% (263) | undecaprenyl diphosphate synthase |
| M. thermoresistible (build 8) | TH_2165 | uppS | 1e-126 | 82.58% (264) | undecaprenyl diphosphate synthase |
| M. ulcerans Agy99 | MUL_0193 | uppS | 1e-128 | 83.40% (265) | short (C15) chain Z-isoprenyl diphosphate synthase, UppS |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4662|M.vanbaalenii_PYR-1 -------MIVDLIPRRLKEPMYRLYELRLRQGLTASRSELPRHIAVLCDG
Mflv_2055|M.gilvum_PYR-GCK ---------MDLIPRRLKEPMYRLYEMRLRQGLSVKRSELPRHIAVLCDG
MMAR_4380|M.marinum_M ---------MEIIPPRLKEPLYRLYELRLRQGLAATSSELPRHIAVLCDG
MUL_0193|M.ulcerans_Agy99 MRVTVVWILVEIIPPRLKEPLYRLYELRLRQGLAATSSELPRHIAVLCDG
MLBr_02467|M.leprae_Br4923 ---------MEIIPPRLKEPLYALYELRLRQGLTASESRLPRHIAVLCDG
Mb1115|M.bovis_AF2122/97 ---------MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDG
Rv1086|M.tuberculosis_H37Rv ---------MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDG
MAV_1211|M.avium_104 -------MFVEIIPPRLKEPLYRIYEMRLRQELGAAKADLPRHIAVLCDG
MSMEG_5256|M.smegmatis_MC2_155 ---------MDIIPPRLKEPAYRIYEMRLRHELVRSKAQLPRHIAVLCDG
TH_2165|M.thermoresistible__bu ---------VDIIPPRLKEPAYRLYEMRLRQELARSKSQLPRHIAVLCDG
MAB_1209|M.abscessus_ATCC_1997 ---------MEIIPPRLKEPLYKLYEMRLRQELVKASK--PRHIAVLCDG
:::** ***** * :**:***: * **********
Mvan_4662|M.vanbaalenii_PYR-1 NRRWARESGHDDVSYGYRAGARKIAEMLRWCQEAGIEMATVYLLSTENLQ
Mflv_2055|M.gilvum_PYR-GCK NRRWARETGHDDVAYGYRVGAGKIAEMLRWCQEAGIEMATVYLLSTENLQ
MMAR_4380|M.marinum_M NRRWARDAGYDDVSYGYRMGAAKIAEMLRWCQEAGIEMTTVYLLSTENLQ
MUL_0193|M.ulcerans_Agy99 NRRWARDAGYDDVSYGYRMGAAKIAEMLRWCQEAGIEMTTVYLLSTENLQ
MLBr_02467|M.leprae_Br4923 NRRWARDAGYDDVSYGYRMGAAKIAEMLRWCQEAGIEMTTVYLLSTENLQ
Mb1115|M.bovis_AF2122/97 NRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELATVYLLSTENLQ
Rv1086|M.tuberculosis_H37Rv NRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELATVYLLSTENLQ
MAV_1211|M.avium_104 NRRWARDAGYDDVSYGYRMGAVKIAEMLRWCQAAGIEMTTVYLLSTENLQ
MSMEG_5256|M.smegmatis_MC2_155 NRRWARDAGYDDVSIGYRKGAAKIAEMLRWCQAAGIEMATIYLLSTENLQ
TH_2165|M.thermoresistible__bu NRRWARDAGHDDVSYGYRKGAAKIAEMLRWCQDTGIELATIYLLSTENLQ
MAB_1209|M.abscessus_ATCC_1997 NRRWARSAGYTDVSHGYRMGARKISEMLGWCQDAGVEMATVYLLSAENLT
******.:*: **: *** ** **:*** **: :*:*::*:****:***
Mvan_4662|M.vanbaalenii_PYR-1 RDTEELSALIEIITEVVEEICAPANQWSVRTVGDLELIGEESARRLRDAV
Mflv_2055|M.gilvum_PYR-GCK REPEELSCLIEIITEVVEEICAPANQWSVRTVGDLELIGEDQARRLRDAV
MMAR_4380|M.marinum_M RDADELAALIEIITDVVEEICAPANRWSVRTVGDLELLGDEPARRLREAV
MUL_0193|M.ulcerans_Agy99 RDADELAALIEIITDVVEEICAPANRWSVRTVGDLELLGDEPARRLREAV
MLBr_02467|M.leprae_Br4923 RDPDELAALIEIITDVVEEICAPANRWSVRTVGDLELLGEEPACRLRGAV
Mb1115|M.bovis_AF2122/97 RDPDELAALIEIITDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAV
Rv1086|M.tuberculosis_H37Rv RDPDELAALIEIITDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAV
MAV_1211|M.avium_104 RDPDELAGLIEIITDVVEEICAPANRWSVRTVGDLELLGEEPARRLRGAV
