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VMSAGPRRAAVLGSPIAHSRSPQLHLAAYRALGLTDWTYERIECTGEQLPGVVAGFGPEWVGVSVTMPGK FAALRVADEATDRARMVGSANTLVRSSAGWRADNTDIDGVVGALSGVQVTDRAMVIGSGGTAPAVVVGLV TLGARFVTVAARHADKASALVELAVRCGARAGWVDLQHGRLAEEVAGVEVVVNTVPADAVAPHAAALAGT PVLLDAIYDPWPTPLAAAVQAAGGQVISGLEMLLNQAFTQVEQFTGLPAPKEAMRAALESA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2643 | aroE | - | 100% (271) | shikimate 5-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4817 | - | 1e-18 | 31.42% (261) | shikimate 5-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2582c | aroE | 1e-98 | 69.08% (262) | shikimate 5-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3760 | aroE | 1e-109 | 74.90% (263) | shikimate 5-dehydrogenase |
| M. tuberculosis H37Rv | Rv2552c | aroE | 1e-101 | 69.29% (267) | shikimate 5-dehydrogenase |
| M. leprae Br4923 | MLBr_00515 | aroE | 1e-99 | 67.92% (265) | shikimate 5-dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2848c | aroE | 3e-88 | 61.13% (265) | shikimate 5-dehydrogenase |
| M. marinum M | MMAR_2173 | aroE | 1e-98 | 68.56% (264) | shikimate 5-dehydrogenase AroE |
| M. avium 104 | MAV_3428 | aroE | 1e-100 | 68.40% (269) | shikimate 5-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3028 | aroE | 1e-104 | 71.32% (265) | shikimate 5-dehydrogenase |
| M. thermoresistible (build 8) | TH_0111 | aroE | 1e-101 | 74.03% (258) | PROBABLE SHIKIMATE 5-DEHYDROGENASE AROE (5-DEHYDROSHIKIMATE |
| M. ulcerans Agy99 | MUL_1757 | aroE | 1e-97 | 67.80% (264) | shikimate 5-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2643|M.vanbaalenii_PYR-1 MMS----AGP--------------------RRAAVLGSPIAHSRSPQLHL
Mflv_3760|M.gilvum_PYR-GCK MSSTPAADRP--------------------RRAAVLGSPIAHSRSPQLHL
MSMEG_3028|M.smegmatis_MC2_155 MPGRRPAAPGE------------------PRKAAVLGSPIAHSRSPQLHL
TH_0111|M.thermoresistible__bu ----------------------------------VLGSPIAHSRSPQLHL
Mb2582c|M.bovis_AF2122/97 MSSTARDERR-------------------SQKAGVLGSPIAHSRSPQLHL
Rv2552c|M.tuberculosis_H37Rv MSEGPK-------------------------KAGVLGSPIAHSRSPQLHL
MLBr_00515|M.leprae_Br4923 MSLTACANKG-------------------PRKAGIIGSPIAHSRSPHLHL
MAV_3428|M.avium_104 MSSTAPPASGDRKRGGAGRSGSPPGQAAGPRRAAVLGKPIAHSKSPQLHL
MMAR_2173|M.marinum_M MSSGQEHSQPPR-----------------GRKAAVLGSPIAHSRSPQLHL
MUL_1757|M.ulcerans_Agy99 MSSGQEHNQPPR-----------------GRKAAVLGSPIAHSRSPQLHL
