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MMYVLGVTLFALAILVSVALHECGHMWVARATGMKVRRYFVGFGPTLWSTWRPNKLGQTEYGVKAIPLGG FCDIAGMTAVEELDPEDRPYAMYKQKTWKRVAVLFAGPAMNFVIGLVLIYAIALIWGLPNITAPTTAVVG ETSCIKSEVSQGELGDCVANSPAAAAGIQAGDVIVKVGDTEVPTFDALVEAVRRQNGPTTLTVQRDENGE PREFTTTVDVTPSQRYVAGENGGPAVPVDVGSIGVTAAQFGPTQYNPLTAVPGTFVFTKDLAVALGKAIV KIPTKIGALVHSITGGERDPETPISVVGASRIGGETVEHGIWVAFWFFLAQLNFVLGAVNLIPLLPLDGG HISIALYEKLRNKLREARGKVAAGPVNYLKLMPVTYVVIIVMVGFTLLTVTADVINPITLFQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2261 | - | - | 100% (412) | peptidase M50 |
| M. vanbaalenii PYR-1 | Mvan_4494 | - | 2e-06 | 35.42% (96) | peptidase S1 and S6, chymotrypsin/Hap |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2894c | - | 1e-161 | 65.29% (412) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_4082 | - | 0.0 | 91.50% (412) | peptidase M50 |
| M. tuberculosis H37Rv | Rv2869c | - | 1e-160 | 65.05% (412) | transmembrane protein |
| M. leprae Br4923 | MLBr_01582 | - | 1e-159 | 63.83% (412) | putative integral membrane protein |
| M. abscessus ATCC 19977 | MAB_3170c | - | 1e-135 | 58.10% (420) | protease/peptidase |
| M. marinum M | MMAR_1837 | - | 1e-162 | 66.02% (412) | transmembrane protein |
| M. avium 104 | MAV_3726 | - | 1e-160 | 65.78% (415) | peptidase M50 |
| M. smegmatis MC2 155 | MSMEG_2579 | - | 1e-170 | 69.98% (413) | zinc metalloprotease |
| M. thermoresistible (build 8) | TH_1400 | - | 0.0 | 75.49% (412) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_2086 | - | 1e-161 | 65.78% (412) | transmembrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2261|M.vanbaalenii_PYR-1 -MMYVLGVTLFALAILVSVALHECGHMWVARATGMKVRRYFVGFGPTLWS
Mflv_4082|M.gilvum_PYR-GCK -MMYVLGVTLFALAILVSVALHECGHMWVARATGMKVRRYFVGFGPTLWS
TH_1400|M.thermoresistible__bu -MMFAIGVALFALAILVSVALHECGHMWVARATGMKVRRYFVGFGPTLWS
MSMEG_2579|M.smegmatis_MC2_155 -MMFGIGIVLFALAILVSVALHECGHMWVARATGMKVRRYFVGFGPTLWS
MLBr_01582|M.leprae_Br4923 -MMFALGIVLFAIAILISVALHECGHLWVACATGMKVRRYFVGFGPTLWS
MAV_3726|M.avium_104 -MMFVIGIVLFALAILISVALHECGHMWVARATGMKVRRYFVGFGPTLWS
Mb2894c|M.bovis_AF2122/97 -MMFVTGIVLFALAILISVALHECGHMWVARRTGMKVRRYFVGFGPTLWS
Rv2869c|M.tuberculosis_H37Rv -MMFVTGIVLFALAILISVALHECGHMWVARRTGMKVRRYFVGFGPTLWS
MMAR_1837|M.marinum_M -MMFVVGIVLFALAILISVALHECGHMWVARATGMKVRRYFVGFGPTLWS
MUL_2086|M.ulcerans_Agy99 -MMFVVGIVLFALAILISVALHECGHMWVARATGMKVRRYFVGFGPTLWS
MAB_3170c|M.abscessus_ATCC_199 MAAYAIGIALFALAILVSVALHECGHMWVAQATGMKVRRYFVGFGPTLWS
: *:.***:***:*********:*** ******************
Mvan_2261|M.vanbaalenii_PYR-1 TWRPNKL-------GQTEYGVKAIPLGGFCDIAGMTAVEELDPEDRPYAM
