For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
HVSDPIAQANQRPSAGLADGPGRAAKRLMDAAAQRKPCAPVRDILGESDIALAYEAQEAIVNDRIHGGGV VTGRKIGLTAPAVQQQLGVNQPDFGVLFADMDVSSMTRVPAHLLLQPKVEAEIAFGLSRDLDIPDIDMPT LRDSVAWAAAALEIVDSRIANWDIRITDTVADNASSGLYVLSGSRIPLQNFVPREVTMRMFIDGEPVSEG TGAACLGDPLEALLWLARTARQYGRPLRGGQVVLSGALGAMVPVAPGSKVTAEISSLGEVSAWLGHRDEL QP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4393 | - | - | 100% (283) | hydratase/decarboxylase |
| M. vanbaalenii PYR-1 | Mvan_0595 | - | 3e-43 | 41.77% (249) | 4-oxalocrotonate decarboxylase |
| M. vanbaalenii PYR-1 | Mvan_5236 | - | 6e-38 | 34.68% (248) | 4-oxalocrotonate decarboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3566c | - | 1e-38 | 35.77% (246) | hydratase |
| M. gilvum PYR-GCK | Mflv_1520 | - | 3e-41 | 35.89% (248) | 4-oxalocrotonate decarboxylase |
| M. tuberculosis H37Rv | Rv3536c | - | 1e-38 | 35.77% (246) | hydratase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4373 | - | 7e-77 | 60.24% (249) | putative hydratase/decarboxylase |
| M. marinum M | MMAR_5023 | - | 3e-36 | 33.47% (248) | 2-keto-4-pentenoate hydratase |
| M. avium 104 | MAV_0625 | - | 4e-38 | 35.37% (246) | 2-keto-4-pentenoate hydratase |
| M. smegmatis MC2 155 | MSMEG_5940 | - | 7e-40 | 36.29% (248) | 2-keto-4-pentenoate hydratase |
| M. thermoresistible (build 8) | TH_0369 | - | 9e-38 | 34.96% (246) | PROBABLE HYDRATASE |
| M. ulcerans Agy99 | MUL_4097 | - | 2e-36 | 33.47% (248) | 2-keto-4-pentenoate hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5940|M.smegmatis_MC2_155 --------------------------------------------------
TH_0369|M.thermoresistible__bu --------------------------------------------------
Mflv_1520|M.gilvum_PYR-GCK --------------------------------------------------
Mb3566c|M.bovis_AF2122/97 --------------------------------------------------
Rv3536c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5023|M.marinum_M --------------------------------------------------
MUL_4097|M.ulcerans_Agy99 MRRQGQPPCRRRRFRPRRRRSPVMSCRTRYRIARVGRYWPGHHDARKTRG
MAV_0625|M.avium_104 --------------------------------------------------
Mvan_4393|M.vanbaalenii_PYR-1 -----------------------------------------------MHV
MAB_4373|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_5940|M.smegmatis_MC2_155 ---MLSDEVR---------ARLAADLAQAERSRQPITPLTDGNPDIDVVD
