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VQATLCGRPVAGDRPLIMAIVNRTPDSFYDKGATFSDAAARDAVHRAVAEGADVIDVGGVKAGPGQDVDP DTEIGRLVPFVEWLRDAYPEQVISVDTWRSEVARRACAAGADLINDTWAGVDPAIVEVAAEFGAGLVCAH TGGARPRTRPFRVSYGTTTRGVVDDVIREVTAAAERAVAAGVARDRVLIDPAHDFGKNTWHGLLLLRHVA DLVKTGWPVLMALSNKDFVGETLGVDLTERLEGTLAATALAAAAGARMFRVHEIAATRRVLEMVASIQGT RPPTRTVRGLA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0958 | folP2 | - | 100% (291) | dihydropteroate synthase 2 FolP2 |
| M. ulcerans Agy99 | MUL_4190 | folP1 | 4e-29 | 36.90% (271) | dihydropteroate synthase 1 FolP1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1239 | folP2 | 1e-149 | 89.97% (289) | dihydropteroate synthase 2 FolP2 |
| M. gilvum PYR-GCK | Mflv_2186 | - | 1e-133 | 78.35% (291) | dihydropteroate synthase |
| M. tuberculosis H37Rv | Rv1207 | folP2 | 1e-149 | 89.97% (289) | dihydropteroate synthase 2 FolP2 |
| M. leprae Br4923 | MLBr_01063 | folP2 | 1e-143 | 85.91% (291) | dihydropteroate synthase |
| M. abscessus ATCC 19977 | MAB_1345 | - | 1e-129 | 75.95% (291) | dihydropteroate synthase |
| M. marinum M | MMAR_4231 | folP2 | 1e-166 | 99.31% (291) | dihydropteroate synthase 2 FolP2 |
| M. avium 104 | MAV_1352 | folP | 1e-148 | 87.97% (291) | dihydropteroate synthase |
| M. smegmatis MC2 155 | MSMEG_5085 | folP | 1e-134 | 79.04% (291) | dihydropteroate synthase |
| M. thermoresistible (build 8) | TH_0657 | folP2 | 1e-104 | 82.14% (224) | PROBABLE DIHYDROPTEROATE SYNTHASE 2 FOLP2 (DHPS 2) |
| M. vanbaalenii PYR-1 | Mvan_4509 | - | 1e-129 | 79.43% (282) | dihydropteroate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2186|M.gilvum_PYR-GCK ---------------------------MQSTFLGRPVAGDRALIMAIVNR
Mvan_4509|M.vanbaalenii_PYR-1 ------------------------------------MAGDRALIMAIVNR
MSMEG_5085|M.smegmatis_MC2_155 ---------------------------MFSTFCGRPVAHDRALIMAIVNR
TH_0657|M.thermoresistible__bu --------------------------------------------------
MUL_0958|M.ulcerans_Agy99 ---------------------------MQATLCGRPVAGDRPLIMAIVNR
MMAR_4231|M.marinum_M ---------------------------MQATLCGRPVAGDRPLIMAIVNR
Mb1239|M.bovis_AF2122/97 MRSTPPASAGRSTPPALAGHSTPPALAGHSTLCGRPVAGDRALIMAIVNR
Rv1207|M.tuberculosis_H37Rv MRSTPPASAGRSTPPALAGHSTPPALAGHSTLCGRPVAGDRALIMAIVNR
MLBr_01063|M.leprae_Br4923 ---------------------------MQSMLCGRPVAADRQLIMAIVNR
MAV_1352|M.avium_104 ---------------------------MQSTFCGRPVAGDRALIMAIINR
MAB_1345|M.abscessus_ATCC_1997 ----------------MARRAALHNEDVRETFCGRPVRTDRALIMAIVNR
