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VERYPPRYHASRGFRHQQLRKGLTSMTAPATIDSHDLHQMLGSATPPRVLDVRTPGEFETAHINGAYNVP LDLLREHRDEIIGHLDQDVVLVCRSGQRAAQAEETLRNTGLTNVHILDGGITAWEAQGFAVNRGATRWDL ERQVRLVAGSLVLTAILGSIAAPKLKWLAAGVGGGLTFAAVSNTCAMGTLLSKLPYNRGTATCDAHTIVT QLVDANTTDKNKKVS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4024 | - | - | 100% (225) | rhodanese domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1829 | - | e-126 | 97.78% (225) | rhodanese domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1797 | - | 7e-09 | 29.00% (100) | molybdopterin biosynthesis-like protein MoeZ |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3143 | moeB2 | 8e-12 | 44.74% (76) | molybdenum cofactor biosynthesis protein MoeB |
| M. gilvum PYR-GCK | Mflv_0984 | - | 8e-92 | 84.97% (193) | rhodanese domain-containing protein |
| M. tuberculosis H37Rv | Rv3116 | moeB2 | 8e-12 | 44.74% (76) | molybdenum cofactor biosynthesis protein MoeB |
| M. leprae Br4923 | MLBr_00817 | moeZ | 2e-10 | 33.67% (98) | molybdopterin biosynthesis-like protein MoeZ |
| M. abscessus ATCC 19977 | MAB_3525c | - | 4e-10 | 31.73% (104) | molybdenum cofactor biosynthesis protein MoeB1 |
| M. marinum M | MMAR_1352 | moeB1 | 2e-09 | 35.00% (100) | molybdenum cofactor biosynthesis protein MoeB1 |
| M. avium 104 | MAV_4153 | - | 8e-11 | 34.00% (100) | molybdopterin biosynthesis-like protein MoeZ |
| M. smegmatis MC2 155 | MSMEG_5386 | - | 1e-73 | 68.00% (200) | rhodanese-like domain-containing protein |
| M. thermoresistible (build 8) | TH_1233 | - | 1e-78 | 76.34% (186) | rhodanese-like domain protein |
| M. ulcerans Agy99 | MUL_2527 | moeB1 | 6e-10 | 35.00% (100) | molybdopterin biosynthesis-like protein MoeZ |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1352|M.marinum_M --MSTTALPPLVAPAATLSREEVARYSRHLIIPDLGVDGQKRLKNARVLV
MUL_2527|M.ulcerans_Agy99 --MSTTALPPLVAPAATLSREEVARYSRHLIIPDLGVDGQKRLKNARVLV
MAB_3525c|M.abscessus_ATCC_199 --MPT--LPPLVRPAAELTREEVARYSRHLIIPDLGVDGQKRLKNAKVLV
MLBr_00817|M.leprae_Br4923 MSTSSTSLPPLVEPAGQLSRDEVIRYSRHLIIPDIGVDGQMRLKSARVLV
MAV_4153|M.avium_104 --MSTP-LPPLVAPADQLTADEMARYSRQLIIPGLGVDGQKRLKNARVLV
Mb3143|M.bovis_AF2122/97 --MTEALIPAPSQIS--LTRDEVRRYSRHLIIPDIGVNGQQRLKDARVLC
Rv3116|M.tuberculosis_H37Rv --MTEALIPAPSQIS--LTRDEVRRYSRHLIIPDIGVNGQQRLKDARVLC
Mvan_4024|M.vanbaalenii_PYR-1 ------------------------------------------------ME
Mflv_0984|M.gilvum_PYR-GCK --------------------------------------------------
TH_1233|M.thermoresistible__bu --------------------------------------------------
MSMEG_5386|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1352|M.marinum_M IGAGGLGSPTLLYLAAAGVGTIGIVDFDVVDESNLQRQIIHGVADVGRSK
MUL_2527|M.ulcerans_Agy99 IGAGGLGSPTLLYLAAAGVGTIGIVDFDVVDESNLQRQIIHGVADVGRSK
MAB_3525c|M.abscessus_ATCC_199 IGAGGLGSPTLLYLAAAGVGTIGIVEFDVVDESNLQRQIIHGQSDIGRSK
MLBr_00817|M.leprae_Br4923 IGAGGLGAPVLLYLAAAGVGTIGIIDFDVVDESNLQRQIIHGVADVGRSK
MAV_4153|M.avium_104 IGAGGLGAPTLLYLAAAGVGTIGIVEFDAVEESNLQRQIIHGVADVGRSK
Mb3143|M.bovis_AF2122/97 IGAGGLGSPALLYLAAAGVGTIGIIDGDHVDESNLQRQIIHGTSDVGRPK
Rv3116|M.tuberculosis_H37Rv IGAGGLGSPALLYLAAAGVGTIGIIDGDHVDESNLQRQIIHGTSDVGRPK
Mvan_4024|M.vanbaalenii_PYR-1 RYPPRYHASRGFRHQQLRKGLTSMTAPATIDSHDLHQMLGSATPPRVLDV
Mflv_0984|M.gilvum_PYR-GCK -----------------------MTAPVTIDSHDLSQMLGSPTPPRVLDV
TH_1233|M.thermoresistible__bu -----------------------MTA--TIDCRHLRDCLDSDSPPRVLDV
MSMEG_5386|M.smegmatis_MC2_155 -----------------------MLSPGVVTATHLDAQLKSATSPQILDV
: : .* : .
MMAR_1352|M.marinum_M AQSARDSIVAINPLIEVRLHEFRLESDNAVDLFGHYDLIIDGTDNFATRY
MUL_2527|M.ulcerans_Agy99 AQSARDSIVAINPLIEVRLHEFRLESDNAVDLFGHYDLIIDGTDNFATRY
MAB_3525c|M.abscessus_ATCC_199 AQSARDSVLEINPLVEVRLHELRLDPENAVELFAQYDLILDGTDNFATRY
MLBr_00817|M.leprae_Br4923 AQSARDSIVAINPLVQVRLHEFRLESSNVVNLFKQYDLIVDGTDNFATRY
MAV_4153|M.avium_104 AASARDSIAAINPLVDVRLHEFRLDASNAVELFGHYDLIVDGTDNFATRY
Mb3143|M.bovis_AF2122/97 VESAAEAVAEINPHVRVTQYREMLTHDNALEIFGDHDLIVDGTDNFTTRY
Rv3116|M.tuberculosis_H37Rv VESAAEAVAEINPHVRVTQYREMLTHDNALEIFGDHDLIVDGTDNFTTRY
Mvan_4024|M.vanbaalenii_PYR-1 RTPGEFETAHINGAYNVPLDLLREHRDEIIGHLDQDVVLVCRSG------
Mflv_0984|M.gilvum_PYR-GCK RTPGEFETAHIAGAYNVPLDLLREHRDEIVKHLDEDVVLVCRSG------
TH_1233|M.thermoresistible__bu RTPGEFETAHIAGAYNVPLDLLREHRDEIARHLDQDVILVCRSG------
MSMEG_5386|M.smegmatis_MC2_155 RTPAEFETNHIAGSYNVPLDLLREHRDEIVEHLDTDVVVVCRSG------
.. * * .: : ::: :.
MMAR_1352|M.marinum_M LVNDAAVLAGKPYVWGSIYRFEGQVSVFWEDAPGGLGLNYRDLYPEPPPP
MUL_2527|M.ulcerans_Agy99 LVNDAAVLAGKPYVWGSIYRFEGQVSVFWEDAPGGLGLNYRDLYPEPPPP
MAB_3525c|M.abscessus_ATCC_199 LVNDAAVLAHKPYVWGSIYRFEGQVSVFWEDAPDGLGLNYRDLYPEPPPP
MLBr_00817|M.leprae_Br4923 LINDAAVLAKKPYVWGSLYRFEGQVSVFWEDAPDGLGLNYRDLYLEPPPP
MAV_4153|M.avium_104 LINDAAVLAGKPYVWGSIYRFEGQASVCWEDAPDGRGLNYRDLYPEPPPP
Mb3143|M.bovis_AF2122/97 LINDAAVLAGKPYVWGSIYRFNGQTSVFWP----GRGPCYRCLHPAPPPP
Rv3116|M.tuberculosis_H37Rv LINDAAVLAGKPYVWGSIYRFNGQTSVFWP----GRGPCYRCLHPAPPPP
Mvan_4024|M.vanbaalenii_PYR-1 ---QRAAQAEETLRNTGLTNVH----------------------------
Mflv_0984|M.gilvum_PYR-GCK ---QRAAQAEETLRNAGLSNVH----------------------------
TH_1233|M.thermoresistible__bu ---QRAAQAEETLRAAGLTNVH----------------------------
MSMEG_5386|M.smegmatis_MC2_155 ---QRATQAGETLRNAGLTNVH----------------------------
: *. * :. .: ...
MMAR_1352|M.marinum_M GMVPSCAEGGVLGIICASIASVMGTEAVKLITGIGETLLGRLMIYDALEM
MUL_2527|M.ulcerans_Agy99 GMVPSCAEGGVLGIICASIASVMGTEAVKLITGIGETLLGRLMIYDALEM
MAB_3525c|M.abscessus_ATCC_199 GMVPSCAEGGVLGILCASIASVMGTEAIKLITGIGDSLLGRLMVYDALDM
MLBr_00817|M.leprae_Br4923 GMVPSCAEGGVLGIVCASIASVMGTEAIKLITGIGAPLLGRLMIYNALEM
MAV_4153|M.avium_104 GAVPSCAEGGVLGVVCAAIASVMSTEVIKLITGIGESLLGRLMIYDALEM
Mb3143|M.bovis_AF2122/97 GLVPSCAEGGVLGAICATIASIQVTEVLKLLTGVGTPLVGRLLMYEALDA
Rv3116|M.tuberculosis_H37Rv GLVPSCAEGGVLGAICATIASIQVTEVLKLLTGVGTPLVGRLLMYEALDA
Mvan_4024|M.vanbaalenii_PYR-1 -----ILDGGITAWEAQGFAVNRGATRWDLER------------------
Mflv_0984|M.gilvum_PYR-GCK -----ILDGGITAWEAKGFAVNRGAQRWDLER------------------
TH_1233|M.thermoresistible__bu -----ILEGGITAWEAQGFDVVRGRQRWDLER------------------
MSMEG_5386|M.smegmatis_MC2_155 -----ILEGGITAWEAAGFAVDRGAQRWDLER------------------
:**: . . : .*
MMAR_1352|M.marinum_M TYRTIRIRKDP------ATPKITALIDYEQFCG---VVSDDVARAASDST
MUL_2527|M.ulcerans_Agy99 TYRTIRIRKDP------ATPKITALIDYEQFCG---VVSDDVARAASDST
MAB_3525c|M.abscessus_ATCC_199 TYRTIKIRKDP------ATPKITELIDYEAFCG---VISDEASAAVADST
MLBr_00817|M.leprae_Br4923 SYRRIRIHKDP------SRPKITELTDYQQFCG---VVSDDAAQVATGSI
MAV_4153|M.avium_104 SYRTIAIRRDPCD---ASRPAITTLVDYEQLCGAAPAASTDAATGGAEAA
Mb3143|M.bovis_AF2122/97 TYHQIRIAKNPDCAICGDAPTITELVDDSVSCA-------STQSVDPELV
Rv3116|M.tuberculosis_H37Rv TYHQIRIAKNPDCAICGDAPTITELVDDSVSCA-------STQSVDPELV
Mvan_4024|M.vanbaalenii_PYR-1 -----------------------------------------QVRLVAGSL
Mflv_0984|M.gilvum_PYR-GCK -----------------------------------------QVRLVAGSI
TH_1233|M.thermoresistible__bu -----------------------------------------QVRLVAGAI
MSMEG_5386|M.smegmatis_MC2_155 -----------------------------------------QVRLVAGSI
.
MMAR_1352|M.marinum_M ITPQELRAMIDSGKKLALIDVREQVEWDIVHIDGAQLIPKSLISTGEGLA
MUL_2527|M.ulcerans_Agy99 ITPQELRAMINSGKKLALIDVREQVEWDIVHIDGAQLIPKSLISTGEGLA
MAB_3525c|M.abscessus_ATCC_199 ITPRELRELLDTDKKVALIDVREPVEWDIVHIDGAELVPKSTLESGDGLA
MLBr_00817|M.leprae_Br4923 VTPRELRELLDSGKKLALIDVREPVEWDIVHIDGAQLIPRSLINSGEGLA
MAV_4153|M.avium_104 ITPRQLRELLDSGAKLALIDVREPVEFDIVHLDGAQLIPQSSINSGEGLA
Mb3143|M.bovis_AF2122/97 ISCDELRTKQQSDQNFLLVDVREPAEFDIAHIPGSILIPKGEIGSAAGLA
Rv3116|M.tuberculosis_H37Rv ISCDELRTKQQSDQNFLLVDVREPAEFDIAHIPGSILIPKGEIGSAAGLA
Mvan_4024|M.vanbaalenii_PYR-1 VLTAILGSIAAPKLKWLAAGVGGGLTFAAVSN---------TCAMGTLLS
Mflv_0984|M.gilvum_PYR-GCK VLSSILGSIAAPKLKWVAGAVGGGLTFAALSN---------TCAMGMLLS
TH_1233|M.thermoresistible__bu VLFSVLASVVVPGLQWVAAAIGGGLMFAALTN---------TCAMGMLLA
MSMEG_5386|M.smegmatis_MC2_155 VLTGVLASVAVPAAKWVAAAVGSGLAIAALTN---------TCAMGMALA
: * . : : . *:
MMAR_1352|M.marinum_M KLPQDRTTVLYCKTGVRSAEALAALKKAGFADAVHLQGGIVAWANQMQPD
MUL_2527|M.ulcerans_Agy99 KLPQDRTTVLYCKTGVRSAEALAALKKAGFADAAHLQGGIVAWANQMQPD
MAB_3525c|M.abscessus_ATCC_199 KLPQDRQAVLYCKTGIRSAEALVAVKKAGFSDAVHLQGGIAAWAKQVDPD
MLBr_00817|M.leprae_Br4923 KLPQDRMSVLYCKTGVRSAETLATVKKAGFSDAVHLQGGIVAWAKQVQPD
MAV_4153|M.avium_104 KLPADRMPVLYCKTGVRSAQALAVVRQAGFSDAVHLQGGIVAWAQQMQPD
Mb3143|M.bovis_AF2122/97 QLPLDKEIVLYCKSGIRSAQALTTLKAAGLHNVKHLDGGIAEWTRTIDSS
Rv3116|M.tuberculosis_H37Rv QLPLDKEIVLYCKSGIRSAQALTTLKAAGLHNVKHLDGGIAEWTRTIDSS
Mvan_4024|M.vanbaalenii_PYR-1 KLPYNRGTATCDAHTIVTQLVDANTTDKNKKVS-----------------
Mflv_0984|M.gilvum_PYR-GCK KLPYNRG-ASCDAEGIVAQLVEGSAS------------------------
TH_1233|M.thermoresistible__bu KLPYNRG-ATCDARTIVAQLIDSGPETGRS--------------------
MSMEG_5386|M.smegmatis_MC2_155 KLPYNRG-TACDAASILAQLAGPKNRKAA---------------------
:** :: . : :
MMAR_1352|M.marinum_M MVMY
MUL_2527|M.ulcerans_Agy99 MVMY
MAB_3525c|M.abscessus_ATCC_199 MVMY
MLBr_00817|M.leprae_Br4923 MVIY
MAV_4153|M.avium_104 MILY
Mb3143|M.bovis_AF2122/97 LLVY
Rv3116|M.tuberculosis_H37Rv LLVY
Mvan_4024|M.vanbaalenii_PYR-1 ----
Mflv_0984|M.gilvum_PYR-GCK ----
TH_1233|M.thermoresistible__bu ----
MSMEG_5386|M.smegmatis_MC2_155 ----