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MTVEQREASRLGPLFDSCRAENRAALIGYLPTGYPDVNTSVRAMTELVESGCDIVEVGVPYSDPGMDGPT IQRATEAALSGGVRVRDALTAVESISKAGGRAVVMTYWNPVLRYGVDAFARDLAAAGGHGLITPDLIPDE AQQWLAASDEHGLDRIFLVAPSSTPERLANTVAASRGFVYAASTMGVTGARDAVSNAAPDLVARVKAVSD IPVGVGLGVRSREQAAEIGRYADGVIVGSALVSALGDGLPSLRSLTEELAAGVRQRNSP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2415 | trpA | - | 100% (269) | tryptophan synthase, alpha subunit TrpA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1639 | trpA | 1e-126 | 87.12% (264) | tryptophan synthase subunit alpha |
| M. gilvum PYR-GCK | Mflv_3598 | trpA | 1e-117 | 82.56% (258) | tryptophan synthase subunit alpha |
| M. tuberculosis H37Rv | Rv1613 | trpA | 1e-126 | 87.12% (264) | tryptophan synthase subunit alpha |
| M. leprae Br4923 | MLBr_01273 | trpA | 1e-126 | 84.21% (266) | tryptophan synthase subunit alpha |
| M. abscessus ATCC 19977 | MAB_2643c | trpA | 1e-103 | 72.59% (259) | tryptophan synthase subunit alpha |
| M. avium 104 | MAV_3173 | trpA | 1e-127 | 85.77% (267) | tryptophan synthase subunit alpha |
| M. smegmatis MC2 155 | MSMEG_3221 | trpA | 1e-114 | 78.85% (260) | tryptophan synthase subunit alpha |
| M. thermoresistible (build 8) | TH_1074 | trpA | 1e-115 | 79.46% (258) | Probable tryptophan synthase, alpha subunit trpA |
| M. ulcerans Agy99 | MUL_1593 | trpA | 1e-148 | 98.88% (269) | tryptophan synthase subunit alpha |
| M. vanbaalenii PYR-1 | Mvan_2818 | trpA | 1e-116 | 80.62% (258) | tryptophan synthase subunit alpha |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3598|M.gilvum_PYR-GCK --------MSRLAGLFDSCRAEGRSGLIGYLPTGFPDVDTSIQAMVALVE
Mvan_2818|M.vanbaalenii_PYR-1 --------MSRLAGLFDSCRAEGRSALIGYLPTGFPDVETSIAAMVALVE
TH_1074|M.thermoresistible__bu --------MSRLAPLFESCRGEQRAALIGYLPTGFPDVATSISAMTALVE
MSMEG_3221|M.smegmatis_MC2_155 --------MSRLGAMFDSCRAEDRAALIGYLPTGFPDVPTSIAAMTALVE
MMAR_2415|M.marinum_M -MTVEQREASRLGPLFDSCRAENRAALIGYLPTGYPDVNTSVRAMTELVE
MUL_1593|M.ulcerans_Agy99 -MTVEQREASRLGPLFDSCRAENRAALIGYLPTGYPDVNTSVRAMTELVE
Mb1639|M.bovis_AF2122/97 MVAVEQSEASRLGPVFDSCRANNRAALIGYLPTGYPDVPASVAAMTALVE
Rv1613|M.tuberculosis_H37Rv MVAVEQSEASRLGPVFDSCRANNRAALIGYLPTGYPDVPASVAAMTALVE
MLBr_01273|M.leprae_Br4923 MMVLEQSETSRLGPVFDSCRADNRAALIGYLPTGYPDVPTSVDAMIELVE
MAV_3173|M.avium_104 -MTVKQSQASRLGPIFEACRDDDRAALIGYLPTGYPDVPTSVQAMVALVE
MAB_2643c|M.abscessus_ATCC_199 -----MTQPGRLTEVFDKCRAEERAALIGYLPNGYPDLDTSIELMTTLVR
.** :*: ** : *:.******.*:**: :*: * **.
