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SFPYFISPEQAMRERSELARKGIARGRSVIALAYADGVLFVAENPSRSLQKVSELYDRIGFAAVGRFNEF NNLRSGGIRFADTQGYAYSRRDVTGRQLANVYAQTLGTIFTEQAKPYEVELCVAEVAHHGETKAPELYRI TYDGSIADEPHFVVMGGTTEPISTALNESYKENLSLADAVSIAVKALGAGVNGAEPRTLGPATLEVAVLD ANRPRRAFRRITGSALEALLPEVDSSESSNEAEAGAEKGSGES*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3448 | - | - | 100% (254) | 20S proteasome, A and B subunits |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2133c | prcA | 1e-110 | 81.30% (246) | proteasome (alpha subunit) PrcA |
| M. gilvum PYR-GCK | Mflv_3078 | - | 1e-127 | 90.73% (248) | 20S proteasome, A and B subunits |
| M. tuberculosis H37Rv | Rv2109c | prcA | 1e-110 | 81.30% (246) | proteasome (alpha subunit) PrcA |
| M. leprae Br4923 | MLBr_01323 | prcA | 1e-108 | 78.60% (257) | proteasome alpha-type subunit 1 |
| M. abscessus ATCC 19977 | MAB_2173 | - | 3e-94 | 68.87% (257) | proteasome (alpha subunit) PrcA |
| M. marinum M | MMAR_3084 | prcA | 1e-106 | 75.97% (258) | proteasome (alpha subunit) PrcA |
| M. avium 104 | MAV_2405 | - | 1e-105 | 76.92% (247) | peptidase, T1 family protein |
| M. smegmatis MC2 155 | MSMEG_3894 | - | 1e-117 | 86.36% (242) | proteasome alpha subunit |
| M. thermoresistible (build 8) | TH_0504 | prcA | 1e-110 | 84.26% (235) | proteasome (alpha subunit) PrcA |
| M. ulcerans Agy99 | MUL_2330 | prcA | 1e-107 | 76.36% (258) | proteasome (alpha subunit) PrcA |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2133c|M.bovis_AF2122/97 MSFPYFISPEQAMRERSELARKGIARAKSVVALAYAGGVLFVAENPSRSL
Rv2109c|M.tuberculosis_H37Rv MSFPYFISPEQAMRERSELARKGIARAKSVVALAYAGGVLFVAENPSRSL
MLBr_01323|M.leprae_Br4923 MSFPYFISPEQAMRERSELARKGIARGRSVVALAYAGGVLFVAENPSRSL
MMAR_3084|M.marinum_M MSFPYFISPEQAMRERSELARKGIARGKSVVALAFAGGVLFVAENPSRSL
MUL_2330|M.ulcerans_Agy99 MSFPYFISPEQAMRERSELARKGIARGKSVVALAFAGGVLFVAENPSRSL
MAV_2405|M.avium_104 MSFPYFISPEQAMRERSELARKGIARGKSVVALVYAGGVLFVAENPSRSL
Mvan_3448|M.vanbaalenii_PYR-1 MSFPYFISPEQAMRERSELARKGIARGRSVIALAYADGVLFVAENPSRSL
Mflv_3078|M.gilvum_PYR-GCK MSFPYFISPEQAMRERSELARKGIARGRSVIALAYADGVLFVAENPSRSL
MSMEG_3894|M.smegmatis_MC2_155 MSFPYFISPEQAMRERSELARKGIARGRSVVALAYSEGVLFVAENPSRSL
TH_0504|M.thermoresistible__bu VTFPYFISPEQAMRERSELARKGIARGRSVVVLAYADGVLFVAENPSRSL
MAB_2173|M.abscessus_ATCC_1997 MTFPYYASVEQLMRDRSELARKGISRGRSVVALTYTDGVLFVAENPSNSL
::***: * ** **:*********:*.:**:.*.:: **********.**
Mb2133c|M.bovis_AF2122/97 QKISELYDRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLA
Rv2109c|M.tuberculosis_H37Rv QKISELYDRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLA
MLBr_01323|M.leprae_Br4923 QKISELYDRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLA
MMAR_3084|M.marinum_M QKISELYDRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLA
MUL_2330|M.ulcerans_Agy99 QKISELYDRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLA
MAV_2405|M.avium_104 QKISELYDRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLA
Mvan_3448|M.vanbaalenii_PYR-1 QKVSELYDRIGFAAVGRFNEFNNLRSGGIRFADTQGYAYSRRDVTGRQLA
Mflv_3078|M.gilvum_PYR-GCK QKVSELYDRVGFAAVGRFNEFNNLRSGGIRFADTQGYAYSRRDVTGRQLA
MSMEG_3894|M.smegmatis_MC2_155 QKVSELYDRVGFAAVGRFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLA
TH_0504|M.thermoresistible__bu QKVSELYDRVGFAAVGRFNEFNNLRRGGIQFADTQGYAYSRRDVTGRQLA
MAB_2173|M.abscessus_ATCC_1997 QKVSEVYDRVGFAAVGKFNEFDRLRRGGIQWADMRGYAYDRRDVSGRQLA
**:**:***:****.*:****:.** ***::** :****.****:*****
Mb2133c|M.bovis_AF2122/97 NVYAQTLGTIFTEQAKPYEVELCVAEVAHYGETKPPELYRITYDGSIADE
Rv2109c|M.tuberculosis_H37Rv NVYAQTLGTIFTEQAKPYEVELCVAEVAHYGETKRPELYRITYDGSIADE
MLBr_01323|M.leprae_Br4923 NVYAQTLGTIFTEQAKPYEVELCVAEVAHYGETKPPELYRITYDGSINDE
MMAR_3084|M.marinum_M NVYAQTLGTIFTEQAKPYEVELCVAEVAHYGESKAPELYRITYDGSIADE
MUL_2330|M.ulcerans_Agy99 NVYAQTLGTIFTEQAKPYEVELCVAEVAHYGETKAPELYRITYDGSIADE
MAV_2405|M.avium_104 NVYAQTLGTIFTEQAKPYEVELCVAEVAHYGETKPPELYRITYDGSIADE
Mvan_3448|M.vanbaalenii_PYR-1 NVYAQTLGTIFTEQAKPYEVELCVAEVAHHGETKAPELYRITYDGSIADE
Mflv_3078|M.gilvum_PYR-GCK NVYAQTLGTIFTEQAKPYEVELCVAEVAHYGETKAPELYRITYDGSIADE
MSMEG_3894|M.smegmatis_MC2_155 NVYAQTLGTIFTEQAKPYEVELCVAEVAHYGETKAPELYRITYDGSIADE
TH_0504|M.thermoresistible__bu NVYAQTLGTIFTEQPKPYEVELCIAEVAHYGESKPPELYRITYDGSIADE
MAB_2173|M.abscessus_ATCC_1997 NIYAEALGTIFNEQAKPYEVELCVGEVAHYGRDTEPVLYRITYDGSIADE
*:**::*****.**.********:.****:*. . * ********** **
Mb2133c|M.bovis_AF2122/97 PHFVVMGGTTEPIANALKESYAENASLTDALGIAVAALRAGSADTSGGDQ
Rv2109c|M.tuberculosis_H37Rv PHFVVMGGTTEPIANALKESYAENASLTDALRIAVAALRAGSADTSGGDQ
MLBr_01323|M.leprae_Br4923 PHFMVMGGTTESIANALKESYAENASLTDALGIAVAALRAGSADAAGSDQ
MMAR_3084|M.marinum_M PHFVVMGGTTEPITTALKNTYTENADLPDALGIAVEALRAGSAENSSNDQ
MUL_2330|M.ulcerans_Agy99 PHFVVMGGTTEPITTALKNTYTENADLPDALDIAVEALRAGSAENSSNDQ
MAV_2405|M.avium_104 PHFVVMGGTTEPITTALKDSYAENANLREATRIAVRALRAGS-ESSNGDQ
Mvan_3448|M.vanbaalenii_PYR-1 PHFVVMGGTTEPISTALNESYKENLSLADAVSIAVKALGAGV---NGAEP
Mflv_3078|M.gilvum_PYR-GCK PHFVVMGGTTEPIATALNESYAENASLEDAVRIAVAALGAGG---NGAEP
MSMEG_3894|M.smegmatis_MC2_155 PHFVVMGGTTEPIIAALNESYTENASLQDAVEIAVKALSASA---EGAEP
TH_0504|M.thermoresistible__bu PHFVVMGGTTEPIIAALNESYTENADLTTAMRIAVNALQAAP---EGGEQ
MAB_2173|M.abscessus_ATCC_1997 PHWVVMGGNTEPVINSLKESYVEDSALKDAVGFAVKALQAGTAGANGSEG
**::****.**.: :*:::* *: * * :** ** *. . :
Mb2133c|M.bovis_AF2122/97 PTLGVASLEVAVLDANRPRRAFRRITGSALQALLVDQES-----------
Rv2109c|M.tuberculosis_H37Rv PTLGVASLEVAVLDANRPRRAFRRITGSALQALLVDQES-----------
MLBr_01323|M.leprae_Br4923 PTLGVASLEVAVLDANRPRRAFRRIIGSGLEALLREKDSKGSKGAQNPKG
MMAR_3084|M.marinum_M PVLGVASLEAAILDANKPRRAFRRLTRSTLETLLQERDSKESAESEEPKE
MUL_2330|M.ulcerans_Agy99 PVLGVASLEAAILDANKPRRAFRRLTRSTLETLLQERDSKESAESEEPIE
MAV_2405|M.avium_104 SALDVGSLEVAILDVNRPRRAFRRINRPTLENLLRELDSNGSDGNGDAPE
Mvan_3448|M.vanbaalenii_PYR-1 RTLGPATLEVAVLDANRPRRAFRRITGSALEALLPEVDSSESSNEAEAGA
Mflv_3078|M.gilvum_PYR-GCK RTLGPSTLEVAILDANRPRRAFRRITGAALEALLPQADTKDDSQDSEGAA
MSMEG_3894|M.smegmatis_MC2_155 RSLGPSTLEVAILDAGRPRRAFRRITGAALEALLPEQ-----PQQADSGD
TH_0504|M.thermoresistible__bu RVLGPETLEVAVLDATKRRRAFRRLTGSVLEELLPKPDPGTPPQQEPPQP
MAB_2173|M.abscessus_ATCC_1997 RALG--GLEVAVLEQSRPRRAFRRIKGAALEALLPEDFSPGQTEGGGDPA
*. **.*:*: : ******: . *: ** .
Mb2133c|M.bovis_AF2122/97 --------PQSDGESSG
Rv2109c|M.tuberculosis_H37Rv --------PQSDGESSG
MLBr_01323|M.leprae_Br4923 ARDSKN--SKSYGESTD
MMAR_3084|M.marinum_M SEEGKKTGKKSDADSSD
MUL_2330|M.ulcerans_Agy99 SEEGKKTGKKSDADSSD
MAV_2405|M.avium_104 LNGG----------SSD
Mvan_3448|M.vanbaalenii_PYR-1 EKGSGES----------
Mflv_3078|M.gilvum_PYR-GCK EPDA-------------
MSMEG_3894|M.smegmatis_MC2_155 KPTE-------------
TH_0504|M.thermoresistible__bu AR---------------
MAB_2173|M.abscessus_ATCC_1997 PESGDSKDAKDN-----