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MRRLTSLLIAGVLASMLVLHTSGVATAGHGSEPDGDSETVAGLVAAVAEVNQHVADIGADIQHMQESVNR ALVELATAREAVSEAHRRLADSEKALADSQTAIDATQQRFDEFAASTYMNGPSRSLPLASSPEDILSAAS TQQTYLLAFGRVKDDLRRSQTERANRLSAAKQARLDADAAAAEAQRRQDGAVAELVAAQRAFTNQQSDLT RLAAERDSAQTRLTTARPVAATTRQPTAAQPGTPVPPSGQWDRSSPAPADSSGTGQWDTTLPMVPSANVA GDPIAIINAVLKIMATSLQLTADMGRNFLTKLGILSPATAAADPGITNGRIPRLYGRQASEFVIRRAMSQ LGVPYSWGGGNANGPSRGIDQGANTVGFDCSGLMLYAFAGVGIKLDHYSGSQYNAGRKVPSSQMQRGDLI FYGPNASQHEAMYLGDGMMIEAPYTGSVVKISPVRSSGMTPYVTRLIEY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3656 | - | - | 100% (469) | NLP/P60 protein |
| M. vanbaalenii PYR-1 | Mvan_2747 | - | e-137 | 55.46% (476) | NLP/P60 protein |
| M. vanbaalenii PYR-1 | Mvan_2333 | - | 2e-92 | 42.73% (440) | NLP/P60 protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1513 | - | 1e-136 | 54.27% (468) | invasion protein |
| M. gilvum PYR-GCK | Mflv_0895 | - | 0.0 | 93.39% (469) | NLP/P60 protein |
| M. tuberculosis H37Rv | Rv1477 | - | 1e-136 | 54.27% (468) | invasion protein |
| M. leprae Br4923 | MLBr_01812 | - | 1e-132 | 53.60% (472) | putative exported p60 protein homologue |
| M. abscessus ATCC 19977 | MAB_2728c | - | 1e-109 | 45.74% (470) | invasion protein Inv1 |
| M. marinum M | MMAR_2284 | iipA | 1e-127 | 51.06% (472) | invasion and intracellular persistence protein, IipA |
| M. avium 104 | MAV_3301 | - | 1e-129 | 52.67% (469) | invasion protein |
| M. smegmatis MC2 155 | MSMEG_3145 | - | 1e-142 | 56.93% (476) | secreted cell wall-associated hydrolase |
| M. thermoresistible (build 8) | TH_0436 | - | 1e-130 | 54.89% (450) | Possible inv protein |
| M. ulcerans Agy99 | MUL_1486 | - | 1e-127 | 50.85% (472) | cell wall-associated hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3656|M.vanbaalenii_PYR-1 ------------MRR--LTSLLIAGVLASMLVLHTSGVATAGHGSEPDGD
Mflv_0895|M.gilvum_PYR-GCK ------------MRR--LTSLLTTGVTFAVLALHTSGLATAGHGSEPDGE
MMAR_2284|M.marinum_M MRRTRRSSASRSAAR--LVRPAIPSVVSVALLVSVPAVVNADS------R
MUL_1486|M.ulcerans_Agy99 MRRTRRSSASRSAAR--LVRPAIPSVVSVALLVTVPAVANADS------R
Mb1513|M.bovis_AF2122/97 MRRNRRGSPARPAAR--FVRPAIPSALSVALLVCTPGLATADP------Q
Rv1477|M.tuberculosis_H37Rv MRRNRRGSPARPAAR--FVRPAIPSALSVALLVCTPGLATADP------Q
MLBr_01812|M.leprae_Br4923 MKRPRRGSVSRPTAR--FVRPAIPSLVSAALLVSLPVLATADP------D
MAV_3301|M.avium_104 ----------------------MPSVLSVALLICTPGLAQADP------A
MSMEG_3145|M.smegmatis_MC2_155 MRRTVRALATRVHGR--VCAVPLVVGMLLATALYGGGPAAADPA-----A
TH_0436|M.thermoresistible__bu --------------------------MALATTINCGSVAVADPG-----D
MAB_2728c|M.abscessus_ATCC_199 MKRTVNDRFAVRGKRTVATALMVPPLLVAGLMMFPTTVAVTSA------E
: . :.
