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MSAAQQPDCRPGRRPFTYDPFDPDVMADPLPYYRVLRDEHPVYYLQKWDTYALSRFDDIWNVLEINDGTF VASEGTLPSAAVLAGHNDGPVADPPLHPMPFHANFDAPIYDEVRRCTAAPFRPRNVAKLADRIRVLANER LDELLPRGRFDLTQEYGGIVAASVVCELVGLPADLAPDVLATVNAGSLAQPGSGVEVANARPGYLEYLTP VVARRRAGQGSELPIVDNLLNYRLPDGSALSDTEAAVQMLGVFIGGTETVPKIVAHGLWELSSRPDQLAE VRSDMDANVPVAREEMIRYCAPAQWFARTLRRPFTLHDTTMRPGQRIISLLASANRDEREFPDADRFVWN RPMPRLLAFGRGQHFCLGAHLARLEIAIMVTEWLKRVPEFRVDTAAAFRPPSSFQWGWSELPVEV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2239 | - | - | 100% (415) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_0317 | - | 1e-50 | 34.32% (405) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_5159 | - | 2e-45 | 34.07% (408) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 3e-45 | 31.71% (410) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_4107 | - | 0.0 | 89.45% (398) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 3e-45 | 31.71% (410) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-35 | 28.12% (409) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 5e-47 | 32.77% (412) | cytochrome P450 |
| M. marinum M | MMAR_0399 | cyp191A3 | 1e-177 | 72.00% (400) | cytochrome P450 191A3 Cyp191A3 |
| M. avium 104 | MAV_5123 | - | 1e-174 | 70.57% (401) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2563 | - | 0.0 | 81.75% (400) | cytochrome P450 superfamily protein |
| M. thermoresistible (build 8) | TH_3299 | - | 0.0 | 75.81% (401) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_1049 | cyp191A3 | 1e-173 | 71.00% (400) | cytochrome P450 191A3 Cyp191A3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2239|M.vanbaalenii_PYR-1 ---------------------MSAAQQPDCRPGRRPFTYDPFDPDVMADP
Mflv_4107|M.gilvum_PYR-GCK ------------------------------------MRYDPFDPAVMADP
MSMEG_2563|M.smegmatis_MC2_155 ------------------------MKPPVTEAVTGEFSYDPFDPAVMADP
TH_3299|M.thermoresistible__bu ------------------------MTVSHETFSHETFSYDPFDPDVMADP
MMAR_0399|M.marinum_M ----------------------------------MNFSYDPFGARVMADP
MUL_1049|M.ulcerans_Agy99 ----------------------------------MNFSYDPFGARVMADP
MAV_5123|M.avium_104 ----------------------------------MDFAYDPFDAEVMANP
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: . :*
Mvan_2239|M.vanbaalenii_PYR-1 LPYYRVLRDEHPVYYLQKWDTYALSRFDDIWNVLEINDGTFVASEGTLPS
Mflv_4107|M.gilvum_PYR-GCK LPYYRVLRDEHPVHYLETWDTYALSRFDDIWNVLEINDGTFVASEGTLPA
MSMEG_2563|M.smegmatis_MC2_155 TPYYRVLREKYPLYHIEKWDTWALSRFSDIWEVLEVNDGTFVASEGTLPA
TH_3299|M.thermoresistible__bu LPYYRVLRDRHPVYHVAKWDTYALSRFEDIWQVLEVNDGTFVASEGTLPP
MMAR_0399|M.marinum_M LPYYRVLRDQHPVYYLPQWDTFAISRFDDIWRVLEVNDGTFVASEGTLPA
MUL_1049|M.ulcerans_Agy99 LPYYRVLRDQHPVYYLPQWDTFAISRFDDIWRVLEVNDGTFVASEGTLPA
MAV_5123|M.avium_104 LPYYRILRDHHPVYYMPQWDTFALSRFDDIWRVLEVNNGTFVASEGTLPP
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
* ** * : *: ..* . * . :. . ::
Mvan_2239|M.vanbaalenii_PYR-1 AAVLAGHNDGPVADPPLHPMPFHANFDAPIYDEVRRCTAAPFRPRNVAKL
Mflv_4107|M.gilvum_PYR-GCK AAVLARHNDGPVADPPLHPMPFHANFDSPIYEDVRRCTATPFRPKNVAKL
MSMEG_2563|M.smegmatis_MC2_155 ATVLAEHNDGAVPDPPWHPMPFHANFDTPIYDSVRRCTSPQFRPRSVTKL
TH_3299|M.thermoresistible__bu ATTLARHNSGPVPDPPLQPLPFHAVFDAPLYNSVRRTHSAPFRPRSVAGM
MMAR_0399|M.marinum_M ASVLARHNSGPVDDPPWHPLPFHAVFDAPLYGEIRRAHSPPLRPKSVAGL
MUL_1049|M.ulcerans_Agy99 ALVLARHNSGPVDDPPWHPLPFRAVFDAPLCGEIRRAHSPPLRPKSVAGL
MAV_5123|M.avium_104 ASVLAQHNDGPVDDPPLHPLPFHAMFDADLYGEIRRTHSRPFRPRAVTDL
Mb0789c|M.bovis_AF2122/97 SSRTS----------EAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIREL
Rv0766c|M.tuberculosis_H37Rv SSRTS----------EAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIREL
MAB_1216c|M.abscessus_ATCC_199 ASFGP----------HAKLVMSFLAMDDPEHLRLRALVSKGFTPRRIREL
MLBr_02088|M.leprae_Br4923 QAIAAGA------EPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQAL
. :* :* : : *: : :
Mvan_2239|M.vanbaalenii_PYR-1 ADRIRVLANERLDELLPRGR---FDLTQEYGGIVAASVVCELVGLPADLA
Mflv_4107|M.gilvum_PYR-GCK RDRIRVLANERLDELLPLGR---FDLTQDYGGIVAASVVCELVGLPAEMA
MSMEG_2563|M.smegmatis_MC2_155 ADRIRTLANERLDELLPRGQ---FDLTQDYGGIVAASVVCELVGLPVDLA
TH_3299|M.thermoresistible__bu RDRIRELATERLDALLPRGT---FDLTQEYAGVVAAAMVCDLLGVPTKLA
MMAR_0399|M.marinum_M EARIRELANERLDRLLPQGS---FDLTQDYGGVVVASIVCELLGMPASLA
MUL_1049|M.ulcerans_Agy99 EARIRELANERLNRLLPQGS---FDLTQDYGGVVVASIVCELLGMPASLA
MAV_5123|M.avium_104 EGRIRTLANERLDELLARGS---FDLTQEYGGVVVATIVCELLGIPTDLA
Mb0789c|M.bovis_AF2122/97 EPQVLELARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDR
Rv0766c|M.tuberculosis_H37Rv EPQVLELARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDR
MAB_1216c|M.abscessus_ATCC_199 EGQVVALARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVPESDR
MLBr_02088|M.leprae_Br4923 EGDIAALVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVPYEDA
: *. *: **. : . : ::. *:*:*
Mvan_2239|M.vanbaalenii_PYR-1 PDVLATVNAGSLAQPGSGVEV----------ANARPGYLEYLTPVVARRR
Mflv_4107|M.gilvum_PYR-GCK ADVLATVNAGSLAQPGSGVEV----------ANARPGYLEYLTPVVERTR
