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STGDRLKCFQVPDLGEGLEEVTVTSWAVAVGDDVELNQVLCSVETAKAEVEIPSPYAGRIVELGGAEGDV IKVGAALVRIDTAPELSAPTNGEIAVPTLVGYGADAAIDTSRRPGRPRAAPPVRKLAKELMVDLASLQRG STVITRADVLAAAKGAGASARVREVRGVQAHMAEKMSLSHQEIPAAKASVEVDCTELLGLSEQFRAVVPP ATPFALALRMLVIALKNNEILNSTWVDSPGGPQVHLHPGVHLGFGVATERGLLVPVIADAHRMTTRELVC RAAELITGAREGTLAPGQLRGWTFTVSNYGALGVDDGVPVINHPDAAILGMGSIKPRPVVRGDEVVVRPT MSLTCVFDHRVADGAQVARFICELRGLIEAPETALLDL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3773 | pdhC | - | 100% (389) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. ulcerans Agy99 | MUL_3575 | sucB | 1e-39 | 29.24% (448) | dihydrolipoamide acetyltransferase |
| M. ulcerans Agy99 | MUL_4500 | kgd | 2e-11 | 23.26% (331) | alpha-ketoglutarate decarboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2523c | pdhC | 1e-164 | 76.59% (393) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. gilvum PYR-GCK | Mflv_2935 | - | 9e-37 | 29.32% (457) | dihydrolipoamide acetyltransferase |
| M. tuberculosis H37Rv | Rv2495c | pdhC | 1e-164 | 76.34% (393) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. leprae Br4923 | MLBr_00861 | - | 9e-39 | 31.55% (412) | dihydrolipoamide acetyltransferase |
| M. abscessus ATCC 19977 | MAB_4916c | - | 9e-65 | 38.37% (443) | putative dihydrolipoamide acyltransferase component |
| M. marinum M | MMAR_3842 | pdhC | 0.0 | 98.20% (389) | dihydrolipoamide S-acetyltransferase E2 component PdhC |
| M. avium 104 | MAV_1677 | - | 1e-159 | 74.87% (386) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. smegmatis MC2 155 | MSMEG_4710 | - | 1e-124 | 59.85% (401) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. thermoresistible (build 8) | TH_0716 | pdhC | 1e-120 | 60.35% (396) | PROBABLE DIHYDROLIPOAMIDE S-ACETYLTRANSFERASE E2 COMPONENT |
| M. vanbaalenii PYR-1 | Mvan_4084 | - | 1e-118 | 58.54% (398) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3773|M.ulcerans_Agy99 MSTGDRLKCFQVPDLGEGLEEVTVTSWAVAVGDDVELNQVLCSVETAKAE
MMAR_3842|M.marinum_M MSTGDRLKCFQVPDLGEGLEEVTVTSWAVAVGDDVELNQVLCSVETAKAE
Mb2523c|M.bovis_AF2122/97 MSGEDSIRSFPVPDLGEGLQEVTVTCWSVAVGDDVEINQTLCSVETAKAE
Rv2495c|M.tuberculosis_H37Rv MSGEDSIRSFPVPDLGEGLQEVTVTCWSVAVGDDVEINQTLCSVETAKAE
MAV_1677|M.avium_104 MS-DERVKPFLVPDLGEGLEEVTVTHWNVAVGDDVELNQVLCTVETAKAE
MSMEG_4710|M.smegmatis_MC2_155 ----MSTRDFLVPDLGEGLQDATITSWNVDVGDTVELNQTLCTVETNKAE
TH_0716|M.thermoresistible__bu --MNGSIREFLLPDLGEGLEDATITDWSVTVGDEVELNQPLCTVETNKAE
Mvan_4084|M.vanbaalenii_PYR-1 ---MSTVREFLVPDLGEGLEEATVTAWQVAIGDVVTLNQTLCTVETNKAE
MAB_4916c|M.abscessus_ATCC_199 ----MAVKQFLLPDLGEGLTEADLISWKVRVGDEVKLNQVLADVETAKAM
Mflv_2935|M.gilvum_PYR-GCK -----MAISVQMPALGESVTEGTVTRWLKQEGDTVEEDEPLLEVSTDKVD
MLBr_00861|M.leprae_Br4923 -----MACSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVD
. :* ***.: : : * ** * :: * *.* *.
