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PKERKPGAVVVKQSPILAAGAVLWRPKEFTGTPEIAVIHRPRYDDWSLPKGKVDPGETEAVTAVREIAEE TGYRAHLGRRLPTVTYPVDTDIKKVRYWAARCVGGEFAANDEVDELRWLPVAQAMSMLSYPHDRKVLRRF QKLPADTQTVIIVRHGTAGDRSRYRGDDRNRPLDKHGRAQAESLVGQLLAFGAEELFAADRVRCHQTLDP LAEELGAVIHDEPALTEEAYADDRKAARQRILEIAEKSAAPVICTQGKVIPDLITWWCERDGVRPDKSRN RKGSTWVMSLSDGRLVAADHISSPLPPKK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2138 | - | - | 100% (310) | NUDIX hydrolase |
| M. vanbaalenii PYR-1 | Mvan_6062 | - | 1e-12 | 39.58% (96) | NUDIX hydrolase |
| M. vanbaalenii PYR-1 | Mvan_3482 | - | 9e-06 | 32.14% (84) | phosphoglycerate mutase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3009 | mutT1 | 1e-118 | 70.17% (295) | hydrolase MutT1 |
| M. gilvum PYR-GCK | Mflv_4224 | - | 1e-142 | 78.93% (299) | NUDIX hydrolase |
| M. tuberculosis H37Rv | Rv2985 | mutT1 | 1e-118 | 70.17% (295) | hydrolase MutT1 |
| M. leprae Br4923 | MLBr_01682 | - | 1e-108 | 63.61% (294) | hypothetical protein MLBr_01682 |
| M. abscessus ATCC 19977 | MAB_3291 | - | 1e-112 | 65.66% (297) | MutT/NUDIX hydrolase |
| M. marinum M | MMAR_1729 | mutT1 | 1e-120 | 70.00% (290) | hydrolase MutT1 |
| M. avium 104 | MAV_3835 | - | 1e-117 | 66.02% (309) | hydrolase, NUDIX family protein |
| M. smegmatis MC2 155 | MSMEG_2390 | - | 1e-114 | 67.91% (296) | hydrolase, NUDIX family protein |
| M. thermoresistible (build 8) | TH_2045 | mutT1 | 1e-122 | 68.18% (308) | POSSIBLE HYDROLASE MUTT1 |
| M. ulcerans Agy99 | MUL_1971 | mutT1 | 1e-120 | 70.00% (290) | hydrolase MutT1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2138|M.vanbaalenii_PYR-1 ------MPKERKPGAVVVK-QSPILAAGAVLWR----PKEFT---GTPEI
Mflv_4224|M.gilvum_PYR-GCK -----------------MT-KTSIMAAGAVLWR----PQDGT---DAPEI
TH_2045|M.thermoresistible__bu ------VPKEVRPKTIPSDPASAVRAAGAVLWR----PGVDS---SAPEI
Mb3009|M.bovis_AF2122/97 -------MSIQNSSARRRSAGRIVYAAGAVLWR----PGSADSE-GPVEI
Rv2985|M.tuberculosis_H37Rv -------MSIQNSSARRRSAGRIVYAAGAVLWR----PGSADSE-GPVEI
MMAR_1729|M.marinum_M -------MSIPSSSVRRRSGDRIVYAAGAVLWR----PGKAK---GAIEI
MUL_1971|M.ulcerans_Agy99 -------MSIPSSSVRRRSGDRIVYAAGAVLWR----PGKAK---GAIEI
MAV_3835|M.avium_104 -------MPTQNSSTARRAGTRVVYAAGAVLWR----PGDAEPDGGDVEV
MLBr_01682|M.leprae_Br4923 -------MAIWNSSCQWPK-SQIVYAAGAVLWR----PGNSD---PAVEI
MSMEG_2390|M.smegmatis_MC2_155 MMPVDDLQEIPLSKDTTEKSKHTVRAAGAVLWRDASEHGGTTGHPATVEV
MAB_3291|M.abscessus_ATCC_1997 ------------MPDPISRTGAAVLAAGAALWRHQEHPEQDN-AAGAIEV
: ****.*** *:
Mvan_2138|M.vanbaalenii_PYR-1 AVIHRPRYDDWSLPKGKVDPGETEAVTAVREIAEETGYRAHLGRRLPTVT
