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SARAGIVVTGTEVLTGRVQDQNGPWLADRLLELGVELGHITLCGDRPADIEAQLRFLAGQGVDLIITSGG LGPTADDMTVEIVSRFCGRELVLDAAVEARIGEIVKGMMARFPGVDADAVLAANRKQALVPAGAVVLDPV GTAPGVVVAGSPTVVVLPGPPRELQPMWHAAVATDAVQTAIAGRTRYQQQTIRMFGLPESGLADTLRDAE KTVADFDRLEITTCLRRGELEIVTRFEPRDTATYAALEGLLRDRHAREIFSTDGALVDDQIAELLAGRSI ATAESCTAGMLAARLTERAGSSAYVAGGVVAYSNAAKTELLGVDAGLIERHGAVSEPVAEAMAAGALQRF GADTAVAITGIAGPGGGTPTKPVGTVCFSVALAGGASVTRATRLPGNRSDIRERSTTVAMHLLRRALTGG G*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2999 | - | - | 100% (422) | competence damage-inducible protein A |
| M. vanbaalenii PYR-1 | Mvan_2396 | - | 1e-21 | 42.50% (160) | CinA domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4841 | - | 1e-05 | 28.57% (154) | molybdenum cofactor synthesis domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1936 | cinA | 1e-178 | 73.29% (423) | competence damage-inducible protein A |
| M. gilvum PYR-GCK | Mflv_3280 | - | 0.0 | 83.89% (422) | competence damage-inducible protein A |
| M. tuberculosis H37Rv | Rv1901 | cinA | 1e-178 | 73.29% (423) | competence damage-inducible protein A |
| M. leprae Br4923 | MLBr_02015 | cinA | 1e-172 | 72.38% (420) | competence damage-inducible protein A |
| M. abscessus ATCC 19977 | MAB_2443 | - | 1e-120 | 53.11% (418) | competence damage-inducible protein A |
| M. marinum M | MMAR_2796 | cinA | 1e-180 | 75.12% (422) | competence/damage-inducible protein CinA |
| M. avium 104 | MAV_2800 | - | 1e-177 | 74.42% (430) | competence damage-inducible protein A |
| M. smegmatis MC2 155 | MSMEG_3512 | - | 1e-165 | 70.59% (425) | competence damage-inducible protein A |
| M. thermoresistible (build 8) | TH_0499 | cinA | 1e-175 | 72.71% (425) | PROBABLE CINA-LIKE PROTEIN CINA |
| M. ulcerans Agy99 | MUL_2956 | cinA | 1e-178 | 75.12% (422) | competence damage-inducible protein A |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2999|M.vanbaalenii_PYR-1 ------MSARAGIVVTGTEVLTGRVQDQNGPWLADRLLELGVELGHITLC
Mflv_3280|M.gilvum_PYR-GCK ------MSARAGIVVTGTEVLTGRVQDLNGPWLADRLLELGVELSHITLC
MMAR_2796|M.marinum_M ----MAVSARAGIVVTGTEVLTGRVQDRNGPWIADQLLELGVELAHITIC
MUL_2956|M.ulcerans_Agy99 MRRLRPVSARAGIVVTGTEVLTGRVQDRNGPWIADQLLELGVELAHITIC
MAV_2800|M.avium_104 ----MPVSARAGIVVTGTEVLTGRVQDANGPWIADRLLELGVELAHITIC
Mb1936|M.bovis_AF2122/97 ----MAVSARAGIVITGTEVLTGRVQDRNGPWIADRLLELGVELAHITIC
Rv1901|M.tuberculosis_H37Rv ----MAVSARAGIVITGTEVLTGRVQDRNGPWIADRLLELGVELAHITIC
MLBr_02015|M.leprae_Br4923 MRRLMVVSARAGIVVTGTEILTGRVRDRNGPWLADRLLELGVKLAHITIC
MSMEG_3512|M.smegmatis_MC2_155 ---MHVVSARAGIVITGTEVLTGRIQDLNGPWLADQLLELGVELAHITIC
TH_0499|M.thermoresistible__bu ------VSTRAGIVVTGTEVLTGRIQDQNGPWLADRLLELGVELAHVTIC
MAB_2443|M.abscessus_ATCC_1997 -------MLRAGIVVTGTEVLTGRVADANGPWLAEHLRKVGVDVAHLCVC
*****:****:****: * ****:*::* ::**.:.*: :*
Mvan_2999|M.vanbaalenii_PYR-1 GDRPADIEAQLRFLAGQGVDLIITSGGLGPTADDMTVEIVSRFCGRELVL
Mflv_3280|M.gilvum_PYR-GCK GDRPADIEAQLRFLADQGVDLIITSGGLGPTADDMTVEVVSRFCGRELEL
MMAR_2796|M.marinum_M GDRPADIEAQLRFMADQDLDLIITSGGLGPTADDMTVEVVARFCGRELIL
MUL_2956|M.ulcerans_Agy99 GDRPADIGAQLRFMADQDLDLIITSGGLGPTADDMTVEVVARFCGRELIL
MAV_2800|M.avium_104 GDRPHDIEAQLRFLADQGVDLIVTSGGLGPTADDMTVEVVARFCGRELVL
Mb1936|M.bovis_AF2122/97 GDRPADIEAQLRFMAEQGVDLIVTSGGLGPTADDMTVEVVARYCGRELVL
Rv1901|M.tuberculosis_H37Rv GDRPADIEAQLRFMAEQGVDLIVTSGGLGPTADDMTVEVVARYCGRELVL
MLBr_02015|M.leprae_Br4923 GDCPADIEAQLRFMAEAGVDLIVTSGGLGPTADDMTVEVVARFCNREMVL
MSMEG_3512|M.smegmatis_MC2_155 GDRPGDIAAQLKFLADEGVDLIITSGGLGPTADDLTVATVAEFCGRELVL
TH_0499|M.thermoresistible__bu GDRPADLEAQLRFHADTGVDLLITTGGLGPTADDLTVETVARFCGRELML
MAB_2443|M.abscessus_ATCC_1997 GDRREDLLAQLKFLTDQGVDLIVTSGGLGPTADDMTLPTVAEFAGTTLIF
** *: ***:* : .:**::*:*********:*: *:.:.. : :
Mvan_2999|M.vanbaalenii_PYR-1 DAAVEARIGEIVKGMMARFPGVD-------ADAVLAANRKQALVPAGAVV
Mflv_3280|M.gilvum_PYR-GCK DPGLETRIGEIVTRLMARFPDVD-------PAAVIAANRKQAFVPDGAVI
MMAR_2796|M.marinum_M DAELEDTIANILKRLMARNPGFD----PGNFDSVRAANQKQAMIPAGAQV
MUL_2956|M.ulcerans_Agy99 DTKLEDTIANILKRLMARNPGFD----PGNFDSVLAANQKQAMVPAGAQV
MAV_2800|M.avium_104 DAEVEEKIANILKKLMARNPAFQSALDPGTFESLRAANRKQAMVPAGAQV
Mb1936|M.bovis_AF2122/97 DDELENRIANILKKLMGRNPAIE----PANFDSIRAANRKQAMIPAGSQV
Rv1901|M.tuberculosis_H37Rv DDELENRIANILKKLMGRNPAIE----PANFDSIRAANRKQAMIPAGSQV
MLBr_02015|M.leprae_Br4923 DVELENKIAAILNSLMTR---FN----PGDFEAVRAANRKQAMIPAGSQV
MSMEG_3512|M.smegmatis_MC2_155 DEALEERIAAILRRLTAGRNLSE-----ENFEAVRTANRKQALIPQGAEI
TH_0499|M.thermoresistible__bu DAVVEEKIAAILRTMMGRIGPNETGAGMTDFEAVRAANRKQAMVPAGATV
MAB_2443|M.abscessus_ATCC_1997 DDVLETAIMDRLRPMANRWENVD-------WEALRVGIAKQALVPARGQI
* :* * : : : :: .. ***::* . :
Mvan_2999|M.vanbaalenii_PYR-1 LDPVGTAPGVVVAGSP---TVVVLPGPPRELQPMWHAAVATDAVQTAIAG
Mflv_3280|M.gilvum_PYR-GCK LDPVGTAPGVVVPGTP---TVVVLPGPPRELQPMWQAAVAADAVQTAIAD
MMAR_2796|M.marinum_M INPVGTAPGLVVPGKP---AVMVLPGPPRELQPMWHSAIQMPGAQEAIAG
MUL_2956|M.ulcerans_Agy99 INPVGTAPGLVVPGKP---AVVVLPGPPRELQPMWHSAIQMPGAQEAIAG
MAV_2800|M.avium_104 LDPVGTAPGVVVPGKP---AVIVLPGPPRELQPMWHTAIQTPAAQQAIAG
Mb1936|M.bovis_AF2122/97 IDPVGTAPGLVVPGRP---AVMVLPGPPRELQPIWSKAIQTAPVQDAIAG
Rv1901|M.tuberculosis_H37Rv IDPVGTAPGLVVPGRP---AVMVLPGPPRELQPIWSKAIQTAPVQDAIAG
MLBr_02015|M.leprae_Br4923 LDPIGTAPGLVVPGKP---TVMVLPGPPSELQPMWRRAVMTAATREAIAD
MSMEG_3512|M.smegmatis_MC2_155 LEPVGTAPGVVVPGSPGSPTVVVLPGPPRELQPMWLRAVDTEPVRRAIAG
TH_0499|M.thermoresistible__bu LDPVGTAPGLVVAGTP---TVVVLPGPPRELQPMWRRALTTAEVQRAIAG
MAB_2443|M.abscessus_ATCC_1997 LDPVGTAPGAIMSAGD--VLIVVLPGPPHELQRMWQTAVNAAPFRALVGD
::*:***** ::.. ::****** *** :* *: : :..