TH_0369|M.thermoresistible__bu ---MLSAQVR---------EQLAAELAQAERSRVPITPLTDRHPGIDVVD
Mflv_1520|M.gilvum_PYR-GCK ---MLPAEVR---------EKLAADLAEAEQSRKPISPLTDAHPDIDVVD
Mb3566c|M.bovis_AF2122/97 ---MLRDATR---------DELAADLAQAERSRDPIGQLTAAHPEIDVVD
Rv3536c|M.tuberculosis_H37Rv ---MLRDATR---------DELAADLAQAERSRDPIGQLTAAHPEIDVVD
MMAR_5023|M.marinum_M ---MLADSTR---------DKIAADLAQAERSRQPITPLTPSYPDIDVVD
MUL_4097|M.ulcerans_Agy99 LREMLADSTR---------DKIAADLAQAERSRQPITPLTPSYPDIDVVD
MAV_0625|M.avium_104 ---MLSVATR---------DELAAELAQAERSGEPIPPLTAAYPEIDVVD
Mvan_4393|M.vanbaalenii_PYR-1 SDPIAQANQRPSAGLADGPGRAAKRLMDAAAQRKPCAPVRDILGESDIAL
MAB_4373|M.abscessus_ATCC_1997 --MIAGADIR----------TAAERLEFAAVTGIPCAPVRDIIGADDIDT
: * * * * * : *:
MSMEG_5940|M.smegmatis_MC2_155 AYEIQLINIRQRIAEGAKVVGHKVGLSSKAMQEMMGVDEPDYGHLLDDMQ
TH_0369|M.thermoresistible__bu AYEIQLINIRQRVAEGARVVGHKVGLSSEAMQKMMGVDEPDYGHLLDDMQ
Mflv_1520|M.gilvum_PYR-GCK AYEIQLINIRRRVADGARIIGHKVGLSSEAMQKMMGVDEPDYGHLLEEMQ
Mb3566c|M.bovis_AF2122/97 AYEIQLINIRQRVAEGARVVGHKVGLSSPIMQQMMGVDEPDYGHLLDDMQ
Rv3536c|M.tuberculosis_H37Rv AYEIQLINIRQRVAEGARVVGHKVGLSSPIMQQMMGVDEPDYGHLLDDMQ
MMAR_5023|M.marinum_M AYQIQLINIRRRVAEGGRVVGHKVGLSSPVMQQMMGVDEPDYGHLLDNMR
MUL_4097|M.ulcerans_Agy99 AYQIQLINIRRRVAEGGRVVGHKVGLSSPVMQQMMGVDEPDYGHLLDNMR
MAV_0625|M.avium_104 AYEIQLINIRQRVAEGARVLGHKVGLSSLAIQQMMGVDEPDYGHLLDDMQ
Mvan_4393|M.vanbaalenii_PYR-1 AYEAQEAIVNDRIHGGGVVTGRKIGLTAPAVQQQLGVNQPDFGVLFADMD
MAB_4373|M.abscessus_ATCC_1997 AYLVQRSVIDRRVTRGASVAGHKIGLTSEAVQRQLGVHQPDFGVLLSDMD
** * : *: *. : *:*:**:: :*. :**.:**:* *: :*
MSMEG_5940|M.smegmatis_MC2_155 VYEDQPVKSANYLYPRVEVEVGFILADDLPGAGCTEEDVLAATAAFAPAI
TH_0369|M.thermoresistible__bu VFEDKPVKSANYLYPRVEVEVGFILAADLPGADCTEEDVLAATEAFAPAI
Mflv_1520|M.gilvum_PYR-GCK VFEDVPVGSGRYLYPRVEVEVGFILSDDLPGAGCTEDDVLAATAAFAPAI
Mb3566c|M.bovis_AF2122/97 VFEDTPVQASRYLSPRVEVEVGFILAADLPGAGCTEDDVLAATEALVPAI
Rv3536c|M.tuberculosis_H37Rv VFEDTPVQASRYLSPRVEVEVGFILAADLPGAGCTEDDVLAATEALVPAI
MMAR_5023|M.marinum_M VFEDAPVRTANYLYPRVEVEVGFILAADLPGADCTEDDVLAATEALVPSI
MUL_4097|M.ulcerans_Agy99 VFEDAPVRTANYLYPRVEVEVGFILAADLPGADCTEDDVLAATEALVPSI
MAV_0625|M.avium_104 LFEDTPVKTNRYLYPRVEVEVGFILNADLPGAGCTEDDVMAATEAFVPAI
Mvan_4393|M.vanbaalenii_PYR-1 VSSMTRVPAHLLLQPKVEAEIAFGLSRDLDIPDIDMPTLRDSVAWAAAAL
MAB_4373|M.abscessus_ATCC_1997 VSALQHVPSDRLLQPKIEAEIAFRLGEDLDNGDLGPSQVRAAVDAICAAL
: * : * *::*.*:.* * ** . : :. .::
MSMEG_5940|M.smegmatis_MC2_155 ELIDTRITNWQIKLCDTIADNASSAGWVLGEARVSPKDIDIRNIDAVLKN
TH_0369|M.thermoresistible__bu ELIDTRITDWKIKLCDTIADNASSAGWVLGEARVSPEEIDITTIEATLTN
Mflv_1520|M.gilvum_PYR-GCK ELIDTRITNWQIKLCDTIADNASSAGWVLGEARVSPKDVDIRAIDAVLTN
Mb3566c|M.bovis_AF2122/97 ELIDTRIKDWQIKICDTIADNASAAGFVLGAARVPPADLDVRAIDAKLTR
Rv3536c|M.tuberculosis_H37Rv ELIDTRIKDWQIKICDTIADNASAAGFVLGAARVPPADLDVRAIDAKLTR
MMAR_5023|M.marinum_M ELIDTRIKDWQIKICDTIADNASAAGFVLGAARVSPAEVDVKAIDAVLTR
MUL_4097|M.ulcerans_Agy99 ELIDTRIKDWQIKICDTIADNASAAGFVLGAARVSPAEVDVKAIDAVLTR
MAV_0625|M.avium_104 ELIDTRITDWKIELCDTIADNASSAGFVLGAARVSPQDIDIKGIDAVLRR
Mvan_4393|M.vanbaalenii_PYR-1 EIVDSRIANWDIRITDTVADNASSGLYVLSGSRIPLQNFVPREVTMRMFI
MAB_4373|M.abscessus_ATCC_1997 EIVDSRIANWDITIADTVADNGSSGLYVLNGHWTGLDACEPREVTMRMYT
*::*:** :*.* : **:***.*:. :**. : :
MSMEG_5940|M.smegmatis_MC2_155 NGEVVAEGRSDAVLGNPVTAVAWLARKVESFGVRLKAGDIVLPGSCTRAI
TH_0369|M.thermoresistible__bu NGEVVAQGRSDAVLGNPVTAVAWLARKVDSFGVRLKAGDIVLPGSCTRAI
Mflv_1520|M.gilvum_PYR-GCK NGEVVAEGRSDAVLGNPVTAVAWLARKVEAFGVRLKAGDIVLPGSCTRAI
Mb3566c|M.bovis_AF2122/97 NGEVVAEGRSDAVLGNPATAVAWLAGKVESFGVRLRKGDIVLPGSCTFAV
Rv3536c|M.tuberculosis_H37Rv NGEVVAEGRSDAVLGNPATAVAWLAGKVESFGVRLRKGDIVLPGSCTFAV
MMAR_5023|M.marinum_M NGELAAEGRSDAVLGNPATAVAWLARKVEGFGVRLRKGDIVLPGSCTFAV
MUL_4097|M.ulcerans_Agy99 NGELAAEGRSDAVLGNPATAVAWLARKVEGFGVRLRKGDIVLPGSCTFAV
MAV_0625|M.avium_104 NGEVVAEGRTDAVLGNPVTAVAWLARKVDGFGVRLRKGDVVLPGSCTKAI
Mvan_4393|M.vanbaalenii_PYR-1 DGEPVSEGTGAACLGDPLEALLWLARTARQYGRPLRGGQVVLSGALGAMV
MAB_4373|M.abscessus_ATCC_1997 GDLRVCEGTGTACLGDPLIALAWLARTTRKLGRPLRAGQIVLSGALGPMI
.. ..:* * **:* *: *** .. * *: *::**.*: :
MSMEG_5940|M.smegmatis_MC2_155 DAPAGSDFVADFAGLGSVHLRFE------------
TH_0369|M.thermoresistible__bu DAPAGSHFVADFSGLGSVQLSFE------------
Mflv_1520|M.gilvum_PYR-GCK DAPPGSRFVADFTGLGSVRLDFE------------
Mb3566c|M.bovis_AF2122/97 EARAGDEFVADFTGLGLVRLSFE------------
Rv3536c|M.tuberculosis_H37Rv EARAGDEFVADFTGLGLVRLSFE------------
MMAR_5023|M.marinum_M DANAGDEFVADFTGLGSVRLSFQ------------
MUL_4097|M.ulcerans_Agy99 DANAGDEFVADFTGLGSVRLSFQ------------
MAV_0625|M.avium_104 DAHPGDEFVADFAGLGSVRLSFE------------
Mvan_4393|M.vanbaalenii_PYR-1 PVAPGSKVTAEISSLGEVSAWL-----GHRDELQP
MAB_4373|M.abscessus_ATCC_1997 TPLPNTTIRAELSGLGTVTARFPPQSQGNDDDASV
.. . *:::.** * :