Mflv_4224|M.gilvum_PYR-GCK AIIHRPRYDDWSLPKGKVDPGETDTVATVREIGEETGFRSHLGRRLPTVT
TH_2045|M.thermoresistible__bu AVIHRPRYDDWSLPKGKVDPGEIEPVTAVREIEEETGYRSVLGRELTEIT
Mb3009|M.bovis_AF2122/97 AVIHRPRYDDWSLPKGKVDPGETAPVGAVREILEETGHRANLGRRLLTVT
Rv2985|M.tuberculosis_H37Rv AVIHRPRYDDWSLPKGKVDPGETAPVGAVREILEETGHRANLGRRLLTVT
MMAR_1729|M.marinum_M ALIHRPRYDDWSLPKGKVDPGETAAVAAAREVCEETGQHAHLGRRLIMVS
MUL_1971|M.ulcerans_Agy99 ALIHRPRYDDWSLPKGKVDPGETAAVAAAREVCEETGQHAHLGRRLIMVS
MAV_3835|M.avium_104 AIIHRPRYDDWSLPKGKVDPGETAPVAAVREVREETGQCAVLGRRLDTVR
MLBr_01682|M.leprae_Br4923 AVIHRPRYDDWSLSKGKVDPGETAPMAAVREVFEETGHHATLGARLVVVN
MSMEG_2390|M.smegmatis_MC2_155 AVIHRPRYDDWSLPKGKLDQGETEPVAAAREIHEETGHTAVLGRRLGRVT
MAB_3291|M.abscessus_ATCC_1997 ALVHRPRYDDWSLPKGKLDPGETAAIAAVREIAEETGFTARLGRRLPSVS
*::**********.***:* ** .: :.**: **** : ** .* :
Mvan_2138|M.vanbaalenii_PYR-1 YPVDT---DIKKVRYWAARCVGGEFAANDEVDELRWLPVAQAMSMLSYPH
Mflv_4224|M.gilvum_PYR-GCK YPVDG---AVKKVRYWAARAVGGEFVPNDEVDEMKWLPADRAIAELGYPH
TH_2045|M.thermoresistible__bu YPLAN---GVKRVRYWAARALDGSFAPNDEVDELKWLPVSDALQRLDYPQ
Mb3009|M.bovis_AF2122/97 YPTDSPFRGVKKVHYWAARSTGGEFTPGSEVDELIWLPVPDAMNKLDYAQ
Rv2985|M.tuberculosis_H37Rv YPTDSPFRGVKKVHYWAARSTGGEFTPGSEVDELIWLPVPDAMNKLDYAQ
MMAR_1729|M.marinum_M YPVEQ---GLKKVYYWAARSLGGEFTAGNEVDKLIWLPVADAMTKLDYAQ
MUL_1971|M.ulcerans_Agy99 YPVEQ---GLKKVYYWAARSLGGEFTAGNEVDKLIWLPVADAMTKLDYAQ
MAV_3835|M.avium_104 YPIEQ---GVKKVYYWSARATGGEFVPGDEVDQLLWLPVTEAMQRLNYTQ
MLBr_01682|M.leprae_Br4923 YPIGQ---HVKKVYYWAARSIEGQFVPGSEVDELLWLPVVDAMKKLDYVQ
MSMEG_2390|M.smegmatis_MC2_155 YPIPQ---GTKRVWYWAAKSTGGDFSPNDEVDKLVWLPVDAAMDQLQYPD
MAB_3291|M.abscessus_ATCC_1997 YPVSQ---GTKRVKYWAAEALDGKFEANDEVDELRWLPVKDAIKTVSYAV
** *:* **:*.. *.* ...***:: ***. *: : *
Mvan_2138|M.vanbaalenii_PYR-1 DRKVLRRFQKLPADTQTVIIVRHGTAGDRSRYRGDDRNRPLDKHGRAQAE
Mflv_4224|M.gilvum_PYR-GCK DRKVVRRFLKLPADTKTVLIVRHGTAGDKKRYRGDDRKRPLDKHGRAQAE
TH_2045|M.thermoresistible__bu DRDVLQRFAEHPARTRTVLIVRHATAGSRSRWQGDDRLRPLDKHGRAQAE
Mb3009|M.bovis_AF2122/97 DRKVLCRFAKHPADTQTVLVVRHGTAGSKAHFSGDDSKRPLDKRGRAQAE
Rv2985|M.tuberculosis_H37Rv DRKVLCRFAKHPADTQTVLVVRHGTAGSKAHFSGDDSKRPLDKRGRAQAE
MMAR_1729|M.marinum_M DRKVLRRFGKKPADTKTVLVVRHGSAGSKSRFSGDDTQRPLDKKGRAQAE
MUL_1971|M.ulcerans_Agy99 DRKVLRRFGKKPADTKTVLVVRHGSAGSKSRFSGDDTQRPLDKKGRAQAE
MAV_3835|M.avium_104 DRKVLRHFNKKPADTHTVLVVRHGTAGRKSRFSGDDAKRPLDKRGRAQAE
MLBr_01682|M.leprae_Br4923 DRKVLRQFAKQPAYTRTVLIVRHGTAGRKSRLSEDDTKRPLDKQGRAQAE
MSMEG_2390|M.smegmatis_MC2_155 DRKVLRRFVKRPVDTKTVLVVRHGTAGRRSRYKGDDRKRPLDKRGRAQAE
MAB_3291|M.abscessus_ATCC_1997 DRKVLRNFAKHQIDTRTLIIVRHAKAGRKERYSGDDTLRPLDKKGRAQAE
**.*: .* : *:*:::***..** : : ** *****:******
Mvan_2138|M.vanbaalenii_PYR-1 SLVGQLLAFGAEELFAADRVRCHQTLDPLAEELGAVIHDEPALTEEAYAD
Mflv_4224|M.gilvum_PYR-GCK SLVGQLLAFGAAELFAADRVRCRQTLEPLAEELGVSIAGEPTLTEEAYAE
TH_2045|M.thermoresistible__bu ALVGVLLAFGADRLHAADRVRCEQTLEPLADEIAQPIHPEPTLNEESYTR
Mb3009|M.bovis_AF2122/97 ALVPQLLAFGATDVYAADRVRCHQTMEPLAAELNVTIHNEPTLTEESYAN
Rv2985|M.tuberculosis_H37Rv ALVPQLLAFGATDVYAADRVRCHQTMEPLAAELNVTIHNEPTLTEESYAN
MMAR_1729|M.marinum_M ALVPQLLAFGADTVYAADRLRCHQTVQPLAEELGVVIHNERTLTEEAYAK
MUL_1971|M.ulcerans_Agy99 ALVPQLLAFGADTVYAADRLRCHQTVQPLAEELGVVIHNERTLTEEAYAK
MAV_3835|M.avium_104 ALVPQLLAFGASQVHAADRVRCHQTVQPLAEELDVPVHNETTLTEEAYAK
MLBr_01682|M.leprae_Br4923 ALIGQLLAFGATDVYAADQLHCHQTVEPLAAELGVPIHNEPSLTKEAFAK
MSMEG_2390|M.smegmatis_MC2_155 ALVAQLMAFGATTLYAADRVRCHQTIEPLAQELDQLIHNEPLLTEEAYAA
MAB_3291|M.abscessus_ATCC_1997 ALTGQLLAFGASAIHAADRLRCRQTVEPLAEELNTVIFSEPALSEEAYWA
:* *:**** :.***:::*.**::*** *: : * *.:*::
Mvan_2138|M.vanbaalenii_PYR-1 DRKAARQRILEIAEKSAAPVICTQGKVIPDLITWWCERDGVRPDKSRNRK
Mflv_4224|M.gilvum_PYR-GCK DRKAARARILDIAETAGTPVICSQGKVIPDLIAWWCERDGVRADKSRNRK
TH_2045|M.thermoresistible__bu NRTAGRQRLLEIAAAGGTPVVCTQGKVIPDLIAWWCERDGVRPADTENRK
Mb3009|M.bovis_AF2122/97 NPKRGRHRVLQIVEQVGTPVICTQGKVIPDLITWWCERDGVHPDKSRNRK
Rv2985|M.tuberculosis_H37Rv NPKRGRHRVLQIVEQVGTPVICTQGKVIPDLITWWCERDGVHPDKSRNRK
MMAR_1729|M.marinum_M NAKRGRQRLLQIATRDGTPVICSQGKVIPDLIAWWCERDGVRSDRSRNHK
MUL_1971|M.ulcerans_Agy99 NAKRGRQRLLQIATRDGTPVICSQGKVIPDLIAWWCERDGVRSDRSRNHK
MAV_3835|M.avium_104 NPKRARHRMLEIAGEPGTPVVCTQGKVIPDLIAWWCDRDGVRPDKSRNHK
MLBr_01682|M.leprae_Br4923 NPKRGLHRVLRIAAQSGTPVICLQGKIIPDLIAWWCERDGVRPKKSHNYK
MSMEG_2390|M.smegmatis_MC2_155 DHKAARKRLLEIAGRPGNPVICTQGKVIPGLIEWWCERAKVRPETTGNRK
MAB_3291|M.abscessus_ATCC_1997 DRKRAHRRVLEIAELDGIRVLCTQGKVIPDLIEWWAQRDGVRPDKSRNRK
: . . *:* *. . *:* ***:**.** **.:* *:. : * *
Mvan_2138|M.vanbaalenii_PYR-1 GSTWVMSLSDGRLVAADHISSPLPPKK--
Mflv_4224|M.gilvum_PYR-GCK GSTWVLSLAEGRLVAADHLSSALPPKK--
TH_2045|M.thermoresistible__bu GSVWVMSLVEGRLIAADHIASPLPVR---
Mb3009|M.bovis_AF2122/97 GSTWVLSLSAGRLVTADHIGGALAANVRA
Rv2985|M.tuberculosis_H37Rv GSTWVLSLSAGRLVTADHIGGALAANVRA
MMAR_1729|M.marinum_M GSTWVLSLSGGRVIAADHIGGALAANVRA
MUL_1971|M.ulcerans_Agy99 GSTWVLSLSGGRVIAADHIGGALAANVRA
MAV_3835|M.avium_104 GSTWVLSLSAGRLVAADHIGGALAANVRA
MLBr_01682|M.leprae_Br4923 GSTWVLSLLAGQLVAVDHVGSTLAANVQP
MSMEG_2390|M.smegmatis_MC2_155 GSTWVLSLSDGELVGADYLS---PPDEK-
MAB_3291|M.abscessus_ATCC_1997 GSMWVLSMRGQKLLAADHLDSPLPAGS--
** **:*: .:: .*:: .