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GITDPVTKTLGLLSTMVRAGVIAPMRPDKYLRIAGAMQRENMAITSGFAAAAQRCPDRAGLIDELGILTW RQIDQRADAFAAALQALPGGQPEVIALMARNHRGFVDALIAANRIGADVLLLNTSFAGPALAEVMEREGE GRSVAVVYDEEFTDTVDRALAGRPDTTRIVAWTDTPGDRLTVEGMIAEHGGQEPVRAPEKSRVILLTSGT TGTPKGASHSGGDPSVLKAILDRTPWRAEQPVVIVAPMFHAWGFSQLAFAASMSCTIVTRRRFDPEATLE LVDKYRATGLCVVPVMFDRIMDLPDEVLDKYSGRSLRFAAASGSRMRPDVVIKFMDRFGDVIYNNYNATE AGMIATATPRDLRAAPDTAGRPAEGTEIRILDADFNEVPTGEVGGIYVRNSTQFDGYTTGKTKDFHEGFM SSGDVGYFDEAGRLFVVGRDDEMIVSGGENVYPIEVEKTLAAHPDVAEATVLGVDDEKFGQRLEAFVVLT ADAAATPETLKQHVRDNLANYKVPREITILDELPRGVTGKISRKDLQDRLDNA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0232 | - | - | 100% (544) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4225 | - | 0.0 | 71.43% (532) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0397 | - | e-109 | 43.31% (501) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1462c | fadD12 | 0.0 | 74.95% (535) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0435 | - | 0.0 | 89.34% (544) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1427c | fadD12 | 0.0 | 74.95% (535) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-112 | 41.90% (537) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4340c | - | 1e-105 | 42.37% (498) | acyl-CoA synthetase |
| M. marinum M | MMAR_2233 | fadD12 | 0.0 | 74.49% (541) | long-chain-fatty-acid--CoA ligase FadD12 |
| M. avium 104 | MAV_3349 | - | 0.0 | 76.39% (449) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_0304 | - | 0.0 | 77.63% (541) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4130 | - | 0.0 | 68.91% (550) | PUTATIVE putative cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_1191 | fadD2 | 1e-108 | 43.69% (499) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1462c|M.bovis_AF2122/97 -----------------MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAA
Rv1427c|M.tuberculosis_H37Rv -----------------MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAA
MMAR_2233|M.marinum_M ---------------MAPRIDQILGLITTLARSGLIAPMRPDRYLKIAAA
MAV_3349|M.avium_104 --------------------------------------------------
Mvan_0232|M.vanbaalenii_PYR-1 ---------MG----ITDPVTKTLGLLSTMVRAGVIAPMRPDKYLRIAGA
Mflv_0435|M.gilvum_PYR-GCK ---------MG----ITDPVTNALGLISTMMRAGVIAPMRPDKYMRIVGA
MSMEG_0304|M.smegmatis_MC2_155 ---------MGLLDRITDPLIDTVGMVTTMRRAGLIAPLRPDKYLRIVAA
TH_4130|M.thermoresistible__bu -------------------MAKTIDTLRTLTRAGLIAPLRPDKYLRMTAA
MLBr_02546|M.leprae_Br4923 ---------MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVA
MUL_1191|M.ulcerans_Agy99 MPNLSDLPGVAKIQQYVDRGAAELHYVRKIIESGAFRLESPLNYAAMATE
MAB_4340c|M.abscessus_ATCC_199 MSITAERPLFSKLQTLAKRGGAELHYLRKVIEAGMLKLDPPNVLAGLVRD