MSMEG_5256|M.smegmatis_MC2_155 RDPDELTALIEIITDVVEEICAPYNKWSVRTVGDLELLGDEPARRLREAV
TH_2165|M.thermoresistible__bu RDPDELTALIEIITEVVEEICAPANKWSVRTVGDLALLGEEPARRLREAV
MAB_1209|M.abscessus_ATCC_1997 RDPDQLTELLEIITDVVEELCAPQNKWSVRSVGDLDLLPDEVAERMRQAV
*:.::*: *:****:****:*** *:****:**** *: :: * *:* **
Mvan_4662|M.vanbaalenii_PYR-1 SSTDGNG--GTFHVNVAVGYGGRQEIVDAVRALLSKELANGLTGEQLIES
Mflv_2055|M.gilvum_PYR-GCK SSTDGNG--GAFHVNVAVGYGGRQEIVDAVRALLSKELANGATGDQLVEA
MMAR_4380|M.marinum_M ESTP-AT--AQFHVNVAVGYGGRREIVDAVRALLSKELANGATAEELIDA
MUL_0193|M.ulcerans_Agy99 ESTP-AT--AQFHVNVAVGYGGRREIVDAVRALLSKELANGATAEELIDA
MLBr_02467|M.leprae_Br4923 ESTP-GV--APFHVNVAVGYGGRREIVGAVRALLGKELANGATAEELVEA
Mb1115|M.bovis_AF2122/97 ESTP-EV--ASFHVNVAVGYGGRREIVDAVRALLSKELANGATAEELVDA
Rv1086|M.tuberculosis_H37Rv ESTP-EV--ASFHVNVAVGYGGRREIVDAVRALLSKELANGATAEELVDA
MAV_1211|M.avium_104 ESTP-VE--ASFHVNVAVGYGGRREIVDAVRSLLSKELANGATAEELIDA
MSMEG_5256|M.smegmatis_MC2_155 ESTTTKG--ANFHVNVAVAYGGRQEIVDAVRSLLSKELANGATAEQLIEA
TH_2165|M.thermoresistible__bu DRTETVADAAAFHVNVAVGYGGRQEIVDAVRALLSKELANGASPEQLIQS
MAB_1209|M.abscessus_ATCC_1997 KSAPSDA---GFHVNVAVGYGGRQEITDAVRTLLNKELANGASAEQLVQA
. : *******.****:**..***:**.****** : ::*:::
Mvan_4662|M.vanbaalenii_PYR-1 VTAEAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAYW
Mflv_2055|M.gilvum_PYR-GCK VTAEAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAYW
MMAR_4380|M.marinum_M VSVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHW
MUL_0193|M.ulcerans_Agy99 VSVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHW
MLBr_02467|M.leprae_Br4923 VTVEGIARNLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTETHW
Mb1115|M.bovis_AF2122/97 VTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHW
Rv1086|M.tuberculosis_H37Rv VTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHW
MAV_1211|M.avium_104 VTVDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHW
MSMEG_5256|M.smegmatis_MC2_155 VTVDGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAYW
TH_2165|M.thermoresistible__bu VTIDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHW
MAB_1209|M.abscessus_ATCC_1997 VTVDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTDAYW
*: :.*:.**************************************:::*
Mvan_4662|M.vanbaalenii_PYR-1 PEFRRVDFLRALRDYSARHRRYGR
Mflv_2055|M.gilvum_PYR-GCK PEFRRVDFLRALRDYSARHRRYGR
MMAR_4380|M.marinum_M PAFRRVDFLRALRDYSMRHRRYGK
MUL_0193|M.ulcerans_Agy99 PAFRRVDFLRALRDYSMRHRRYGK
MLBr_02467|M.leprae_Br4923 PAFRRVDFLRALRDYSMRHRRYGK
Mb1115|M.bovis_AF2122/97 PAFRHVDFLRALRDYSARHRRYGR
Rv1086|M.tuberculosis_H37Rv PAFRHVDFLRALRDYSARHRSYGR
MAV_1211|M.avium_104 PAFRRVDFLRALRDYSQRHRRYGK
MSMEG_5256|M.smegmatis_MC2_155 PAFRRVDFLRALRDYTARHRRFGK
TH_2165|M.thermoresistible__bu PAFRRVDFLRALRDYTRRHRRFGM
MAB_1209|M.abscessus_ATCC_1997 PEFRRVDFLRALRDYAARNRRFGQ
* **:**********: *:* :*