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NADIETVLRRHRYDGTRLLDILWDIQHLFGHIPDEHLPQVATALNRTVLDIVETASFYHFFHTTPSGRHR IYLSNTVIAKMNGYQAVHDALELETGARFGGTDEAGMFGLFETACIGLSDQEPAMLLDGVVFTRLTPGTV ADIVAQLKAGRVAADIVNPAGLPEDGIAYIDTLVESTVRTRGPVFFSGDVDHAMTLKRCLANTPEQTVDM ISESGLRGFGGAGFRTGLKWRLCRAAPGEDKYVICNADEGEPGTFKDRALLTRSPKDVFLGMVIAAYSIG ARDGILYLRAEYAYLARYLQRQLQELRDDGLLGADIGGLPGFDFDIRIQLGAGAYICGEESALIESCEGN RGTPRLKPPYPIQEGYLGKPTTVNNVETFVAASRVTAEGAEWFRSMGTADSAGTRLLSVAGDCSAPGVYE VEWGITLDDVLAMVGAPDARAVQIGGPSGECVSVAVDGRRRIAYEDIPCNGAVTIFNATRDLLECVTDYT KFFADESCGICVPCRAGTVDLHDTMRRILAGNGTRQDLDDVAGRGALIRSTSRCGLGATAANPILTTLTK FPEMYQERLCAQADTLLPAFDLDAALAGYGKALSELKADGAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4116 | - | - | 100% (603) | hydrogen dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1880 | - | 2e-72 | 40.57% (387) | NADH-quinone oxidoreductase, F subunit |
| M. vanbaalenii PYR-1 | Mvan_4169 | - | 4e-32 | 29.54% (369) | respiratory-chain NADH dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3174 | nuoF | 5e-72 | 38.38% (383) | NADH dehydrogenase I chain F |
| M. gilvum PYR-GCK | Mflv_4486 | - | 5e-72 | 39.79% (387) | NADH-quinone oxidoreductase, F subunit |
| M. tuberculosis H37Rv | Rv3150 | nuoF | 5e-72 | 38.38% (383) | NADH dehydrogenase I chain F |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2139 | - | 3e-73 | 38.90% (383) | NADH-quinone oxidoreductase, F subunit NuoF |
| M. marinum M | MMAR_1478 | nuoF | 3e-72 | 39.43% (388) | NADH dehydrogenase I (chain F) NuoF (NADH- ubiquinone |
| M. avium 104 | MAV_4038 | nuoF | 3e-73 | 39.43% (383) | NADH-quinone oxidoreductase, F subunit |
| M. smegmatis MC2 155 | MSMEG_2058 | nuoF | 1e-70 | 39.29% (392) | NADH-quinone oxidoreductase, F subunit |
| M. thermoresistible (build 8) | TH_0632 | nuoF | 1e-74 | 40.65% (401) | PROBABLE NADH DEHYDROGENASE I (CHAIN F) NUOF |
| M. ulcerans Agy99 | MUL_2464 | nuoF | 3e-72 | 39.43% (388) | NADH dehydrogenase I (chain F) NuoF (NADH- ubiquinone |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4486|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2058|M.smegmatis_MC2_155 --------------------------------------------------
TH_0632|M.thermoresistible__bu --------------------------------------------------
Mb3174|M.bovis_AF2122/97 --------------------------------------------------
Rv3150|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1478|M.marinum_M --------------------------------------------------
MUL_2464|M.ulcerans_Agy99 --------------------------------------------------
MAV_4038|M.avium_104 --------------------------------------------------
MAB_2139|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4116|M.vanbaalenii_PYR-1 MNADIETVLRRHRYDGTRLLDILWDIQHLFGHIPDEHLPQVATALNRTVL
Mflv_4486|M.gilvum_PYR-GCK ------------------------MTSLTPVLSRFWDEPQPWTMDTYIRH
MSMEG_2058|M.smegmatis_MC2_155 ------------------------MTPLTPVLSRFWDEPEPWTLETYRRH
TH_0632|M.thermoresistible__bu ------------------------MTPLTPVLTRFWDEPEPWSLDTYRRH
Mb3174|M.bovis_AF2122/97 ---------MTT-----------QATPLTPVISRHWDDPESWTLATYQRH
Rv3150|M.tuberculosis_H37Rv ---------MTT-----------QATPLTPVISRHWDDPESWTLATYQRH
MMAR_1478|M.marinum_M ---------MTS-----------QATPLTPVISRYWDDPESWTLATYRRH
MUL_2464|M.ulcerans_Agy99 ---------MTS-----------QATPLTPVISRYWDDPESWTLATYRRH
MAV_4038|M.avium_104 ---------MTTTSETSEASGAPQATPLTPVISRFWDDPESWTLQTYHRH
MAB_2139|M.abscessus_ATCC_1997 ----------------------MTSSILSPVLSEHWDEPDAWTLDGYLRH
Mvan_4116|M.vanbaalenii_PYR-1 DIVETASFYHFFHTTPSGRHRIYLSNTVIAKMNGYQAVHDALELETGARF
. : . :. . :. : *.