Mb1462c|M.bovis_AF2122/97 MRREGMGFTAGFAGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQA
Rv1427c|M.tuberculosis_H37Rv MRREGMGFTAGFAGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQA
MMAR_2233|M.marinum_M MRREGMGFTAGFAAAAQRCPDRPGLVDELGTLTWRQLDERSNALAAALQA
MAV_3349|M.avium_104 --------------------------------------------------
Mvan_0232|M.vanbaalenii_PYR-1 MQRENMAITSGFAAAAQRCPDRAGLIDELGILTWRQIDQRADAFAAALQA
Mflv_0435|M.gilvum_PYR-GCK MQRENMAITSGFAAAAQRCPDRAGLVDELGILTWRQIDQRADALAAALQA
MSMEG_0304|M.smegmatis_MC2_155 MARENMSVTSGFASAAQRCPDRPGLVDELGTLTWREIDQQADALAAGLQA
TH_4130|M.thermoresistible__bu VRRTGVSVTVGFAVAAQRCGDRIGLVDEIGELTWRELDDECNALAAALQD
MLBr_02546|M.leprae_Br4923 MRKWG-DLAMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIA
MUL_1191|M.ulcerans_Agy99 IAKWG-EFGMLPSFNARRHPHRAACIDEEGEFTYQQLDEAGHAVANALLA
MAB_4340c|M.abscessus_ATCC_199 FYRFG-EIGAVPAFGAHRSPSRTAIIDDEGSITYAELNDAVNALAHGLNR
Mb1462c|M.bovis_AF2122/97 LPAGPPR-------VVGIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGP
Rv1427c|M.tuberculosis_H37Rv LPAGPPR-------VVGIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGP
MMAR_2233|M.marinum_M LPAGSPK-------VVGIMCRNHRGFVEALVAANRIGADILLLNTAFAGP
MAV_3349|M.avium_104 --------------MIGIMCRNHRGFVEAPVAADRIGADIVLLNTSFAGP
Mvan_0232|M.vanbaalenii_PYR-1 LPGGQPE-------VIALMARNHRGFVDALIAANRIGADVLLLNTSFAGP
Mflv_0435|M.gilvum_PYR-GCK LPEGQPE-------VIGLMARNHRGFVDSLIAANRIGADVLLLNTSFAGP
MSMEG_0304|M.smegmatis_MC2_155 LSGGAPR-------VLGIMARNHRGFVLSLIAANRIGADVLLLNTSFSGP
TH_4130|M.thermoresistible__bu RAAGQGKDGGKGRGAIGIMCRNHRGFIEALVAADRIGATVLLLNTSFAGP
MLBr_02546|M.leprae_Br4923 KGVRGGD-------GIAILARNHRWFVIANYGCARVGARIILLNSEFSGP
MUL_1191|M.ulcerans_Agy99 KGVSAGD-------GVAILARNHRWFLIANYGAARAGARIILLNSEFSGP
MAB_4340c|M.abscessus_ATCC_199 LGIKGGD-------GVAILARNHRWFIIANYAAHRAGARVILLNTDFSGP
:.::.**** *: : . * ** ::***: *:**
Mb1462c|M.bovis_AF2122/97 ALAEVVTREG---VDTVVYDEEFSATVDRALAEKPQA-TRIVAWTDED--
Rv1427c|M.tuberculosis_H37Rv ALAEVVTREG---VDTVVYDEEFSATVDRALAEKPQA-TRIVAWTDED--
MMAR_2233|M.marinum_M ALADVVAREG---VDTVIYDEEFTATVDRAFDGRPQA-TRIVAWSDGQ--
MAV_3349|M.avium_104 ALADVITREG---VDAVIYDEEFTATVDRALAGRPDA-IRIVAWTDTE--
Mvan_0232|M.vanbaalenii_PYR-1 ALAEVMEREGEGRSVAVVYDEEFTDTVDRALAGRPDT-TRIVAWTDTPG-
Mflv_0435|M.gilvum_PYR-GCK ALAEVLQREGEGRAVAVIYDEEFTETVDRAVADRPET-TRILAWTDSDT-
MSMEG_0304|M.smegmatis_MC2_155 ALAEVVSRE---KVDAVIYDEEFTDTVDRALAGAPEAPTRIVAWTDTAA-
TH_4130|M.thermoresistible__bu ALAEVVDREG---VDTIVYDEEFTDIVDRALADRPTA-TRILAWVDEPAS
MLBr_02546|M.leprae_Br4923 QIKEVSEREG---AKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPP
MUL_1191|M.ulcerans_Agy99 QIKEVSEREG---AKLIIYDDEYTGAVSKAEPPLGKLRALGVNPDSEEDS
MAB_4340c|M.abscessus_ATCC_199 QTKEVAEREG---ARVLIYDAEYAEFLDGYSPELGRIMALPTNPDNPDQP
:* ** ::** *:: :. .
