For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TSDPGSALQHRKRRHIDVCLTEAVDYQSLTTGFERYRLPYNALTQTDLHSVDLSTEFLGSHLRAPVLIGA MTGGAALSGIINRNLAAAAQQLGIGMMLGSQRVMIDDEAAAASFEVRGVAPDILLIGNIGLAQLRSSMVP GLAAALDRVGANGLAVHTNPLQEAMQHDGDTDFSGSIGRLCDVAGAIGYPVVLKEVGHGIGAAAAAELVG CPIAAIDVAGAGGTSWARIEQFVRYGDVRYPALAEWGVPTAQALTEVRQMLPDVPLVASGGIRTGMDAAK ALAMGARVVAVARPLLAPAVESVEAVVDWLQRFIDELLVCLHGCGAANLSALRGRGVTELP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2176 | - | - | 100% (342) | isopentenyl pyrophosphate isomerase |
| M. vanbaalenii PYR-1 | Mvan_5512 | - | 3e-06 | 26.52% (264) | ferredoxin-dependent glutamate synthase |
| M. vanbaalenii PYR-1 | Mvan_2206 | - | 9e-05 | 41.18% (51) | FMN-dependent alpha-hydroxy acid dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0713 | lldD1 | 3e-05 | 37.78% (90) | L-lactate dehydrogenase (cytochrome) LldD1 |
| M. gilvum PYR-GCK | Mflv_4187 | - | 1e-171 | 87.13% (342) | isopentenyl pyrophosphate isomerase |
| M. tuberculosis H37Rv | Rv0694 | lldD1 | 3e-05 | 37.78% (90) | L-lactate dehydrogenase (cytochrome) LldD1 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3242 | - | 1e-107 | 64.42% (312) | isopentenyl pyrophosphate isomerase |
| M. marinum M | MMAR_4812 | idi2 | 1e-135 | 69.83% (348) | isopentenyl pyrophosphate isomerase type 2 Idi2 |
| M. avium 104 | MAV_3894 | fni | 1e-136 | 71.56% (334) | isopentenyl pyrophosphate isomerase |
| M. smegmatis MC2 155 | MSMEG_2337 | fni | 1e-108 | 71.07% (280) | isopentenyl pyrophosphate isomerase |
| M. thermoresistible (build 8) | TH_2565 | - | 3e-05 | 30.67% (150) | PUTATIVE FMN-dependent dehydrogenase |
| M. ulcerans Agy99 | MUL_0380 | idi2 | 1e-136 | 69.83% (348) | isopentenyl pyrophosphate isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2176|M.vanbaalenii_PYR-1 -----------MTSDPGSALQHRKRRHIDVCLTEAVDYQSLTTGFERY-R
Mflv_4187|M.gilvum_PYR-GCK -----------MTPDPASALQHRKRRHIDVCLTDPVDYQTLTTGFERY-Q
MMAR_4812|M.marinum_M -----------MTNDPA-EISSRKRRHIDVCLNDEVNYVGVTTGLERY-R
MUL_0380|M.ulcerans_Agy99 -----------MTNDPA-EISSRKRRHIDVCLNDEVNYVGVTTGLERY-R
MAV_3894|M.avium_104 -----------MD-----AMTHRKRRHIDVCLSDPVEFDGVTTGLDRY-R
MSMEG_2337|M.smegmatis_MC2_155 -----------MRVTGDRDAVARKRRHIDVCLNEAVDHQSVSTGLERY-R
MAB_3242|M.abscessus_ATCC_1997 -----------------------------------MQYVTRTTGLERL-D
Mb0713|M.bovis_AF2122/97 --MA-EAWFETVAIAQQRAKRRLPKSVYSSLIAASEKGITVADNVAAFSE
Rv0694|M.tuberculosis_H37Rv --MA-EAWFETVAIAQQRAKRRLPKSVYSSLIAASEKGITVADNVAAFSE
TH_2565|M.thermoresistible__bu VTMARDKWFETVSIAQERAKKRLPKSVYGALIAGSEKGLTVSDNVEAFGE
. : ..
Mvan_2176|M.vanbaalenii_PYR-1 LPYNALTQTDLHSVDLSTEFLGSHLRAPVLIGAMTGGAALSGIINRNLAA
Mflv_4187|M.gilvum_PYR-GCK LPYNALTQTDLHSVDLGTEFMGSRLRAPVLIGAMTGGAALSGIINRNLAE
MMAR_4812|M.marinum_M LPFNALTQTSLADIDLSAEFFGAPLRAPVLIGAMTGGAELSATINRNLAT
MUL_0380|M.ulcerans_Agy99 LPFNALTQTSLADIDLSAEFFGAPLRAPVLIGAMTGGAELSAMINRNLAT
MAV_3894|M.avium_104 LPYHALTQTSLGDIDVSTSFFGANLRAPILIGAMTGGAEMSKTINRNLAA
MSMEG_2337|M.smegmatis_MC2_155 LPYHALTQTNLTEIDLTTNFLGKPLRAPVLIGAMTGGAELSGTINRNLAA
MAB_3242|M.abscessus_ATCC_1997 LPYMALPNSSLAGVDLSTEFLGRRLAAPVLIGAMTGGAKLAATINRNLAA
Mb0713|M.bovis_AF2122/97 LGFAPHVIGATDKRDLSTTVMGQEVSLPVIISP-TGVQAVDPGGEVAVAR
Rv0694|M.tuberculosis_H37Rv LGFAPHVIGATDKRDLSTTVMGQEVSLPVIISP-TGVQAVDPGGEVAVAR
TH_2565|M.thermoresistible__bu LGFAPHVVGGPAKRDMATTVMGQEISLPVVISP-TGVQAVHPDGEVAVAR
* : . *: : .:* : *::*.. ** : : :*
Mvan_2176|M.vanbaalenii_PYR-1 AAQQLGIGMMLGSQRVMID-DEA---AAASFEVRGVAPDILLIGNIGLAQ
Mflv_4187|M.gilvum_PYR-GCK AAQQLGVGMMLGSQRVMID-DAV---AAESFDVRGVAPDVLVIGNIGLAQ
MMAR_4812|M.marinum_M AAQRLGIGMMLGSQRIMLD-DARGQRAASSFAVREVAPDVLLIGNIGLAQ
MUL_0380|M.ulcerans_Agy99 AAQRLGIGMMLGSQRIMLD-DARGQRAASSFAVREVAPDVLLIGNIGLAQ
MAV_3894|M.avium_104 AAQQLGIGMMLGSQRIMLD-SALGERAADSFAVRDVAPDVLLFGNIGLSQ
MSMEG_2337|M.smegmatis_MC2_155 AAQKLGVGMMLGSQRIMLRSGEQAAHRSESFAVRDVAPDVLLVGNIGLSQ
MAB_3242|M.abscessus_ATCC_1997 AAQELGIGMMLGSQRVMLVEPDS----ADTFAVREVAPDILLIGNIGLAQ
Mb0713|M.bovis_AF2122/97 AAAARGTVMGLSSFASKPIEEVIAANPKTFFQVYWQGGRDALAERVERAR
Rv0694|M.tuberculosis_H37Rv AAAARGTVMGLSSFASKPIEEVIAANPKTFFQVYWQGGRDALAERVERAR
TH_2565|M.thermoresistible__bu AAAARGTAMGLSSFASKPIEEVIAANPKLFFQVYWLGGRDAIAARVERAR
** * * *.* * * . : .: ::
Mvan_2176|M.vanbaalenii_PYR-1 LR-SSMVPGLAAALDRVGAN-GLAVHTNPLQEAMQHDGDTDFSGSIGRLC
Mflv_4187|M.gilvum_PYR-GCK LQ-PSMVPALAAALDRVGAN-GLAVHTNPLQEAMQHNGDTDFSGSMSRLR
MMAR_4812|M.marinum_M LT-KAAVPAVAAALRRVGAN-ALAVHANSLQEAMQHGGDTDFSGSLGRLR
MUL_0380|M.ulcerans_Agy99 LT-KAAVPAVAAALRRVGAN-ALAVHANSLQEAMQHGGDTDFSGSLGRLR
MAV_3894|M.avium_104 LA-KTAVPHLVKALDRVGAD-ALAVHTNPLQEAMQHNGDTDFSGSLSRLR
MSMEG_2337|M.smegmatis_MC2_155 LT-HDNAPLITDALRRVGAD-ALAVHTNPLQEAIQANGDTDFAGSRERLL
MAB_3242|M.abscessus_ATCC_1997 LGNIAPAAQLNSLVRRVGAD-ALAVHTNPLQEAVQPGGDTDFTGQVYRLA
Mb0713|M.bovis_AF2122/97 QAGAVGLVVTTDWTFSHGRDWGSPKIPEEMNLKTILRLSPEAITRPRWLW
Rv0694|M.tuberculosis_H37Rv QAGAVGLVVTTDWTFSHGRDWGSPKIPEEMNLKTILRLSPEAITRPRWLW
TH_2565|M.thermoresistible__bu EAGAAGLIVTTDWSFSHGRDWGSPKIPESMNLRTILRMLPEGLSRPRWMM
* : . . .: :: .: :
Mvan_2176|M.vanbaalenii_PYR-1 DVAGAIGYP--VVLKEVGHGIGAAAAAELVG----CPIAAIDVAGAGGTS
Mflv_4187|M.gilvum_PYR-GCK EVVDSLGYP--VMLKEVGHGIGASAAAQLVD----CPVAAVDVAGAGGTS
MMAR_4812|M.marinum_M DAADLLDYP--VLLKEVGHGIGAAAVAQLLRLPGGLPVSGIDVAGAGGTS
MUL_0380|M.ulcerans_Agy99 DAADLLDYP--VLLKEVGHGIGAAAVAQLLRLPGGLPVSGIDVAGAGGTS
MAV_3894|M.avium_104 EAAAALDYP--VLLKEVGHGIGGAAAAELVGGEGQPPVAGIDVAGAGGTS
MSMEG_2337|M.smegmatis_MC2_155 EIGPSIGCP--LLLKEVGHGIGAAAVAELTGGRDDVPVAAIDVAGAGGTS
MAB_3242|M.abscessus_ATCC_1997 ELTHAVEFP--VLLKEVGHGISGAAARRLGG----CRLAAIDVAGAGGTS
Mb0713|M.bovis_AF2122/97 KFAKTLRPPDLRVPNQGRRGEPGPPFFAAYGEWMATPPPTWEDIGWLREL
Rv0694|M.tuberculosis_H37Rv KFAKTLRPPDLRVPNQGRRGEPGPPFFAAYGEWMATPPPTWEDIGWLREL
TH_2565|M.thermoresistible__bu QWAKTLRPPNLRVPNQAARGEAGPPFFHAYGEWMGTPPPTWDDIAWLREL
. : * : :: :* ... . : .
Mvan_2176|M.vanbaalenii_PYR-1 WAR---IEQFVRYGDVR--------YPALAEWGVPTAQALTEVRQMLP--
Mflv_4187|M.gilvum_PYR-GCK WAR---IEQFVRYGEVR--------YPALAEWGIPTAQALTEVRGILP--
MMAR_4812|M.marinum_M WSR---VEQLVRYGELR--------YPELADWGIPTAEAIVEVRQALP--
MUL_0380|M.ulcerans_Agy99 WSR---VEQLVRYGELR--------YPELADWGIPTAEAIVEVRQALP--
MAV_3894|M.avium_104 WSR---VEQFVRYGELR--------YPDLADWGVPTARAIVEVRRLLP--
MSMEG_2337|M.smegmatis_MC2_155 WSR---VEQFVRYGTVR--------YPDLADWGVPTARAIIEVRQALP--
MAB_3242|M.abscessus_ATCC_1997 WAR---VEQFVRFGAIT--------SPELAEWGIPTAEALVEVHAELP--
Mb0713|M.bovis_AF2122/97 WGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAV
Rv0694|M.tuberculosis_H37Rv WGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAV
TH_2565|M.thermoresistible__bu WGGPFMLKGVIRVDDAKRAVDAGVSAISVSNHGGNNLDSTPAAIRALPAI
*. :: .:* . ::: * . . **
Mvan_2176|M.vanbaalenii_PYR-1 ------DVPLVASGGIRTGMDAAKALAMGARVVAVARP-LLAPAVESVEA
Mflv_4187|M.gilvum_PYR-GCK ------DVPLVASGGIRTGMDAAKALAMGAEVVAIARP-LLAPAVESVGA
MMAR_4812|M.marinum_M ------AVPLVASGGIRTGMDAAKAIALGADVVAIARP-LLAPAIESATA
MUL_0380|M.ulcerans_Agy99 ------AVPLVASGGIRTGMDAAKSIALGADVVAIARP-LLAPAIESATA
MAV_3894|M.avium_104 ------EIPLVASGGIRTGMDAAKAIALGADVVAVARP-LLPAAIESSAA
MSMEG_2337|M.smegmatis_MC2_155 ------RIPLVASGGIRTGMDAAKGLFALDGVETIS---CFRAVIEGS--
MAB_3242|M.abscessus_ATCC_1997 ------HMPLIGSGGIRTGMDAAKAIALGASVVSVALP-LLAPAVQSPQA
Mb0713|M.bovis_AF2122/97 SAAVGDQVEVLLDGGIRRGSDVVKAVALGARAVMIGRAYLWGLAANGQAG
Rv0694|M.tuberculosis_H37Rv SAAVGDQVEVLLDGGIRRGSDVVKAVALGARAVMIGRAYLWGLAANGQAG
TH_2565|M.thermoresistible__bu VDAVGDQVEVLLDGGIRRGSDVVKAVALGARAVMIGRAYLWGLAAEGQAG
: :: .**** * *..*.: . :. . :.
Mvan_2176|M.vanbaalenii_PYR-1 VVDWLQRFIDELLVCLHGCGAANLSALRGRGVTELP--------------
Mflv_4187|M.gilvum_PYR-GCK VVDWLQRFIDELLVCLHGSGAANLSALRERGVTELP--------------
MMAR_4812|M.marinum_M VQGWLQLFLDELRVCLHCCGARDLTSLRDIGVTAIR--------------
MUL_0380|M.ulcerans_Agy99 VQDWLQLFLDELRVCLHCCGAPDLTSLRDIGVTAIR--------------
MAV_3894|M.avium_104 VVDWLRPFIDELRVCLHGCGVADLAGLRAVELIRLA--------------
MSMEG_2337|M.smegmatis_MC2_155 --GWLG-------VCRRRSGRARGRAECPGAVWTWRCCRS----------
MAB_3242|M.abscessus_ATCC_1997 VVAWLQQFLDELRIAMHCADVSTIADLRRISLRPRSSPR-----------
Mb0713|M.bovis_AF2122/97 VENVLDILRGGIDSALMGLGHASVHDLSPADILVPTGFIRDLGVPSRRDV
Rv0694|M.tuberculosis_H37Rv VENVLDILRGGIDSALMGLGHASVHDLSPADILVPTGFIRDLGVPSRRDV
TH_2565|M.thermoresistible__bu VENVLDILRGGIDSALLGLGRASVHDLTPDDVVVPPGFTRALGVDPTRP-
* . . :