Mflv_4082|M.gilvum_PYR-GCK TRRPNKL-------GETEYGIKAVPLGGFCDIAGMTAVEELDPADRPYAM
TH_1400|M.thermoresistible__bu THRPNRL-------GSTEYGIKAVPLGGFCDIAGMTAIDELKPDEQPYAM
MSMEG_2579|M.smegmatis_MC2_155 TRRANRL-------GSTEYGIKAIPLGGFCDIAGMTSVDEIAPEDRPYAM
MLBr_01582|M.leprae_Br4923 TRR-----------GETQYGIKAVPLGGFCDIVGMTSVEKLEPDESDRAM
MAV_3726|M.avium_104 TRR-----------GETEYGLKAVPLGGFCDIAGMTSVEELAPDEADRAM
Mb2894c|M.bovis_AF2122/97 TRR-----------GETEYGVKAVPLGGFCDIAGMTPVEELDPDERDRAM
Rv2869c|M.tuberculosis_H37Rv TRR-----------GETEYGVKAVPLGGFCDIAGMTPVEELDPDERDRAM
MMAR_1837|M.marinum_M TRR-----------GETEYGVKAIPAGGFCDIAGMTPVEDLEPDEHDRAM
MUL_2086|M.ulcerans_Agy99 TRR-----------GETEYGVKAIPAGGFCDIAGMTPVEDLEPDEHDRAM
MAB_3170c|M.abscessus_ATCC_199 TKRKSNRPNKQGANDIVEYGVKAVPLGGFCDIAGMTSVEELTPEESDRAM
* * . .:**:**:* ******.***.::.: * : **
Mvan_2261|M.vanbaalenii_PYR-1 YKQKTWKRVAVLFAGPAMNFVIGLVLIYAIALIWGLPNITAPTTAVVGET
Mflv_4082|M.gilvum_PYR-GCK YRQKTWKRVAVLFAGPAMNFIIGLVLIYGIAIVWGLPNITAPTTAVVGET
TH_1400|M.thermoresistible__bu YRQKTWKRVAVLFAGPGMNFVIGLVLIYAIAVIWGLPTLNPPTTAVVGET
MSMEG_2579|M.smegmatis_MC2_155 YKQKVWKRVAVLFAGPAMNFVIGLVLIYGIAIVWGLPNLHQPTTAIVGET
MLBr_01582|M.leprae_Br4923 YKQATWKRVAVLFAGPAMNFVICLVLIYGIALVWGLPNLHMPTRAVIGET
MAV_3726|M.avium_104 FKQATWKRVAVLFAGPGANFVICLVLLYAIALIWGLPNLHPPTKAIVGET
Mb2894c|M.bovis_AF2122/97 YKQATWKRVAVLFAGPGMNLAICLVLIYAIALVWGLPNLHPPTRAVIGET
Rv2869c|M.tuberculosis_H37Rv YKQATWKRVAVLFAGPGMNLAICLVLIYAIALVWGLPNLHPPTRAVIGET
MMAR_1837|M.marinum_M YKQATWKRVAVLFAGPGMNFVICLVLIYGIAVVWGLPNLHPPTQAIIGET
MUL_2086|M.ulcerans_Agy99 YKQATWKRVAVLFAGPGMNFVICLVLIYGIAVVWGLPNLHPPTQAIIGET
MAB_3170c|M.abscessus_ATCC_199 YKQKVWKRVAVLFAGPAMNFLIGIVVFYGVVLFWGLPDNNAPTHPEITQT
::* .***********. *: * :*::*.:.:.**** ** . : :*
Mvan_2261|M.vanbaalenii_PYR-1 SCIKSEVSQG--ELGDCVANSPAAAAGIQAGDVIVKVGDTEVPTFDALVE
Mflv_4082|M.gilvum_PYR-GCK SCIKSEVTQG--ELGDCVANSPAAAAGIEAGDVIVRVGDTEVPTFDALVE
TH_1400|M.thermoresistible__bu SCVAAEVRQG--ELSECSGPGPAALAGIQPGDVIVKVGDAEVADFTEMAT
MSMEG_2579|M.smegmatis_MC2_155 GCVAPQITLE--EMGECTGPGPAALAGIQAGDEIVKVGDTEVKDFAGMAA
MLBr_01582|M.leprae_Br4923 ACVASELDQG--KLGNCTGPGPAALAGLRAGDVVVKIGDTTVSTFDDMAA
MAV_3726|M.avium_104 ACVAPEVAPG--KLADCTGPGPAALAGIRPGDVIVKVGDTPVSTFDDMAA
Mb2894c|M.bovis_AF2122/97 GCVAQEVSQG--KLEQCTGPGPAALAGIRSGDVVVKVGDTPVSSFDEMAA
Rv2869c|M.tuberculosis_H37Rv GCVAQEVSQG--KLEQCTGPGPAALAGIRSGDVVVKVGDTPVSSFDEMAA
MMAR_1837|M.marinum_M GCVAPETAQG--KLEQCTGPGPAALAGLRAGDVVVKVGDTAVSTFDEMAT
MUL_2086|M.ulcerans_Agy99 GCVAPETAQG--KLEQCTGPGPAALAGLRAGDVVVKVGDTAVSTFGEMAT
MAB_3170c|M.abscessus_ATCC_199 SCVAPQKSADPRDVVACTGEGPAALAGLRAGDQVLTAGGTSVSTSTDLVT
.*: : .: * . .*** **:..** :: *.: * :.
Mvan_2261|M.vanbaalenii_PYR-1 AVRRQNGPTTLTVQRDENGEPREFTTTVDVTPSQRYVAGENGGPA---VP
Mflv_4082|M.gilvum_PYR-GCK AVRQESGPTVLTVQRDENGQVREFTTTVDVTPSQRYVAGEDGGPA---VP
TH_1400|M.thermoresistible__bu AVRQHRGPTELTVQRTVDGVTTEFTTVVDVTPTQRFTAGEDGEP----VP
MSMEG_2579|M.smegmatis_MC2_155 AVRKLDGPTRIEFKRDG----RVMDTVVDVTPTQRFTSADASAP------
MLBr_01582|M.leprae_Br4923 VVRKLHGTVPIVFERDG----TAITSYVDITPTQRYMSKGKGSQ---LEP
MAV_3726|M.avium_104 AIRKVHGNVPIVVDRDG----TAITAYVDVTPTQRYLSGGSGPQGAPPQP
Mb2894c|M.bovis_AF2122/97 AVRKSHGSVPIVVERDG----TAIVTYVDIESTQRWIPNGQGGE---LQP
Rv2869c|M.tuberculosis_H37Rv AVRKSHGSVPIVVERDG----TAIVTYVDIESTQRWIPNGQGGE---LQP
MMAR_1837|M.marinum_M AIRKLHGSVPIVVERDG----TTVTANVVIESTRRWVPNEQGNQ---LEP
MUL_2086|M.ulcerans_Agy99 AIRKLHGSMPIVVERDG----TTVTANVVIESTRRWVPNEQGNQ---LEP
MAB_3170c|M.abscessus_ATCC_199 AIRGLRGPQVFEIVRDG----KPQSLMVNVTETQRWD--EKAGK-----L
.:* * : . * * : ::*: .
Mvan_2261|M.vanbaalenii_PYR-1 VDVGSIGVTAAQFG-PTQYNPLTAVPGTFVFTKDLAVALGKAIVKIPTKI
Mflv_4082|M.gilvum_PYR-GCK VDVGSIGVTAAQFG-PTQYNAFTAVPGTFVFTKDLAVELGKAVVKIPTKI
TH_1400|M.thermoresistible__bu AEVGAIGVTAAQFG-PTQYNVLSAVPATFTFTGELAVELGKALAKIPTKV
MSMEG_2579|M.smegmatis_MC2_155 STVGAIGVSAVPVQPPAQYNPITAVPATFAFTGDLAVELGKSLAKIPTKI
MLBr_01582|M.leprae_Br4923 ATVGAIGVGAHHLL-PTHYGVFSALPATAAFAGDLTVEVGKALVTIPTKL
MAV_3726|M.avium_104 STVGAIGVGAVKVA-PAHYGVFSAIPASVVFAGDLTVEVGKALVTIPTKV
Mb2894c|M.bovis_AF2122/97 ATVGAIGVGAARVG-PVRYGVFSAMPATFAFTGDLTVEVGKALAALPTKV
Rv2869c|M.tuberculosis_H37Rv ATVGAIGVGAARVG-PVRYGVFSAMPATFAVTGDLTVEVGKALAALPTKV
MMAR_1837|M.marinum_M ATVGAIGVGAAQSG-PTQYGILSALPATFAFTGDLTVEVGRALVAIPTKV
MUL_2086|M.ulcerans_Agy99 ATVGAIGVGAAQSG-PTQYGILSALPATFAFTGDLTVEVGRALVAIPTKV
MAB_3170c|M.abscessus_ATCC_199 VPVGAVGASLSTYVPQKHYNPVTAIPATGNLIGTVAVETVKAIGKIPMKV
**::*. :*. .:*:*.: . ::* ::: :* *:
Mvan_2261|M.vanbaalenii_PYR-1 GALVHSITGGERDPETPISVVGASRIGGETVEHGIWVAFWFFLAQLNFVL
Mflv_4082|M.gilvum_PYR-GCK GALVDSISGGERDPETPISVVGASRIGGETVEAGIWVAFWFFLAQLNFVL
TH_1400|M.thermoresistible__bu GALVASITGDERDPETPISVVGASIIGGDTVNHGLWVAFWFFLAQLNFVL
MSMEG_2579|M.smegmatis_MC2_155 GALVEAIGGGERDKETPISVVGASIIGGETVDAGLWVAFWFFLAQLNFVL
MLBr_01582|M.leprae_Br4923 GALVHAIGGGQRDPQTPMSVVGASIIGGDTVDHGLWVAFWFFLAQLNLIL
MAV_3726|M.avium_104 GALVHAIGGGQRDPQTPMSVVGASIIGGDTVDHGLWVAFWFFLAQLNLIL
Mb2894c|M.bovis_AF2122/97 GALVRAIGGGQRDPQTPISVVGASIIGGDTVDHGLWVAFWFFLAQLNLIL
Rv2869c|M.tuberculosis_H37Rv GALVRAIGGGQRDPQTPISVVGASIIGGDTVDHGLWVAFWFFLAQLNLIL
MMAR_1837|M.marinum_M GALVHAIGGGQRDPQTPISVVGASIIGGDTVDHGLWVAFWFFLAQLNLIL
MUL_2086|M.ulcerans_Agy99 GALVHAIGGGQRDPQTPISVVGASIIGGDTVDHGLWVAFWFFLAQLNLIL
MAB_3170c|M.abscessus_ATCC_199 GALWDSITGSERAMDTPMSIVGASRMGGETVEHDMWIMFWILLAQLNFAL
*** :* *.:* :**:*:**** :**:**: .:*: **::*****: *
Mvan_2261|M.vanbaalenii_PYR-1 GAVNLIPLLPLDGGHISIALYEKLRNKLREARGKVAAGPVNYLKLMPVTY
Mflv_4082|M.gilvum_PYR-GCK GGINLVPLLPLDGGHISIALYEKVRNKIREARGKVAAAPVNYLKLMPLTY
TH_1400|M.thermoresistible__bu GAINLVPLLPFDGGHIAIATYEKIRNMIRSARGLTAAAPVNYLKLMPATY
MSMEG_2579|M.smegmatis_MC2_155 GAINLVPLLPFDGGHIAVATYEKIRNMIRSARGMVAAGPVNYLKLMPATY
MLBr_01582|M.leprae_Br4923 GAINLVPLLPFDGGHIAIAVFERIRNLIRSARGVVVAAPVNYLKLMPATY
MAV_3726|M.avium_104 GAINLVPLLPFDGGHIAIAVFEKVRNLIRSARGMVAAAPVNYLKLMPATY
Mb2894c|M.bovis_AF2122/97 AAINLLPLLPFDGGHIAVAVFERIRNMVRSARGKVAAAPVNYLKLLPATY
Rv2869c|M.tuberculosis_H37Rv AAINLLPLLPFDGGHIAVAVFERIRNMVRSARGKVAAAPVNYLKLLPATY
MMAR_1837|M.marinum_M GAINLLPLLPFDGGHIAVAVFEKIRNMIRAARGKVAAAPVNYLKLMPATY
MUL_2086|M.ulcerans_Agy99 GAINLLPLLPFDGGHIAVAVFEKIRNMIRAARGKVAAAPVNYLKLMPATY
MAB_3170c|M.abscessus_ATCC_199 GAINLLPLLPFDGGHIAVATYEKVRNMIRSARGLAVGAPVNYMKLMPATY
..:**:****:*****::* :*::** :* *** ....****:**:* **
Mvan_2261|M.vanbaalenii_PYR-1 VVIIVMVGFTLLTVTADVINPITLFQ
Mflv_4082|M.gilvum_PYR-GCK VVIIVMVGFTLLTVTADVVNPITLFQ
TH_1400|M.thermoresistible__bu VILVVVAGYMLLTVTADLVNPIRLFQ
MSMEG_2579|M.smegmatis_MC2_155 VVLAVVAGYMLLTVTADLVNPLSIFQ
MLBr_01582|M.leprae_Br4923 VVLVFVVGYVLLTVTADLVNPIRLFQ
MAV_3726|M.avium_104 VVLVFVVGYMLLTVTADLVNPIRLFQ
Mb2894c|M.bovis_AF2122/97 VVLVLVVGYMLLTVTADLVNPIRLFQ
Rv2869c|M.tuberculosis_H37Rv VVLVLVVGYMLLTVTADLVNPIRLFQ
MMAR_1837|M.marinum_M VVLVFVVGYMLLTVTADLVNPIRLFQ
MUL_2086|M.ulcerans_Agy99 VVLVFVVGYMLLTVTADLVNPIRLFQ
MAB_3170c|M.abscessus_ATCC_199 LVLVVVVGYMLLTITADIVNPIRLFQ
::: .:.*: ***:***::**: :**