Mvan_2999|M.vanbaalenii_PYR-1 -RTRYQQQTIRMFGLPESGLADTLRDAEKTVADFDRLEITTCLRRGELEI
Mflv_3280|M.gilvum_PYR-GCK -RVSYRQDTVRMFGLPESGLAETLREAEGSVAGFDRLEITTCLRRGELEI
MMAR_2796|M.marinum_M -RTTYRQETIRMFGLPESGLAETLRSAETTIPDFGALEITTCLRRGEIEM
MUL_2956|M.ulcerans_Agy99 -RTTYRQETIRMFGLPESGLAATLRSAETTIPDFGALEITTCLRRGEIEM
MAV_2800|M.avium_104 -RTVYRQEMLRMFGLPESGLAETLREAEAAVPGFGQLEITTCLRRGEIEM
Mb1936|M.bovis_AF2122/97 -RTTYRQETIRIFGLPESSLADTLRDAEAAIPGFDLVEITTCLRRGEIEM
Rv1901|M.tuberculosis_H37Rv -RTTYRQETIRIFGLPESSLADTLRDAEAAIPGFDLVEITTCLRRGEIEM
MLBr_02015|M.leprae_Br4923 -RTIYRQQTLRMFGLSESGLAETLRDAQASIPGFDALEITTCLRRGEIEM
MSMEG_3512|M.smegmatis_MC2_155 -RTVYRQEMIRMFGLAESGLAETLRAAEQAISGFDRLEITTCLRRGELEI
TH_0499|M.thermoresistible__bu -RTHYRQDTVRMFGLPESRLAETLRDARERIPGFDALEITTCLRRGEVEM
MAB_2443|M.abscessus_ATCC_1997 DAAAIEETVLRLYGITEPDIAETLRLAENALGGLAALEITTCLRRSEVEV
. .: :*::*:.*. :* *** *. : .: :********.*:*:
Mvan_2999|M.vanbaalenii_PYR-1 VTRFEPRDTATYAALEGLLRDRHAREIFSTDGALVDDQIAELLAGRSIAT
Mflv_3280|M.gilvum_PYR-GCK VTRYEPRDADAYDGLLNMLRDKHSRELFSEDGALVDDQVAALLAGRTIAT
MMAR_2796|M.marinum_M VTRYEPGAADTYAQVARLLRDRHGDQIYSEDGSQVDDLVARLLADRRIAT
MUL_2956|M.ulcerans_Agy99 VTRYELGAADTYAQVARLLRDRHGDQIYSEDGSQVDDLVARLLADRRIAT
MAV_2800|M.avium_104 VTRYEPTAATAYAQLTKLLRDKHGDQLYSEDGSRVDDLVARLLAGRRIAT
Mb1936|M.bovis_AF2122/97 VTRFEPNAAQVYTQLARLLRDRHGHQVYSEDGASVDELVAKLLTGRRIAT
Rv1901|M.tuberculosis_H37Rv VTRFEPNAAQVYTQLARLLRDRHGHQVYSEDGASVDELVAKLLTGRRIAT
MLBr_02015|M.leprae_Br4923 VTRYEPDVVNVYVELTQLLRDRHGHQLYSEDGARVDDLIAHLLAGRRIAT
MSMEG_3512|M.smegmatis_MC2_155 VTRYEPAAADAYGQLLDVLRDRHGDAVYSEDGSTVDQQVAALLAGRRIAT
TH_0499|M.thermoresistible__bu VTRYEPAAAPSYAELVELLIERHPREVFSTDGALVDEQVAELLRGRRLAV
MAB_2443|M.abscessus_ATCC_1997 VTRFDSSARSVWQGLYEFIRARHGVALFSSDGSTVDEVVAALLHGRRLAV
***:: : : .: :* ::* **: **: :* ** .* :*.
Mvan_2999|M.vanbaalenii_PYR-1 AESCTAGMLAARLTERAGSSAYVAGGVVAYSNAAKTELLGVDAGLIERHG
Mflv_3280|M.gilvum_PYR-GCK AESCTAGLLAARLTDRAGSSAYVAGGVVSYSNDAKTDLLGVDAELIAAHG
MMAR_2796|M.marinum_M AESCTAGLLAARLTDRPGSSGYVMGGVVSYSNEAKAELLGVDPALIEMHG
MUL_2956|M.ulcerans_Agy99 AESCTAGLLAARLTDRPGSSAYVMGGVVSYSNEAKAELLGVDPALIEMHG
MAV_2800|M.avium_104 AESCTAGLLAARLTDRPGSSDYVAGGVVAYSNEAKAELLGVDPALIETHG
Mb1936|M.bovis_AF2122/97 AESCTAGLLAARLTDRPGSSKYVAGAVVAYSNEAKAQLLGVDPALIEAHG
Rv1901|M.tuberculosis_H37Rv AESCTAGLLAARLTDRPGSSKYVAGAVVAYSNEAKAQLLGVDPALIEAHG
MLBr_02015|M.leprae_Br4923 AESCTAGLLAARLTERPGSSDYVAGALVAYSNEAKVTLLGVDPALIAEHG
MSMEG_3512|M.smegmatis_MC2_155 AESCTAGLLAARLTDQPGASEYMMGGIVAYANTPKAEMLNVDPVLIAEHG
TH_0499|M.thermoresistible__bu AESCTAGLLAARLTERPGASAYLAGGVVAYANDAKTDLLEVAPALLESFG
MAB_2443|M.abscessus_ATCC_1997 AESCTAGLLGARIADVPGSSAYFLGGVISYANDVKVGQLCVDPDLLASHG
*******:*.**::: .*:* *. *.:::*:* *. * * . *: .*
Mvan_2999|M.vanbaalenii_PYR-1 AVSEPVAEAMAAGALQRFGADTAVAITGIAGPGGGTPTKPVGTVCFSVAL
Mflv_3280|M.gilvum_PYR-GCK AVSEPVAEAMAAGALQRFGADTAVAITGIAGPGGGTPAKPVGTVCFSVAL
MMAR_2796|M.marinum_M AVSEPVAQAMAAGALQRFGADTAVAITGIAGPGGGTEQKPVGTVCFCVLV
MUL_2956|M.ulcerans_Agy99 AVSEPVAQAMAAGAFQRFGADTAVAITGIAGPGGGTEQKPVGTVCFCVLV
MAV_2800|M.avium_104 AVSEPVAQAMAAGARQRFAADTAVAITGIAGPGGGTEEKPVGTVCFSVQV
Mb1936|M.bovis_AF2122/97 AVSEPVAQAMAAGALQGFGADTATAITGIAGPSGGTPEKPVGTVCFTVLL
Rv1901|M.tuberculosis_H37Rv AVSEPVAQAMAAGALQGFGADTATAITGIAGPSGGTPEKPVGTVCFTVLL
MLBr_02015|M.leprae_Br4923 EVSEPVVEAMAAGALQRFDVDTAAAISGIAGPGGGTAEKPIGTVCFTVML
MSMEG_3512|M.smegmatis_MC2_155 AVSEPVAEAMATGAMHHFEADTAVAITGIAGPGGGSTEKPVGTVCFAVRA
TH_0499|M.thermoresistible__bu AVSEPVAEAMAAGVLRRFGADTAVAVTGIAGPGGGSPDKPVGTVCFAVLL
MAB_2443|M.abscessus_ATCC_1997 AVSPEVAEAMADGALKALGADIAVSTTGVAGPGGGSPDKPVGTVCFCAKT
** *.:*** *. : : .* *.: :*:***.**: **:***** .
Mvan_2999|M.vanbaalenii_PYR-1 A----GGASVTRATRLPGNRSDIRERSTTVAMHLLRRALTGGG----
Mflv_3280|M.gilvum_PYR-GCK A----DGTFLTRTSQLPGNRSDVRERSTTVAMHLLRRALSGGG----
MMAR_2796|M.marinum_M G----DGRNVTRTLRLPGNRSDIRERSTTVAMHLLRRALSE------
MUL_2956|M.ulcerans_Agy99 G----DGRNVTRTLRLPGNRSDIRERSTTVAMHLLRRALSE------
MAV_2800|M.avium_104 GPPGATARSDTRTLRLPGNRLDIRERSTTVAMHLLRRLLTDA-----
Mb1936|M.bovis_AF2122/97 D----DGRTTTRTVRLPGNRSDIRERSTTVAMHLLRRTLSGIPGSP-
Rv1901|M.tuberculosis_H37Rv D----DGRTTTRTVRLPGNRSDIRERSTTVAMHLLRRTLSGIPGSP-
MLBr_02015|M.leprae_Br4923 AD---GGPTLTRTLRLPGNRSDIRERSTTVAMHLLRHALSDTDSVP-
MSMEG_3512|M.smegmatis_MC2_155 E-----GASITRTLLLPGNRSDIRERSTTVAMHLLRRALRGESD---
TH_0499|M.thermoresistible__bu D----DGRKAARTVRLPGGRADVRERSTTVALHLLRRALLEAAPAGA
MAB_2443|M.abscessus_ATCC_1997 A----AGEKAELRVVIPGNRNQIRERATTVALHLLRRLLS-------
. :**.* ::***:****:****: *