Mvan_3656|M.vanbaalenii_PYR-1 SETVAGLVAAVAEVNQHVADIGADIQHMQESVNRALVELATAREAVSEAH
Mflv_0895|M.gilvum_PYR-GCK TETVAGLVAAVAEANQHVADIGADIQHKQESVNRALVELATAREAVTEAH
MMAR_2284|M.marinum_M TDSIAALIADVARANQRLDDLSAAVELEQEGVNKAMVAVETARDEAAAAE
MUL_1486|M.ulcerans_Agy99 TDSIAALIADVARANQRLDDLSAAVELEQEGVNKAMVAVETARDEAAAAE
Mb1513|M.bovis_AF2122/97 TDTIAALIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAE
Rv1477|M.tuberculosis_H37Rv TDTIAALIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAE
MLBr_01812|M.leprae_Br4923 GDNLGTLIADVAKVNQRLEDLGAAIETEEQSVNKAMVSVEMARDNAVAAE
MAV_3301|M.avium_104 ADNLAALIANVAKANQRLQNLSAEIQTEQESVNKALVDVETARDNAAAAQ
MSMEG_3145|M.smegmatis_MC2_155 PDNLATLVAKVASADQKLQELGAAIQTQQETVNKAIVDVQAARDAAAAAQ
TH_0436|M.thermoresistible__bu PNEVATLVAAVANVNQKLQELGAAVQQKKESVNKALVDLQEARDAAEAAQ
MAB_2728c|M.abscessus_ATCC_199 PNDMASLITQLADTNQQIEQLTADVQTQQESINKGLVDLQAARDNAASAA
: :. *:: :* .:*:: :: :: :: :*:.:* : **: . *
Mvan_3656|M.vanbaalenii_PYR-1 RRLADSEKALADSQTAIDATQQRFDEFAASTYMNGPSRSLPLASSPEDIL
Mflv_0895|M.gilvum_PYR-GCK RTLDDSEKALADSQTAIDATQQRFDDFAASTYMNGPSRALPLASSPQDIL
MMAR_2284|M.marinum_M HELEASQQAVKDANAAIAAAQHRFDTFAAATYMNGPSDSYLTATSPDEII
MUL_1486|M.ulcerans_Agy99 HELEASQQAVKDANAAIAAAQHRFDTFAAATYMNGPSDSYLTATSPDEII
Mb1513|M.bovis_AF2122/97 DDLEVSQRAVKDANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEII
Rv1477|M.tuberculosis_H37Rv DDLEVSQRAVKDANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEII
MLBr_01812|M.leprae_Br4923 HDCEVSQQSVKDANTAINAAQHRFDSFAAATYMNGPSGSYLTATSPDDII
MAV_3301|M.avium_104 HDLEASQQAVKDANAAIAGAQRRFDTFAAAAYMNGPSNSYLTARNPDDII
MSMEG_3145|M.smegmatis_MC2_155 RELEAGQRGVADANAAIEAAQKRFDSFAAATYMNGPSRSYLTATDPADIV
TH_0436|M.thermoresistible__bu AELKAAQESVETANTAIEDAQKRFDTFAAATYVNGPSVSYLTASDPADVL
MAB_2728c|M.abscessus_ATCC_199 AQVAEGQRAVDAANGAIEEAQGKFDRMAAATYMAGPSTSYLTATNPDDVV
.:..: :: ** :* :** :**::*: *** : * .* :::
Mvan_3656|M.vanbaalenii_PYR-1 SAASTQQTYLLAFGRVKDDLRRSQTERANRLSAAKQARLDADAAAAEAQR
Mflv_0895|M.gilvum_PYR-GCK SAASTQQTYLLAFGRVKEDLRRSQTERANRLSAAKQARLDADAAAAEAQR
MMAR_2284|M.marinum_M AAATAAKTLAASAQTVMANLERARTRQVNKESASRLAKQKADKAAEEAKT
MUL_1486|M.ulcerans_Agy99 AAATAAKTLAASAQTVMANLERARTRQVNKESASRLAEQKADKAAEDAKT
Mb1513|M.bovis_AF2122/97 ATVTAAKTLSASSQAVMANLQRARTERVNTESAARLAKQKADKAAADAKA
