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ARPAAVALAITVTTVVCGVGPAASVRAEPEAPDAGTLASLIVRIAEADQSLHDLDAQIQTLREEVNKTIA DLATAHEHAARADLDAEATAVSLHDAVRAVDTALERFDRFAVATYVHGPGISLVAPDGPEDLLGNVAYAN ALHISAANAAEDLQRARTEQTNRNSAARQARQRADASLNSARRRQLDAVAALRTAQDRLAAKQTEFAALV DQRDHAVAAVNSTSLTVTRRDELILQPSITRLPRDLGAVIDSLVAIARDSTSATAEMGRAFLAQAGVGPD AVSISASAPTGELPRSVRWQASEYVVARALSQRGVPYSWGGGAATGPSRGIDTGADVVGFDCSGLILYAF AGVGIALPHYTGHQYQAGRQVPVTQMRRGDVIFFGPGGSEHVALYLGNGVMLEAPRPGQFVQVSPVRTSG MTPYAVRFIEY*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2333 | - | - | 100% (432) | NLP/P60 protein |
| M. vanbaalenii PYR-1 | Mvan_2747 | - | 3e-94 | 42.95% (475) | NLP/P60 protein |
| M. vanbaalenii PYR-1 | Mvan_3656 | - | 1e-92 | 42.73% (440) | NLP/P60 protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1513 | - | 1e-98 | 43.40% (470) | invasion protein |
| M. gilvum PYR-GCK | Mflv_3663 | - | 2e-94 | 42.65% (476) | NLP/P60 protein |
| M. tuberculosis H37Rv | Rv1477 | - | 1e-98 | 43.40% (470) | invasion protein |
| M. leprae Br4923 | MLBr_01812 | - | 3e-95 | 43.51% (439) | putative exported p60 protein homologue |
| M. abscessus ATCC 19977 | MAB_2728c | - | 3e-78 | 38.20% (466) | invasion protein Inv1 |
| M. marinum M | MMAR_2284 | iipA | 1e-93 | 43.11% (450) | invasion and intracellular persistence protein, IipA |
| M. avium 104 | MAV_3301 | - | 4e-99 | 44.30% (456) | invasion protein |
| M. smegmatis MC2 155 | MSMEG_3145 | - | 1e-95 | 42.48% (492) | secreted cell wall-associated hydrolase |
| M. thermoresistible (build 8) | TH_0436 | - | 6e-93 | 42.18% (467) | Possible inv protein |
| M. ulcerans Agy99 | MUL_1486 | - | 3e-93 | 42.39% (460) | cell wall-associated hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1513|M.bovis_AF2122/97 MRRNRRGSPARPAARFVRPAIPS-ALSVALLVCTPGLATADP-QTDTIAA
Rv1477|M.tuberculosis_H37Rv MRRNRRGSPARPAARFVRPAIPS-ALSVALLVCTPGLATADP-QTDTIAA
MMAR_2284|M.marinum_M MRRTRRSSASRSAARLVRPAIPS-VVSVALLVSVPAVVNADS-RTDSIAA
MUL_1486|M.ulcerans_Agy99 MRRTRRSSASRSAARLVRPAIPS-VVSVALLVTVPAVANADS-RTDSIAA
MLBr_01812|M.leprae_Br4923 MKRPRRGSVSRPTARFVRPAIPS-LVSAALLVSLPVLATADP-DGDNLGT
MAV_3301|M.avium_104 --------------------MPS-VLSVALLICTPGLAQADP-AADNLAA
MSMEG_3145|M.smegmatis_MC2_155 MRRTVRALATRVHGRVCAVPLVV-GMLLATALYGGGPAAADPAAPDNLAT
TH_0436|M.thermoresistible__bu -------------------------MALATTINCGSVAVADPGDPNEVAT
Mflv_3663|M.gilvum_PYR-GCK MRRTPGGAS---ASRLCAASLAF-GMVLTVPNLAPHLALAQPAQADGIAR
MAB_2728c|M.abscessus_ATCC_199 MKRTVNDRFAVRGKRTVATALMVPPLLVAGLMMFPTTVAVTSAEPNDMAS
Mvan_2333|M.vanbaalenii_PYR-1 MARP----------AAVALAITVTTVVCGVGPAASVRAEPEAPDAGTLAS
: . . . :.