MUL_3773|M.ulcerans_Agy99 VEIPSPYAGRIVELGGAEGDVIKVGAALVRIDTAP---------------
MMAR_3842|M.marinum_M VEIPSPYAGRIVELGGAEGDVIKVGAALVRIDTAP---------------
Mb2523c|M.bovis_AF2122/97 VEIPSPYAGRIVELGGAEGDVLKVGAELVRIDTGP---------------
Rv2495c|M.tuberculosis_H37Rv VEIPSPYAGRIVELGGAEGDVLKVGAELVRIDTGP---------------
MAV_1677|M.avium_104 VELPSPYAGRIVEMNGAEGDVLKVGAVLVRLDTAP---------------
MSMEG_4710|M.smegmatis_MC2_155 VEIPSPYAGKVEALGGAAGDTLAVGSLLVRIATS----------------
TH_0716|M.thermoresistible__bu VEIPSPYAGRIVELGGAAGETLPVGAVLVRIETS----------------
Mvan_4084|M.vanbaalenii_PYR-1 VEIPSPFAGRIAELGGAAGQTLPVGSVLVRIDLGND--------------
MAB_4916c|M.abscessus_ATCC_199 VELPSPFEGTVVALQAAENSTVAVGAPLISIEVAG---------------
Mflv_2935|M.gilvum_PYR-GCK TEIPSPASGVLKKIVAQEDDTVEVGGELAVIGDADDSDSDDSDSDDAGDS
MLBr_00861|M.leprae_Br4923 TEIPSPAAGVLTKIIAQEDDTVEVGGELAVIGAP----------------
.*:*** * : : . ...: **. * :
MUL_3773|M.ulcerans_Agy99 -----------------------------------------ELSAPTNGE
MMAR_3842|M.marinum_M -----------------------------------------ELPAPTNGE
Mb2523c|M.bovis_AF2122/97 -----------------------------------------TAVAQPNGE
Rv2495c|M.tuberculosis_H37Rv -----------------------------------------TAVAQPNGE
MAV_1677|M.avium_104 -----------------------------------------ESAEPPAAE
MSMEG_4710|M.smegmatis_MC2_155 -----------------------------------SDEPVEAQPMNGEVP
TH_0716|M.thermoresistible__bu -----------------------------------SAG-----------A
Mvan_4084|M.vanbaalenii_PYR-1 ---------------------------TENDRAGDTDSDGDSATDAEKDA
MAB_4916c|M.abscessus_ATCC_199 -----------------------------------------------AEP
Mflv_2935|M.gilvum_PYR-GCK DDSEAEDSGDEAEPAAEESEPEPEPEPEDEDEPEPEPKKKSSGGSGSSGS
MLBr_00861|M.leprae_Br4923 ---------SEAAAAAPAPRPEPKAQPEPAASSQPAAPAQQPSG---AAT
MUL_3773|M.ulcerans_Agy99 IAVPTLVGYGADAAIDTSRRPG----------------------------
MMAR_3842|M.marinum_M IAVPTLVGYGADAAIDTSRRPG----------------------------
Mb2523c|M.bovis_AF2122/97 GAVPTLVGYGADAAIETSRRTS----------------------------
Rv2495c|M.tuberculosis_H37Rv GAVPTLVGYGADTAIETSRRTS----------------------------
MAV_1677|M.avium_104 -TAPTLVGYGADAGIDTSRRTA----------------------------
MSMEG_4710|M.smegmatis_MC2_155 QRKSVLVGYGADDSMDASRRRTHGP-------------------------
TH_0716|M.thermoresistible__bu DRDPVLVGYGADDAMDTSRRTPHRAT------------------------
Mvan_4084|M.vanbaalenii_PYR-1 PRRPVLVGYGADHTMDGSRR------------------------------
MAB_4916c|M.abscessus_ATCC_199 DAPANLVGYGPSDSAGQTRRRRRSGAGAAALALVEQTTEPEPAVAAPAAQ
Mflv_2935|M.gilvum_PYR-GCK GTSVTMPELGESVTEGTVTRWLKEVGDTVEVDEPLVEVSTDKVDTEIPSP