Mflv_4486|M.gilvum_PYR-GCK GGYQ----------------------------------------------
MSMEG_2058|M.smegmatis_MC2_155 DGYQ----------------------------------------------
TH_0632|M.thermoresistible__bu DGYR----------------------------------------------
Mb3174|M.bovis_AF2122/97 DRYRGY--------------------------------------------
Rv3150|M.tuberculosis_H37Rv DRYRGY--------------------------------------------
MMAR_1478|M.marinum_M DGYR----------------------------------------------
MUL_2464|M.ulcerans_Agy99 DGYR----------------------------------------------
MAV_4038|M.avium_104 GGYA----------------------------------------------
MAB_2139|M.abscessus_ATCC_1997 GGYR----------------------------------------------
Mvan_4116|M.vanbaalenii_PYR-1 GGTDEAGMFGLFETACIGLSDQEPAMLLDGVVFTRLTPGTVADIVAQLKA
.
Mflv_4486|M.gilvum_PYR-GCK ---------------------------------------------ALERA
MSMEG_2058|M.smegmatis_MC2_155 ---------------------------------------------GLQRA
TH_0632|M.thermoresistible__bu ---------------------------------------------ALEKA
Mb3174|M.bovis_AF2122/97 --------------------------------------------QALQKA
Rv3150|M.tuberculosis_H37Rv --------------------------------------------QALQKA
MMAR_1478|M.marinum_M ---------------------------------------------ALEKA
MUL_2464|M.ulcerans_Agy99 ---------------------------------------------ALEKA
MAV_4038|M.avium_104 ---------------------------------------------AMKKA
MAB_2139|M.abscessus_ATCC_1997 ---------------------------------------------GLRTA
Mvan_4116|M.vanbaalenii_PYR-1 GRVAADIVNPAGLPEDGIAYIDTLVESTVRTRGPVFFSGDVDHAMTLKRC
:. .
Mflv_4486|M.gilvum_PYR-GCK LAMSPDDVIGTVKDSGLRGRGGAGFPTGTKWSFIPQ------GGE---GA
MSMEG_2058|M.smegmatis_MC2_155 LSMGPDDVIAFVKDSGLRGRGGAGFPTGTKWSFIPQER----GDQPAGGP
TH_0632|M.thermoresistible__bu LKMAPDEVIALVKESGLRGRGGAGFPTGTKWSFIPQAASTQAGAAGGSDP
Mb3174|M.bovis_AF2122/97 LTMPPDDVISIVKDSGLRGRGGAGFATGTKWSFIPQGD---------TGA
Rv3150|M.tuberculosis_H37Rv LTMPPDDVISIVKDSGLRGRGGAGFATGTKWSFIPQGD---------TGA
MMAR_1478|M.marinum_M LAMGPDAVIGTVKDSGLRGRGGAGFSTGTKWSFIPQGD---------AGP
MUL_2464|M.ulcerans_Agy99 LAMGPDAVIGTVKDSGLRGRGGAGFSTGTKWSFIPQGD---------AGP
MAV_4038|M.avium_104 LAMEPDAVIGMVKDSGLRGRGGAGFSTGTKWSFIPQGD---------TGA
MAB_2139|M.abscessus_ATCC_1997 LGMDPDAVIALVKEAGLRGRGGAGFPTGAKWSFIPQGD------------
Mvan_4116|M.vanbaalenii_PYR-1 LANTPEQTVDMISESGLRGFGGAGFRTGLKWRLCRAAP------------
* *: .: :.::**** ***** ** ** :
Mflv_4486|M.gilvum_PYR-GCK AAKPHYLVINADESEPGTCKDIPLMLTTPHFLVEGAIIAAYAIRANHAFI
MSMEG_2058|M.smegmatis_MC2_155 AAKPHYLVINADESEPGTCKDIPLLLTTPHFLVEGAIIAAYAIRARHAFI
TH_0632|M.thermoresistible__bu AARPHYLVVNADESEPGTCKDIPLMLTTPHFLVEGAIIAAYAIRARHAFI
Mb3174|M.bovis_AF2122/97 AAKPHYLVVNADESEPGTCKDIPLMLATPHVLIEGVIIAAYAIRAHHAFV
Rv3150|M.tuberculosis_H37Rv AAKPHYLVVNADESEPGTCKDIPLMLATPHVLIEGVIIAAYAIRAHHAFV
MMAR_1478|M.marinum_M AAKPHYLVVNADESEPGTCKDIPLMLATPHVLVEGVIIAAYAIRASHAFI
MUL_2464|M.ulcerans_Agy99 AAKPHYLVVNADESEPGTCKDIPLMLATPHVLVEGVIIAAYAIRASHAFI
MAV_4038|M.avium_104 AAKPHYLVVNADESEPGTCKDIPLMLATPHVLIEGVIIAAYAIRANHAFI
MAB_2139|M.abscessus_ATCC_1997 -GKPHYLVVNADESEPGTCKDIPLMLATPHTLIEGIVIAAFAIRASQAFI
Mvan_4116|M.vanbaalenii_PYR-1 -GEDKYVICNADEGEPGTFKDRALLTRSPKDVFLGMVIAAYSIGARDGIL
.. :*:: ****.**** ** .*: :*: :. * :***::* * ..::
Mflv_4486|M.gilvum_PYR-GCK YLRGEVVPVLRRLQAAVAEAYAAGHLGHDIHGS-GFDLELTVHAGAGAYI
MSMEG_2058|M.smegmatis_MC2_155 YVRGEVLPVLRRLQAAVAEAYAAGYLGTDIMGS-GFDLDLIVHAGAGAYI
TH_0632|M.thermoresistible__bu YLRGEVVPVLRRLQQAVAEAYEAGYLGADIRGS-GFDLDLIVHAGAGAYI
Mb3174|M.bovis_AF2122/97 YVRGEVVPVLRRLHNAVAEAYAAGFLGRNIGGS-GFDLELVVHAGAGAYI
Rv3150|M.tuberculosis_H37Rv YVRGEVVPVLRRLHNAVAEAYAAGFLGRNIGGS-GFDLELVVHAGAGAYI
MMAR_1478|M.marinum_M YVRGEVLPVLRRLQNAVAEAYAAGLLGRNINGS-GFDLELVVHAGAGAYI
MUL_2464|M.ulcerans_Agy99 YVRGEVLPVLRRLQNAVAEAYAAGLLGRNINGS-GFDLELVVHAGAGAYI
MAV_4038|M.avium_104 YVRGEVLPVLRRLQNAVAEAYAAGYLGRDIDGS-GFDLELVVHAGAGAYI
MAB_2139|M.abscessus_ATCC_1997 YVRGEVISVIRRLHAAVAQAYKAGYLGRNILDS-GFDLELVVHAGAGAYI
Mvan_4116|M.vanbaalenii_PYR-1 YLRAEYAYLARYLQRQLQELRDDGLLGADIGGLPGFDFDIRIQLGAGAYI
*:*.* : * *: : : * ** :* . ***::: :: ******
Mflv_4486|M.gilvum_PYR-GCK CGEETALLDSLEGRRGQPRLRPPFPAVAGLYACPTVVNNVESIASVPPIL
MSMEG_2058|M.smegmatis_MC2_155 CGEETALLDSLEGRRGQPRLRPPFPAVAGLYACPTVVNNVESIASVPPIM
TH_0632|M.thermoresistible__bu CGEETALLDSLEGRRGQPRLRPPFPAVAGLYACPTVVNNVESIASVPPIV
Mb3174|M.bovis_AF2122/97 CGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSII
Rv3150|M.tuberculosis_H37Rv CGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSII
MMAR_1478|M.marinum_M CGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSII
MUL_2464|M.ulcerans_Agy99 CGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSII
MAV_4038|M.avium_104 CGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSII
MAB_2139|M.abscessus_ATCC_1997 CGEETALLDSLEGRRGQPRLRPPFPAVAGLYASPTVVNNVESIASVPVIL
Mvan_4116|M.vanbaalenii_PYR-1 CGEESALIESCEGNRGTPRLKPPYPIQEGYLGKPTTVNNVETFVAASRVT
****:**::* **.** ***:**:* * . **.:****::.:.. :
Mflv_4486|M.gilvum_PYR-GCK LNGVDWFRSMGSEKSPGFTLYSLSGHVTTPGQYEAPLGITLRELLDYAGG
MSMEG_2058|M.smegmatis_MC2_155 VNGVDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLEYAGG
TH_0632|M.thermoresistible__bu LNGIDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGG
Mb3174|M.bovis_AF2122/97 LGGIDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGG
Rv3150|M.tuberculosis_H37Rv LGGIDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGG
MMAR_1478|M.marinum_M LNGVDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGG
MUL_2464|M.ulcerans_Agy99 LNGVDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGG
MAV_4038|M.avium_104 GNGVDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGG
MAB_2139|M.abscessus_ATCC_1997 RRGAEWFRTMGTEKSPGFTLYSLSGHVRTPGQYEAPLGVTLRQLLELAGG
Mvan_4116|M.vanbaalenii_PYR-1 AEGAEWFRSMGTADSAGTRLLSVAGDCSAPGVYEVEWGITLDDVLAMVG-
* :***:**: .*.* * *::*. ** **. *:** ::* .*
Mflv_4486|M.gilvum_PYR-GCK VRAGHELKFWTPGGSSTPLLTADHLDVPLDYEGMAGVGSMLGTKALQIFD
MSMEG_2058|M.smegmatis_MC2_155 VRAGHQLKFWTPGGSSTPLLTAEHLDVPLDYEGMASVGSMLGTKALQIFD
TH_0632|M.thermoresistible__bu VRAGRSLKFWTPGGSSTPLLTAEHLDVPLDYEGIAGVGSMLGTKALQIFD
Mb3174|M.bovis_AF2122/97 VRAGHRLKFWTPGGSSTPLLTDEHLDVPLDYEGVGAAGSMLGTKALEIFD
Rv3150|M.tuberculosis_H37Rv VRAGHRLKFWTPGGSSTPLLTDEHLDVPLDYEGVGAAGSMLGTKALEIFD
MMAR_1478|M.marinum_M IRAGHQLKFWTPGGSSTPLLTDEHLDVPLDYEGVGGVGSMLGTKALEIFD
MUL_2464|M.ulcerans_Agy99 IRAGHQLKFWTPGGSSTPLLTDEHLDVPLDYEGVGGVGSMLGTKALEIFD
MAV_4038|M.avium_104 VRAGHRLKFWTPGGSSTPLLTDEHLDVPLDYEGVGGVGSMLGTKALEIFD
MAB_2139|M.abscessus_ATCC_1997 VRDGRALKFWTPGGSSTPLFTAEQLDVPLDYEGVSAAGSMLGTKALQIFD
Mvan_4116|M.vanbaalenii_PYR-1 APDARAVQIGGPSG--------ECVSVAVDGRRRIAYEDIPCNGAVTIFN