Mb1513|M.bovis_AF2122/97 LIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAEDDLEVS
Rv1477|M.tuberculosis_H37Rv LIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAEDDLEVS
MMAR_2284|M.marinum_M LIADVARANQRLDDLSAAVELEQEGVNKAMVAVETARDEAAAAEHELEAS
MUL_1486|M.ulcerans_Agy99 LIADVARANQRLDDLSAAVELEQEGVNKAMVAVETARDEAAAAEHELEAS
MLBr_01812|M.leprae_Br4923 LIADVAKVNQRLEDLGAAIETEEQSVNKAMVSVEMARDNAVAAEHDCEVS
MAV_3301|M.avium_104 LIANVAKANQRLQNLSAEIQTEQESVNKALVDVETARDNAAAAQHDLEAS
MSMEG_3145|M.smegmatis_MC2_155 LVAKVASADQKLQELGAAIQTQQETVNKAIVDVQAARDAAAAAQRELEAG
TH_0436|M.thermoresistible__bu LVAAVANVNQKLQELGAAVQQKKESVNKALVDLQEARDAAEAAQAELKAA
Mflv_3663|M.gilvum_PYR-GCK LVTDVANVNQQLQDLGAQIQMQQESVNKAILDVQTARDDAAAAQLDVDAS
MAB_2728c|M.abscessus_ATCC_199 LITQLADTNQQIEQLTADVQTQQESINKGLVDLQAARDNAASAAAQVAEG
Mvan_2333|M.vanbaalenii_PYR-1 LIVRIAEADQSLHDLDAQIQTLREEVNKTIADLATAHEHAARADLDAEAT
*:. :* .:* :.:* :: .: :** : : *:: * * :
Mb1513|M.bovis_AF2122/97 QRAVKDANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEIIATVTAA
Rv1477|M.tuberculosis_H37Rv QRAVKDANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEIIATVTAA
MMAR_2284|M.marinum_M QQAVKDANAAIAAAQHRFDTFAAATYMNGPSDSYLTATSPDEIIAAATAA
MUL_1486|M.ulcerans_Agy99 QQAVKDANAAIAAAQHRFDTFAAATYMNGPSDSYLTATSPDEIIAAATAA
MLBr_01812|M.leprae_Br4923 QQSVKDANTAINAAQHRFDSFAAATYMNGPSGSYLTATSPDDIIATATAA
MAV_3301|M.avium_104 QQAVKDANAAIAGAQRRFDTFAAAAYMNGPSNSYLTARNPDDIIATEAAA
MSMEG_3145|M.smegmatis_MC2_155 QRGVADANAAIEAAQKRFDSFAAATYMNGPSRSYLTATDPADIVNTTATG
TH_0436|M.thermoresistible__bu QESVETANTAIEDAQKRFDTFAAATYVNGPSVSYLTASDPADVLDTAVAG
Mflv_3663|M.gilvum_PYR-GCK AQRVKDANAAIAAAQARFDKFAAAMYVRGPSSSYLTASDPTDILHTAAAG
MAB_2728c|M.abscessus_ATCC_199 QRAVDAANGAIEEAQGKFDRMAAATYMAGPSTSYLTATNPDDVVRLASVT
Mvan_2333|M.vanbaalenii_PYR-1 AVSLHDAVRAVDTALERFDRFAVATYVHGPGISLVAPDGPEDLLGNVAYA
