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MSASGRLLHTVTLARASVVLCKRGMVDPLRPRDALRASRAVRRYGAFGGLASFTAAQYRHWPALTDDTET LTFVELDQQSNARAQAIPAAAGGPAVVGLLRRSGVELVLDLAAANKAGVRTVLLNTGFAAPQLADVCLRE GVTTVVADDEFAPLLRDLDPDVVRLTGTQMASRAATKSTAIPVVPRRPGGLVLLTSGTTGIPKGAPRDRL NPLQSAQLLDRIPWPRNSAYVVAAPLFHATGLATCTVGLALGNHVVLHRRFDARETLEAVQKHHARALIL VPTMLSRILDLPPAALNAFDTSSLSVVFVAGSSLSPELYRRAAAHFGEVLYNLYGSTEVATAAVATPAEL RRAPGTVGRPPIGCTIAAYDSRDRRITRAGEVGTIYVSSGLSFGGYTGGGSKKTVDGLLSSGDTGHFDDD GLWFIDGREDDMVISGGENVYPLEIENLLVELPGVREAAVVGVRDDDFGMCLRAFVVPAAGADIDADQIR HAVRSRLARHKVPRDVLFVDALPRNETGKVLKRDLARMEQR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2344 | - | - | 100% (531) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0397 | - | e-103 | 41.20% (517) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0232 | - | 2e-94 | 39.51% (534) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0276 | fadD2 | 1e-102 | 42.69% (506) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_1993 | - | 1e-136 | 48.86% (528) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv0270 | fadD2 | 1e-102 | 42.69% (506) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-101 | 41.18% (510) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4340c | - | 5e-99 | 40.99% (505) | acyl-CoA synthetase |
| M. marinum M | MMAR_0528 | fadD2 | 1e-102 | 40.24% (507) | fatty-acid-CoA ligase FadD2 |
| M. avium 104 | MAV_4891 | - | 1e-100 | 39.65% (517) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_0599 | - | 1e-102 | 40.08% (519) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4533 | - | 1e-105 | 41.76% (510) | PUTATIVE acyl-CoA synthase |
| M. ulcerans Agy99 | MUL_1191 | fadD2 | 1e-102 | 40.24% (507) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0528|M.marinum_M MPNLSDLPG-------VAKIQ----QYVDRGAAELHYVRKIIESGAFRLE
MUL_1191|M.ulcerans_Agy99 MPNLSDLPG-------VAKIQ----QYVDRGAAELHYVRKIIESGAFRLE
MAV_4891|M.avium_104 MPNLLGLPGQAT--KAVAKVQ----QYVERGSAELHYLRRIIESGAFRLE
Mb0276|M.bovis_AF2122/97 MPNLTDLPG-----QAVSKLQKSIGQYVARGTAELHYLRKIIESGAIGLE
Rv0270|M.tuberculosis_H37Rv MPNLTDLPG-----QAVSKLQKSIGQYVARGTAELHYLRKIIESGAIGLE
MLBr_02546|M.leprae_Br4923 ----------------MTKLR----HYLERGAAEVHYLRSIFESGALGFE
MSMEG_0599|M.smegmatis_MC2_155 ---------------MTAKAK----EYAERGVAELHYARKMFEAGALRLE
TH_4533|M.thermoresistible__bu MAKLTDLPRLAADKLPLSRLQ----LYAERGAAELHYLRKMLEAGALKIE
MAB_4340c|M.abscessus_ATCC_199 MSITAERPL-------FSKLQ----TLAKRGGAELHYLRKVIEAGMLKLD
Mvan_2344|M.vanbaalenii_PYR-1 -----------------MSAS----GRLLHTVTLARASVVLCKRGMVDPL
Mflv_1993|M.gilvum_PYR-GCK ------------MNDALGSVR----QKLQQVSESGRALKRLIDTGIIDFS
: : : . * .
MMAR_0528|M.marinum_M SPLNYAAMATEIAKWGEFGMLPSFNARRHPHRAACIDEEGEFTYQQLDEA
MUL_1191|M.ulcerans_Agy99 SPLNYAAMATEIAKWGEFGMLPSFNARRHPHRAACIDEEGEFTYQQLDEA
MAV_4891|M.avium_104 PPQNYAAMAADIYKWGEFGMLPSLNARRTPDRAAVIDEEGELSYAELDRA
Mb0276|M.bovis_AF2122/97 PPLNYAALAADIRKWGEVGMLPSHNARRAPNRAAVIDEEGTLTFSELDEA
Rv0270|M.tuberculosis_H37Rv PPLNYAALAADIRKWGEVGMLPSHNARRAPNRAAVIDEEGTLTFSELDEA
MLBr_02546|M.leprae_Br4923 PPLTYAAMAVAMRKWGDLAMLPAMPARRSPHRAALIDEEGTLTYKELDRA
MSMEG_0599|M.smegmatis_MC2_155 PPQHMLALVADIRTWGEIGMIPALNARRHPNRVAVIDDEGEFTFGELDAA
TH_4533|M.thermoresistible__bu SPTRIAALLADIRRWGEIGMIPALNARRWPDRVAVIDDEGEMTFAELNDA
MAB_4340c|M.abscessus_ATCC_199 PPNVLAGLVRDFYRFGEIGAVPAFGAHRSPSRTAIIDDEGSITYAELNDA
Mvan_2344|M.vanbaalenii_PYR-1 RPRDALRASRAVRRYGAFGGLASFTAAQYRHWPALTDDTETLTFVELDQQ
Mflv_1993|M.gilvum_PYR-GCK DLPASVRTAKLSRVYGPQATMAIQGGRKYADLPAIVDERGTLTYKQVDDQ
:* . :. . : * *: ::: :::
MMAR_0528|M.marinum_M AHAVANALLAKGVSAGDGVAILARNHRWFLIANYGAARAGARIILLNSEF
MUL_1191|M.ulcerans_Agy99 GHAVANALLAKGVSAGDGVAILARNHRWFLIANYGAARAGARIILLNSEF
MAV_4891|M.avium_104 AHAVANGLIAKGVKAGDGVAILARNHRWFLIANYGAARVGARIILLNSEF
Mb0276|M.bovis_AF2122/97 AHAVANGLLAKGVRAGDGVAILARNHRWFVIANYGAARVGARIILLNSEF
Rv0270|M.tuberculosis_H37Rv AHAVANGLLAKGVRAGDGVAILARNHRWFVIANYGAARVGARIILLNSEF
MLBr_02546|M.leprae_Br4923 AHALANGLIAKGVRGGDGIAILARNHRWFVIANYGCARVGARIILLNSEF
MSMEG_0599|M.smegmatis_MC2_155 AHALANELLARGVRGGDGVGILARNHRWFLVSLYGAARVGARIIMLNTEF
TH_4533|M.thermoresistible__bu AHAVANALLAKGVRGGDGVAILARNHRWFLVSMYGAARVGARIILLNTEF
MAB_4340c|M.abscessus_ATCC_199 VNALAHGLNRLGIKGGDGVAILARNHRWFIIANYAAHRAGARVILLNTDF
Mvan_2344|M.vanbaalenii_PYR-1 SNARAQAIP-AAAGGPAVVGLLRRSGVELVLDLAAANKAGVRTVLLNTGF
Mflv_1993|M.gilvum_PYR-GCK SWALAHGLRRLGVSAGSVVGVLCRDHRGLVITMAACGKLGARMVLMNTGF
* *: : . . :.:* *. ::: .. : *.* :::*: *
MMAR_0528|M.marinum_M SGPQIKEVSEREGAKLIIYDDEYTGAVSKAEPPLGKLRALGVNPDSEEDS
MUL_1191|M.ulcerans_Agy99 SGPQIKEVSEREGAKLIIYDDEYTGAVSKAEPPLGKLRALGVNPDSEEDS
MAV_4891|M.avium_104 SGPQIKEVSEREGAKVIIYDDEYTKAVSKAEPPLGKLRALGSNPDADEPS
Mb0276|M.bovis_AF2122/97 SGPQIKEVSDREGAKVIIYDDEYTKAVSLAQPPLGKLRALGVNPDDDKPS
Rv0270|M.tuberculosis_H37Rv SGPQIKEVSDREGAKVIIYDDEYTKAVSLAQPPLGKLRALGVNPDDDKPS
MLBr_02546|M.leprae_Br4923 SGPQIKEVSEREGAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPP
MSMEG_0599|M.smegmatis_MC2_155 SGPQIKEVAAREGARVIIYDDEYTAAVAQAETELGKLRALGTNPDKEEPS
TH_4533|M.thermoresistible__bu SGPQICEVSDREGAKLIIYDDEYTAAVSGVEPELGKLRALGHNPDSDEPS
MAB_4340c|M.abscessus_ATCC_199 SGPQTKEVAEREGARVLIYDAEYAEFLDGYSPELGRIMALPTNPDNPDQP
Mvan_2344|M.vanbaalenii_PYR-1 AAPQLADVCLREGVTTVVADDEFAPLLRDLDPDVVRLT--------GTQM
Mflv_1993|M.gilvum_PYR-GCK AKPQFAEVCKRENVAVVLHDSEFLGLLEALPADMPRVLTW---VDDGTEV
: ** :*. **.. :: * *: : . : ::
MMAR_0528|M.marinum_M GSTDETLAELIARSSTAPAPKAGKHASIIILTSGTTGTPKGANRSTPPTL
MUL_1191|M.ulcerans_Agy99 GSTDETLAELIARSSTAPAPKAGKHASIIILTSGTTGTPKGANRSTPPTL
MAV_4891|M.avium_104 GSTDETLAELIERSSSEPAPKADRHASIIILTSGTTGTPKGANRSTPPTL
Mb0276|M.bovis_AF2122/97 GSSDETLAELIAHSSTAPAPKASRRASIIILTSGTTGTPKGANRNTPPTL
Rv0270|M.tuberculosis_H37Rv GSSDETLAELIAHSSTAPAPKASRRASIIILTSGTTGTPKGANRNTPPTL
MLBr_02546|M.leprae_Br4923 GSTDETLAELIARSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASL
MSMEG_0599|M.smegmatis_MC2_155 GSTDETLAEVIARSGKRPAPKASRHASIIILTSGTTGTPKGANRAAPPSL
TH_4533|M.thermoresistible__bu GSTDETLADIIERVGAKPAPKATRHSSIIILTSGTTGTPKGATRKAPPSL
MAB_4340c|M.abscessus_ATCC_199 ASTDETIASVIKRNSTSPAPRPSKYSSLVILTSGTTGTPKGAPRKLALTL
Mvan_2344|M.vanbaalenii_PYR-1 AS-------RAATKSTAIPVVPRRPGGLVLLTSGTTGIPKGAPRDRLNPL
Mflv_1993|M.gilvum_PYR-GCK PPGVPTLDDIVTANSTEPLPAPDKSGGSVILTSGTTGLPKGAPRDSVSPL
. . : .. ::******* **** * .*
MMAR_0528|M.marinum_M APVGGILSHVPFKANEVTSLPAPMFHALGYLHATIAMFLGSTLVLRRKFK
MUL_1191|M.ulcerans_Agy99 APVGGILSHVPFKANEVTSLPAPMFHALGYLHATIAMFLGSTLVLRRKFK
MAV_4891|M.avium_104 APVGGILSHVPFKAGEVTSLPSPMFHALGYLHATIAMFLGSTLVLRRKFK
Mb0276|M.bovis_AF2122/97 APIGGILSHVPFKAGEVTLLPSPMFHALGYMHAALAMFLGSTLVLRRRFK
Rv0270|M.tuberculosis_H37Rv APIGGILSHVPFKAGEVTLLPSPMFHALGYMHAALAMFLGSTLVLRRRFK
MLBr_02546|M.leprae_Br4923 APLGGILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFK
MSMEG_0599|M.smegmatis_MC2_155 APIGGVLSHVPFKAGEVTALPAPMFHALGFLHATIAMMLGSTLVLRRRFK
TH_4533|M.thermoresistible__bu APIGGVLSHVPFKSGEVTSLPAPMFHALGYLHATIAMMLGNTLLLRRRFK
MAB_4340c|M.abscessus_ATCC_199 APVGGMFSHVPFRSGEVTSVPAPMFHALGYLHQSLALTLGCTLILRRKFK
Mvan_2344|M.vanbaalenii_PYR-1 QSAQ-LLDRIPWPRNSAYVVAAPLFHATGLATCTVGLALGNHVVLHRRFD
Mflv_1993|M.gilvum_PYR-GCK ATAQ-IIDRIPFPHKGTMVIVSPIFHSTGWATYTVGAAFGNKIVTSRRFK
. ::.::*: . : :*:**: * ::. :* :: *:*.
