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MSRLAGLFDSCRAEGRSALIGYLPTGFPDVETSIAAMVALVESGCDLIEVGIAYSDPGMDGPTIAAATEV ALRGGVRVRDTFRAVEAITNAGGRAVVMTYWNPVLSKGVDAFARDLASAGGLGLITPDLIPDEADEWLAA SEAHDLDRIFVVAPSSTPQRLAETVQASRGFVYAASTMGVTGARDAVSNAAPELVRRIKGISDIPVGVGL GVRSREQAAEIASYADGVIVGSALVSALKEGIPAVRSLTEELADGVRQRITA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2818 | trpA | - | 100% (262) | tryptophan synthase subunit alpha |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1639 | trpA | 1e-116 | 80.46% (261) | tryptophan synthase subunit alpha |
| M. gilvum PYR-GCK | Mflv_3598 | trpA | 1e-134 | 91.22% (262) | tryptophan synthase subunit alpha |
| M. tuberculosis H37Rv | Rv1613 | trpA | 1e-116 | 80.46% (261) | tryptophan synthase subunit alpha |
| M. leprae Br4923 | MLBr_01273 | trpA | 1e-112 | 77.91% (258) | tryptophan synthase subunit alpha |
| M. abscessus ATCC 19977 | MAB_2643c | trpA | 1e-105 | 74.61% (256) | tryptophan synthase subunit alpha |
| M. marinum M | MMAR_2415 | trpA | 1e-116 | 80.62% (258) | tryptophan synthase, alpha subunit TrpA |
| M. avium 104 | MAV_3173 | trpA | 1e-114 | 79.77% (262) | tryptophan synthase subunit alpha |
| M. smegmatis MC2 155 | MSMEG_3221 | trpA | 1e-120 | 81.30% (262) | tryptophan synthase subunit alpha |
| M. thermoresistible (build 8) | TH_1074 | trpA | 1e-123 | 83.59% (262) | Probable tryptophan synthase, alpha subunit trpA |
| M. ulcerans Agy99 | MUL_1593 | trpA | 1e-116 | 80.62% (258) | tryptophan synthase subunit alpha |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2818|M.vanbaalenii_PYR-1 --------MSRLAGLFDSCRAEGRSALIGYLPTGFPDVETSIAAMVALVE
Mflv_3598|M.gilvum_PYR-GCK --------MSRLAGLFDSCRAEGRSGLIGYLPTGFPDVDTSIQAMVALVE
TH_1074|M.thermoresistible__bu --------MSRLAPLFESCRGEQRAALIGYLPTGFPDVATSISAMTALVE
MSMEG_3221|M.smegmatis_MC2_155 --------MSRLGAMFDSCRAEDRAALIGYLPTGFPDVPTSIAAMTALVE
Mb1639|M.bovis_AF2122/97 MVAVEQSEASRLGPVFDSCRANNRAALIGYLPTGYPDVPASVAAMTALVE
Rv1613|M.tuberculosis_H37Rv MVAVEQSEASRLGPVFDSCRANNRAALIGYLPTGYPDVPASVAAMTALVE
MLBr_01273|M.leprae_Br4923 MMVLEQSETSRLGPVFDSCRADNRAALIGYLPTGYPDVPTSVDAMIELVE
MMAR_2415|M.marinum_M -MTVEQREASRLGPLFDSCRAENRAALIGYLPTGYPDVNTSVRAMTELVE
MUL_1593|M.ulcerans_Agy99 -MTVEQREASRLGPLFDSCRAENRAALIGYLPTGYPDVNTSVRAMTELVE
MAV_3173|M.avium_104 -MTVKQSQASRLGPIFEACRDDDRAALIGYLPTGYPDVPTSVQAMVALVE
MAB_2643c|M.abscessus_ATCC_199 -----MTQPGRLTEVFDKCRAEERAALIGYLPNGYPDLDTSIELMTTLVR
.** :*: ** : *:.******.*:**: :*: * **.