: * *: * :** :*.* *: **. * ::. .* :::
Mb1513|M.bovis_AF2122/97 KTLSASSQAVMANLQRARTERVNTESAARLAKQKADKAAADAKASQDAAV
Rv1477|M.tuberculosis_H37Rv KTLSASSQAVMANLQRARTERVNTESAARLAKQKADKAAADAKASQDAAV
MMAR_2284|M.marinum_M KTLAASAQTVMANLERARTRQVNKESASRLAKQKADKAAEEAKTSQDAAV
MUL_1486|M.ulcerans_Agy99 KTLAASAQTVMANLERARTRQVNKESASRLAEQKADKAAEDAKTSQDAAV
MLBr_01812|M.leprae_Br4923 RTLTASSQAVMANLQRARTEQVNKESAARLAKQKADKAADDAKASMDAAV
MAV_3301|M.avium_104 KTLTASSQTVMAKLQQARTEQVNRESAARLAKQNADKAAADAKASQDAAV
MSMEG_3145|M.smegmatis_MC2_155 QALIASSQQVMAKLQRARTEQVNRESAARLAKEKADQAARDAESSQDNAV
TH_0436|M.thermoresistible__bu QVLATSAQQVMKNLQQARTEQVNKESLARLAKQRADEKLAAAQASQEAAV
Mflv_3663|M.gilvum_PYR-GCK QSLSISSQKVMADLQRARTEQVNKESAARLAKQKADDAVKAAETSQQDAV
MAB_2728c|M.abscessus_ATCC_199 KSVEASSQTVMDNLRRARTEQVNKQSQARAIQEKADQAAADAQQQQDDLV
Mvan_2333|M.vanbaalenii_PYR-1 NALHISAANAAEDLQRARTEQTNRNSAARQARQRADASLNSARRRQLDAV
. : *: . .*.:***.:.* :* :* .:.** *. *
Mb1513|M.bovis_AF2122/97 AALTETRRKFDEQREEVQRLAAERDAAQARLQAARLVAWSSE---GG--Q
Rv1477|M.tuberculosis_H37Rv AALTETRRKFDEQREEVQRLAAERDAAQARLQAARLVAWSSE---GG--Q
MMAR_2284|M.marinum_M TALTDTQRKFDQQREEVNRLAAERDEAEAKLQAARLVAWSSA---GA--E
MUL_1486|M.ulcerans_Agy99 TALTDTQRKFDQQREEVNRLAAERDEAEAKLQAARLVAWSSA---GA--E
MLBr_01812|M.leprae_Br4923 AALTASKRKFDEQRDEVNRLAAERDEAQARLEVAQIAAATWVPGMGG--H
MAV_3301|M.avium_104 AALTNSRQKFDEQREQMIRLATERDQAQAKLEAAKRQLSTPG-------S
MSMEG_3145|M.smegmatis_MC2_155 AALKQAQQTFNAQQGELERLAAERAAAQAELDSVRKVSATGNAAPAA-AP
TH_0436|M.thermoresistible__bu NALTEAQETFGAQQAELQKLTAEREAAQAKLNEVRTMSAATAGATSG-AN
Mflv_3663|M.gilvum_PYR-GCK SALTKAQETFKAQQTELDRLTAERAQAQARLQQARSLAAPSSPAPSSPAP
MAB_2728c|M.abscessus_ATCC_199 SAMKDVQKKLEAQRGVAADLTAKKKSAEAQLAAARGPAYAASTATAR---
Mvan_2333|M.vanbaalenii_PYR-1 AALRTAQDRLAAKQTEFAALVDQRDHAVAAVNSTSLTVTRRD--------
*: : : :: *. :: * * : .
Mb1513|M.bovis_AF2122/97 GAPPF------------RMWDPG----SGPAGGRAWDGL-----------
Rv1477|M.tuberculosis_H37Rv GAPPF------------RMWDPG----SGPAGGRAWDGL-----------
MMAR_2284|M.marinum_M GPPPG------------AMWDPG----ARPGNGRRWDG------------
MUL_1486|M.ulcerans_Agy99 GPPPG------------AMWDPG----ARPGNGRRWDG------------
MLBr_01812|M.leprae_Br4923 GTPPFG-----------DRWEPGSPASAGPAGGRKWDG------------
MAV_3301|M.avium_104 G----------------DRWETGSAGAPAPSAGRQWDGA-----------
MSMEG_3145|M.smegmatis_MC2_155 AAAPAPAAAPAPVPNSAPAPVPGAQ-PNPQAAAGNWDRAPSGPASSGQNW
TH_0436|M.thermoresistible__bu GSAPA------------AAPTPGAA-SGTQDPARNWDRAPGGPVVPYGDP
Mflv_3663|M.gilvum_PYR-GCK AAAPT------------GAATGAGA-PAPGGSGSSWDVDP----ATGNRE
MAB_2728c|M.abscessus_ATCC_199 VINPS-------------AAIAGNGNEWTEGPAPVSSGGQ----------
Mvan_2333|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1513|M.bovis_AF2122/97 --WDPTLPMIPSANIPGDPIAVVNQVLGISATSAQVTANMGRKFLEQLGI
Rv1477|M.tuberculosis_H37Rv --WDPTLPMIPSANIPGDPIAVVNQVLGISATSAQVTANMGRKFLEQLGI
MMAR_2284|M.marinum_M --WDPTLPQIPSANIPGDPIAVVNQVLGISATSAQVTANMGRNFLQQLGI
MUL_1486|M.ulcerans_Agy99 --WDPTLPQIPSANIPGDPIAVVNQVLGISATSAQVTANMGQNFLQQLGI
MLBr_01812|M.leprae_Br4923 --WDPTLPQVPSANVPGDPIAVINQVLGYAATSTQVTASMGRNFLQQLGI
MAV_3301|M.avium_104 --WDPTLPMIPSANVPGDPIAVINQVLGISATSTQVTAGLGRNFLQQLGI
MSMEG_3145|M.smegmatis_MC2_155 AVWDPTLPAIPSAFVSGDPIAIINAVLGIASTSAQVTADMGRSFLQKLGI
TH_0436|M.thermoresistible__bu SQWDLTLPAIPSAFVSGDPIAIINASLQIAATSAQVTADLGRRFLQRLGL
Mflv_3663|M.gilvum_PYR-GCK TAWDMTLPQIPSAFVSGDPIQIINAVLKIITTSVEITQNLGRKFLQSIGL
MAB_2728c|M.abscessus_ATCC_199 --WDTTLPMIASANVPTDPTQTINMVLGIGNTAANVGQSA---VCGVIGI
Mvan_2333|M.vanbaalenii_PYR-1 ----ELILQPSITRLPRDLGAVIDSLVAIARDSTSATAEMGRAFLAQAGV
: . : :. * :: : :.. . *:
Mb1513|M.bovis_AF2122/97 LQPTDTGITNAPAGSAQGRIPRVYGRQASEYVIRRGMSQIGVPYSWGGGN
Rv1477|M.tuberculosis_H37Rv LQPTDTGITNAPAGSAQGRIPRVYGRQASEYVIRRGMSQIGVPYSWGGGN
MMAR_2284|M.marinum_M LKPTDTGITNAATGATR--IPRVYGRQASEYVIRRGMAQIGVPYSWGGGN
MUL_1486|M.ulcerans_Agy99 LKPTDTGITNAATGATR--IPRVYGRQASEYVIRRGMAQIGVPYSWGGGN
MLBr_01812|M.leprae_Br4923 LKPNDTGITNAPIGSTQGRIPRVYGRQASEYVIRRGISQIGVPYSWGGGN
MAV_3301|M.avium_104 LKPDDTGITNAAPGGVGARIPRVYGRQATEYVIRRGMSQIGVPYSWGGGN
MSMEG_3145|M.smegmatis_MC2_155 L-PTPTGFTN-------GAIPRVYGREAVEYVIRRGMSQIGVPYSWGGGN
TH_0436|M.thermoresistible__bu V-PTPTGYTNE------GGIPRVYGRQATEYVIQRAMSQIGVPYSWGGGN
Mflv_3663|M.gilvum_PYR-GCK L-PTPTGITN-------GAIPALHGRNATEYVIKRGMSQMGVPYSWGGGN
MAB_2728c|M.abscessus_ATCC_199 FCPKAAPAAAAS-GEGGEYLPKVYGRENVERVIARAGSAMGTPYSWGGGS