Rv1477|M.tuberculosis_H37Rv ATVTAAKTLSASSQAVMANLQRARTERVNTESAARLAKQKADKAAADAKA
MLBr_01812|M.leprae_Br4923 ATATAARTLTASSQAVMANLQRARTEQVNKESAARLAKQKADKAADDAKA
MAV_3301|M.avium_104 ATEAAAKTLTASSQTVMAKLQQARTEQVNRESAARLAKQNADKAAADAKA
MSMEG_3145|M.smegmatis_MC2_155 NTTATGQALIASSQQVMAKLQRARTEQVNRESAARLAKEKADQAARDAES
TH_0436|M.thermoresistible__bu DTAVAGQVLATSAQQVMKNLQQARTEQVNKESLARLAKQRADEKLAAAQA
MAB_2728c|M.abscessus_ATCC_199 RLASVTKSVEASSQTVMDNLRRARTEQVNKQSQARAIQEKADQAAADAQQ
. : : * .*.:::*.:.* * :: . ** *:
Mvan_3656|M.vanbaalenii_PYR-1 RQDGAVAELVAAQRAFTNQQSDLTRLAAERDSAQTRLTTARPVAATTR--
Mflv_0895|M.gilvum_PYR-GCK RQDAAVTELVGAQRAFADQQSDLTRLAAERDSAQTRLTTARPVAATAH--
MMAR_2284|M.marinum_M SQDAAVTALTDTQRKFDQQREEVNRLAAERDEAEAKLQAARLVAWSSA--
MUL_1486|M.ulcerans_Agy99 SQDAAVTALTDTQRKFDQQREEVNRLAAERDEAEAKLQAARLVAWSSA--
Mb1513|M.bovis_AF2122/97 SQDAAVAALTETRRKFDEQREEVQRLAAERDAAQARLQAARLVAWSSE--
Rv1477|M.tuberculosis_H37Rv SQDAAVAALTETRRKFDEQREEVQRLAAERDAAQARLQAARLVAWSSE--
MLBr_01812|M.leprae_Br4923 SMDAAVAALTASKRKFDEQRDEVNRLAAERDEAQARLEVAQIAAATWVPG
MAV_3301|M.avium_104 SQDAAVAALTNSRQKFDEQREQMIRLATERDQAQAKLEAAKRQLSTPG--
MSMEG_3145|M.smegmatis_MC2_155 SQDNAVAALKQAQQTFNAQQGELERLAAERAAAQAELDSVRKVSATGNAA
TH_0436|M.thermoresistible__bu SQEAAVNALTEAQETFGAQQAELQKLTAEREAAQAKLNEVRTMSAATAGA
MAB_2728c|M.abscessus_ATCC_199 QQDDLVSAMKDVQKKLEAQRGVAADLTAKKKSAEAQLAAARGPAYAAS--
: * : :. : *: *:::: *::.* .: :
Mvan_3656|M.vanbaalenii_PYR-1 --QPTAAQPG-----------TPVPPSGQWDRSSPAPADSSGTG------
Mflv_0895|M.gilvum_PYR-GCK --QPTAAQPG-----------AAVPPSGQWDRSSPAPADSSGAG------
MMAR_2284|M.marinum_M --GAEGPPPG------------AMWDPG----ARPGNGRRWDG-------
MUL_1486|M.ulcerans_Agy99 --GAEGPPPG------------AMWDPG----ARPGNGRRWDG-------
Mb1513|M.bovis_AF2122/97 --GGQGAPPF------------RMWDPG----SGPAGGRAWDGL------
Rv1477|M.tuberculosis_H37Rv --GGQGAPPF------------RMWDPG----SGPAGGRAWDGL------
MLBr_01812|M.leprae_Br4923 -MGGHGTPPFG-----------DRWEPGSPASAGPAGGRKWDG-------
MAV_3301|M.avium_104 ----SG----------------DRWETGSAGAPAPSAGRQWDGA------
MSMEG_3145|M.smegmatis_MC2_155 PAAAPAAAPAPAAAPAPVPNSAPAPVPG-AQPNPQAAAGNWDRAPSGPAS
TH_0436|M.thermoresistible__bu TSGANGSAPA------------AAPTPG-AASGTQDPARNWDRAPGGPVV
MAB_2728c|M.abscessus_ATCC_199 --TATARVIN-----------PSAAIAGNGNEWTEGPAPVSSGG------
. .* . .
Mvan_3656|M.vanbaalenii_PYR-1 ------QWDTTLPMVPSANVAGDPIAIINAVLKIMATSLQLTADMGRNFL
Mflv_0895|M.gilvum_PYR-GCK ------QWDTTLPMVPSANVAGDPIAIINAVLKIMATSLQLTADMGRNFL
MMAR_2284|M.marinum_M -------WDPTLPQIPSANIPGDPIAVVNQVLGISATSAQVTANMGRNFL
MUL_1486|M.ulcerans_Agy99 -------WDPTLPQIPSANIPGDPIAVVNQVLGISATSAQVTANMGQNFL
Mb1513|M.bovis_AF2122/97 -------WDPTLPMIPSANIPGDPIAVVNQVLGISATSAQVTANMGRKFL
Rv1477|M.tuberculosis_H37Rv -------WDPTLPMIPSANIPGDPIAVVNQVLGISATSAQVTANMGRKFL
MLBr_01812|M.leprae_Br4923 -------WDPTLPQVPSANVPGDPIAVINQVLGYAATSTQVTASMGRNFL
MAV_3301|M.avium_104 -------WDPTLPMIPSANVPGDPIAVINQVLGISATSTQVTAGLGRNFL
MSMEG_3145|M.smegmatis_MC2_155 SGQNWAVWDPTLPAIPSAFVSGDPIAIINAVLGIASTSAQVTADMGRSFL
TH_0436|M.thermoresistible__bu PYGDPSQWDLTLPAIPSAFVSGDPIAIINASLQIAATSAQVTADLGRRFL
MAB_2728c|M.abscessus_ATCC_199 ------QWDTTLPMIASANVPTDPTQTINMVLGIGNTAANVGQSA---VC
** *** :.** :. ** :* * *: :: . .
Mvan_3656|M.vanbaalenii_PYR-1 TKLGILSPATAAADPG---ITNGRIPRLYGRQASEFVIRRAMSQLGVPYS
Mflv_0895|M.gilvum_PYR-GCK VKLGILSPATAAADPG---ITNGRIPRLYGRQASEFVIRRAMSQLGVPYS
MMAR_2284|M.marinum_M QQLGILKPTDTGITNAATGATR--IPRVYGRQASEYVIRRGMAQIGVPYS
MUL_1486|M.ulcerans_Agy99 QQLGILKPTDTGITNAATGATR--IPRVYGRQASEYVIRRGMAQIGVPYS
Mb1513|M.bovis_AF2122/97 EQLGILQPTDTGITNAPAGSAQGRIPRVYGRQASEYVIRRGMSQIGVPYS
Rv1477|M.tuberculosis_H37Rv EQLGILQPTDTGITNAPAGSAQGRIPRVYGRQASEYVIRRGMSQIGVPYS
MLBr_01812|M.leprae_Br4923 QQLGILKPNDTGITNAPIGSTQGRIPRVYGRQASEYVIRRGISQIGVPYS
MAV_3301|M.avium_104 QQLGILKPDDTGITNAAPGGVGARIPRVYGRQATEYVIRRGMSQIGVPYS
MSMEG_3145|M.smegmatis_MC2_155 QKLGIL-PTPTGFTN-------GAIPRVYGREAVEYVIRRGMSQIGVPYS
TH_0436|M.thermoresistible__bu QRLGLV-PTPTGYTNE------GGIPRVYGRQATEYVIQRAMSQIGVPYS
MAB_2728c|M.abscessus_ATCC_199 GVIGIFCPKAAPAAAAS-GEGGEYLPKVYGRENVERVIARAGSAMGTPYS
:*:. * : :*::***: * ** *. : :*.***
Mvan_3656|M.vanbaalenii_PYR-1 WGGGNANGPSRGIDQGANTVGFDCSGLMLYAFAGVGIKLDHYSGSQYNAG
Mflv_0895|M.gilvum_PYR-GCK WGGGNANGPSRGIDQGANTVGFDCSGLMLYAFAGVGIKLDHYSGSQYNAG
MMAR_2284|M.marinum_M WGGGNAAGPSKGIDSGAGITGFDCSGLVLYSFAGVGIKLPHYSGSQYNLG
