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TEQLTPTDIDEVDFFTDNTVLHDPYGYLAAMRNECPVRRERHHDVVMITGYEEAVAVYNDNARFSSCTAV TGPFPGFPVPLVGDDVSGLIAEHRDKLPFNDQLPTLDPPLHTDHRALLSRMITPKRLKENEEFMWRLADR QYDEALAGGRCEFVGEFGNPFAMLVIADLLGVPESDHNDFKDQLLTSTGTIGSSGGDAMHHSPLEYLYGK FTDYITDRRENPRDDVLTGLASALFPDGRTPPVIDVVCVAANLFAAGQETTVRLLSTAVMMIAEDPALQA KLRADRSLIPGFVEEALRFESPIRGDFRLSKVPVSVGGVELPAGTTVMLNNAAANRDPRRFTDPDTFDLQ RPNARQHIAFGRGAHSCPGAPLARAEAKVSINRLLDRTSDIWIDEDKHGPVDARRYKYLPTFILRGLTRL HIEFS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4317 | - | - | 100% (426) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_4180 | - | e-151 | 61.94% (423) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_4141 | - | e-131 | 54.12% (425) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1806 | cyp144 | 1e-46 | 32.78% (424) | cytochrome p450 144 CYP144 |
| M. gilvum PYR-GCK | Mflv_2474 | - | 1e-152 | 62.00% (421) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1777 | cyp144 | 1e-46 | 32.78% (424) | cytochrome p450 144 CYP144 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-34 | 30.49% (328) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1939 | - | 5e-46 | 31.26% (419) | cytochrome P450 |
| M. marinum M | MMAR_4737 | cyp150A5 | 1e-154 | 62.53% (419) | cytochrome P450 150A5 Cyp150A5 |
| M. avium 104 | MAV_0912 | - | 1e-156 | 63.25% (419) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_4823 | - | 1e-156 | 62.89% (415) | cytochrome p450 |
| M. thermoresistible (build 8) | TH_4148 | - | 1e-151 | 62.17% (423) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0314 | cyp150A6 | 1e-131 | 53.72% (417) | cytochrome P450 150A6 Cyp150A6 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1806|M.bovis_AF2122/97 -MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDP
Rv1777|M.tuberculosis_H37Rv -MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDP
MAB_1939|M.abscessus_ATCC_1997 -----------------------------------MNTDELFDPQVLEDP
Mflv_2474|M.gilvum_PYR-GCK ------------------------------MTEDLTTVDFFRDSRLTDDP
TH_4148|M.thermoresistible__bu ------------------------------MAEDITAVDFFRDDRLTDDP
MSMEG_4823|M.smegmatis_MC2_155 ---------------------------MTHMAIDPAGIDWFKDPRLVDDP
MMAR_4737|M.marinum_M -------------------------------MNDCAEPDFFRDSGLVENP
MAV_0912|M.avium_104 ------------------------------MTNEFSELDFFRGSELIENP
Mvan_4317|M.vanbaalenii_PYR-1 -------------------------MTEQLTPTDIDEVDFFTDNTVLHDP
MUL_0314|M.ulcerans_Agy99 -------------------------------MSSYESIDFFTDPSLIPDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: . :*
Mb1806|M.bovis_AF2122/97 YPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTY
Rv1777|M.tuberculosis_H37Rv YPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTY
MAB_1939|M.abscessus_ATCC_1997 YPFYRRLRETAPVWPVGDSGFYFVSRWDLVVEATERAEDFSSNLTAALMK
Mflv_2474|M.gilvum_PYR-GCK YTFYEALRNKCPVAKEDHYGITMVTGWQEAVDVYNDADTFSSCISVTGPF
TH_4148|M.thermoresistible__bu YPFYAALRDKCPVTREKFYGVTMVTGWQEAVDVYNDAESFSSCISVTGPF
MSMEG_4823|M.smegmatis_MC2_155 YPYFNALRDKCPVQSEDHYGVTMVTGWEEAVSVYNDEKSFSSCTSVTGPF
MMAR_4737|M.marinum_M YPYYETLRQRCPVTGEGHHGVTMVTGWDEAVSVLNDAETFSSCISVTGPF
MAV_0912|M.avium_104 YPYYEALRQRCPVTKESHHNVTMITGWDEACAVLNDAETWSSCISVTGPF
Mvan_4317|M.vanbaalenii_PYR-1 YGYLAAMRNECPVRRERHHDVVMITGYEEAVAVYNDNARFSSCTAVTGPF
MUL_0314|M.ulcerans_Agy99 HPYFDYLRRQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPF
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKAT---
. : .: . . :. . *.
Mb1806|M.bovis_AF2122/97 T-----------AEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRH
Rv1777|M.tuberculosis_H37Rv T-----------AEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRH
MAB_1939|M.abscessus_ATCC_1997 S-----------AEGLAV-APMGPPADPTHVLATGDDPLHHAHRRLVLPT
Mflv_2474|M.gilvum_PYR-GCK PGFPVSLEGRENDDITDLIKEHRDEIPFSDQLPTLDPPTHTDHRALLMRL
TH_4148|M.thermoresistible__bu PGFPVSLEGKENEDITELINEHRDEIPFSDQLPTLDPPTHTNHRALLMRL
MSMEG_4823|M.smegmatis_MC2_155 PGFPVPLEGR--DDVAELIEKHRDELPFSDQLPTLDPPVHTNHRSLMMRL
MMAR_4737|M.marinum_M PGFPVPLEGD---DVTELIERHRSELPFSDQLPTLDPPTHTNHRALLMRL
MAV_0912|M.avium_104 PGFPVPLEGD---DVTELIERHRDELPFSDQLPTLDPPTHTNHRSLLMRL
Mvan_4317|M.vanbaalenii_PYR-1 PGFPVPLVGD---DVSGLIAEHRDKLPFNDQLPTLDPPLHTDHRALLSRM
MUL_0314|M.ulcerans_Agy99 PPLPFTPNGD---DVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRL
MLBr_02088|M.leprae_Br4923 ------------LAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKA
: * * * * ::
Mb1806|M.bovis_AF2122/97 LAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIG
Rv1777|M.tuberculosis_H37Rv LAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIG
MAB_1939|M.abscessus_ATCC_1997 LVARRITALEPVMAQTGSCLWERGVNGDGIDWMAAMGDALPMTMVARLIG
Mflv_2474|M.gilvum_PYR-GCK ITPKRLKENEDAMWQLADDNLDRFLAPGEGEFIKGFAGPFTLQVIADLLG
TH_4148|M.thermoresistible__bu ITPKRLKENEDAMWQIADDILDDFLAPGHGEFINGFAGPFTLRVIADLLG
MSMEG_4823|M.smegmatis_MC2_155 ITPKRLKENEDAMWQLADEVLDDFLAPGKGEFIKGFASPFTLLVIADLLG
MMAR_4737|M.marinum_M ITPKRLKENEDAMWVLADRVLDDYLAAGEGEFIKGFASPFTLLVIADLLG
MAV_0912|M.avium_104 ITPKRLKENEDAMWVLADQALDTFLAPGHGEFIKGFAGPFTLLVIADLLG
Mvan_4317|M.vanbaalenii_PYR-1 ITPKRLKENEEFMWRLADRQYDEALAGGRCEFVGEFGNPFAMLVIADLLG
MUL_0314|M.ulcerans_Agy99 LTPSRLKQNEEFMWRLADRQLDEFLGAAECEFISEYAKPFATLVIADLLG
MLBr_02088|M.leprae_Br4923 FAPKVVQALEGDIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLG
:.. : * . : : . :. ::. *:*
Mb1806|M.bovis_AF2122/97 LPDPDIAQLVKWGYAATQLLEGLVENDQLV-----AAGVALMELSGYIFE
Rv1777|M.tuberculosis_H37Rv LPDPDIAQLVKWGYAATQLLEGLVENDQLV-----AAGVALMELSGYIFE
MAB_1939|M.abscessus_ATCC_1997 LPAGDVPQLVQWGYSSTEMLGGLNTPQRQA-----QVVTDTMHLVLYLRE
Mflv_2474|M.gilvum_PYR-GCK VPEGDREELLER--LARGTHGSGLGNADKA-----LTKTPLEYLYDVFAT
TH_4148|M.thermoresistible__bu VPEEDRPELLER--LARGTHGSGLGNADKT-----LAKTPLEYLYDVFAE
MSMEG_4823|M.smegmatis_MC2_155 IPAEDRNAFVDG--ISQNSGGGVGSTGDES-----LSHSPLEFLYGQFEA
MMAR_4737|M.marinum_M VPPEDRQTFVNN--IHHHAGGGVGGTGKEA-----LAHNPLEFLYGAFAD
MAV_0912|M.avium_104 VPEEDRDKFVKG--IRQHSGGGVGGTGEET-----LAHSPLEFLYGLFSD
Mvan_4317|M.vanbaalenii_PYR-1 VPESDHNDFKDQ--LLTST-GTIGSSGGDA-----MHHSPLEYLYGKFTD
MUL_0314|M.ulcerans_Agy99 VPEDDRKDFRVV--LGADRMGRVGALDHES-----VGVNPLQWLDDKFSA
MLBr_02088|M.leprae_Br4923 VPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQ
:* * : * :
Mb1806|M.bovis_AF2122/97 QFDRAAADPRDNLLGELATACASGE--LDTLTAQVMMVTLFAAGGESTAA
Rv1777|M.tuberculosis_H37Rv QFDRAAADPRDNLLGELATACASGE--LDTLTAQVMMVTLFAAGGESTAA
MAB_1939|M.abscessus_ATCC_1997 HLEEELAAPGDDLLGYLAQACNRGD--ISLDIGVMILVQLVGAGGESTAG
Mflv_2474|M.gilvum_PYR-GCK YVEDRRAEPRDDVLTGLATATFPDGRLPEVGDVVRVATNVFSAGQETTVR
TH_4148|M.thermoresistible__bu YVEDRRRNPRDDVLTGLATATFPGGTTPEVGDVVRVATNVFSAGQETTVR
MSMEG_4823|M.smegmatis_MC2_155 YIEDRRSNPREDILTGMATALFPDGTTPSPGDVARVATNVFSAGQETTVR
MMAR_4737|M.marinum_M YVRDRRREPREDVLTGLATATFPDGTVPDVEDVARVACNVFSAGQETTVR
MAV_0912|M.avium_104 YVRDRRRQPREDVLTGLATATYPDGSIPEVEDVARVASNVFSAGQETTVR
Mvan_4317|M.vanbaalenii_PYR-1 YITDRRENPRDDVLTGLASALFPDGRTPPVIDVVCVAANLFAAGQETTVR
MUL_0314|M.ulcerans_Agy99 YIEDRRRRPRNDVLTALATATYPDGSTPEIIDVVRWATFLFAAGQETTAK
MLBr_02088|M.leprae_Br4923 LVKCRRGTPGEDLISRLIELD-ESGDQLTEEEIIATCGLLLVAGHETTVN
. * :::: : . :. ** *:*.
Mb1806|M.bovis_AF2122/97 LLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGQYRHVRNA
Rv1777|M.tuberculosis_H37Rv LLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNA
MAB_1939|M.abscessus_ATCC_1997 LMGNAVRILGENPRLQQRIRENRALLPTFLEEALRLESPFRGHHRHVLTD
Mflv_2474|M.gilvum_PYR-GCK LLSTALKVMGDQPEVQAKLRENRELLGNFIEECLRIESPVKGDFRLSRMP
TH_4148|M.thermoresistible__bu LLSTALKVLGDRPDIQERVRADRSLLPNFIEECLRIESPVKGDFRLSRVP
MSMEG_4823|M.smegmatis_MC2_155 LLGTALKVLGDRPDVQKMVREDRSLLPNFIEEALRHESPVKGDFRLSRCP
MMAR_4737|M.marinum_M LLGAALQIIGERADIQQQLRRDRSLIPNFIEEALRIESPVKGDFRLSRVP
MAV_0912|M.avium_104 LLGAALQTLGERPDIQAQLRKDRSLIPNFIEESLRHESPVKGDFRLNRRP
Mvan_4317|M.vanbaalenii_PYR-1 LLSTAVMMIAEDPALQAKLRADRSLIPGFVEEALRFESPIRGDFRLSKVP
MUL_0314|M.ulcerans_Agy99 QLTAAMRVLGDRPDIQRQLRENRSLIPNFIEESLRMDSPVKSDSRLARKR
MLBr_02088|M.leprae_Br4923 LIANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKD
: *: : . : : .:** ** :...: *
Mb1806|M.bovis_AF2122/97 TTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKG
Rv1777|M.tuberculosis_H37Rv TTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKG
MAB_1939|M.abscessus_ATCC_1997 TTLGGVQLPAGSHLTLLWGAANRDPAIFEDPDVLRLDRPSPRGHITFGKG
Mflv_2474|M.gilvum_PYR-GCK TTIGDQPLGAGCTVMVINGAANRDPRRFEDPDTFDPERKNARQHLAFGRG
TH_4148|M.thermoresistible__bu TTVGGQPLGAGCTVMVINGAANRDPRRFENPDEFDPDRKNARQHLAFGRG
MSMEG_4823|M.smegmatis_MC2_155 VTVGDKDLPSGRTVMVVNGAANRDPRRFENPDDFDPARKNARQHLAFGRG
MMAR_4737|M.marinum_M TTVGEVDLPAGTTVMVLQAAANRDPRRFVEPATFDPARKNARQHLSFGRG
MAV_0912|M.avium_104 VTVGGVDLPAGTTVMVVQAAANRDPRRFDDPATFDPARKNARQHISFGRG
Mvan_4317|M.vanbaalenii_PYR-1 VSVGGVELPAGTTVMLNNAAANRDPRRFTDPDTFDLQRPNARQHIAFGRG
MUL_0314|M.ulcerans_Agy99 TTVGGLDIAAGTVVMVLSGAANRDPRRFEDPHEFRLDRPNVREHMAFARG
MLBr_02088|M.leprae_Br4923 MTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSR-HLAFAVG
::. : . : : .****** : * : * . : *::*. *
Mb1806|M.bovis_AF2122/97 AHFCVGAALARLEARIVLRLLLDRTSVIEAADVGG---------WLPSIL
Rv1777|M.tuberculosis_H37Rv AHFCVGAALARLEARIVLRLLLDRTSVIEAADVGG---------WLPSIL
MAB_1939|M.abscessus_ATCC_1997 LHFCVGAALARLEARTAINLLLDRTREFAIKPDGAH--------WVPSIM
Mflv_2474|M.gilvum_PYR-GCK IHSCPGAPLARAETRVGLERLLDRTTDIRISERKHGPVGNRRYEYIPTYI
TH_4148|M.thermoresistible__bu IHSCPGAPLARAETRVGLERLLDRTSDIRISEAHHGPPENRRYSYIPTYI
MSMEG_4823|M.smegmatis_MC2_155 IHSCPGAPLARAETRVGLERLLDRTTDIRISEEHHGPAANRDYKYIPTFI
MMAR_4737|M.marinum_M IHSCPGAPLARAETRVAIERLLDRTADITISERVHGPANDRRYQYVPTYI
MAV_0912|M.avium_104 IHSCPGAPLARAETRVAIERLLDRTTDIRINENIHGPANDRRYQYVPTYI
Mvan_4317|M.vanbaalenii_PYR-1 AHSCPGAPLARAEAKVSINRLLDRTSDIWIDEDKHGPVDARRYKYLPTFI
MUL_0314|M.ulcerans_Agy99 VHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYEPTYI
MLBr_02088|M.leprae_Br4923 SHFCLGAALARLEATVTLSAISARFPQVQLAGELV---------YKPNVA
* * *..*** * : : * . : *.
Mb1806|M.bovis_AF2122/97 VRRIERLELAVQ-------
Rv1777|M.tuberculosis_H37Rv VRRIERLELAVQ-------
MAB_1939|M.abscessus_ATCC_1997 VRRHQKLELEVSAA-----
Mflv_2474|M.gilvum_PYR-GCK LRGLTELHLEFD-----LR
TH_4148|M.thermoresistible__bu LRGLTELHLEFDGVSGGAR
MSMEG_4823|M.smegmatis_MC2_155 LRGLTHLHLEFD-----VK
MMAR_4737|M.marinum_M LRGLTELHLDFT-----PA
MAV_0912|M.avium_104 LRGLTELHLEFT-----LA
Mvan_4317|M.vanbaalenii_PYR-1 LRGLTRLHIEFS-------
MUL_0314|M.ulcerans_Agy99 LRGLTELHITFTPAG----
MLBr_02088|M.leprae_Br4923 MRGMSALPVQV--------
:* * : .