.: ::: *.* : :.*.:* . . .: . *: **:
Mflv_4486|M.gilvum_PYR-GCK DTTCVVRAVRRWTQFYAHESCGKCTPCREGTYWLAQIYERLETGRGTEAD
MSMEG_2058|M.smegmatis_MC2_155 ETTCVVRAVRRWTQFYAHESCGKCTPCREGTYWLAQIYARLENGAGTEAD
TH_0632|M.thermoresistible__bu DTTCVVRAVARWTDFYAHESCGKCTPCREGTYWLKQIYARLESGAGTRAD
Mb3174|M.bovis_AF2122/97 ETTCVVRAVRRWTEFYKHESCGKCTPCREGTFWLDKIYERLETGRGSHED
Rv3150|M.tuberculosis_H37Rv ETTCVVRAVRRWTEFYKHESCGKCTPCREGTFWLDKIYERLETGRGSHED
MMAR_1478|M.marinum_M ETTCVVRAVRRWTEFYKHESCGKCTPCREGTFWLDKIYARLETGKGTRED
MUL_2464|M.ulcerans_Agy99 ETTCVVRAVRRWTEFYKHESCGKCTPCREGTFWLDKIYARLETGKGTRED
MAV_4038|M.avium_104 ETTCVVRAVRRWTYFYKHESCGKCTPCREGTFWLDQIYERLETGKGTAED
MAB_2139|M.abscessus_ATCC_1997 DTTCVVRAVLRWTEFYAHESCGKCTPCREGTYWLVRILQRLESGEGKAED
Mvan_4116|M.vanbaalenii_PYR-1 ATRDLLECVTDYTKFFADESCGICVPCRAGTVDLHDTMRRILAGNGTRQD
* ::..* :* *: .**** *.*** ** * *: * *. *
Mflv_4486|M.gilvum_PYR-GCK LDKLLDISDNIFGKSFCALGDGAASPIMSSLKHFRDEYEAHLG---NACP
MSMEG_2058|M.smegmatis_MC2_155 IDKLLDISDNIFGKSFCALGDGAASPIMSSIKHFRDEYVAHLD---GGCP
TH_0632|M.thermoresistible__bu LDKLLDISDIVLGKSFCALGDGAAMPIQSSLRYFRDEYEAHLDPASPGCP
Mb3174|M.bovis_AF2122/97 IDKLLDISDSILGKSFCALGDGAASPVMSSIKHFRDEYLAHVE--GGGCP
Rv3150|M.tuberculosis_H37Rv IDKLLDISDSILGKSFCALGDGAASPVMSSIKHFRDEYLAHVE--GGGCP
MMAR_1478|M.marinum_M IDKLLDISDSILGKSFCALGDGAASPVMSSIKHFQDEYIAHVE--QGGCP
MUL_2464|M.ulcerans_Agy99 IDKLLDISDSILGKSFCALGDGAASPVMSSIKHFQNEYIAHAE--QGGCP
MAV_4038|M.avium_104 IDKLLDISDTILGKSFCALGDGAASPVMSSIKYFRDEYVAHVE--NGRCP
MAB_2139|M.abscessus_ATCC_1997 LDKLLDISDIVLGKSFCALGDGAASPIMSSLKYFRTEYEAHLD---NGCP
Mvan_4116|M.vanbaalenii_PYR-1 LDDVAGRGALIRSTSRCGLGATAANPILTTLTKFPEMYQERLCAQADTLL
:*.: . . : ..* *.** ** *: ::: * * :
Mflv_4486|M.gilvum_PYR-GCK FDPYASMLAAPEGVGV---------
MSMEG_2058|M.smegmatis_MC2_155 FDPHASTLMATEGAGV---------
TH_0632|M.thermoresistible__bu FDPHASTLMATEEVRA---------
Mb3174|M.bovis_AF2122/97 FDPRDSMLVANGVDA----------
Rv3150|M.tuberculosis_H37Rv FDPRDSMLVANGVDA----------
MMAR_1478|M.marinum_M FDPRDSMLTAGRNTAKGTGPQ----
MUL_2464|M.ulcerans_Agy99 FDPRDSMLTAGRNTAKGTGPQ----
MAV_4038|M.avium_104 FDPRDSMLTPNGSDS----------
MAB_2139|M.abscessus_ATCC_1997 FDPAASTVFGEVSA-----------
Mvan_4116|M.vanbaalenii_PYR-1 PAFDLDAALAGYGKALSELKADGAL
.