Mvan_2818|M.vanbaalenii_PYR-1 SGCDLIEVGIAYSDPGMDGPTIAAATEVALRGGVRVRDTFRAVEAITNAG
Mflv_3598|M.gilvum_PYR-GCK SGCDIVEVGVAYSDPGMDGPVIAAATEVALRGGVRVHDAFRAVEAISNAG
TH_1074|M.thermoresistible__bu SGCDLVEVGVPYSDPGMDGPTVAAATDVALRGGVRVRDSLAAVEAISNAG
MSMEG_3221|M.smegmatis_MC2_155 SGCDLVEVGVPYSDPGMDGPTIAAATETALAGGVKVRDTLTAVEAISNAG
Mb1639|M.bovis_AF2122/97 SGCDIIEVGVPYSDPGMDGPTIARATEAALRGGVRVRDTLAAVEAISIAG
Rv1613|M.tuberculosis_H37Rv SGCDIIEVGVPYSDPGMDGPTIARATEAALRGGVRVRDTLAAVEAISIAG
MLBr_01273|M.leprae_Br4923 SGCDIIEVGVPYSDPGMDGPTIARATEVALRGGVRVRDTLAAVEAISQAG
MMAR_2415|M.marinum_M SGCDIVEVGVPYSDPGMDGPTIQRATEAALSGGVRVRDALTAVESISKAG
MUL_1593|M.ulcerans_Agy99 SGCDIVEVGVPYSDPGMDGPTIQRATEAALSGGVRVRDALTAVESISKAG
MAV_3173|M.avium_104 SGCDIVEVGVPYSDPGMDGPTIARATEAALHGGVRVRDTLAAVEAISAAG
MAB_2643c|M.abscessus_ATCC_199 GGCDIIEVGIAYSDPMMDGPMIAAAAETALANGVRVADVFTTVRAITDAG
.***::***:.**** **** : *::.** .**:* * : :*.:*: **
Mvan_2818|M.vanbaalenii_PYR-1 GRAVVMTYWNPVLSKGVDAFARDLASAGGLGLITPDLIPDEADEWLAASE
Mflv_3598|M.gilvum_PYR-GCK GKAVVMTYWNPVLRKGVDTFARDLASAGGLGLITPDLIPDEADDWFAASE
TH_1074|M.thermoresistible__bu GKAVVMSYWNPVLRWGVDAFARDLASAGGLGLITPDLIPDEADEWMAASE
MSMEG_3221|M.smegmatis_MC2_155 GRAVVMTYWNPVLRKGVDAFARDLANAGGYGLITPDLIPEEADEWMAASE
Mb1639|M.bovis_AF2122/97 GRAVVMTYWNPVLRYGVDAFARDLAAAGGLGLITPDLIPDEAQQWLAASE
Rv1613|M.tuberculosis_H37Rv GRAVVMTYWNPVLRYGVDAFARDLAAAGGLGLITPDLIPDEAQQWLAASE
MLBr_01273|M.leprae_Br4923 GRAVVMTYWNPVLRYGVCAFARDLESAGGHGLVTPDLIPDEARQWIAASE
MMAR_2415|M.marinum_M GRAVVMTYWNPVLRYGVDAFARDLAAAGGHGLITPDLIPDEAQQWLAASD
MUL_1593|M.ulcerans_Agy99 GRAVVMTYWNPVLRYGGDAFARDLAAAGGHGLITPDLIPDEAQQWLAASD
MAV_3173|M.avium_104 GRAVVMTYWNPVLRYGVDAFARDLAAAGGYGLITPDLIPDEAGQWLAASE
MAB_2643c|M.abscessus_ATCC_199 GHAVVMSYWNPVLRYGVDAFARELAAAGGLGIITPDLIPDEADDWIAASD
*:****:****** * :***:* *** *::******:** :*:***:
Mvan_2818|M.vanbaalenii_PYR-1 AHDLDRIFVVAPSSTPQRLAETVQASRGFVYAASTMGVTGARDAVSNAAP
Mflv_3598|M.gilvum_PYR-GCK AHDLDRIFLVAPSSTPERLAETVQASRGFVYAASTMGVTGARDAVSNAAP
TH_1074|M.thermoresistible__bu AHDLDRIFLVAPSSTPERLAMTVKASRGFVYAASTMGVTGARDAVSSAAP