MAB_2848c|M.abscessus_ATCC_199 MLAEIR-------------------------RAAVLGSPIGHSRSPDLHV
::*.**.**:**.**:
Mvan_2643|M.vanbaalenii_PYR-1 AAYRALGLTDWTYERIECTGEQLPGVVAGFGPEWVGVSVTMPGKFAALRV
Mflv_3760|M.gilvum_PYR-GCK AAYAALGLSSWRYDRIECGEDELPGFVAGLGDEWVGLSVTMPGKFAALRC
MSMEG_3028|M.smegmatis_MC2_155 AAYRALGLTDWTYERIECTAEQLPGLVEAAGPEWVGFSVTMPGKFAALQF
TH_0111|M.thermoresistible__bu AAYRALGLTGWTYERIECDAEQLPVLVGGFGPEWVGVSVTMPGKFAALTF
Mb2582c|M.bovis_AF2122/97 AAYRALGLHDWTYERIECGAAELPVVVGGFGPEWVGVSVTMPGKFAALRF
Rv2552c|M.tuberculosis_H37Rv AAYRALGLHDWTYERIECGAAELPVVVGGFGPEWVGVSVTMPGKFAALRF
MLBr_00515|M.leprae_Br4923 AAYRALRLHDWTYERIECDAEELPTVVSGFGPQWVGVSVTMPGKFAALRF
MAV_3428|M.avium_104 AAYRALGLHDWTYERIECDADQLPGVVGGFGPEWVGVSVTMPGKFAALRF
MMAR_2173|M.marinum_M AAYRALGLTDWTYQRIECDAAQLPAVVGGFGPEWVGVSVTMPGKFAALQF
MUL_1757|M.ulcerans_Agy99 AAYRALGLTDWTYQRIECDAAQLPAVVGGFGPEWVGVSVTMPGKFAALQF
MAB_2848c|M.abscessus_ATCC_199 AAYRALGLTGWTYERIECTAEQLPDVVGGAGPEWVGFSVTMPGKFAALRF
*** ** * .* *:**** :** .* . * :***.***********
Mvan_2643|M.vanbaalenii_PYR-1 ADEATDRARMVGSANTLVRSS-AGWRADNTDIDGVVGALSGVQ---VTDR
Mflv_3760|M.gilvum_PYR-GCK ADEATERARLVGSANTLVHTA-TGWRADNTDIDGVAGALADAG---VSGS
MSMEG_3028|M.smegmatis_MC2_155 ADQRTDRAELVGSANTLVRTEAGGWRADNTDVDGVAGALGTA-----GEA
TH_0111|M.thermoresistible__bu ADQRTARAELVGSANTLVRRD-GGWLADNTDIDGVKGALGAV-----GEH
Mb2582c|M.bovis_AF2122/97 ADERTARADLVGSANTLVRTP-HGWRADNTDIDGVAGALGAA-----AGH
Rv2552c|M.tuberculosis_H37Rv ADERTARADLVGSANTLVRTP-HGWRADNTDIDGVAGALGAA-----AGH
MLBr_00515|M.leprae_Br4923 ADEHTARASLVGSANTLLRTQ-RGWRADNTDIDGVAGALAAIGP--LAGR
MAV_3428|M.avium_104 ADERTERARRVGSANTLVRTA-TGWRADNTDIDGVAGALGAA-----SGW
MMAR_2173|M.marinum_M ADERTARAELVGSANTLVRTP-RGWRADNTDIDGVAGALGQA-----SGP
MUL_1757|M.ulcerans_Agy99 ADERTARAELVGSANTLVRTP-RGWRADNTDIDGVAGALGQA-----SGP
MAB_2848c|M.abscessus_ATCC_199 ASTSTERARSIGAANTLVRSG-DGWHADNTDVDGVSGALAGAGIDPAGQS
*. * ** :*:****:: ** *****:*** ***.
Mvan_2643|M.vanbaalenii_PYR-1 AMVIGSGGTAPAVVVGLVTLGARFVTVAARHADKASALVELAVRCGARAG
Mflv_3760|M.gilvum_PYR-GCK AVVVGSGGTAPAVVAGLVQLGAHHVTVVARNAEKAQGLVALGRRCGATTE
MSMEG_3028|M.smegmatis_MC2_155 ALVIGSGGTAPAAVVGLAEMGVQHITIVARNADKAAALVDLAGRCGAQGD
TH_0111|M.thermoresistible__bu VMVVGSGGTAPAAVVAVVESGARQVTVAARNREKAAPLVELAERLGASAR
Mb2582c|M.bovis_AF2122/97 ALVLGSGGTAPAAVVGLAELGVTDITVVARNSDKAARLVDLGTRVGVATR
Rv2552c|M.tuberculosis_H37Rv ALVLGSGGTAPAAVVGLAELGVTDITVVARNSDKAARLVDLGTRVGVATR
MLBr_00515|M.leprae_Br4923 ALVCGSGGTAPAAVMGLAELGVTDITVLARNPDKASRLVDLGVQVGVATR
MAV_3428|M.avium_104 ALVCGSGGTAPAAVAGLAQLGVAGITVVARNPDKAARLVRLGDELGVPTR
MMAR_2173|M.marinum_M AIVCGSGGTAPAAVVGLAELGVTEITIAARNADKAARLVDLGARLGVASR
MUL_1757|M.ulcerans_Agy99 AIVCGSGGTAPAAVVGLAELGVTEITIAARNADKAARLVDLGARLGVASR
MAB_2848c|M.abscessus_ATCC_199 AVIVGAGGTARPAIVALAAMGVRALTVVARDAGRAQGVLELAEHLGLRAS
.:: *:**** ..: .:. *. :*: **. :* :: *. . *
Mvan_2643|M.vanbaalenii_PYR-1 WVDLQHGRLAEEVAGVEVVVNTVPADAVAPHAAALAGTPVLLDAIYDPWP
Mflv_3760|M.gilvum_PYR-GCK WVDLTGDDVTGAVAAADVVVNTVPADAVAPYAPRLAGTPVLLDAIYDPWP
MSMEG_3028|M.smegmatis_MC2_155 WCDIAGPALTDAVAQASAAVSTIPADAAAGYAPTLAAVPRLLDAIYNPWP
TH_0111|M.thermoresistible__bu WQDLAG----VTAAGVDAVVSTIPADAAARYAAALSATPVLVDAIYDPWP
Mb2582c|M.bovis_AF2122/97 FCAFDSGGLADAVAAAEVLVSTIPAEVAAGYAGTLAAIPVLLDAIYDPWP
Rv2552c|M.tuberculosis_H37Rv FCAFDSGGLADAVAAAEVLVSTIPAEVAAGYAGTLAAIPVLLDAIYDPWP
MLBr_00515|M.leprae_Br4923 LCGLDSGGLADEVKAAEVLVSTVPADVAARYVDVFATVPVLLDAIYDPWP
MAV_3428|M.avium_104 FCALDGAGLADEVAAAEVLVSTLPAEVAERYAGTLARVGVLLDAVYDPWP
MMAR_2173|M.marinum_M FCGLDDPELGERAASAAALVSTIPAEVASRYAATFATVPVLLDAIYNPWP
MUL_1757|M.ulcerans_Agy99 FCGLDDPELGERAASAAALVSTIPAEVASRYAATFATVPVVLDAIYNSWP
MAB_2848c|M.abscessus_ATCC_199 VLSFTDAELSSVCQAAGVLVSTVPAEAAAPYARSLAAAPAILDVIYHPWP
: . . *.*:**:.. :. :: ::*.:*..**
Mvan_2643|M.vanbaalenii_PYR-1 TPLAAAVQAAGGQVISGLEMLLNQAFTQVEQFTGLPAPKEAMRAALESA-
Mflv_3760|M.gilvum_PYR-GCK TPLAAAVTAAGGRVISGLEMLLNQAFAQVEQFTGMPAPQKAMRGALGLA-
MSMEG_3028|M.smegmatis_MC2_155 TPLATAVQAAGGEVISGLQMLLNQAYSQVELFTGRPAPKEAMRAALEEP-
TH_0111|M.thermoresistible__bu TPLAAAVAEAGGRVISGLEMLLNQAFTQVELFTGRPAPKEAMRAALNQP-
Mb2582c|M.bovis_AF2122/97 TPLAAAVGSAGGRVISGLQMLLHQAFAQVEQFTGLPAPREAMTCALAALD
Rv2552c|M.tuberculosis_H37Rv TPLAAAVGSAGGRVISGLQMLLHQAFAQVEQFTGLPAPREAMTCALAALD
MLBr_00515|M.leprae_Br4923 TPLVAAVSAAGGRVISGLQMLLHQAFAQVEQFTGMPAPREAMACALAGLH
MAV_3428|M.avium_104 TPLAAAVSAAGGRVISGMQMLLHQAFAQVEQFTGLPAPREAMTCAAADAD
MMAR_2173|M.marinum_M TPLAAAVAAAGGRVISGLHMLLHQAFAQVEQFTGLPAPRAAMTCALEALD
MUL_1757|M.ulcerans_Agy99 TPLAAAVAAAGGRVISGLHMLLHQAFAQVEQFTGLPAPRAAMTCALEALD
MAB_2848c|M.abscessus_ATCC_199 TTLAAAAQRRGAVVVGGLDMLLNQAFTQVELFTGLSAPRAAMAAALH---
*.*.:*. *. *:.*:.***:**::*** *** .**: ** *