MUL_1486|M.ulcerans_Agy99 WGGGNAAGPSKGIDSGAGITGFDCSGLVLYSFAGVGIKLPHYSGSQYNLG
Mb1513|M.bovis_AF2122/97 WGGGNAAGPSKGIDSGAGTVGFDCSGLVLYSFAGVGIKLPHYSGSQYNLG
Rv1477|M.tuberculosis_H37Rv WGGGNAAGPSKGIDSGAGTVGFDCSGLVLYSFAGVGIKLPHYSGSQYNLG
MLBr_01812|M.leprae_Br4923 WGGGNAAGPSRGIDSGAGITGFDCSGLVLYSFAGVGIRLPHYSGSQYNLG
MAV_3301|M.avium_104 WGGGNAAGPSKGIDSGANIVGFDCSGLVLYSFAGVGIKLPHYSGSQYNLG
MSMEG_3145|M.smegmatis_MC2_155 WGGGNAAGPSRGIDSGAGTVGFDCSGLMLYMFAGVGIKLDHYSGSQYNAG
TH_0436|M.thermoresistible__bu WGGGNAAGPSRGIDSGANTVGFDCSGLVLYAFAGVGIKLPHYSGAQYNLG
MAB_2728c|M.abscessus_ATCC_199 WGGGSYNGPTRGIDSGAGTVGYDCSGLMMYGFAAVGIRLRHYTGYQYNSG
****. **::***.**. .*:*****::* **.***:* **:* *** *
Mvan_3656|M.vanbaalenii_PYR-1 RKVPSSQMQRGDLIFYGPNASQHEAMYLGDGMMIEAPYTGSVVKISPVRS
Mflv_0895|M.gilvum_PYR-GCK RKVPSSQMQRGDLIFYGPNASQHEAMYLGDGMMLEAPYTGSVVKISPVRS
MMAR_2284|M.marinum_M RKIPTSQMRRGDVIFYGPGGSQHVTLYLGNGQMLEAPDIGLKVRVAPVRT
MUL_1486|M.ulcerans_Agy99 RKIPTSQMRRGDVIFYGPGGSQHVTLYLGNGQMLEAPDIGLKVRVAPVRT
Mb1513|M.bovis_AF2122/97 RKIPSSQMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGLKVRVAPVRT
Rv1477|M.tuberculosis_H37Rv RKIPSSQMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGLKVRVAPVRT
MLBr_01812|M.leprae_Br4923 RKIPSAQMRRGDVIFYGPGGSQHVTIYLGHGQMLEAPDIGLRVRVAPVRT
MAV_3301|M.avium_104 RKIPSSQMRRGDVIFYGPGGSQHVTIYLGDGQMLEAPDIGLKVRVAPVRT
MSMEG_3145|M.smegmatis_MC2_155 RKIPSSQMRRGDMIFYGPNASQHVAMYLGNGQMLEAPYTGSHVKVSPVRT
TH_0436|M.thermoresistible__bu RKIPSAQMRRGDVIFYGPGGSQHVTIYLGNGQMIEAPYTGSHVKISPVRT
MAB_2728c|M.abscessus_ATCC_199 RKVPSAQMKRGDMIFYGPNASQHVALYLGNGQMLEAPNTGDVVKVSPVRT
**:*::**:***:*****..*** ::***.* *:*** * *:::***:
Mvan_3656|M.vanbaalenii_PYR-1 SGMTPYVTRLIEY
Mflv_0895|M.gilvum_PYR-GCK SGMTPYVTRLIEY
MMAR_2284|M.marinum_M SGMTPFVVRYIEY
MUL_1486|M.ulcerans_Agy99 SGMTPFVVRYIEY
Mb1513|M.bovis_AF2122/97 AGMTPYVVRYIEY
Rv1477|M.tuberculosis_H37Rv AGMTPYVVRYIEY
MLBr_01812|M.leprae_Br4923 SGMTPYVVRYIEY
MAV_3301|M.avium_104 SGMTPYVVRYIEW
MSMEG_3145|M.smegmatis_MC2_155 SGMTPYVTRLIEY
TH_0436|M.thermoresistible__bu SGMTPYVVRYIEW
MAB_2728c|M.abscessus_ATCC_199 SGMTPYVTRMIEW
:****:*.* **: