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VPGVQDRVIVVTGAGGGLGREYALTLAREGASVVVNDLGGARDGTGAGSAMADEVVKEIKAAGGRAVANY DSVAEPEGAANIIKTAVDEFGKVDGVVSNAGILRDGTFHKMEFANWDAVLKVHLYGGYNVIRAAWPHFRE NGFGRVVVATSTSGLFGNFGQANYGAAKLGLVGLINTLAQEGAKYNIKANAVAPIAATRMTQDILPPEVF EKLTPEYVAPIVSYLCTEEVPETASVFIVGGGKVQRVALFQNSGVTFTEVPSVDDVAARWGEITDLSAAE RATFSLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0106 | - | - | 100% (287) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4960 | - | 1e-59 | 46.04% (278) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_2341 | - | 8e-54 | 43.57% (280) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0153 | - | 1e-135 | 83.57% (286) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_0741 | - | 1e-160 | 98.26% (287) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0148 | - | 1e-135 | 83.57% (286) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 1e-21 | 34.31% (204) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_4604c | - | 1e-127 | 78.72% (282) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0360 | - | 1e-135 | 82.17% (286) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5146 | - | 1e-138 | 85.21% (284) | peroxisomal multifunctional enzyme type 2 |
| M. smegmatis MC2 155 | MSMEG_0096 | - | 1e-140 | 87.02% (285) | peroxisomal hydratase-dehydrogenase-epimerase |
| M. thermoresistible (build 8) | TH_3158 | - | 1e-143 | 87.15% (288) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4759 | - | 1e-135 | 82.17% (286) | short-chain type dehydrogenase/reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0153|M.bovis_AF2122/97 --------------------------------------------------
Rv0148|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0360|M.marinum_M --------------------------------------------------
MUL_4759|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0106|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0741|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0096|M.smegmatis_MC2_155 --------------------------------------------------
TH_3158|M.thermoresistible__bu --------------------------------------------------
MAV_5146|M.avium_104 --------------------------------------------------
MAB_4604c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mb0153|M.bovis_AF2122/97 -----------MPGVQDRVIVVTGAGG-----------------------
Rv0148|M.tuberculosis_H37Rv -----------MPGVQDRVIVVTGAGG-----------------------
MMAR_0360|M.marinum_M -----------MPGVQDRVVVVTGAGG-----------------------
MUL_4759|M.ulcerans_Agy99 -----------MPGVQDRVVVVTGAGG-----------------------
Mvan_0106|M.vanbaalenii_PYR-1 -----------MPGVQDRVIVVTGAGG-----------------------
Mflv_0741|M.gilvum_PYR-GCK -----------MPGVQDRVIVVTGAGG-----------------------
MSMEG_0096|M.smegmatis_MC2_155 --------------MQDR-VVVTGAGG-----------------------
TH_3158|M.thermoresistible__bu -----------MPGVQDRVIVVTGAGG-----------------------
MAV_5146|M.avium_104 --------------MQDRVIVVTGAGG-----------------------
MAB_4604c|M.abscessus_ATCC_199 -----------MPGVQDRVIVVTGAGG-----------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
:* :* .. **
Mb0153|M.bovis_AF2122/97 GLGREYALTLAGEGASVVVNDLGGARDGT---------------------
Rv0148|M.tuberculosis_H37Rv GLGREYALTLAGEGASVVVNDLGGARDGT---------------------
MMAR_0360|M.marinum_M GLGREYALTLAREGASVVVNDLGGARDGT---------------------
MUL_4759|M.ulcerans_Agy99 GLGREYALTLAREGASVVVNDLGGARDGT---------------------
Mvan_0106|M.vanbaalenii_PYR-1 GLGREYALTLAREGASVVVNDLGGARDGT---------------------
Mflv_0741|M.gilvum_PYR-GCK GLGREYALTLAREGASVVVNDLGGARDGT---------------------
MSMEG_0096|M.smegmatis_MC2_155 GLGREYALTLAREGASVVVNDLGGARDGT---------------------
TH_3158|M.thermoresistible__bu GLGREYALTLAREGASVVVNDLGGARDGT---------------------
MAV_5146|M.avium_104 GLGREYALTLAREGASVVVNDLGGARDGT---------------------
MAB_4604c|M.abscessus_ATCC_199 GLGREYALTLAGEGASVVVNDLGGARDGS---------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
** . :: * * .. * :* : *.:
Mb0153|M.bovis_AF2122/97 --------------------------------------------------
Rv0148|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0360|M.marinum_M --------------------------------------------------
MUL_4759|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0106|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0741|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0096|M.smegmatis_MC2_155 --------------------------------------------------
TH_3158|M.thermoresistible__bu --------------------------------------------------
MAV_5146|M.avium_104 --------------------------------------------------
MAB_4604c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mb0153|M.bovis_AF2122/97 -------------------GAGSAMADEVVAEIRDKGGRAVAN-------
Rv0148|M.tuberculosis_H37Rv -------------------GAGSAMADEVVAEIRDKGGRAVAN-------
MMAR_0360|M.marinum_M -------------------GAGSAMADQVVTEIREGGGRAVAN-------
MUL_4759|M.ulcerans_Agy99 -------------------GAGSAMADQVVTEIREGGGRAVAN-------
Mvan_0106|M.vanbaalenii_PYR-1 -------------------GAGSAMADEVVKEIKAAGGRAVAN-------
Mflv_0741|M.gilvum_PYR-GCK -------------------GAGSAMADEVVKEIKDAGGRAVAN-------
MSMEG_0096|M.smegmatis_MC2_155 -------------------GSGSAMADQVVAEIKEAGGRAVAN-------
TH_3158|M.thermoresistible__bu -------------------GSGSAMADQVVAEIKEAGGRAVAN-------
MAV_5146|M.avium_104 -------------------GAGHNMADQVVKEIKDAGGRAVAN-------
MAB_4604c|M.abscessus_ATCC_199 -------------------GAGSAMADGVVDEIKAAGGRAVAN-------
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
*:. :. :. : *.*.**
Mb0153|M.bovis_AF2122/97 -YDSVATEDG---------AANIIKTALDEFGAVHG-----VVSNAGILR
Rv0148|M.tuberculosis_H37Rv -YDSVATEDG---------AANIIKTALDEFGAVHG-----VVSNAGILR
MMAR_0360|M.marinum_M -YDSVATEDG---------AANIIKTALDEFGAVHG-----VVSNAGILR
MUL_4759|M.ulcerans_Agy99 -YDSVATEDG---------AANIIKTALDEFGAVHG-----VVSNAGILR
Mvan_0106|M.vanbaalenii_PYR-1 -YDSVAEPEG---------AANIIKTAVDEFGKVDG-----VVSNAGILR
Mflv_0741|M.gilvum_PYR-GCK -YDSVAEPEG---------AANIIKTAVDEFGKVDG-----VVSNAGILR
MSMEG_0096|M.smegmatis_MC2_155 -YDSVAESEG---------AENIIKTAIDEFGKIDG-----VVSNAGILR
TH_3158|M.thermoresistible__bu -YDSVAEPEG---------AENIIKTALDEFGRVDG-----VVSNAGILR
MAV_5146|M.avium_104 -YDSVAEPAG---------AENIIKTALDEFGAVHG-----VVSNAGILR
MAB_4604c|M.abscessus_ATCC_199 -YDSVATEEG---------AANIVKTALDEFGAIHG-----VVSNAGILR
MLBr_02565|M.leprae_Br4923 ALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITR
*..* * * : :.. :.: .* :*.**** *
Mb0153|M.bovis_AF2122/97 DGTFHKMSFENWDAVLKVHLYGGYHVLRAAWPHFREQSYGRVVVATSTSG
Rv0148|M.tuberculosis_H37Rv DGTFHKMSFENWDAVLKVHLYGGYHVLRAAWPHFREQSYGRVVVATSTSG
MMAR_0360|M.marinum_M DGTFHKMTSENWDAVLKVHLYGGYNVVRAAWPHFREQSYGRVVVATSTSG
MUL_4759|M.ulcerans_Agy99 DGTFHKMTSENWDAVLKVHLYGGYNVVRAAWPHFREQSYGRVVVATSTSG
Mvan_0106|M.vanbaalenii_PYR-1 DGTFHKMEFANWDAVLKVHLYGGYNVIRAAWPHFRENGFGRVVVATSTSG
Mflv_0741|M.gilvum_PYR-GCK DGTFHKMEFANWDAVLKVHLYGGYNVIRAAWPHFRENGFGRVVVATSTSG
MSMEG_0096|M.smegmatis_MC2_155 DGTFHKMTYDNWDAVLKVHLYGGYNVIRAAWPHFREQSFGRVVVATSTSG
TH_3158|M.thermoresistible__bu DGTFHKMSYENWDAVQKVHLYGGYNVLRAAWPHFREQNFGRVVVATSTSG
MAV_5146|M.avium_104 DGTFHKMSFENWDAVLKVHLYGGYNVIRAAWPHFREQSYGRVVVATSTSG
MAB_4604c|M.abscessus_ATCC_199 DGTFHKMTYDNWHAVQQVHLYGGYNITRAAWPHFREQGYGRIVVATSTSG
MLBr_02565|M.leprae_Br4923 DKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSMAG
* : :* .*.** :*:* . .: .. : . **::* :* :*
Mb0153|M.bovis_AF2122/97 LFGNFGQTNYGAAKLGLVGLINTLALEGAKYNIHANALAP-IAATRMTQD
Rv0148|M.tuberculosis_H37Rv LFGNFGQTNYGAAKLGLVGLINTLALEGAKYNIHANALAP-IAATRMTQD
MMAR_0360|M.marinum_M LFGNFGQTNYGAAKLGLVGLINTLALEGAKYNIHSNAVAP-IAATRMTQD
MUL_4759|M.ulcerans_Agy99 LFGNFGQTNYGAAKLGLVGLINTLALEGAKYNIHSNAVAP-IAATRMTQD
Mvan_0106|M.vanbaalenii_PYR-1 LFGNFGQANYGAAKLGLVGLINTLAQEGAKYNIKANAVAP-IAATRMTQD
Mflv_0741|M.gilvum_PYR-GCK LFGNFGQANYGAAKLGLVGLINTLSQEGAKYNIKANAIAP-IAATRMTQD
MSMEG_0096|M.smegmatis_MC2_155 LFGNFGQANYGAAKLGLVGLINTLAQEGAKYNIKTNAIAP-IAATRMTQD
TH_3158|M.thermoresistible__bu LFGNFGQANYGAAKLGLVGLINTLAQEGAKYNIKTNAIAP-IAATRMTQD
MAV_5146|M.avium_104 LFGNFGQTNYGAAKLGLVGLINSLALEGAKYNIHANAIAP-IAATRMTED
MAB_4604c|M.abscessus_ATCC_199 LFGNFGQANYGAAKLGLVGLINTLALEGAKYNIHSNAIAP-IAATRMTAD
MLBr_02565|M.leprae_Br4923 IAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMTAA
: ** **:**.:** *::** ::*: *: .* **:** : *:**
Mb0153|M.bovis_AF2122/97 ILPPEVLEKLTPEFVAPVVAYLCTEECADNASVYVVGGGKVQRVALFGND
Rv0148|M.tuberculosis_H37Rv ILPPEVLEKLTPEFVAPVVAYLCTEECADNASVYVVGGGKVQRVALFGND
MMAR_0360|M.marinum_M IMPPEVLEKLTPEFVAPVVAYLCTEECADNGSVFIVGGGKVQRAALFQND
MUL_4759|M.ulcerans_Agy99 IMPPEVLEKLTPEFVAPVVAYLCTEECADNGSVFIVGGGKVQRAALFQND
Mvan_0106|M.vanbaalenii_PYR-1 ILPPEVFEKLTPEYVAPIVSYLCTEEVPETASVFIVGGGKVQRVALFQNS
Mflv_0741|M.gilvum_PYR-GCK ILPPEVFEKLTPEYVAPIVSYLCTEEVPETASVFIVGGGKVQRVALFQNE
MSMEG_0096|M.smegmatis_MC2_155 ILPPEVFEKLTPEYVAPVVAYLMTEELEDTDSVFIVGGGKIQRTALFQNE
TH_3158|M.thermoresistible__bu ILPPEVFEKLTPEYVAPVVAHLMSEEIEDTASVFIVGGGKVQRTALFQNE
MAV_5146|M.avium_104 ILPKEVLAKLTPEYVAPVVAYLCTEENPNSASVFVVGGGKVQRVALFENA
MAB_4604c|M.abscessus_ATCC_199 IASEAVLEQLPPAFVSPVVGYLCTEESTDNGSVFVVGGGKVQRVALFENA
MLBr_02565|M.leprae_Br4923 IP-------------------LATREVGRRLNSLLQGGLPVDVAETIAYF
* * :.* . : ** :: . :
Mb0153|M.bovis_AF2122/97 GANFDK-PPSVQDVAARWAEITDLSGAKIAG-FKL-
Rv0148|M.tuberculosis_H37Rv GANFDK-PPSVQDVAARWAEITDLSGAKIAG-FKL-
MMAR_0360|M.marinum_M GANFQT-PPSVQDIAAQWAQITDLSGAQKAG-FKL-
MUL_4759|M.ulcerans_Agy99 GANFQT-PPSVQDIAAQWAQITDLSGAQKAG-FKL-
Mvan_0106|M.vanbaalenii_PYR-1 GVTFTE-VPSVDDVAARWGEITDLSAAERAT-FSLG
Mflv_0741|M.gilvum_PYR-GCK GVTFTE-VPSVDDVAAKWGEITDLSAAERAT-FSLG
MSMEG_0096|M.smegmatis_MC2_155 GVTFSDGVPTVDDIAAKWNEITDLSAAQLAS-FKLG
TH_3158|M.thermoresistible__bu GVTFTDGVPTVADIAARWNEITDLSDAKLAT-FKLG
MAV_5146|M.avium_104 GVTYDK-PPTVQDVAARWDEITDLSAAKQAD-FKLG
MAB_4604c|M.abscessus_ATCC_199 GATFAS-PPTVDEVAARWGEIEDLATVTKAGPPSLA
MLBr_02565|M.leprae_Br4923 AIPASN---AVTGNVIRVCGQAMLGA----------
. :* . : *.