MSMEG_3221|M.smegmatis_MC2_155 ANDLDRIFLVAPSSTHERLAKTIEVSRGFVYAASTMGVTGARDAVSSSAP
Mb1639|M.bovis_AF2122/97 EHRLDRIFLVAPSSTPERLAATVEASRGFVYAASTMGVTGARDAVSQAAP
Rv1613|M.tuberculosis_H37Rv EHRLDRIFLVAPSSTPERLAATVEASRGFVYAASTMGVTGARDAVSQAAP
MLBr_01273|M.leprae_Br4923 KHRLDRIFLVAPSSTPHRLVTTVGASRGFVYAVSVMGVTGARDAVSQVVP
MMAR_2415|M.marinum_M EHGLDRIFLVAPSSTPERLANTVAASRGFVYAASTMGVTGARDAVSNAAP
MUL_1593|M.ulcerans_Agy99 AHGLDRIFLVAPSSTPERLANTVAASRGFVYAASTMGVTGARDAVSNAAP
MAV_3173|M.avium_104 RHGLDRIFLVAPSSTPQRLALTVEASRGFVYAASTMGVTGARDAVSHAAP
MAB_2643c|M.abscessus_ATCC_199 AHDLDRIFLVAPSSTPERLERTIGACRGFVYAASTMGVTGARDAVSNAAP
: *****:****** .** *: ..******.*.*********** .*
Mvan_2818|M.vanbaalenii_PYR-1 ELVRRIKGISDIPVGVGLGVRSREQAAEIASYADGVIVGSALVSALKEG-
Mflv_3598|M.gilvum_PYR-GCK ELVARVKAISDIPVGVGLGVRSREQAAEIGAYADGVIVGSALVSALKEG-
TH_1074|M.thermoresistible__bu ELVRRVREISQIPVGVGLGVRTAEHAAEIASYADGVIVGSALVTALTDG-
MSMEG_3221|M.smegmatis_MC2_155 ELVRRIREVSDIPVGVGLGVRSGEQAAQIGSYSDGVIVGSALVAALQDG-
Mb1639|M.bovis_AF2122/97 ELVGRVKAVSDIPVGVGLGVRSRAQAAQIAQYADGVIVGSALVTALTEG-
Rv1613|M.tuberculosis_H37Rv ELVGRVKAVSDIPVGVGLGVRSRAQAAQIAQYADGVIVGSALVTALTEG-
MLBr_01273|M.leprae_Br4923 ELVARVKAVSDIAVGVGLGVRSREQAAQIGGYADGVIVGSALVSALGDG-
MMAR_2415|M.marinum_M DLVARVKAVSDIPVGVGLGVRSREQAAEIGRYADGVIVGSALVSALGDG-
MUL_1593|M.ulcerans_Agy99 DLVARVKAVSDIPVGVGLGVRSREQAAEIGRYADGVIVGSALVSALGDG-
MAV_3173|M.avium_104 ELVSRVREISDIPVGVGLGVRSREQAAQIGGYADGVIVGSALVSALGDGG
MAB_2643c|M.abscessus_ATCC_199 ALVSRVREVSDIAVGVGLGVRSGAQAAEIAAYADGVIVGSALVAAAPQG-
** *:: :*:*.********: :**:*. *:**********:* :*
Mvan_2818|M.vanbaalenii_PYR-1 IPAVRSLTEELADGVRQRITA-
Mflv_3598|M.gilvum_PYR-GCK IPAVRSLTAELADGVRQRITA-
TH_1074|M.thermoresistible__bu TPALRALTTELADGVRRRVTA-
MSMEG_3221|M.smegmatis_MC2_155 VDAVSRLTEELAGGVRRRVSA-
Mb1639|M.bovis_AF2122/97 LPRLRALTGELAAGVRLGMSA-
Rv1613|M.tuberculosis_H37Rv LPRLRALTGELAAGVRLGMSA-
MLBr_01273|M.leprae_Br4923 LPRLRALAEELAAGVRQRTFM-
MMAR_2415|M.marinum_M LPSLRSLTEELAAGVRQRNSP-
MUL_1593|M.ulcerans_Agy99 LPSLRSLTEELAAGVRQRKSP-
MAV_3173|M.avium_104 LTALRALTEELAAGVRQRAAAS
MAB_2643c|M.abscessus_ATCC_199 PAAVRSLAEELATGVRRA----
: *: *** ***