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MVVTPAGLGLGQLLLALDRTMVTLVEAPRGLDMPVGSVALVDADDVRLGLAVGPGSVDLFFLLGVADVDA LRWLEHHADRPVAIFVKEPTAEAVARAVALGAAVVAVDPRARWEHLYRLVNYALEHHGDRDDPSRDSGTD LFGLAQSIADRTRGMICIEDADSRMLAYSASSEEADELRRLTILGRAGPPEHLEWIGQWGIFDALRAGPD VVRVAERPELGLRPRLAVGIHLPADTRHAPRFAGTIWLQQGSSALADDAEEILRGGSVLAARIMSRLATA PSQHAARLQQLLGLTGVDVDDVGALARELGIPEDARAAIVGFRGLGTAVPADVIALSAGAFRADAQVAAA GDRVYVLLPKAGAAASLTSWVRGVVAALRRELGLEVRAVTAPLTGPAGAAGARADVDRVFDSAERHPGAI DLVTSLDEARTTVLLDEIVSHVAAQPRLVDPRVRRLRAGDPLLAETLQAFLDGFGDIAAIAARLHVHPNT VRYRIRRVEKLLSTSLEDPDSRLVLALGLRATEPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4527 | - | - | 100% (525) | hypothetical protein Mvan_4527 |
| M. vanbaalenii PYR-1 | Mvan_4779 | - | 2e-32 | 29.73% (481) | putative DNA-binding protein |
| M. vanbaalenii PYR-1 | Mvan_1854 | - | 2e-11 | 27.98% (243) | purine catabolism PurC domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1218c | - | 0.0 | 65.48% (533) | hypothetical protein Mb1218c |
| M. gilvum PYR-GCK | Mflv_1946 | - | 7e-27 | 25.78% (481) | putative DNA-binding protein |
| M. tuberculosis H37Rv | Rv1186c | - | 0.0 | 65.29% (533) | hypothetical protein Rv1186c |
| M. leprae Br4923 | MLBr_01652 | - | 3e-07 | 60.53% (38) | hypothetical protein MLBr_01652 |
| M. abscessus ATCC 19977 | MAB_1880c | - | 1e-07 | 44.44% (63) | hypothetical protein MAB_1880c |
| M. marinum M | MMAR_4254 | - | 0.0 | 66.86% (528) | hypothetical protein MMAR_4254 |
| M. avium 104 | MAV_1330 | - | 0.0 | 66.35% (529) | hypothetical protein MAV_1330 |
| M. smegmatis MC2 155 | MSMEG_5120 | - | 0.0 | 67.43% (522) | hypothetical protein MSMEG_5120 |
| M. thermoresistible (build 8) | TH_2137 | - | 1e-38 | 30.30% (495) | putative DNA-binding protein |
| M. ulcerans Agy99 | MUL_0931 | - | 0.0 | 66.86% (528) | hypothetical protein MUL_0931 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1946|M.gilvum_PYR-GCK --MHTAGPGVASTFVITLDRLINVLGGYGARWQGGSADRQTELRSVVLPE
TH_2137|M.thermoresistible__bu --------------VVTLDRLVNVLGSYGVRLQFCPVPRSTEVRSVALHE
Mb1218c|M.bovis_AF2122/97 --MRIAGVGLGQLLLALDATVVSLVDAP--RGLDLPVASTALIDSDDVRL
Rv1186c|M.tuberculosis_H37Rv --MRIAGVGLGQLLLALDATVVSLVDAP--RGLDLPVASTALIDSDDVRL
MMAR_4254|M.marinum_M --MGVAGVGLGQLLLALDATLVSLVEAP--RGLDLPVASAALVDSDDVRL
MUL_0931|M.ulcerans_Agy99 --MGVAGVGLGQLLLALDATLVSLVEAP--RGLDLPVASAALVDSDDVRL
MAV_1330|M.avium_104 ----MAGVGLGQLLLALDATMVSLVDAP--RGLDQPVASAALIDSDDVRL
MSMEG_5120|M.smegmatis_MC2_155 --MQAPGVSLGQLLLALDATLVRLVEAP--RGLDLPVASAALIDSDDVRF
Mvan_4527|M.vanbaalenii_PYR-1 MVVTPAGLGLGQLLLALDRTMVTLVEAP--RGLDMPVGSVALVDADDVRL
MLBr_01652|M.leprae_Br4923 --------MNHNHFVPAPPRRLPLELLD--TVPDSLLRRLKQYSGRLATE
MAB_1880c|M.abscessus_ATCC_199 --------MPDNPATAPRGFRAARKPRERAEVPEALLHRIKQYSGRLSTE
.