MMAR_0528|M.marinum_M PQLVLEDIEKHKVTAMVVVPVMLSRLLDAVEKIDKKPDLSSLKIVFVSGS
MUL_1191|M.ulcerans_Agy99 PQLVLEDIEKHKVTAMVVVPVMLSRLLDAVEKIDKKPDLSSLKIVFVSGS
MAV_4891|M.avium_104 PPLVLQDIEKYRPTAMVVVPVMLSRILDTLEKMDKKPDLSSLRIVFVSGS
Mb0276|M.bovis_AF2122/97 PALVLEDIEKHKATSMVVVPVMLSRILDQLEKTEPKPDLSSLKIVFVSGS
Rv0270|M.tuberculosis_H37Rv PALVLEDIEKHKATSMVVVPVMLSRILDQLEKTEPKPDLSSLKIVFVSGS
MLBr_02546|M.leprae_Br4923 PATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGS
MSMEG_0599|M.smegmatis_MC2_155 PATVLEDIEKHKVTAAVVVPVMLSRMLDHLEKMPQKPDLSSLRIMFVSGS
TH_4533|M.thermoresistible__bu PATVLTDIEKHNVSAVIVVPVMLSRMLDEWEKMRPKPDLSSLRIVFVSGS
MAB_4340c|M.abscessus_ATCC_199 PENVLADVEKFKVTAIVVVPVMLNRLLNALDELSVKPDLSSLRIVFVSGS
Mvan_2344|M.vanbaalenii_PYR-1 ARETLEAVQKHHARALILVPTMLSRILDLPPAALNAFDTSSLSVVFVAGS
Mflv_1993|M.gilvum_PYR-GCK AEKTLELIATHKADMLVAVPTMLHRMVELGPDVIAKYDTSSLKVILIAGS
. .* : ... : **.** *::: * *** :::::**
MMAR_0528|M.marinum_M QLGAELASRALKDLGPVIYNMYGSTEIAFATIAGPEDLQRNAATVGPVVK
MUL_1191|M.ulcerans_Agy99 QLGAELASRALKDLGPVIYNMYGSTEIAFATIAGPEDLQRNAATVGPVVK
MAV_4891|M.avium_104 QLGAELAARALKDIGPVIYNMYGSTEIAFATIAGPKDLERNAATVGPVVK
Mb0276|M.bovis_AF2122/97 QLGAELATRALGDLGPVIYNMYGSTEVAFATIAGPKDLQFNPSTVGPVVK
Rv0270|M.tuberculosis_H37Rv QLGAELATRALGDLGPVIYNMYGSTEVAFATIAGPKDLQFNPSTVGPVVK
MLBr_02546|M.leprae_Br4923 QLGAELATRALEELGPVIYNMYGSTEIAFATIAGPKDLQINSATVGPVVK
MSMEG_0599|M.smegmatis_MC2_155 QLGAELATRALKELGPVIYNLYGSTEIAFATIARPQDLSRNPATVGPVVK
TH_4533|M.thermoresistible__bu QLGAELASRAMRDLGPVIYNLYGSTEIAFATIARPQDLSINPATVGPVVK
MAB_4340c|M.abscessus_ATCC_199 QLGGELASRAMDTLGPVIYNLYGSTEVAFATIARPQDLAINPSTVGPVVK
Mvan_2344|M.vanbaalenii_PYR-1 SLSPELYRRAAAHFGEVLYNLYGSTEVATAAVATPAELRRAPGTVGRPPI
Mflv_1993|M.gilvum_PYR-GCK ALSPELSNRVQDTFGDVLYNMYGSTECAIASVATPAELRAAPGTAGRAPV
*. ** *. :* *:**:***** * *::* * :* ..*.*
MMAR_0528|M.marinum_M GVKVKILDDNGNEVS-QGQVGRIFVGNAFPFEGYTGGGHKQIIDGLMSSG
MUL_1191|M.ulcerans_Agy99 GVKVKILDDNGNEVS-QGQVGRIFVGNAFPFEGYTGGGHKQIIDGLMSSG
MAV_4891|M.avium_104 GVKVKIFDDNGKELP-QGEVGRIFVGNTFPFAGYTGGGNKQIIDGLLSSG
Mb0276|M.bovis_AF2122/97 GVTVKILDENGNEVP-QGAVGRIFVGNAFPFEGYTGGGGKQIIDGLLSSG
Rv0270|M.tuberculosis_H37Rv GVTVKILDENGNEVP-QGAVGRIFVGNAFPFEGYTGGGGKQIIDGLLSSG
MLBr_02546|M.leprae_Br4923 GVKVKILDDSGKEVP-RGQVGRIFVGNAFPFEGYTGGGGKQIIDGLLSSG
MSMEG_0599|M.smegmatis_MC2_155 GITVKILDDNGKELP-QGEVGRIFVRNTFPFKGYTGGGGKQIIDGMMSSG
TH_4533|M.thermoresistible__bu GVTVKLFDENGKEVP-RGEVGRIFVRNTFPFEGYTGGGHKQIIDGLMSSG
MAB_4340c|M.abscessus_ATCC_199 GATVKILDDEGKPVS-QGTVGRIFVSNAIPFDGYTGGGHKQIIDGLMSSG
Mvan_2344|M.vanbaalenii_PYR-1 GCTIAAYDSRDRRITRAGEVGTIYVSSGLSFGGYTGGGSKKTVDGLLSSG
Mflv_1993|M.gilvum_PYR-GCK TCEVVLYDENDQRIHGTNRRGRIFVRNGAPFSGHTDGRSKQIIDGFMSSG
: *. .. : . * *:* . .* *:*.* *: :**::***
MMAR_0528|M.marinum_M DVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPDVVEATALG
MUL_1191|M.ulcerans_Agy99 DVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEALISGHPDVVEATALG
MAV_4891|M.avium_104 DVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPDVVEATAIG
Mb0276|M.bovis_AF2122/97 DVGYFDERGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPDVVEAAAIG
Rv0270|M.tuberculosis_H37Rv DVGYFDERGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPDVVEAAAIG
MLBr_02546|M.leprae_Br4923 DVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIG
MSMEG_0599|M.smegmatis_MC2_155 DVGYFDEHGLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVIEATAIG
TH_4533|M.thermoresistible__bu DVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEIEDLLSGHPEIVEATAIG
MAB_4340c|M.abscessus_ATCC_199 DVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPEVIEATALG
Mvan_2344|M.vanbaalenii_PYR-1 DTGHFDDDGLWFIDGREDDMVISGGENVYPLEIENLLVELPGVREAAVVG
Mflv_1993|M.gilvum_PYR-GCK DMGHFTDDGLLFVDGRDDDMIVSGGENVFPQEVEQLLEERPDVAEVAVVG
* *:* : .* ::.**:*:*::******:* *:* *: * : *.:.:*
MMAR_0528|M.marinum_M VDDKEWGARLRAFVVKKPDTDLDEETVKHYVRDHLARYKVPREVIFLEEL
MUL_1191|M.ulcerans_Agy99 VDDKEWGARLRAFVVKKPDTDLDEETVKHYVRDHLARYKVPREVIFLEEL
MAV_4891|M.avium_104 VEDKEWGHRLRAFVVKKEGADLDEDTIKHYVRDHLARYKVPREVIFLDEL
Mb0276|M.bovis_AF2122/97 VDDKEFGARLRAFVVKKPGADLDEDTIKQYVRDHLARYKVPREVIFLDEL
Rv0270|M.tuberculosis_H37Rv VDDKEFGARLRAFVVKKPGADLDEDTIKQYVRDHLARYKVPREVIFLDEL
MLBr_02546|M.leprae_Br4923 VDDKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREVIFLEEL
MSMEG_0599|M.smegmatis_MC2_155 VDDKEWGARLRAFVVKAAGSSLTEDDVKAYVRDHLARYKVPREVIFLDEL
TH_4533|M.thermoresistible__bu VEDKEWGQRLRAFVVKAEGSDLDEDEVKRYVREHLARYKVPRDVIFLDEL
MAB_4340c|M.abscessus_ATCC_199 VDDPEWGARLRAFVVRHPDSTVDADGIRAYVRDNLARYKVPRDVVFLDVL
Mvan_2344|M.vanbaalenii_PYR-1 VRDDDFGMCLRAFVVPAAGADIDADQIRHAVRSRLARHKVPRDVLFVDAL
Mflv_1993|M.gilvum_PYR-GCK VDDVEFGKRLRAFIVTEPGAAREPEEIKRHVKENLARHKVPRDVVFVDEL
* * ::* ****:* .: : :: *:..***:****:*:*:: *
MMAR_0528|M.marinum_M PRNPTGKILKRELREMEIE-
MUL_1191|M.ulcerans_Agy99 PRNPTGKILKRELREMEIE-
MAV_4891|M.avium_104 PRNPTGKILKRELREMEV--
Mb0276|M.bovis_AF2122/97 PRNPTGKVLKRELRKL----
Rv0270|M.tuberculosis_H37Rv PRNPTGKVLKRELRKL----
MLBr_02546|M.leprae_Br4923 PRNPTGKVLKRELRDFEVH-
MSMEG_0599|M.smegmatis_MC2_155 PRNPTGKILKRELRNIDA--
TH_4533|M.thermoresistible__bu PRNPTGKILKRELRELEVS-
MAB_4340c|M.abscessus_ATCC_199 PRNPSGKILKRELRELEV--
Mvan_2344|M.vanbaalenii_PYR-1 PRNETGKVLKRDLARMEQR-
Mflv_1993|M.gilvum_PYR-GCK PRNATGKLLRRVLVEMDVES
*** :**:*:* * :