MLBr_00861|M.leprae_Br4923 ATPVLMPELGESVTEGTVTRWLKKIGDSVQADEPLVEVSTDKVDTEIPSP
: * . *
MUL_3773|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3842|M.marinum_M --------------------------------------------------
Mb2523c|M.bovis_AF2122/97 --------------------------------------------------
Rv2495c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1677|M.avium_104 --------------------------------------------------
MSMEG_4710|M.smegmatis_MC2_155 --------------------------------------------------
TH_0716|M.thermoresistible__bu --------------------------------------------------
Mvan_4084|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4916c|M.abscessus_ATCC_199 AE------------------------------------------------
Mflv_2935|M.gilvum_PYR-GCK VAGTLLSITAEEDDTVEVGGELAKIGDAGAEEESEPEPEPEPEPEPEPEP
MLBr_00861|M.leprae_Br4923 VAGVLVSITTNEDTTVPVGGELARIG---VTLDSIATP------------
MUL_3773|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3842|M.marinum_M --------------------------------------------------
Mb2523c|M.bovis_AF2122/97 --------------------------------------------------
Rv2495c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1677|M.avium_104 --------------------------------------------------
MSMEG_4710|M.smegmatis_MC2_155 --------------------------------------------------
TH_0716|M.thermoresistible__bu --------------------------------------------------
Mvan_4084|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4916c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2935|M.gilvum_PYR-GCK EPKQTKPESKPSEEAAPEPKSESKPEAESKPEPKPKPEPEPKRESKPEAE
MLBr_00861|M.leprae_Br4923 ---------------APAPRAESVP---SRPTPARK-------------E
MUL_3773|M.ulcerans_Agy99 ----RPRAAPPVRKLAKELMVDLASLQRGS---TVITRADVLAAAKG---
MMAR_3842|M.marinum_M ----RPRAAPPVRKLAKELMVDLASLQRGS---TVITRADVLAAAKG---
Mb2523c|M.bovis_AF2122/97 ----RPLAAPVVRKLAKELAVDLAALQRGSGAGGVITRADVLAAARGG--
Rv2495c|M.tuberculosis_H37Rv ----RPLAAPVVRKLAKELAVDLAALQRGSGAGGVITRADVLAAARGG--
MAV_1677|M.avium_104 ----RPLAAPPVRKLAKELMVDLGSLRPRSG--AVITREDVLSAAHG---
MSMEG_4710|M.smegmatis_MC2_155 ----RARAKPPVRKLAAELNVDLGALDPGSGPDGIITRDDVLAAAGRSPA
TH_0716|M.thermoresistible__bu ---GRPRAKPPVRRLAADLGVDLTAVAPGSGPDGVITRQDVLAAAGADGA
Mvan_4084|M.vanbaalenii_PYR-1 ----RARAKPRVRKLAADLDVDLSRID-GSGPDGIVTRDDVLAVTDGG--
MAB_4916c|M.abscessus_ATCC_199 SVPSRAAAKPSVRKLAAELGVALELIN-GTGIGGSITRQDVEAYTRSLTA
Mflv_2935|M.gilvum_PYR-GCK SSGDSPYVTPLVRKLAGEHGVDLASVK-GTGVGGRIRKQDVLAAAEKSKA
MLBr_00861|M.leprae_Br4923 ANG-APYVTPLVRKLATENNIDLAKVI-GTGVGGRIRKQDVLAAAEQRKQ