Mflv_1946|M.gilvum_PYR-GCK VVDGRTVSGDVLLAIGATTTAEAVRWARAARA-----VVVLTRGGGDPEP
TH_2137|M.thermoresistible__bu NAGGLRVTGDVLLAVGAESVAEAVRWAETAQA-----VVVLTRAGPDASR
Mb1218c|M.bovis_AF2122/97 GLAAAAGSADVFFLIGVT-DDEAVRWVDDQARQRAPVAIFVKHPSDSVVA
Rv1186c|M.tuberculosis_H37Rv GLAAAAGSADVFFLIGVT-DDEAVRWVDDQARQRAPVAIFVKHPSDSVVA
MMAR_4254|M.marinum_M GLAAAAGSADIFFLLGVT-DHEALRWIDGQAG--TPVAIFVKQPSDAVVA
MUL_0931|M.ulcerans_Agy99 GLAAAAGSADIFFLLGVT-DHEALRWIDGQAG--TPVAIFVKQPSDAVVA
MAV_1330|M.avium_104 GLAAAAGSADVFFLLGVG-DDEALRWIDTQARDRVPVAVFVKEPSDALVG
MSMEG_5120|M.smegmatis_MC2_155 GLAPAAGSADLFFLLGVS-ESDALAWVDHQADHRPPAAIFVKEPSQAIVE
Mvan_4527|M.vanbaalenii_PYR-1 GLAVGPGSVDLFFLLGVA-DVDALRWLEHHADR--PVAIFVKEPTAEAVA
MLBr_01652|M.leprae_Br4923 AVTAMQERLPFFADLEASQRASVTLVVQTAVVN---FVQWMQNPHSDVSY
MAB_1880c|M.abscessus_ATCC_199 AVHVMEDRLPFFTDLEASQRASVALVVQTAINN---FVEWIRDPEGTVGF
.: : . .. . :
Mflv_1946|M.gilvum_PYR-GCK DTAG--VAVLVVDSAMPWSEFAAIVYGLVMEGRETE--SGRGPTDLFALA
TH_2137|M.thermoresistible__bu SCSDGAVAVLTVEPEVSWSELAAVVYGLVLEGRETE--SGRGPTDLFALA
Mb1218c|M.bovis_AF2122/97 GAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDLFGLA
Rv1186c|M.tuberculosis_H37Rv GAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDLFGLA
MMAR_4254|M.marinum_M KAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTDLFGLA
MUL_0931|M.ulcerans_Agy99 KAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTDLFGLA
MAV_1330|M.avium_104 TAVAAGSAVVAVDPRARWERLYQLVNHVLEHHGDRADAADDSGTDLFGLA
MSMEG_5120|M.smegmatis_MC2_155 RATAAGIAVVAVDTRARWERLYRLVNHVFEHHNDRA--LHDSGTDLFGLA
Mvan_4527|M.vanbaalenii_PYR-1 RAVALGAAVVAVDPRARWEHLYRLVNYALEHHGDRDDPSRDSGTDLFGLA
MLBr_01652|M.leprae_Br4923 TAQAFELVPQDLARRIALRHTVDMVRVTMEFFEEVVPLLARSEEQLTALT
MAB_1880c|M.abscessus_ATCC_199 TMQAFEVVPQDLAKRIALRHSVDMVRTAMEFFEEVLPLLARNDEQLVTLT
. : . :* . : . :* *:
Mflv_1946|M.gilvum_PYR-GCK DNLSNAVGGAVVIEDRASQVLAFSRGQLDADPARAKTILARQAPPSLRAV
TH_2137|M.thermoresistible__bu DNLADAVGGPVTIEDRMSRVLAYSQRQQHADPARAQTILARQAPEPLRRL
Mb1218c|M.bovis_AF2122/97 QSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGPPEHLQW
Rv1186c|M.tuberculosis_H37Rv QSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGPPEHLQW
MMAR_4254|M.marinum_M QSLADRIHGMVSIEDAQSHVLAYSASSDEADELRRLSILGRAGPPEHLKW
MUL_0931|M.ulcerans_Agy99 QSLADRIHGMVSIEDAQSHVLAYSASSDEADELRRLSILGRAGPPEHLKW
MAV_1330|M.avium_104 QSLAERIHGMVSIENAQSQVLAYSASNDEADELRRLSILGRAGPPEHLEW
MSMEG_5120|M.smegmatis_MC2_155 QSVAERTHGMVSIEDAQSHVLAYSASNEEADELRRLSILGRAGPPEHLDW
Mvan_4527|M.vanbaalenii_PYR-1 QSIADRTRGMICIEDADSRMLAYSASSEEADELRRLTILGRAGPPEHLEW
MLBr_01652|M.leprae_Br4923 VGILK-----------YSRDLAFTAATAYADAAEARGTWDSRMEASVVDA
MAB_1880c|M.abscessus_ATCC_199 EGILR-----------YSRDLAFGAASAYAEAAETRGAWDSRLEATVVDA
.: *: **: *: .
Mflv_1946|M.gilvum_PYR-GCK FDAHGVFAHLAVSDEPLFVPGDDAVGLTGRMVV-------AARAGRELLG
TH_2137|M.thermoresistible__bu FEQLGVSEHLAAGDDPLFIAARPGHDLTGRTVI-------AVRAGRELLG
Mb1218c|M.bovis_AF2122/97 IGQWGIFDALRAGREVVRVAERPELGLRPRLAIGIHQPGVGALRPPVFAG
Rv1186c|M.tuberculosis_H37Rv IGQWGIFDALRPGREVVRVAERPELGLRPRLAIGIHQPGVGALRPPVFAG
MMAR_4254|M.marinum_M IGQWGIFDALRSGSEVVRVAERPELGLRPRLAIGIHQPPVAARRPPVFAG
MUL_0931|M.ulcerans_Agy99 IGQWGIFDALRSGSEVVRVAERPELGLRPRLAIGIHQPPVAARRPPVFAG
MAV_1330|M.avium_104 IGQWGIFDALRSGTQVVRVAERPELGLRPRLAVGIHQPDPDARRPPVFAG
MSMEG_5120|M.smegmatis_MC2_155 IAQWGIFDALRAKPDVVRVAERPELGLRPRLAIGIFQPAPDERRAPTFAG
Mvan_4527|M.vanbaalenii_PYR-1 IGQWGIFDALRAGPDVVRVAERPELGLRPRLAVGIHLP-ADTRHAPRFAG
MLBr_01652|M.leprae_Br4923 VVRG------DTGPELLSRAAALNWDTT-------------------APA
MAB_1880c|M.abscessus_ATCC_199 VVRG------DTGPDMLSRAAALNWDTN-------------------APA
. : : . . .
Mflv_1946|M.gilvum_PYR-GCK SVWVAVPKPLAGQQRQALADGARTVALHLLRSRASADLERQVESEMVIRL
TH_2137|M.thermoresistible__bu SVWVVTPEPLDDGRRRALADGARTVALHLLRSRASADLERQVESDLVLRL
Mb1218c|M.bovis_AF2122/97 TIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTHALRVQQLLGL
Rv1186c|M.tuberculosis_H37Rv TIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTHALRVQQLLGL
MMAR_4254|M.marinum_M SIWVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPSTHARRVQQLLGL
MUL_0931|M.ulcerans_Agy99 SIWVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPSTHARRVQQLLGL
MAV_1330|M.avium_104 TIWVQQGAQPLADDAEQILRGAAVLAARIMARLAARPSTQARRLQQLLGV
MSMEG_5120|M.smegmatis_MC2_155 TIWVQQGSRPLAEDAEEVLRGAAVLAARIMARLAATPSSDAVRLQELLGL
Mvan_4527|M.vanbaalenii_PYR-1 TIWLQQGSSALADDAEEILRGGSVLAARIMSRLATAPSQHAARLQQLLGL
MLBr_01652|M.leprae_Br4923 TVVVGTPTPNHDGPNGQVSSERASQEVREIAARHGRAALTDVHGTWLVAI
MAB_1880c|M.abscessus_ATCC_199 TVIVGTPRP------DIIAT--ATTLVHEVAQRHGRGALAVIQGTRLLTI
:: : : : : . :: :
Mflv_1946|M.gilvum_PYR-GCK LES-----PADAETVASRLGLPPSALRVIALRALDTTGRH--SALLQMFE
TH_2137|M.thermoresistible__bu LEG-----TSDAAGAAARLGLPQEALRIIAVRARSGVDRQ--GPLLLAFE
Mb1218c|M.bovis_AF2122/97 AELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDTAVRHVRLVDV
Rv1186c|M.tuberculosis_H37Rv AELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDTAVRHVRLVDV
MMAR_4254|M.marinum_M ADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD---KQSRLADV
MUL_0931|M.ulcerans_Agy99 ADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD---KQSRLADV
MAV_1330|M.avium_104 TDS-ETLAPVDLTAIAAELGLAADGCAALVGWAAAEGAS---RHTRLTDV
MSMEG_5120|M.smegmatis_MC2_155 R---ATDEPVDVEQVARELGITADGRAALIGFDAGSPST------RIADV
Mvan_4527|M.vanbaalenii_PYR-1 TG----VDVDDVGALARELGIPEDARAAIVGFRGLGTAVP-------ADV
MLBr_01652|M.leprae_Br4923 ISG-----------------------------------------------
MAB_1880c|M.abscessus_ATCC_199 VSG-----------------------------------------------
Mflv_1946|M.gilvum_PYR-GCK RATAGFGWSRPSRSALADATVYTVLA-AEPAAVARDWVSALISTLPDQVT
TH_2137|M.thermoresistible__bu HATTGFGWSRAGRSALAGDTVYTVLP-ADHAATARRWVEGLQAALPSEVT
Mb1218c|M.bovis_AF2122/97 MALSASAFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRGTISALRAELG
Rv1186c|M.tuberculosis_H37Rv MALSASAFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRGTISALRAELG
MMAR_4254|M.marinum_M LALSASAFRRDAQVGTNGSRIYVVLPQTATARSLTSWVRGTISALRSELG
MUL_0931|M.ulcerans_Agy99 LALSASAFRRDAQVGTNGSRIYVVLPQTATARSLTSWVRGTISALRSELG
MAV_1330|M.avium_104 IALSASAFRHDAHVAGHGSRTYVLLPQPPN-RSVSSWVRGTIAALRAELG
MSMEG_5120|M.smegmatis_MC2_155 LSLSASAFRSDAQITSSRTRVYVLFPNTGKPGAVTSWLRGTVSALRAELG
Mvan_4527|M.vanbaalenii_PYR-1 IALSAGAFRADAQVAAAGDRVYVLLPKAGAAASLTSWVRGVVAALRRELG
MLBr_01652|M.leprae_Br4923 -----------------------------QLAPTDKFFSDLLHAFSDGP-
MAB_1880c|M.abscessus_ATCC_199 -----------------------------PITAHDKFLADLMKVFSDGP-
:. .:
Mflv_1946|M.gilvum_PYR-GCK VKAGISAPAAATDLAVARTEADECLALQES-----TDAGEPP--------
TH_2137|M.thermoresistible__bu VSAGISGIADHTELPDARREADECLALHDALHDARPDTGSPDSDSDALAA
Mb1218c|M.bovis_AF2122/97 VALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI-LGQVT--------
Rv1186c|M.tuberculosis_H37Rv VALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI-LGQVT--------
MMAR_4254|M.marinum_M VELRATIAAPVAGLDGLASARVEVDRVLDSAERHPISIGRVT--------
MUL_0931|M.ulcerans_Agy99 VELRATIAAPVAGLDGLASARVEVDRVLDSAERHPISIGRVT--------
MAV_1330|M.avium_104 VQLRAVIAAPVPGLSGVAAARAEVDRVLDSAERHPLSFGQVT--------
MSMEG_5120|M.smegmatis_MC2_155 IELYAVIAAPVAGLAGAAAARTEVDRVLDSAGRHPGALGQVT--------
Mvan_4527|M.vanbaalenii_PYR-1 LEVRAVTA-PLTGPAGAAGARADVDRVFDSAERHPGAIDLVT--------
MLBr_01652|M.leprae_Br4923 ----VVIGPTAPMLTAAYHSASEAVSGMNAVAGWSGAPRPVQ--------
MAB_1880c|M.abscessus_ATCC_199 ----VVVGPTAGSLSASHTSAVEALSGMDAVSGWRGAPRPVS--------
: ::
Mflv_1946|M.gilvum_PYR-GCK -AYDESWDDLLLRRLKTAARSGRTPTRGAVAELREHDSAHGTAYVPTLRA
TH_2137|M.thermoresistible__bu VVYDESWHDVLLQRLRTAARAGRIPSRGPIAALHEHDLRHATQYVATLRS
Mb1218c|M.bovis_AF2122/97 -SLAEARTTVLLDEIVTLVGTDQRLVDPRIRDLGAQD----PVLAQTLRA
Rv1186c|M.tuberculosis_H37Rv -SLAEARTTVLLDEIVTLVGTDQRLVDPRIRDLGAQD----PVLAQTLRA
MMAR_4254|M.marinum_M -SLAEARTTVLLDEIVTLVGNDARLIDPRIPDLRAKD----PVLADTLRV
MUL_0931|M.ulcerans_Agy99 -SLAEARTTVLLDEIVTLVGNDARLIDPRIPDLRAKD----PVLADTLRV
MAV_1330|M.avium_104 -SLAEARTTVLLDEIVTLVGRDERLVDPRIVALHDRE----PVLAQTLRT
MSMEG_5120|M.smegmatis_MC2_155 -SLAEARTTVLLDEIITAIASDDRLIDPRVRALRTEE----PVLAETLRV
Mvan_4527|M.vanbaalenii_PYR-1 -SLDEARTTVLLDEIVSHVAAQPRLVDPRVRRLRAGD----PLLAETLQA
MLBr_01652|M.leprae_Br4923 -----ARELLPERALMGDASAIVALHTDVMLPLADAG----PTLIETLDA
MAB_1880c|M.abscessus_ATCC_199 -----SRELLPERALLGDKAAIAALNTEVMRPLADAG----PALTETLDA
: : : : * . **
Mflv_1946|M.gilvum_PYR-GCK WLQERGDPVRTAAHLGVHENTVRYRMRRMAELTELHLDDARKRFAMTIEL
TH_2137|M.thermoresistible__bu WLAAQGDPAAAGAVLGVHENTVRYRLRKMTAVTQLDLQDPDKRLAMMIEL
Mb1218c|M.bovis_AF2122/97 YLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGDPDVRLLFSLGL
Rv1186c|M.tuberculosis_H37Rv YLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGDPDVRLLFSLGL
MMAR_4254|M.marinum_M YLDSFGDIGLAAQSLQVHPNTVRYRIRRVEKLLSTSFADPDVRLVFSLGL
MUL_0931|M.ulcerans_Agy99 YLDSFGDIGLAAQSLQVHPNTVRYRIRRVEKLLSTSFADPDVRLVFSLGL
MAV_1330|M.avium_104 YLDAFGDIAAAAHALRVHPNTVRYRVRRIEKLLSVSLADPEVRLLFALAL
MSMEG_5120|M.smegmatis_MC2_155 YLDSFGDVAAAAQSMHVHPNTVRYRVRRVEQLLGTSLGDPDVRLLLSLSL
Mvan_4527|M.vanbaalenii_PYR-1 FLDGFGDIAAIAARLHVHPNTVRYRIRRVEKLLSTSLEDPDSRLVLALGL
MLBr_01652|M.leprae_Br4923 YLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGHDPTLPRDAYVLRVAA
MAB_1880c|M.abscessus_ATCC_199 YLDSGGAIEACARALFVHPNTVRYRLKRITDFTGRDPTSPRDAYVLRVAA
:* * . : ** ******:::: . . : :
Mflv_1946|M.gilvum_PYR-GCK AVLD-------------------------
TH_2137|M.thermoresistible__bu AAIEGPPILSG------------------
Mb1218c|M.bovis_AF2122/97 RAMERTA----------------------
Rv1186c|M.tuberculosis_H37Rv RAMERTA----------------------
MMAR_4254|M.marinum_M RATDRSS----------------------
MUL_0931|M.ulcerans_Agy99 RATDHSS----------------------
MAV_1330|M.avium_104 RAAER------------------------
MSMEG_5120|M.smegmatis_MC2_155 RATA-------------------------
Mvan_4527|M.vanbaalenii_PYR-1 RATEPR-----------------------
MLBr_01652|M.leprae_Br4923 TVGKLNYPTHH------------------
MAB_1880c|M.abscessus_ATCC_199 TVGRLAQDHADAFTPEPGVTPVTINVIKT
.