MSMEG_2563|M.smegmatis_MC2_155 ADVLATVNAGSLAEPGSGVEV----------ANARPGYLEYLTPVVQRRR
TH_3299|M.thermoresistible__bu PDVLATVNAGSLPQQDKGVDT----------AAARPGYLEYLVPVVQRRR
MMAR_0399|M.marinum_M PEVLAAVNAGSLTEPGVGVDT----------AETRPNYLEFLVPVVRQRR
MUL_1049|M.ulcerans_Agy99 PEVLAAVNAGSLTEPGVGVDT----------AETRPNYLEFLVPVVRQRR
MAV_5123|M.avium_104 PQVLAAVNAGSLAEPGVGVDT----------GQARPNYFEFLLPAVQRRR
Mb0789c|M.bovis_AF2122/97 ARIRALADAVLHREDGVADVP-------PPAMAASIELMRYYADLIAEFR
Rv0766c|M.tuberculosis_H37Rv ARIRALADAVLHREDGVADVP-------PPAMAASIELMRYYADLIAEFR
MAB_1216c|M.abscessus_ATCC_199 ARIRELADGVMHREDGLADVP-------PEAIQASFDLMTYYIEMVRERR
MLBr_02088|M.leprae_Br4923 PEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRR
. . : : : *
Mvan_2239|M.vanbaalenii_PYR-1 AGQGS-ELPIVDNLLNYRLPDGSALSDTEAAVQMLGVFIGGTETVPKIVA
Mflv_4107|M.gilvum_PYR-GCK AGEPG-DLPIVDNLLAYRLPDGSALSDMEAAVQMLGVFIGGTETVPKIVA
MSMEG_2563|M.smegmatis_MC2_155 AGEGR-ELPIVDNLLQYRLPDGSAFSDLEAAVQMLGVFIGGTETVPKIVA
TH_3299|M.thermoresistible__bu AEDADGSLPIVDGLIRYRLPDGRALDDVEVATQMLCVFIGGTETVPKIVA
MMAR_0399|M.marinum_M ADPTG-ELPVVDGLLRYRLPDGSALDDTEVATQMLCIFIGGTETVPKIVA
MUL_1049|M.ulcerans_Agy99 ADPTG-ELPVVDGLLRYRLPDGSALDDTEVATQMLCIFIGGTETVPKIVA
MAV_5123|M.avium_104 ADPSGPPLEVVDGLLGYQLPDGSALDDLEVATQMLCIFIGGTETVPKIVA
Mb0789c|M.bovis_AF2122/97 RRPAN---NLTSALLAAEL-DGDRLSDQEIMAFLFLMVIAGNETTTKLLA
Rv0766c|M.tuberculosis_H37Rv RRPAN---NLTSALLAAEL-DGDRLSDQEIMAFLFLMVIAGNETTTKLLA
MAB_1216c|M.abscessus_ATCC_199 RRPTE---DLTSALLQAEI-DGDRLTDEEVLAFLFLMVIAGNETTTKLLA
MLBr_02088|M.leprae_Br4923 GTPGE---DLISRLIELDE-SGDQLTEEEIIATCGLLLVAGHETTVNLIA
: . *: .* : : * . :.:.* **. :::*
Mvan_2239|M.vanbaalenii_PYR-1 HGLWELSSRPDQLAEVRSDMDANVPVAREEMIRYCAPAQWFARTLRRPFT
Mflv_4107|M.gilvum_PYR-GCK HGLWELSSRPDQLADVVSDLDANVPVAREEMIRYCAPAQWFARTLRRPFT
MSMEG_2563|M.smegmatis_MC2_155 HGLWELTRHPEQLAAVRTDLDANVPIAREEMIRFCAPAQWFARTVRKPFT
TH_3299|M.thermoresistible__bu HGLWELADRPDQLAAVRADPDTAVPQAREEMIRYCAPAQWFARTLRKPYT
MMAR_0399|M.marinum_M HGLWELSRRPDQLAAVRTDPQSNVNVAREEMIRYCAPAQWFARTARKPFT
MUL_1049|M.ulcerans_Agy99 RGLWELSRRPDQLAAVRTDPQSNVNVAREEMIRYCASAQWFARTARKPFT
MAV_5123|M.avium_104 QGLWELSRHPDQLAAVRADPQHNIPVAREEMIRYCAPAQWFARTVRKPFD
Mb0789c|M.bovis_AF2122/97 NAVYWAAHHPGQLARVFADHS-RIPMWVEETLRYDTSSQILARTVAHDLT
Rv0766c|M.tuberculosis_H37Rv NAVYWAAHHPGQLARVFADHS-RIPMWVEETLRYDTSSQILARTVAHDLT
MAB_1216c|M.abscessus_ATCC_199 NAVYWGHRNPDQLATVHADHD-RIPLWVEESLRYDTSSQILARTVAEDIT
MLBr_02088|M.leprae_Br4923 NAVLAMLRNPSQWKALSSNPQ-RAPLVVEETLRYDPAIHLIGRVAAKDMT
..: .* * : :: . ** :*: .. : :.*. .
Mvan_2239|M.vanbaalenii_PYR-1 LHDTTMRPGQRIISLLASANRDEREFPDADRFVWNRPM-PRLLAFGRGQH
Mflv_4107|M.gilvum_PYR-GCK LHGTTMRPGQRIISLLASANRDEREYPQPDEFLWNRPI-ARLLAFGRGQH
MSMEG_2563|M.smegmatis_MC2_155 LHGTTLQPGQRVITLLASAGRDEREYPDPDSFIWDRRI-ERLLAFGRGQH
TH_3299|M.thermoresistible__bu LHGVTMRPGQRIITLLASANRDEREFDRPDEFRWNRPI-PRTLAFGRGQH
MMAR_0399|M.marinum_M IGDQTIEPGQRVITLLASANRDEREYPDPDEFIWDRPI-RRSLAFGRGQH
MUL_1049|M.ulcerans_Agy99 IGDQTIEPGQRVITLLASANRDEREYPDPDEFIWDRPI-RRSLAFGRGQH
MAV_5123|M.avium_104 IHGQTLNPGQRVITLLASANRDEREYPDPDDFVWDRPI-RRSLAFGRGQH
Mb0789c|M.bovis_AF2122/97 LYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAH
Rv0766c|M.tuberculosis_H37Rv LYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAH
MAB_1216c|M.abscessus_ATCC_199 VYDTKIPAGDILLLLPGSANRDDRVFDDADQYRIGREIGAKLVSFGSGAH
MLBr_02088|M.leprae_Br4923 IGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPS-SRHLAFAVGSH
: .: *: :: * .:*.** : .* : .* : ::*. * *
Mvan_2239|M.vanbaalenii_PYR-1 FCLGAHLARLEIAIMVTEWLKRVPEFRVDTAAAFRPPSSFQWGWSELPVE
Mflv_4107|M.gilvum_PYR-GCK FCLGAHLARLEITIMVTEWLKRVPEFRVDAAAASRPPSSFQWGWNNLPVD
MSMEG_2563|M.smegmatis_MC2_155 FCLGVHLARLEITIMVTEWLKRVGEFRVDERAARRPPSSFQWGWNNVPVE
TH_3299|M.thermoresistible__bu FCLGFHLARLEIDVMVTEWLRRVPEYRIRAEDAYRPPSSFQWGWSVVPVE
MMAR_0399|M.marinum_M FCIGYHLARLEISVLLQEWFRRVPEFQICAAQATRLPSSFQWGWNKIPVE
MUL_1049|M.ulcerans_Agy99 FCIGYHLARLEIAVLLQEWFRRVPEFQICAAQATRLPSSFQWGWNKIPVE
MAV_5123|M.avium_104 FCIGYHLARLEVAVLLQEWLRRVPDYAIRADAATRLPSSFQWGWNKIPVE
Mb0789c|M.bovis_AF2122/97 FCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPIS
Rv0766c|M.tuberculosis_H37Rv FCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPIS
MAB_1216c|M.abscessus_ATCC_199 FCLGAHLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMT
MLBr_02088|M.leprae_Br4923 FCLGAALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQ
**:* ***:* : : *. : . * :*:
Mvan_2239|M.vanbaalenii_PYR-1 V------
Mflv_4107|M.gilvum_PYR-GCK VHGVGG-
MSMEG_2563|M.smegmatis_MC2_155 V------
TH_3299|M.thermoresistible__bu V------
MMAR_0399|M.marinum_M V------
MUL_1049|M.ulcerans_Agy99 V------
MAV_5123|M.avium_104 V------
Mb0789c|M.bovis_AF2122/97 VQAR---
Rv0766c|M.tuberculosis_H37Rv VQAR---
MAB_1216c|M.abscessus_ATCC_199 VQLREGR
MLBr_02088|M.leprae_Br4923 V------
*