. . * **:** : : * : : : : ** : :
MUL_3773|M.ulcerans_Agy99 -----AGASARVREVR-----------------------GVQAHMAEKMS
MMAR_3842|M.marinum_M -----AGASARVREVR-----------------------GVQAHMAEKMS
Mb2523c|M.bovis_AF2122/97 -----VGAGPDVRPVH-----------------------GVHARMAEKMT
Rv2495c|M.tuberculosis_H37Rv -----VGAGPDVRPVH-----------------------GVHARMAEKMT
MAV_1677|M.avium_104 -----TGNGAEVRPVQ-----------------------GVQARMADKMT
MSMEG_4710|M.smegmatis_MC2_155 AQSAGTPQPSQTRDVR-----------------------GVQAEMARRMA
TH_0716|M.thermoresistible__bu DAPAAPADAADVVEVG-----------------------AVQAAMARRMT
Mvan_4084|M.vanbaalenii_PYR-1 --------TSQDSVVS-----------------------GVRLAMARRMS
MAB_4916c|M.abscessus_ATCC_199 RAP--QGAPAEEEPVAG--------VAVQPGGETRIPIAGVRKHTAAAMV
Mflv_2935|M.gilvum_PYR-GCK PKEDAPKAEPAAEAPGKTTQAPAPEGALAHLRGTTQKANRIRQITAKKTR
MLBr_00861|M.leprae_Br4923 --QQAPTSAPSAAAP-------TPTPVLAHLRGTTQKVSRIRQITAKKTR
. :: *
MUL_3773|M.ulcerans_Agy99 LSHQEIPAAKASVEVDCTELLGLSEQFRAV-----VPPATPFALALRMLV
MMAR_3842|M.marinum_M LSHQEIPAAKASVEVDCTELLRLSEQFRAA-----VPPATPFALALRMLV
Mb2523c|M.bovis_AF2122/97 LSHKEIPTAKASVEVICAELLRLRDWFVSA-----APEITPFALTLRLLV
Rv2495c|M.tuberculosis_H37Rv LSHKEIPTAKASVEVICAELLRLRDRFVSA-----APEITPFALTLRLLV
MAV_1677|M.avium_104 LSHKEIPAATVSVQVDCTALVRLSERLGPA-----EQRITPFVLTLRLLV
MSMEG_4710|M.smegmatis_MC2_155 LSRREIPDAHARVDVDCTALLRLRDRIRSAET---ELPITPFVLTLRLLT
TH_0716|M.thermoresistible__bu QSRREIPDAHGRVEVDCRALLELCAQLG-------ERTVTPFVLTLRLLG
Mvan_4084|M.vanbaalenii_PYR-1 LSRSEIPDAHASVEVDGSELLRLRDRLAAAG----ADGVTPFVLVLRLLV
MAB_4916c|M.abscessus_ATCC_199 RSAFTAPHVTEFLTVDMTSTMGLLAELKAKSP---DLKLTPMTLVARMVL
Mflv_2935|M.gilvum_PYR-GCK ESLQTTAQLTQVHEVDMTRIVALRAKAKAGFAEREGVNLTYLPFIARAVI
MLBr_00861|M.leprae_Br4923 ESLQATAQLTQTHEVDMAKIVGLRAKAKAAFAEREGVNLTFLPFIAKAAI
* . * : * * : : :
MUL_3773|M.ulcerans_Agy99 IALKNNEILNSTWVDSPGGPQVHLHPGVHLGFGVATERGLLVPVIADAHR
MMAR_3842|M.marinum_M IALKNNEILNSTWVDSPGGPQVHLHPGVHLGFGVATERGLLVPVIADAHR
Mb2523c|M.bovis_AF2122/97 IALKHNVILNSTWVDSGEGPQVHVHRGVHLGFGAATERGLLVPVVTDAQD
Rv2495c|M.tuberculosis_H37Rv IALKHNVILNSTWVDSGEGPQVHVHRGVHLGFGAATERGLLVPVVTDAQD
MAV_1677|M.avium_104 IALRRNEIMNSTWVDTPQGPQVRIEHRVHLGVAVATERGLLVPVIADAHT
MSMEG_4710|M.smegmatis_MC2_155 VALRRHVVLNATWMETTGGPQIHQHSAVHLGIGVAAPRGLLVPVVRDAQG
TH_0716|M.thermoresistible__bu IALQHHPNLNATWRDTDDGPRIHRHRAVHLGIAVSAPRGLLVPVVADAHR
Mvan_4084|M.vanbaalenii_PYR-1 VALRRHPVLNATWVDTVDGPRVHVHPAVHLGVGVAAPRGLLVPVVTDAQE
MAB_4916c|M.abscessus_ATCC_199 LALRSHPSLNSAWDEQAG--EIIVKHYVNLGIAAATERGLVVPNVKGADA
Mflv_2935|M.gilvum_PYR-GCK DALKLHPNVNASYNEESK--EITYHEAEHLGIAVDTEQGLLSPVIHNAGD
MLBr_00861|M.leprae_Br4923 DALKIHPNINASYNEDTK--EITYYDAEHLGFAIDTDKGLLSPVIHYAGD
**: : :*::: : .: :**.. : :**: * : *
MUL_3773|M.ulcerans_Agy99 MTTRELVCRAAELITGAREGTLAPGQLRGWTFTVSNYGALGVDDGVPVIN
MMAR_3842|M.marinum_M MTTRELVCRAAELITGAREGTLAPGQLRGSTFTVSNYGALGVDDGVPVIN
Mb2523c|M.bovis_AF2122/97 KNTRELASRVAELITGAREGTLTPAELRGSTFTVSNFGALGVDDGVPVIN
Rv2495c|M.tuberculosis_H37Rv KNTRELASRVAELITGAREGTLTPAELRGSTFTVSNFGALGVDDGVPVIN
MAV_1677|M.avium_104 KTTRELASRAAELISGARAGSLTPGELRGSTFTVSNFGALGVDDGVPVIN
MSMEG_4710|M.smegmatis_MC2_155 MTTRQLAVTVARLVESARAGTLSPAELTGSTFTVSNFGALGVDDGVPVIN
TH_0716|M.thermoresistible__bu MTLPQLGAAVERLVDRARAGTLTPAELTGSTFTVSNFGALGLDDGVPVIN
Mvan_4084|M.vanbaalenii_PYR-1 RSTRRLADEVARLVAAARAGTLKPGELQGSTFTVSNYGALGLDDGVPVIN
MAB_4916c|M.abscessus_ATCC_199 MSLGELATAIAQLVSTARAGKTAPTDMSGGTFTLTNIGVFGVDAGTPIIN
Mflv_2935|M.gilvum_PYR-GCK LSLGGLARAISDIAGRARSGNLKPDELSGGTFTITNIGSQGALFDTPILV
MLBr_00861|M.leprae_Br4923 LSLAGLARAIVDIAARARSGNLKPEELSGGTFTITNIGSQGALFDTPILV
. * : ** *. * :: * ***::* * * ..*::
MUL_3773|M.ulcerans_Agy99 HPDAAILGMGSIKPRPVVRGDE-----VVVRPTMSLTCVFDHRVADGAQV
MMAR_3842|M.marinum_M HPEAAILGMGSIKPRPVVRGDA-----VVVRPTMSLTCVFDHRVADGAQV
Mb2523c|M.bovis_AF2122/97 HPEAAILGLGAIKPRPVVVGGE-----VVARPTMTLTCVFDHRVVDGAQV
Rv2495c|M.tuberculosis_H37Rv HPEAAILGLGAIKPRPVVVGGE-----VVARPTMTLTCVFDHRVVDGAQV
MAV_1677|M.avium_104 HPEAAILGMGAIKPRPVAVGTE-----VVVRPTMSLSAVFDHRIADGAQA
MSMEG_4710|M.smegmatis_MC2_155 YPEAAILGMGSLRERPVVVDGA-----VVARPTMSLTCVFDHRIADGAQA
TH_0716|M.thermoresistible__bu YPEAAILGMGMIKPRPVVIDDA-----VVARPTMTLTCAFDHRVADGAQV
Mvan_4084|M.vanbaalenii_PYR-1 HPEAAIVGVGSLKPRAVVVGGA-----VVARPTMRLTCAFDHRVADGAQV
MAB_4916c|M.abscessus_ATCC_199 PGEAAILALGSVAKRPWVVNGE-----LAVRDVTTLALSFDHRLVDGEQG
Mflv_2935|M.gilvum_PYR-GCK PPQAAMLGTGAIVKRPRIIIDEFGNESIGVRSVSYLPLTYDHRLIDGADA
MLBr_00861|M.leprae_Br4923 PPQAAMLGIGAIVKRPRVVIDASGNESIGVRAICYLPLTYDHRLIDGADA
:**::. * : *. : .* *. :***: ** :
MUL_3773|M.ulcerans_Agy99 ARFICELRGLIEA-PETALLDL-
MMAR_3842|M.marinum_M ARFICELRGLIEA-PETVLLDL-
Mb2523c|M.bovis_AF2122/97 AQFMCELRDLIES-PETALLDL-
Rv2495c|M.tuberculosis_H37Rv AQFMCELRDLIES-PETALLDL-
MAV_1677|M.avium_104 ARFVCELRDLIES-PETALLDL-
MSMEG_4710|M.smegmatis_MC2_155 AAFLGELRGLIEE-PDLALLDL-
TH_0716|M.thermoresistible__bu AAFLDELRGLIES-PSRALLFLR
Mvan_4084|M.vanbaalenii_PYR-1 AAFLAELRSLIEL-PELALLDL-
MAB_4916c|M.abscessus_ATCC_199 SKFLADLGAMLTD-PRMALVV--
Mflv_2935|M.gilvum_PYR-GCK GRFVTTIKRRLEEGAFEADLGL-
MLBr_00861|M.leprae_Br4923 GRFLTTIKHRLEEGAFEADLGL-
. *: : : . . :