Mflv_2186|M.gilvum_PYR-GCK TPDSFYDRGATFSDDAAKEAAHRVIADGADIVDVGGVKAGPGTTVDVDEE
Mvan_4509|M.vanbaalenii_PYR-1 TPDSFYDRGATFTDDAAKEAAHRVVEDGADIIDVGGVKAGPGAIVDVDEE
MSMEG_5085|M.smegmatis_MC2_155 TPDSFYDRGATFTDEAAKAAAHRVIDEGADVIDVGGVKAGPGSNVDAEEE
TH_0657|M.thermoresistible__bu -------------------------------------------VVDAEEE
MUL_0958|M.ulcerans_Agy99 TPDSFYDKGATFSDAAARDAVHRAVAEGADVIDVGGVKAGPGQDVDPDTE
MMAR_4231|M.marinum_M TPDSFYDKGATFSDAAARDAVHRAVAEGADVIDVGGVKAGPGEDVDPDTE
Mb1239|M.bovis_AF2122/97 TPDSFYDKGATFSDAAARDAVHRAVADGADVIDVGGVKAGPGERVDVDTE
Rv1207|M.tuberculosis_H37Rv TPDSFYDKGATFSDAAARDAVHRAVADGADVIDVGGVKAGPGERVDVDTE
MLBr_01063|M.leprae_Br4923 TPDSFYDRGATFSDEAARAAAHRAVAEGADVIDVGGVKAGPGQGVDVDTE
MAV_1352|M.avium_104 TPDSFYDRGATFSDDAARAAVHRAVAEGADVIDVGGVKAGPGQDVDADTE
MAB_1345|M.abscessus_ATCC_1997 TPDSFYDRGATFTDEAAQAAVHQAVADGADVVDIGGVKAGPGENVDADAE
** : *
Mflv_2186|M.gilvum_PYR-GCK IARVVPFIEWLRGTFPDQVISVDTWRAAVAKQACAAGADLINDTWGGTDP
Mvan_4509|M.vanbaalenii_PYR-1 IARVVPFIEWLRATFPDRVISVDTWRAEVAKQACAAGADLINDTWGGADP
MSMEG_5085|M.smegmatis_MC2_155 ITRVVPFIEWLRSTFPDRLISIDTWRAAVAKQACAAGADIINDTWAGADP
TH_0657|M.thermoresistible__bu IARVVPFIEWLRDTYPDQLISVDTWRASVAKQACAAGADLINDTWAGHDP
MUL_0958|M.ulcerans_Agy99 IGRLVPFVEWLRDAYPEQVISVDTWRSEVARRACAAGADLINDTWAGVDP
MMAR_4231|M.marinum_M IGRLVPFVEWLRDAYPEQVISVDTWRSEVARRACAAGADLINDTWAGVDP
Mb1239|M.bovis_AF2122/97 ITRLVPFIEWLRGAYPDQLISVDTWRAQVAKAACAAGADLINDTWGGVDP
Rv1207|M.tuberculosis_H37Rv ITRLVPFIEWLRGAYPDQLISVDTWRAQVAKAACAAGADLINDTWGGVDP
MLBr_01063|M.leprae_Br4923 IARLVPFIEWLRSAYTDLLISVDTWRAEVARLACTAGADLINDSWGGADP
MAV_1352|M.avium_104 IARLVPFIEWLRDAYPDQLISADTWRAEVAKVACAAGADLINDTWGGVDP
MAB_1345|M.abscessus_ATCC_1997 IARVVPFIEWVRGAHPDLLISVDTWRAEVAAKACAAGADLINDTWAGADP
* *:***:**:* :..: :** ****: ** **:****:***:*.* **
Mflv_2186|M.gilvum_PYR-GCK DLAGVAAEFDAGLVCSHTGGAVPRTRPFRVNYGLSERGVVDDVLAEVTAA
Mvan_4509|M.vanbaalenii_PYR-1 DLAGVAAEFGAGLVCSHTGGAVPRTRPFRVNYGLSERGVVDDVIAEVTSA
MSMEG_5085|M.smegmatis_MC2_155 GLAEVAAEFGAGLVCSHTGGATPRTRPFRVNYGISERGVVDDVIAEVTAA
TH_0657|M.thermoresistible__bu ELPAVAAEFNAGLVCSHTGGAAPRTRPFRVNYGITERAVVDDVIAEVTAA
MUL_0958|M.ulcerans_Agy99 AIVEVAAEFGAGLVCAHTGGARPRTRPFRVSYGTTTRGVVDDVIREVTAA
MMAR_4231|M.marinum_M AIVEVAAEFGAGLVCAHTGGARPRTRPFRVSYGTTTRGVVDDVIREVTAA
Mb1239|M.bovis_AF2122/97 AMPEVAAEFGAGLVCAHTGGALPRTRPFRVSYGTTTRGVVDAVISQVTAA
Rv1207|M.tuberculosis_H37Rv AMPEVAAEFGAGLVCAHTGGALPRTRPFRVSYGTTTRGVVDAVISQVTAA
MLBr_01063|M.leprae_Br4923 AMHEVAAELGAGLVCSHTGGALPRTRPFRVSYGTTTRGVVDDVIRQVTAA
MAV_1352|M.avium_104 ALPEVAAEFGAGLVCSHTGNALPRTRPFRVSYGTSTRGVVDDVIAQVTAA
MAB_1345|M.abscessus_ATCC_1997 ELPAVAAAYGAGLVCSHTGGAVPRTRPYRVHYGTEVDGVVRAVLDEVTAS
: *** .*****:***.* *****:** ** .** *: :**::
Mflv_2186|M.gilvum_PYR-GCK AERAVSLGVSRDRILIDPTHDFGKNTYHGLSLLRHVKELVNTGWPVLMAL
Mvan_4509|M.vanbaalenii_PYR-1 AERAVALGVRRDGILIDPTHDFGKNTYHGLSLLRHVKDLVNTGWPVLMAL
MSMEG_5085|M.smegmatis_MC2_155 AERAVATGVQRDRILIDPTHDFGKNTYHGLSLLRHVKDLVNTGWPVLMAL
TH_0657|M.thermoresistible__bu AERAVAAGVPRDAILIDPTHDFGKNTHHGLTLLRHVEDLVNTGWPVLMAL
MUL_0958|M.ulcerans_Agy99 AERAVAAGVARDRVLIDPAHDFGKNTWHGLLLLRHVADLVKTGWPVLMAL
MMAR_4231|M.marinum_M AERAVAAGVARDRVLIDPAHDFGKNTWHGLLLLRHVADLVKTGWPVLMAL
Mb1239|M.bovis_AF2122/97 AERAVAAGVAREKVLIDPAHDFGKNTFHGLLLLRHVADLVMTGWPVLMAL
Rv1207|M.tuberculosis_H37Rv AERAVAAGVAREKVLIDPAHDFGKNTFHGLLLLRHVADLVMTGWPVLMAL
MLBr_01063|M.leprae_Br4923 AERAVAAGVTRDSVLVDPTHDFGKNTFHGLLLLRHVDELVKTGWPVLMSL
MAV_1352|M.avium_104 AERAVGCGVAPDRVLIDPTHDFGKNTFHGLLLLRHVGDLVNTGWPVLMAL
MAB_1345|M.abscessus_ATCC_1997 AERALALGVSKDAILIDPTHDFGKNTFHGLALLRHVNDLVNTGWPVLMAL
****:. ** : :*:**:******* *** ***** :** *******:*
Mflv_2186|M.gilvum_PYR-GCK SNKDFVGETLGVGLTERLEGTLAATALAAADGAAVFRVHEVGPTRRVLEM
Mvan_4509|M.vanbaalenii_PYR-1 SNKDFVGETLGVGLTERLEGTLAATALAAADGAAMFRVHEVGPTRRVLEM
MSMEG_5085|M.smegmatis_MC2_155 SNKDFVGETLGVDLTERLEGTLAATALAAADGAAMFRVHEVGPTRRVLEM
TH_0657|M.thermoresistible__bu SNKDFVGETLGVVLTDRLEGTLAATALAAAAGAAMFRVHEVAPTRRVLEM
MUL_0958|M.ulcerans_Agy99 SNKDFVGETLGVDLTERLEGTLAATALAAAAGARMFRVHEIAATRRVLEM
MMAR_4231|M.marinum_M SNKDFVGETLGVDLTERLEGTLAATALAAAAGARMFRVHEVAATRRVLEM
Mb1239|M.bovis_AF2122/97 SNKDVVGETLGVDLTERLEGTLAATALAAAAGARMFRVHEVAATRRVLEM
Rv1207|M.tuberculosis_H37Rv SNKDVVGETLGVDLTERLEGTLAATALAAAAGARMFRVHEVAATRRVLEM
MLBr_01063|M.leprae_Br4923 SNKDFVGETLGVGLTERLEGTLAATALAAAAGVRMFRVHEVVATRRVLEM
MAV_1352|M.avium_104 SNKDFVGETLGVELTERLEGTLAATALAAAAGARMFRVHEVAPTRRVLEM
MAB_1345|M.abscessus_ATCC_1997 SNKDFIGETLGVGLTERLEGTLAATALAAAAGARMFRVHEVGPTRRTLEM
****.:****** **:************** *. :*****: .***.***
Mflv_2186|M.gilvum_PYR-GCK VASIQGARPPKRTVRGLA
Mvan_4509|M.vanbaalenii_PYR-1 VASIQGARPPKHTVRGLA
MSMEG_5085|M.smegmatis_MC2_155 VASIQGVRKPARTVRGLA
TH_0657|M.thermoresistible__bu VASIQGVRPPTRTVRGLA
MUL_0958|M.ulcerans_Agy99 VASIQGTRPPTRTVRGLA
MMAR_4231|M.marinum_M VASIQGTRPPTRTVRGLA
Mb1239|M.bovis_AF2122/97 VASIQGVRPPTRTVRGLA
Rv1207|M.tuberculosis_H37Rv VASIQGVRPPTRTVRGLA
MLBr_01063|M.leprae_Br4923 VASIQGTRPPTRTVRGLA
MAV_1352|M.avium_104 VASIQGTRPPTRTVRGLA
MAB_1345|M.abscessus_ATCC_1997 VGSIVGTRPPARTVRGLA
*.** *.* * :******