Mvan_2333|M.vanbaalenii_PYR-1 G-PDAVSISASAP---TGELPRSVRWQASEYVVARALSQRGVPYSWGGGA
* . : :* : * *: *. : *.*******
Mb1513|M.bovis_AF2122/97 AAGPSKGIDSGAGTVGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPS
Rv1477|M.tuberculosis_H37Rv AAGPSKGIDSGAGTVGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPS
MMAR_2284|M.marinum_M AAGPSKGIDSGAGITGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPT
MUL_1486|M.ulcerans_Agy99 AAGPSKGIDSGAGITGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPT
MLBr_01812|M.leprae_Br4923 AAGPSRGIDSGAGITGFDCSGLVLYSFAGVGIRLPHYSGSQYNLGRKIPS
MAV_3301|M.avium_104 AAGPSKGIDSGANIVGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPS
MSMEG_3145|M.smegmatis_MC2_155 AAGPSRGIDSGAGTVGFDCSGLMLYMFAGVGIKLDHYSGSQYNAGRKIPS
TH_0436|M.thermoresistible__bu AAGPSRGIDSGANTVGFDCSGLVLYAFAGVGIKLPHYSGAQYNLGRKIPS
Mflv_3663|M.gilvum_PYR-GCK AAGPSRGIDSGAGTVGFDCSGLMLYMFAGVGIKLDHYSGSQYNAGRKVPS
MAB_2728c|M.abscessus_ATCC_199 YNGPTRGIDSGAGTVGYDCSGLMMYGFAAVGIRLRHYTGYQYNSGRKVPS
Mvan_2333|M.vanbaalenii_PYR-1 ATGPSRGIDTGADVVGFDCSGLILYAFAGVGIALPHYTGHQYQAGRQVPV
**::***:**. .*:*****::* **.*** * **:* **: **::*
Mb1513|M.bovis_AF2122/97 SQMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGLKVRVAPVRTAGMTP
Rv1477|M.tuberculosis_H37Rv SQMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGLKVRVAPVRTAGMTP
MMAR_2284|M.marinum_M SQMRRGDVIFYGPGGSQHVTLYLGNGQMLEAPDIGLKVRVAPVRTSGMTP
MUL_1486|M.ulcerans_Agy99 SQMRRGDVIFYGPGGSQHVTLYLGNGQMLEAPDIGLKVRVAPVRTSGMTP
MLBr_01812|M.leprae_Br4923 AQMRRGDVIFYGPGGSQHVTIYLGHGQMLEAPDIGLRVRVAPVRTSGMTP
MAV_3301|M.avium_104 SQMRRGDVIFYGPGGSQHVTIYLGDGQMLEAPDIGLKVRVAPVRTSGMTP
MSMEG_3145|M.smegmatis_MC2_155 SQMRRGDMIFYGPNASQHVAMYLGNGQMLEAPYTGSHVKVSPVRTSGMTP
TH_0436|M.thermoresistible__bu AQMRRGDVIFYGPGGSQHVTIYLGNGQMIEAPYTGSHVKISPVRTSGMTP
Mflv_3663|M.gilvum_PYR-GCK SQMRRGDMIFYGPNASQHVAMYLGDGQMLEAPYTGSVVKISPVRTSGMTP
MAB_2728c|M.abscessus_ATCC_199 AQMKRGDMIFYGPNASQHVALYLGNGQMLEAPNTGDVVKVSPVRTSGMTP
Mvan_2333|M.vanbaalenii_PYR-1 TQMRRGDVIFFGPGGSEHVALYLGNGVMLEAPRPGQFVQVSPVRTSGMTP
:**:***:**:**..*:**::***.* *:*** * *:::****:****
Mb1513|M.bovis_AF2122/97 YVVRYIEY
Rv1477|M.tuberculosis_H37Rv YVVRYIEY
MMAR_2284|M.marinum_M FVVRYIEY
MUL_1486|M.ulcerans_Agy99 FVVRYIEY
MLBr_01812|M.leprae_Br4923 YVVRYIEY
MAV_3301|M.avium_104 YVVRYIEW
MSMEG_3145|M.smegmatis_MC2_155 YVTRLIEY
TH_0436|M.thermoresistible__bu YVVRYIEW
Mflv_3663|M.gilvum_PYR-GCK YVTRMIEW
MAB_2728c|M.abscessus_ATCC_199 YVTRMIEW
Mvan_2333|M.vanbaalenii_PYR-1 YAVRFIEY
:..* **: