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NTTTIPVDPEKLMGFVLRSVEEAGAALNCALVVMGQRLGYYRCLVEHGPCTPAELAEHTGTDEHYAREWL NAQAAGSFVAYDDSTGRYHLPPEQATALYDETSPAFVGGLFQLAYGTLRDATHIVEVARTGDGMGWGEHN SDVHVGCERFFLPTYAAQIVDNWIPALEGVADRLADGARVADVGCGHGGSTLLMARAFPNSTFVGTDVHA GSVETARQRAREANADRRVSFEVGSADQLGGGPYDLVTMFDCLHDMGDPIGAARRVREVIAEDGSWMIVE PAAGDRVQDNFNSIGRAYYGFSTLLCTPSSLAQPVGLALGTQAGPARIRDVVTAAGFTRFRVAAQTPFNH VFQVRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3870 | - | - | 100% (357) | methyltransferase type 12 |
| M. vanbaalenii PYR-1 | Mvan_3765 | - | 5e-33 | 27.99% (343) | methyltransferase type 12 |
| M. vanbaalenii PYR-1 | Mvan_1888 | - | 5e-06 | 39.76% (83) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2282c | - | 4e-34 | 30.21% (331) | transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2768 | - | 4e-31 | 27.33% (344) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv2258c | - | 4e-34 | 30.21% (331) | transcriptional regulator |
| M. leprae Br4923 | MLBr_01783 | - | 9e-17 | 26.71% (277) | putative transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4742c | - | 4e-27 | 27.68% (336) | hypothetical protein MAB_4742c |
| M. marinum M | MMAR_3349 | - | 3e-35 | 28.21% (351) | transcriptional regulatory protein |
| M. avium 104 | MAV_2182 | - | 2e-28 | 29.36% (344) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_4338 | - | 3e-33 | 28.25% (361) | transcriptional regulatory protein |
| M. thermoresistible (build 8) | TH_4552 | - | 1e-156 | 73.60% (356) | PUTATIVE Methyltransferase type 12 |
| M. ulcerans Agy99 | MUL_1293 | - | 2e-35 | 28.49% (351) | transcriptional regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2282c|M.bovis_AF2122/97 ------------MSGALETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLD
Rv2258c|M.tuberculosis_H37Rv ------------MSGALETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLD
MMAR_3349|M.marinum_M ---------MTAIDGGTETTEEFGGRIVAAIDSAGLTILLSVGHQTGLLD
MUL_1293|M.ulcerans_Agy99 ---------MTAIDGGTETTEEFGGRIVAAIDSAGLTILLSVGHQTGLLD
MAV_2182|M.avium_104 ------------MT-ALETTDEFTDRITAAIDGASLALLLSIGHQTALLD
Mflv_2768|M.gilvum_PYR-GCK -----MTTLAENSAPSSETTEEFAQRIVGALDAASLALLVSIGHQTHLFD
MSMEG_4338|M.smegmatis_MC2_155 -MNLDEVTVSTTTSPTPDTTEDFAARVVECLDSASTAILLSIGHQTGLFD
MAB_4742c|M.abscessus_ATCC_199 -------MTAPSANPVPETTEEFSERLTAAIDNAALVLLMSIGHQTGLLD
MLBr_01783|M.leprae_Br4923 --------------------------------------------------
Mvan_3870|M.vanbaalenii_PYR-1 MNTTTIP-------VDPEKLMGFVLRSVEEAGAALNCALVVMGQRLGYYR
TH_4552|M.thermoresistible__bu MTAPRTPSGPTTRGVDPENLMAFVLRAVTEVGAALNAALVVMGDRLGYYR
Mb2282c|M.bovis_AF2122/97 TMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPA
Rv2258c|M.tuberculosis_H37Rv TMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPA
MMAR_3349|M.marinum_M VISQLPPSTSTQIAEAVGLDERYVREWLGGMTAGQVIEYDAETATYSLPE
MUL_1293|M.ulcerans_Agy99 VISQLPPSTSAQIAEAVGLDERYVREWLGGMTAGQVIEYDAETATYSLPE
MAV_2182|M.avium_104 TMAGLPPATSDRIAEAAGLNERYVREWLAGMTTGRVVDYHPATAEYSLPA
Mflv_2768|M.gilvum_PYR-GCK TMANLPPSTSTQIADAAGLNERYVREWLGGVAAGRIVDYDPAAQTFSLPA
MSMEG_4338|M.smegmatis_MC2_155 TMRSLPPATSTQIADAAGLNERYVREWLGGLVAAKVIEYAPDERTYHLPE
MAB_4742c|M.abscessus_ATCC_199 TLAASAGSTSEQLADAAGLEERYVREWLAGMTVAHVVDYEPVSAIYTLPS
MLBr_01783|M.leprae_Br4923 -MVGLSLVTSTQIAYVAGLNERYVREWLGDMTTGHVVDYYAETGTYSLSV
Mvan_3870|M.vanbaalenii_PYR-1 CLVEHGPCTPAELAEHTGTDEHYAREWLNAQAAGSFVAYDDSTGRYHLPP
TH_4552|M.thermoresistible__bu SLAAHGASTPAELAERTGTDEHYAREWLNAQAAGAFVSYDPTTGRYLLPP
: *. .:* .* :*:*.**** ... .: * : *.
Mb2282c|M.bovis_AF2122/97 HRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEY-PR
Rv2258c|M.tuberculosis_H37Rv HRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEY-PR
MMAR_3349|M.marinum_M HRAAMLTRAAGPNNLARVTQFISLLGEVEQKVIACFREGGGVHYTQY-PR
MUL_1293|M.ulcerans_Agy99 HRAAMLTRAAGPNNLARVTQFISLLGEVEQKVIACFREGGGVHYTQY-PR
MAV_2182|M.avium_104 HRAKVLTRAAGPDNLALVALFLPLLAEVEQKIIGCFRTGGGLPYTEF-PR
Mflv_2768|M.gilvum_PYR-GCK HRAAVLTRTAGPDNLARVTQFIPLLSEVEQKVIACFRDGGGLSYAEY-PR
MSMEG_4338|M.smegmatis_MC2_155 HRAAMLTRAAGPDNLARVAQFIPLLAEVEQKIVDRFRHGGGLPYSEY-PR
MAB_4742c|M.abscessus_ATCC_199 HRAATLTREAGLNNLARLAQYLPLLSEVEQKILGCFRRGGGLQYQDY-PR
MLBr_01783|M.leprae_Br4923 HRVAVLVWATGTNNLASVAQFIPLFSGFEQQFIGGFCDDVGGPYSEF-PR
Mvan_3870|M.vanbaalenii_PYR-1 EQATALYDETSPAFVGGLFQLAYGTLRDATHIVEVARTGDGMGWGEHNSD
TH_4552|M.thermoresistible__bu EHAEALTDETSPAFVGGLFQIAHGTVCDTASILEAARTGGGVGWGDHNAD
.:. * :. :. : .: . * : :. .
Mb2282c|M.bovis_AF2122/97 FHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVK
Rv2258c|M.tuberculosis_H37Rv FHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVK
MMAR_3349|M.marinum_M FHTLMAEMSGEVFDSALVDVIVPLVEGLPERLQAGAEAADFGCGSGHAVN
MUL_1293|M.ulcerans_Agy99 FHTLMAEMSGEVFDSALVDVIVPLVESLPERLQAGAEVADFGCGSGHAVN
MAV_2182|M.avium_104 FHALMAEQSGVVFDTALVDVVLPLVDGLVPWLRRGADVADFGCGSGHAIN
Mflv_2768|M.gilvum_PYR-GCK FHTLMAEQSGEVFDAALVDGILPMAEGLTDRLRQGVDVADFGCGSGHAVN
MSMEG_4338|M.smegmatis_MC2_155 FHRLMAEQSGEVFDAALIDVILPMASGLVDRLQAGADLADIGCGSGHAVN
MAB_4742c|M.abscessus_ATCC_199 FHAVMGERSREVFDKALIRTVLPLVEGLPEGLEGGLDVADFGCGSGYAIN
MLBr_01783|M.leprae_Br4923 FYSLMAEMSGAMFDAAFVDVVLPLANGLPERLRSGAGVADFDCGSGHVVN
Mvan_3870|M.vanbaalenii_PYR-1 VHVGCERFFLPTYAAQIVDNWIPALEGVADRLADGARVADVGCGHGGSTL
TH_4552|M.thermoresistible__bu VHIGCERFFRPTYHAHLLAEWLPALDGVLDKLTAGASVADVGCGHGASTR
.: . : :: :* ..: * * **..** *
Mb2282c|M.bovis_AF2122/97 LMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVG
Rv2258c|M.tuberculosis_H37Rv LMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVG
MMAR_3349|M.marinum_M LLAQAFPKSRFTGIDFSEPAIAAASQEAKRRGLSNATFQSRDLTTLDDVG
MUL_1293|M.ulcerans_Agy99 LLAQAFPKSRFTGIDFSEPAIAAASQEAQRRGLSNATFQSRDLTTLDDVG
MAV_2182|M.avium_104 VMAQAFPASRFTGIDFSEHAIAAGIAEAAERGLANASFESHNLADLDRAD
Mflv_2768|M.gilvum_PYR-GCK VMAKAFPASRFTGIDFSEEGLAAGRDEARRLGLTNASFNATDVATYDAAE
MSMEG_4338|M.smegmatis_MC2_155 VIAQAFPASRCTGIDFSEEGLATGRDEAQRLGLDNATFIARDVAELDETE
MAB_4742c|M.abscessus_ATCC_199 LMAQAFPASRFTGVDFSDEAIATAAADAERLGLRNASFLSADVATLNAPA
MLBr_01783|M.leprae_Br4923 VLVRAFPASWFIGIDFSNEAVAIHTAEEDRLGLGTVTFESHNLARLDKAA
Mvan_3870|M.vanbaalenii_PYR-1 LMARAFPNSTFVGTDVHAGSVETARQRAR--EANADRRVSFEVGSADQLG
TH_4552|M.thermoresistible__bu LMAEAFPRSTFQGSDVHAPSIEVARQRAAGTGPDAVRNIAFETAGADAVA
::..** * * *. .: : :
Mb2282c|M.bovis_AF2122/97 --AYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDN
Rv2258c|M.tuberculosis_H37Rv --AYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDN
MMAR_3349|M.marinum_M --VYDVITAFDTIHDQAQPARVLENIYRALRPGGVLLMVDVKASSRLEDN
MUL_1293|M.ulcerans_Agy99 --VYDVITAFDTIHDQAQPARVLENIYRALRPGGVLLMVDVKASSRLEDN
MAV_2182|M.avium_104 --AYDLITVFDAIHDQAQPARVLANIHRALRPGGVLLMADIKASSRLEDN
Mflv_2768|M.gilvum_PYR-GCK --SFDVITAFDAIHDQAHPARVLANIHAALRPGGTFLMVDIKSSSRLENN
MSMEG_4338|M.smegmatis_MC2_155 --AYDVITAFDAIHDQAHPARVLENIHRALRPGGVFLMVDIKASTHVENN
MAB_4742c|M.abscessus_ATCC_199 --TYDLITAFDTIHDQAHPAAVLANIHRALRPGGVLLMADIKASSRLEDN
MLBr_01783|M.leprae_Br4923 --AYDVITVFDASHDHAQPVRVLENIYQALRPGDVLLMASIKVSSQLEDN
Mvan_3870|M.vanbaalenii_PYR-1 GGPYDLVTMFDCLHDMGDPIGAARRVREVIAEDGSWMIVEPAAGDRVQDN
TH_4552|M.thermoresistible__bu GGPYDLITMFDCLHDMGDPVGAARHLREVIADDGTWMIVEPAAGDRVEDN
:*::* ** ** ..* . .: .: .. ::.. . ::::*
Mb2282c|M.bovis_AF2122/97 VGVPLSTYLYTTSLMHCMTVSLALDGA------GLGTVWGRQLATSMLAD
Rv2258c|M.tuberculosis_H37Rv VGVPLSTYLYTTSLMHCMTVSLALDGA------GLGTVWGRQLATSMLAD
MMAR_3349|M.marinum_M VGNPMSTYLYTISMMHCMTVSLALDGV------GLGTVWGSQLATKMLAD
MUL_1293|M.ulcerans_Agy99 VGNPMSTYLYTISMMHCMTVSLALDGV------GLGTVWGSQLATKMLAD
MAV_2182|M.avium_104 VGVPMSTYLYTTSLMHCMTVSLAADGA------GLGTAWGTQLAVAMLGE
Mflv_2768|M.gilvum_PYR-GCK IGVPFAPYLYTVSAMHCMSVSLGLDGD------GLGTCWGREVATTMLAD
MSMEG_4338|M.smegmatis_MC2_155 IGVPFAPYLYTVSTLHCMTVSLALDGD------GLGTVWGRELATSMLAD
MAB_4742c|M.abscessus_ATCC_199 IGVAMSTYRYTVSLTHCMPVSLGLEGA------GLGTMWGRQLAESMLAE
MLBr_01783|M.leprae_Br4923 VDVLMSIYLYTASLMHCMTVSLALQGAPDWMRCGEGGWPPRCSATRDWTT
Mvan_3870|M.vanbaalenii_PYR-1 FNS-IGRAYYGFSTLLCTPSSLAQPVG-----LALGTQAGPARIRDVVTA
TH_4552|M.thermoresistible__bu LTP-IGRAYYGFSTLLCTPASLSQPVG-----LALGTQAGPARIREVVTA
. :. * * * . **. . *
Mb2282c|M.bovis_AF2122/97 AGFTDVTVAEIESDVLNNYYIARK-----
Rv2258c|M.tuberculosis_H37Rv AGFTDVTVAEIESDVLNNYYIARK-----
MMAR_3349|M.marinum_M AGFEDVTVAEIESDPLNNYYIARK-----
MUL_1293|M.ulcerans_Agy99 AGFEDVTVAEIESDPLNNYYIARK-----
MAV_2182|M.avium_104 AGFADVRVAEIESDPINNYYIARKS----
Mflv_2768|M.gilvum_PYR-GCK AGFGDVQVREIESDPINYYYIARK-----
MSMEG_4338|M.smegmatis_MC2_155 AGFDDIVVREIDTDPINYYYVARKR----
MAB_4742c|M.abscessus_ATCC_199 AGFSDVTVREIEQDTSNYFYIARR-----
MLBr_01783|M.leprae_Br4923 CGWS---ISSPTRSTTTYIYIATKLPRLT
Mvan_3870|M.vanbaalenii_PYR-1 AGFTRFRVAAQT--PFNHVFQVRP-----
TH_4552|M.thermoresistible__bu AGFTRFRLVADT--PFNNVFEVRP-----
.*: : . : .