Mb1462c|M.bovis_AF2122/97 ----HDLTVEKLVAAHAGRRPEH---TGSHGKVILLTSGTTGTPKGARHS
Rv1427c|M.tuberculosis_H37Rv ----HDLTVEKLVAAHAGRRPEH---TGSHGKVILLTSGTTGTPKGARHS
MMAR_2233|M.marinum_M ----HDLTVEQLVNAHLGDQPER---TGRTGRLILLTSGTTGTPKGAKHS
MAV_3349|M.avium_104 ----HQHTVDKLIASKAGAQPIR---TGRKGKMILLTSGTTGTPKGAKQS
Mvan_0232|M.vanbaalenii_PYR-1 ----DRLTVEGMIAEHGGQEPVR---APEKSRVILLTSGTTGTPKGASHS
Mflv_0435|M.gilvum_PYR-GCK ----DALTVEGLIAEHGGQEPVR---SVEKARVILLTSGTTGTPKGAKHS
MSMEG_0304|M.smegmatis_MC2_155 ----HDVTVAALTEKFAGRQPQR---GGQKSKVILLTSGTTGTPKGAKHS
TH_4130|M.thermoresistible__bu GPALPHPTVADLVAEHRGRRPAKPAAGDEGSRIILLTSGTTGTPKGARAA
MLBr_02546|M.leprae_Br4923 GS--TDETLAELIARSSSAPAPK---VRKRASIIILTSGTTGTPKGANRN
MUL_1191|M.ulcerans_Agy99 GS--TDETLAELIARSSTAPAPK---AGKHASIIILTSGTTGTPKGANRS
MAB_4340c|M.abscessus_ATCC_199 AS--TDETIASVIKRNSTSPAPR---PSKYSSLVILTSGTTGTPKGAPRK
*: : . : . :::************
Mb1462c|M.bovis_AF2122/97 GG--GIGTLKAILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTIV
Rv1427c|M.tuberculosis_H37Rv GG--GIGTLKAILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTIV
MMAR_2233|M.marinum_M GGSGGIGTLKAILDRTPWRAEQPIVIVAPMFHAWGFSQLVLAASLACTIV
MAV_3349|M.avium_104 GGNAGIGTLKAILDRTPWRAEEPVVIVAPMFHAWGFSQLLLAASFACPVI
Mvan_0232|M.vanbaalenii_PYR-1 GG--DPSVLKAILDRTPWRAEQPVVIVAPMFHAWGFSQLAFAASMSCTIV
Mflv_0435|M.gilvum_PYR-GCK GG--DPGVLKSILDRTPWRAEQPVVIVAPMFHAWGFSQLAFAASMSCTII
MSMEG_0304|M.smegmatis_MC2_155 GG--GPEILKAILDRTPWRAEEPVVIVAPMFHAWGFSQLAFAASMACTII
TH_4130|M.thermoresistible__bu SS-GGAGELAAILGRVPWRAEQTTVIAAPMFHAWGYSQLLFSALLACTIV
MLBr_02546|M.leprae_Br4923 TP-ASLAPLGGILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLV
MUL_1191|M.ulcerans_Agy99 TP-PTLAPVGGILSHVPFKANEVTSLPAPMFHALGYLHATIAMFLGSTLV
MAB_4340c|M.abscessus_ATCC_199 LA-LTLAPVGGMFSHVPFRSGEVTSVPAPMFHALGYLHQSLALTLGCTLI
: .::.:.*::: : : ****** *: : :: :...::
Mb1462c|M.bovis_AF2122/97 TRRRFDPEATLDLIDRHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLRF
Rv1427c|M.tuberculosis_H37Rv TRRRFDPEATLDLIDRHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLRF
MMAR_2233|M.marinum_M TRRKFDPEATLDLIDRHRATGLVVVPVMFDRIMELPTKVLNRYSGRTLRF
MAV_3349|M.avium_104 TRRKFDPEATLDLIDRHRATGLVVVPVMFDRIMDLPAEVRRRYECRSLRF
Mvan_0232|M.vanbaalenii_PYR-1 TRRRFDPEATLELVDKYRATGLCVVPVMFDRIMDLPDEVLDKYSGRSLRF
Mflv_0435|M.gilvum_PYR-GCK TRRKFDPEATLELVDKFRATGLCVVPVMFDRIMELPEEVLDKYSGRSLRF
MSMEG_0304|M.smegmatis_MC2_155 TRRKFDPEATLELVDRHRATGLCVVPVMFDRIMELPEDVLNRYDGRSLRF
TH_4130|M.thermoresistible__bu TRRRFDPEATLQLVDRYRATGLVVVPVMLDRIMELPADVRDRYSGRSLRF
MLBr_02546|M.leprae_Br4923 LRRRFKPATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRV
MUL_1191|M.ulcerans_Agy99 LRRKFKPQLVLEDIEKHKVTAMVVVPVMLSRLLDAVEKIDKKPDLSSLKI
MAB_4340c|M.abscessus_ATCC_199 LRRKFKPENVLADVEKFKVTAIVVVPVMLNRLLNALDELSVKPDLSSLRI
**:*.* .* :::.:.*.: *****:.*::: .: : . :*:.
Mb1462c|M.bovis_AF2122/97 AAASGSRMRPDVVIAFMDQFGDVIYNNYNATEAGMIATATPADLRTAPDT
Rv1427c|M.tuberculosis_H37Rv AAASGSRMRPDVVIAFMDQFGDVIYNNYNATEAGMIATATPADLRTAPDT
MMAR_2233|M.marinum_M AAASGSRMRPDVVVAFMNRFGDVIYNNYNATEAGMIATATPADLRAAPDT
MAV_3349|M.avium_104 AAASGSRMRPDVVVAFMDEFGDVIYNNYNATEAGMIATATPADLRAAPDT
Mvan_0232|M.vanbaalenii_PYR-1 AAASGSRMRPDVVIKFMDRFGDVIYNNYNATEAGMIATATPRDLRAAPDT
Mflv_0435|M.gilvum_PYR-GCK AAASGSRMRPDIVIKFMDRFGDVIYNNYNATEAGMIATATPRDLRAAPDT
MSMEG_0304|M.smegmatis_MC2_155 AAASGSRMRPDVVIAFMDRFGDVIYNNYNATEAGMIATATPADLRAAPDT
TH_4130|M.thermoresistible__bu VTASGSRMRPDVVLDFMDRFGDVIYNNYNATEAGMIATATPADLRAAPST
MLBr_02546|M.leprae_Br4923 VFVSGSQLGAELATRALEELGPVIYNMYGSTEIAFATIAGPKDLQINSAT
MUL_1191|M.ulcerans_Agy99 VFVSGSQLGAELASRALKDLGPVIYNMYGSTEIAFATIAGPEDLQRNAAT
MAB_4340c|M.abscessus_ATCC_199 VFVSGSQLGGELASRAMDTLGPVIYNLYGSTEVAFATIARPQDLAINPST
. .***:: ::. :. :* **** *.:** .: : * * ** . *
Mb1462c|M.bovis_AF2122/97 AGRPAEGTEIRILDQQFTEVPTGEVGTIYVRNDSQFDGYTSGAAKDFHAG
Rv1427c|M.tuberculosis_H37Rv AGRPAEGTEIRILDQQFTEVPTGEVGTIYVRNDSQFDGYTSGAAKDFHAG
MMAR_2233|M.marinum_M AGRPAEGTEIRILDQEFNEVPEGEVGSIFVCNDSQFDGYTSGTTKDFHAG
MAV_3349|M.avium_104 AGRPAGGTEIRILDPEFNELPAGEVGTIYVRNNTQFDGYTSGSSKDFHEG
Mvan_0232|M.vanbaalenii_PYR-1 AGRPAEGTEIRILDADFNEVPTGEVGGIYVRNSTQFDGYTTGKTKDFHEG
Mflv_0435|M.gilvum_PYR-GCK AGRPAEGTEIKILDSEFNEVPTGETGGIWVRNSTQFDGYTSGSTKDFHDG
MSMEG_0304|M.smegmatis_MC2_155 AGRPAEGTEIRILDGDLRDLPTGEVGTIYVRNSTQFDGYTSGTTKDFHEG
TH_4130|M.thermoresistible__bu AGKPADGTEIRILDDALRPVPTGEVGQIFVRSNTLFDGYTSGTTKDFHEG
MLBr_02546|M.leprae_Br4923 VGPVVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGGGGKQIIDG
MUL_1191|M.ulcerans_Agy99 VGPVVKGVKVKILDDNGNEVSQGQVGRIFVGNAFPFEGYTGGGHKQIIDG
MAB_4340c|M.abscessus_ATCC_199 VGPVVKGATVKILDDEGKPVSQGTVGRIFVSNAIPFDGYTGGGHKQIIDG
.* . *. ::*** :. * .* *:* . *:*** * *:: *
Mb1462c|M.bovis_AF2122/97 FMSSGDVGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVAE
Rv1427c|M.tuberculosis_H37Rv FMSSGDVGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVAE
MMAR_2233|M.marinum_M FMSSGDVGYLDRNGRLFVVGRDDEMIVSGGENVYPIEVEKTLATHPEVAE