Mflv_3598|M.gilvum_PYR-GCK SGCDIVEVGVAYSDPGMDGPVIAAATEVALRGGVRVHDAFRAVEAISNAG
Mvan_2818|M.vanbaalenii_PYR-1 SGCDLIEVGIAYSDPGMDGPTIAAATEVALRGGVRVRDTFRAVEAITNAG
TH_1074|M.thermoresistible__bu SGCDLVEVGVPYSDPGMDGPTVAAATDVALRGGVRVRDSLAAVEAISNAG
MSMEG_3221|M.smegmatis_MC2_155 SGCDLVEVGVPYSDPGMDGPTIAAATETALAGGVKVRDTLTAVEAISNAG
MMAR_2415|M.marinum_M SGCDIVEVGVPYSDPGMDGPTIQRATEAALSGGVRVRDALTAVESISKAG
MUL_1593|M.ulcerans_Agy99 SGCDIVEVGVPYSDPGMDGPTIQRATEAALSGGVRVRDALTAVESISKAG
Mb1639|M.bovis_AF2122/97 SGCDIIEVGVPYSDPGMDGPTIARATEAALRGGVRVRDTLAAVEAISIAG
Rv1613|M.tuberculosis_H37Rv SGCDIIEVGVPYSDPGMDGPTIARATEAALRGGVRVRDTLAAVEAISIAG
MLBr_01273|M.leprae_Br4923 SGCDIIEVGVPYSDPGMDGPTIARATEVALRGGVRVRDTLAAVEAISQAG
MAV_3173|M.avium_104 SGCDIVEVGVPYSDPGMDGPTIARATEAALHGGVRVRDTLAAVEAISAAG
MAB_2643c|M.abscessus_ATCC_199 GGCDIIEVGIAYSDPMMDGPMIAAAAETALANGVRVADVFTTVRAITDAG
.***::***:.**** **** : *::.** .**:* * : :*.:*: **
Mflv_3598|M.gilvum_PYR-GCK GKAVVMTYWNPVLRKGVDTFARDLASAGGLGLITPDLIPDEADDWFAASE
Mvan_2818|M.vanbaalenii_PYR-1 GRAVVMTYWNPVLSKGVDAFARDLASAGGLGLITPDLIPDEADEWLAASE
TH_1074|M.thermoresistible__bu GKAVVMSYWNPVLRWGVDAFARDLASAGGLGLITPDLIPDEADEWMAASE
MSMEG_3221|M.smegmatis_MC2_155 GRAVVMTYWNPVLRKGVDAFARDLANAGGYGLITPDLIPEEADEWMAASE
MMAR_2415|M.marinum_M GRAVVMTYWNPVLRYGVDAFARDLAAAGGHGLITPDLIPDEAQQWLAASD
MUL_1593|M.ulcerans_Agy99 GRAVVMTYWNPVLRYGGDAFARDLAAAGGHGLITPDLIPDEAQQWLAASD
Mb1639|M.bovis_AF2122/97 GRAVVMTYWNPVLRYGVDAFARDLAAAGGLGLITPDLIPDEAQQWLAASE
Rv1613|M.tuberculosis_H37Rv GRAVVMTYWNPVLRYGVDAFARDLAAAGGLGLITPDLIPDEAQQWLAASE
MLBr_01273|M.leprae_Br4923 GRAVVMTYWNPVLRYGVCAFARDLESAGGHGLVTPDLIPDEARQWIAASE
MAV_3173|M.avium_104 GRAVVMTYWNPVLRYGVDAFARDLAAAGGYGLITPDLIPDEAGQWLAASE
MAB_2643c|M.abscessus_ATCC_199 GHAVVMSYWNPVLRYGVDAFARELAAAGGLGIITPDLIPDEADDWIAASD
*:****:****** * :***:* *** *::******:** :*:***:
Mflv_3598|M.gilvum_PYR-GCK AHDLDRIFLVAPSSTPERLAETVQASRGFVYAASTMGVTGARDAVSNAAP
Mvan_2818|M.vanbaalenii_PYR-1 AHDLDRIFVVAPSSTPQRLAETVQASRGFVYAASTMGVTGARDAVSNAAP
TH_1074|M.thermoresistible__bu AHDLDRIFLVAPSSTPERLAMTVKASRGFVYAASTMGVTGARDAVSSAAP
MSMEG_3221|M.smegmatis_MC2_155 ANDLDRIFLVAPSSTHERLAKTIEVSRGFVYAASTMGVTGARDAVSSSAP
MMAR_2415|M.marinum_M EHGLDRIFLVAPSSTPERLANTVAASRGFVYAASTMGVTGARDAVSNAAP
MUL_1593|M.ulcerans_Agy99 AHGLDRIFLVAPSSTPERLANTVAASRGFVYAASTMGVTGARDAVSNAAP
Mb1639|M.bovis_AF2122/97 EHRLDRIFLVAPSSTPERLAATVEASRGFVYAASTMGVTGARDAVSQAAP
Rv1613|M.tuberculosis_H37Rv EHRLDRIFLVAPSSTPERLAATVEASRGFVYAASTMGVTGARDAVSQAAP
MLBr_01273|M.leprae_Br4923 KHRLDRIFLVAPSSTPHRLVTTVGASRGFVYAVSVMGVTGARDAVSQVVP
MAV_3173|M.avium_104 RHGLDRIFLVAPSSTPQRLALTVEASRGFVYAASTMGVTGARDAVSHAAP
MAB_2643c|M.abscessus_ATCC_199 AHDLDRIFLVAPSSTPERLERTIGACRGFVYAASTMGVTGARDAVSNAAP
: *****:****** .** *: ..******.*.*********** .*
Mflv_3598|M.gilvum_PYR-GCK ELVARVKAISDIPVGVGLGVRSREQAAEIGAYADGVIVGSALVSALKEG-
Mvan_2818|M.vanbaalenii_PYR-1 ELVRRIKGISDIPVGVGLGVRSREQAAEIASYADGVIVGSALVSALKEG-
TH_1074|M.thermoresistible__bu ELVRRVREISQIPVGVGLGVRTAEHAAEIASYADGVIVGSALVTALTDG-
MSMEG_3221|M.smegmatis_MC2_155 ELVRRIREVSDIPVGVGLGVRSGEQAAQIGSYSDGVIVGSALVAALQDG-
MMAR_2415|M.marinum_M DLVARVKAVSDIPVGVGLGVRSREQAAEIGRYADGVIVGSALVSALGDG-
MUL_1593|M.ulcerans_Agy99 DLVARVKAVSDIPVGVGLGVRSREQAAEIGRYADGVIVGSALVSALGDG-
Mb1639|M.bovis_AF2122/97 ELVGRVKAVSDIPVGVGLGVRSRAQAAQIAQYADGVIVGSALVTALTEG-
Rv1613|M.tuberculosis_H37Rv ELVGRVKAVSDIPVGVGLGVRSRAQAAQIAQYADGVIVGSALVTALTEG-
MLBr_01273|M.leprae_Br4923 ELVARVKAVSDIAVGVGLGVRSREQAAQIGGYADGVIVGSALVSALGDG-
MAV_3173|M.avium_104 ELVSRVREISDIPVGVGLGVRSREQAAQIGGYADGVIVGSALVSALGDGG
MAB_2643c|M.abscessus_ATCC_199 ALVSRVREVSDIAVGVGLGVRSGAQAAEIAAYADGVIVGSALVAAAPQG-
** *:: :*:*.********: :**:*. *:**********:* :*
Mflv_3598|M.gilvum_PYR-GCK IPAVRSLTAELADGVRQRITA-
Mvan_2818|M.vanbaalenii_PYR-1 IPAVRSLTEELADGVRQRITA-
TH_1074|M.thermoresistible__bu TPALRALTTELADGVRRRVTA-
MSMEG_3221|M.smegmatis_MC2_155 VDAVSRLTEELAGGVRRRVSA-
MMAR_2415|M.marinum_M LPSLRSLTEELAAGVRQRNSP-
MUL_1593|M.ulcerans_Agy99 LPSLRSLTEELAAGVRQRKSP-
Mb1639|M.bovis_AF2122/97 LPRLRALTGELAAGVRLGMSA-
Rv1613|M.tuberculosis_H37Rv LPRLRALTGELAAGVRLGMSA-
MLBr_01273|M.leprae_Br4923 LPRLRALAEELAAGVRQRTFM-
MAV_3173|M.avium_104 LTALRALTEELAAGVRQRAAAS
MAB_2643c|M.abscessus_ATCC_199 PAAVRSLAEELATGVRRA----
: *: *** ***