MAV_3349|M.avium_104 FMSSGDLGYLDSAGRLFVVGRDDEMIVSGGENVYPIEVEKTLATHPDVAE
Mvan_0232|M.vanbaalenii_PYR-1 FMSSGDVGYFDEAGRLFVVGRDDEMIVSGGENVYPIEVEKTLAAHPDVAE
Mflv_0435|M.gilvum_PYR-GCK FMSSGDVGYLDEEGRLFVVGRDDEMIVSGGENVYPIEVEKTLTSHPDVAE
MSMEG_0304|M.smegmatis_MC2_155 FMCSGDVGRLDDAGRLFVVGRDDEMIVSGGENVYPIEVEKVLTTHPAVAE
TH_4130|M.thermoresistible__bu FMASGDLGRLDEDGRLFVVGRDDEMIVSGGENVYPIEVEQVLARHPDVAE
MLBr_02546|M.leprae_Br4923 LLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVE
MUL_1191|M.ulcerans_Agy99 LMSSGDVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEALISGHPDVVE
MAB_4340c|M.abscessus_ATCC_199 LMSSGDVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPEVIE
::.***:* :* . *:: *************::* *** :: ** * *
Mb1462c|M.bovis_AF2122/97 AAVIGVDDQQYGQRLAAFVVLKP----GVSATPETLKQHVRDNLANYKVP
Rv1427c|M.tuberculosis_H37Rv AAVIGVDDQQYGQRLAAFVVLKP----GVSATPETLKQHVRDNLANYKVP
MMAR_2233|M.marinum_M AAVIGVDDEQYGQRLAAFVVLEPDADLDENAAPETLKQHVRDNLANYKVP
MAV_3349|M.avium_104 AAVIGVDDEQYGQRLAAFVVLAP----EARATPEALKQHVRDNLANYKVP
Mvan_0232|M.vanbaalenii_PYR-1 ATVLGVDDEKFGQRLEAFVVLTAD----AAATPETLKQHVRDNLANYKVP
Mflv_0435|M.gilvum_PYR-GCK ATVLGVDDEKFGQRLAAFVVLNPG----AAATPEALKQHVRDNLANYKVP
MSMEG_0304|M.smegmatis_MC2_155 AAVIGVDDEQFGQRLAAFVVLSG------DATVDDLKSHVRDNLANYKVP
TH_4130|M.thermoresistible__bu ATVIGVDDEQFGQRLAAFVVLRDG----AGATPDGLKQHVRDNLANYKVP
MLBr_02546|M.leprae_Br4923 ATAIGVDDKEWGARLRAFVVKKQD----ATIDEDAIKAYVRDHLARYKVP
MUL_1191|M.ulcerans_Agy99 ATALGVDDKEWGARLRAFVVKKPD----TDLDEETVKHYVRDHLARYKVP
MAB_4340c|M.abscessus_ATCC_199 ATALGVDDPEWGARLRAFVVRHPD----STVDADGIRAYVRDNLARYKVP
*:.:**** ::* ** **** : :: :***:**.****
Mb1462c|M.bovis_AF2122/97 RDIAVLDELPRGITGKILRTELQSRVGS-
Rv1427c|M.tuberculosis_H37Rv RDIAVLDELPRGITGKILRTELQSRVGS-
MMAR_2233|M.marinum_M REIAVLDELPRGSTGKILRAELQAKVCGT
MAV_3349|M.avium_104 REISVLDELPRSSTGKILRADLRARVGG-
Mvan_0232|M.vanbaalenii_PYR-1 REITILDELPRGVTGKISRKDLQDRLDNA
Mflv_0435|M.gilvum_PYR-GCK REITVLDELPRSITGKISRKDLKDRLDNA
MSMEG_0304|M.smegmatis_MC2_155 RDITILDELPRNSTGKIARRELQEKVNG-
TH_4130|M.thermoresistible__bu RSISVLDELPRGSTGKILRTELQARAQSG
MLBr_02546|M.leprae_Br4923 REVIFLEELPRNPTGKVLKRELRDFEVH-
MUL_1191|M.ulcerans_Agy99 REVIFLEELPRNPTGKILKRELREMEIE-
MAB_4340c|M.abscessus_ATCC_199 RDVVFLDVLPRNPSGKILKRELRELEV--
*.: .*: ***. :**: : :*: