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VSASQNWPAGSSRDRSSLLITVTGRDQPGVTSALFEVLSRHRVDLLNVEQVVIRGRLTLGVLVAAATEVA AGAELRSEVEAAIHGVGLDVSIESSDGLPVLRVPSTHTIVVLGRPITAEAFGVVAREAAALGVNIDFIRG VSDYPVTGLELRVSVPPGAYRELQAVLARVAVEESVDIAVEDYSLSRRAKRLIVFDVDSTLIQGEVIEML AAHAGAEAAVAEVTEAAMRGELDFAESLHRRVATLAGLPASVLDDVADQIELTPGARTTLRTLRRLGYHC GIVSGGFRQVIEPLAHELMMDFVAANELEIVDGKLTGRVVGDVVDRPGKAKALRDFAQQAGVPMEQTVAV GDGANDIDMLSAAGLGVAFNAKPALREVADASLSYPYLDTLLFILGITRGEIEAADALDGVVRRVEIPD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2083 | - | - | 100% (419) | phosphoserine phosphatase SerB |
| M. vanbaalenii PYR-1 | Mvan_0843 | - | 3e-14 | 29.33% (208) | HAD family hydrolase |
| M. vanbaalenii PYR-1 | Mvan_3004 | - | 3e-11 | 27.73% (238) | HAD family hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3068c | serB2 | 1e-179 | 79.85% (402) | phosphoserine phosphatase |
| M. gilvum PYR-GCK | Mflv_4276 | - | 0.0 | 86.39% (404) | phosphoserine phosphatase SerB |
| M. tuberculosis H37Rv | Rv3042c | serB2 | 1e-179 | 79.85% (402) | phosphoserine phosphatase |
| M. leprae Br4923 | MLBr_01727 | - | 1e-174 | 78.61% (402) | putative phosphoserine phosphatase |
| M. abscessus ATCC 19977 | MAB_3388c | - | 1e-166 | 74.26% (408) | phosphoserine phosphatase (SerB2) |
| M. marinum M | MMAR_1652 | serB2 | 1e-179 | 79.16% (403) | phosphoserine phosphatase SerB2 |
| M. avium 104 | MAV_3907 | serB | 1e-176 | 77.94% (408) | phosphoserine phosphatase SerB |
| M. smegmatis MC2 155 | MSMEG_2321 | serB | 0.0 | 88.54% (410) | phosphoserine phosphatase |
| M. thermoresistible (build 8) | TH_1814 | serB2 | 0.0 | 82.57% (413) | PROBABLE PHOSPHOSERINE PHOSPHATASE SERB2 (PSP) |
| M. ulcerans Agy99 | MUL_1888 | serB2 | 1e-178 | 78.66% (403) | phosphoserine phosphatase SerB2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2083|M.vanbaalenii_PYR-1 -------MSASQNWPAGSSRDRSSLLITVTGRDQPGVTSALFEVLSRHRV
Mflv_4276|M.gilvum_PYR-GCK -------MVDLS---------GSSVLITVTGRDQPGVTSALFEVLSRYGV
MSMEG_2321|M.smegmatis_MC2_155 -------MSSAR--------ERSSLLITVTGVDQPGVTSALFEVLSRHKV
TH_1814|M.thermoresistible__bu MAGPTNKKVPTEKVPKKVPKKKVSVLITVTGVDQPGVTSALFEVLARHRV
MLBr_01727|M.leprae_Br4923 -------MNTPP---------KVSVLITVTGVDQPGVTSALFAVLSRHGG
MAV_3907|M.avium_104 -------MNSPP---------KVSVLITVTGVDQPGVTATLFEVLSGHGV
Mb3068c|M.bovis_AF2122/97 ---------MPA---------KVSVLITVTGMDQPGVTSALFEVLAQHGV
Rv3042c|M.tuberculosis_H37Rv ---------MPA---------KVSVLITVTGMDQPGVTSALFEVLAQHGV
MMAR_1652|M.marinum_M -------MSVPA---------KVSVLITVTGIDQPGVTSALFEVLSKHGV
MUL_1888|M.ulcerans_Agy99 ---------MPA---------KVSVLITVTGIDQPGVTSALFEVLSKHGV
MAB_3388c|M.abscessus_ATCC_199 -------MNN-----------RVTVLVTVTGADKPGVTSVLMGVLSRHGV
::*:**** *:****:.*: **: :
Mvan_2083|M.vanbaalenii_PYR-1 DLLNVEQVVIRGRLTLGVLVAAATEVAAGAELRSEVEAAIHGVGLDVSIE
Mflv_4276|M.gilvum_PYR-GCK TLLNVEQVVIRNRLTLGVLVAAAPDVAAGAQFREDVEAAIHGVGLEVTIE
MSMEG_2321|M.smegmatis_MC2_155 ELRNVEQVVIRGRLTLGVLVAAPSDVADGDDLRRDVEAAIHGVGLDVAIE
TH_1814|M.thermoresistible__bu SLLNVEQVVIRGRLTLGVLLAAPPEVADGPALRAEVREAIHRVGLDVTIE
MLBr_01727|M.leprae_Br4923 ELLNVEQVVIRGRLTLGVLVLCPPEVAAYTALRDDVQAAIRRVGLDVTIE
MAV_3907|M.avium_104 ELLNVEQVVIRHRLTLGVLVCCPADVADGPALRHDVEAAIRKVGLDVSIE
Mb3068c|M.bovis_AF2122/97 ELLNVEQVVIRGRLTLGVLVSCPLDVADGTALRDDVASAIHGVGLDVAIE
Rv3042c|M.tuberculosis_H37Rv ELLNVEQVVIRGRLTLGVLVSCPLDVADGTALRDDVAAAIHGVGLDVAIE
MMAR_1652|M.marinum_M ELLNVEQVVIRSRLTLGVLVSCAPEVADGAALREDVEAAIHEVGLDVTVE
MUL_1888|M.ulcerans_Agy99 ELLNVEQVVIRRRLTLGVLVSCAPEVADGGALREDVEAAIHEVGLDVTVE
MAB_3388c|M.abscessus_ATCC_199 DLLNVEQVVIRGKLTLGVLVKAQGRSDAVEALQDELEEAMHTLGFDVDVE
* ******** :******: . :: :: *:: :*::* :*
Mvan_2083|M.vanbaalenii_PYR-1 SSDGLPVLRVPSTHTIVVLGRPITAEAFGVVAREAAALGVNIDFIRGVSD
Mflv_4276|M.gilvum_PYR-GCK GSNGLPVMQVPSTHTIVVLGRPITAEAFGVVAREVAELGVNIDFIRGVSD
MSMEG_2321|M.smegmatis_MC2_155 RSDDLPVMREPSTHTIVVLGRPITAEAFGVVARAVADLGVNIDFIRGVSD
TH_1814|M.thermoresistible__bu RSDDLPVMDEPSSHTITVLGRPITAQAFSAVAREVAALGVNIDSIRGVSD
MLBr_01727|M.leprae_Br4923 RSDDLPIIREPSTHTIFVLGRPITARAFGAVAREVAALDVNIDVIRGISD
MAV_3907|M.avium_104 RSDDVPIIREPSTHTIFVLGRPITAAAFGAVAREVAALGVNIDLIRGVSD
Mb3068c|M.bovis_AF2122/97 RSDDLPIIRQPSTHTIFVLGRPITAGAFSAVAREVAALGVNIDFIRGISD
Rv3042c|M.tuberculosis_H37Rv RSDDLPIIRQPSTHTIFVLGRPITAGAFSAVARGVAALGVNIDFIRGISD
MMAR_1652|M.marinum_M RSDDLPVIREPSTHTIFVLGRPVTAGAFGAVAKEVAALGVNIDFIRGISD
MUL_1888|M.ulcerans_Agy99 RSDDLPVIREPSTHTIFVLGRPVTAGAFGAVAKEVAALGVNIDFIRGISD
MAB_3388c|M.abscessus_ATCC_199 FGGDSSVIKDPSTHTIVVLGRPVTARAFGAVARELAALGINIDLIRGIAD
... .:: **:*** *****:** **..**: * *.:*** ***::*
Mvan_2083|M.vanbaalenii_PYR-1 YPVTGLELRVSVPPG--AYRELQAVLARVAVEESVDIAVEDYSLSRRAKR
Mflv_4276|M.gilvum_PYR-GCK YPVTGLELRVSVPNG--VYGDLQRVLARLSAEEAVDIAVEDYSLARRAKR
MSMEG_2321|M.smegmatis_MC2_155 YPVTGLELRVSVPAGA-AYGQLQQALATVAANEGVDIALEDYTLSRRAKR
TH_1814|M.thermoresistible__bu YPVTGLKLQVSVPEGA-DYDQLQRNLAQVAVDEAVDIALEDYSLSRRAKR
MLBr_01727|M.leprae_Br4923 YPVTGLELRVSAPLE--AAGSLRTALNRVATEEHVDVAVEGYGLARRIKR
MAV_3907|M.avium_104 YPVIGLELRVSVPPG--ADGALRTALNRVSSEEHVDVAVEDYTLERRAKR
Mb3068c|M.bovis_AF2122/97 YPVTGLELRVSVPPG--CVGPLQIALTKVAAEEHVDVAVEDYGLAWRTKR
Rv3042c|M.tuberculosis_H37Rv YPVTGLELRVSVPPG--CVGPLQIALTKVAAEEHVDVAVEDYGLAWRTKR
MMAR_1652|M.marinum_M YPVTGLELRVSVPPG--TYRPLQTALTKVAVDERVDVAVEDYGLAWRTKR
MUL_1888|M.ulcerans_Agy99 YPVTGLELRVSVPPG--TYRPLQTALTKVAVDERVDVAVEDYGLAWRTKR
MAB_3388c|M.abscessus_ATCC_199 YPVTGLELRVTVPQNRLTDVDLHTAMAQVATDEPVDIAVEHSSLDRRAKR
*** **:*:*:.* *: : :: :* **:*:* * * **
Mvan_2083|M.vanbaalenii_PYR-1 LIVFDVDSTLIQGEVIEMLAAHAGAEAAVAEVTEAAMRGELDFAESLHRR
Mflv_4276|M.gilvum_PYR-GCK LIVFDVDSTLIQGEVIEMLAAHAGAEAAVAEVTEAAMRGELDFAESLHRR
MSMEG_2321|M.smegmatis_MC2_155 LIVFDVDSTLIQGEVIEMLAEHAGAAAAVAEVTEAAMRGELDFAESLHRR
TH_1814|M.thermoresistible__bu LIVFDVDSTLIQGEVIEMLAERAGAGAAVAAVTEAAMRGELDFAESLHQR
MLBr_01727|M.leprae_Br4923 LIVFDVDSTLVQGEVIEMLAARAGAQGTVAAITEAAMRGELDFAESLQQR
MAV_3907|M.avium_104 LIVFDVDSTLVQGEVIEMLAAKAGAEGQVAAITDAAMRGELDFAQSLQQR
Mb3068c|M.bovis_AF2122/97 LIVFDVDSTLVQGEVIEMLAARAGAQGQVAAITEAAMRGELDFAESLQRR
Rv3042c|M.tuberculosis_H37Rv LIVFDVDSTLVQGEVIEMLAARAGAQGQVAAITEAAMRGELDFAESLQRR
MMAR_1652|M.marinum_M LIVFDVDSTLVQGEVIEMLAARAGAEGTVAAITEAAMRGELDFAQSLQQR
MUL_1888|M.ulcerans_Agy99 LIVFDVDSTLVQGEVIEMLAARAGAEGTVAAITEAAIRGELDFAQSLQQR
MAB_3388c|M.abscessus_ATCC_199 LIVFDVDSTLIQGEVIEMLADRAGAREQVAAITEAAMRGELDFAQSLHQR
**********:********* :*** ** :*:**:*******:**::*
Mvan_2083|M.vanbaalenii_PYR-1 VATLAGLPASVLDDVADQIELTPGARTTLRTLRRLGYHCGIVSGGFRQVI
Mflv_4276|M.gilvum_PYR-GCK VATLAGLPAEVVDEVAAKLELTPGARTTIRTLRRLGYHCGVVSGGFRQVI
MSMEG_2321|M.smegmatis_MC2_155 VATLAGLPASVLDEVAEQLELTPGARTTIRTLRRLGYYCGVVSGGFRQVI
TH_1814|M.thermoresistible__bu VANLAGLPAEVLDEVAEQIELTPGARTTLRTLRRLGYYCGVVSGGFRQVI
MLBr_01727|M.leprae_Br4923 VATLAGLPVTVVDEVANQLQLMPGARTTLRTLRRLGFRCGVVSGGFRRII
MAV_3907|M.avium_104 VATLAGLPATVIDEVAGQLELMPGARTTLRTLRRLGYACGVVSGGFRRII
Mb3068c|M.bovis_AF2122/97 VATLAGLPATVIDDVAEQLELMPGARTTIRTLRRLGFRCGVVSGGFRRII
Rv3042c|M.tuberculosis_H37Rv VATLAGLPATVIDDVAEQLELMPGARTTIRTLRRLGFRCGVVSGGFRRII
MMAR_1652|M.marinum_M VATLEGLPATVIDDVAAQLQLMPGARTTLRTLQRLGFRCGVVSGGFRRII
MUL_1888|M.ulcerans_Agy99 VATLEGLPATVIDDVAAQLQLMPGARTTLRTLQRLGFRCGVVSGGFRRII
MAB_3388c|M.abscessus_ATCC_199 VATLAGLPESVLEDVADELVLTPGARTTIRTLRRLGYSCGVVSGGFRQVI
**.* *** *:::** :: * ******:***:***: **:******::*
Mvan_2083|M.vanbaalenii_PYR-1 EPLAHELMMDFVAANELEIVDGKLTGRVVGDVVDRPGKAKALRDFAQQAG
Mflv_4276|M.gilvum_PYR-GCK QPLADDLMLDYVAANHLEIVDGKLTGRVIGPVIDRAAKAKALRDFAAQVG
MSMEG_2321|M.smegmatis_MC2_155 EPLAHELMLDYVAANELEIVDGKLTGRVVGDVVDRPGKAKALRDFAQQVG
TH_1814|M.thermoresistible__bu EPLAHELMLDYVAANELEIVDGKLTGRVIGPVIDRAGKAKALRDFAQQVG
MLBr_01727|M.leprae_Br4923 EPLAHELMLDFVAANELEIVDGILTGRVVGTIVDRPGKAKALRYFSEQAG
MAV_3907|M.avium_104 EPLAEELMLDYVAANELEIVDGTLTGRVVGPIIDRAGKATALREFAQRAG
Mb3068c|M.bovis_AF2122/97 EPLARELMLDFVASNELEIVDGILTGRVVGPIVDRPGKAKALRDFASQYG
Rv3042c|M.tuberculosis_H37Rv EPLARELMLDFVASNELEIVDGILTGRVVGPIVDRPGKAKALRDFASQYG
MMAR_1652|M.marinum_M EPLAQELNLDFVAANELEIIDGTLTGRVVGSIVDRPGKAAALREFAGRFG
MUL_1888|M.ulcerans_Agy99 EPLAQELNLDFVAANELEIIDGTLTGRVVGSIVDRPGKAAALREFAGRFG
MAB_3388c|M.abscessus_ATCC_199 DPLAHELALDFVAANVLEIVDGKLTGRVIGEVVDRPGKAKALRQFAYEAG
:*** :* :*:**:* ***:** *****:* ::**..** *** *: . *
Mvan_2083|M.vanbaalenii_PYR-1 VPMEQTVAVGDGANDIDMLSAAGLGVAFNAKPALREVADASLSYPYLDTL
Mflv_4276|M.gilvum_PYR-GCK VPMQQTVAVGDGANDIDMLSAAGLGVAFNAKPALREVADASLNHPYLDTV
MSMEG_2321|M.smegmatis_MC2_155 VPMEQTVAVGDGANDIDMLSAAGLGVAFNAKPALREVADASLSHPYLDTV
TH_1814|M.thermoresistible__bu VPMEQTVAVGDGANDIDMLAAAGLGVAFNAKPALREVADASLSHPYLDTV
MLBr_01727|M.leprae_Br4923 VPMEQTVAVGDGANDIDMLTAAGLGIAFNAKPALRAVADASLSHPYLDTV
MAV_3907|M.avium_104 VPMAQTVAVGDGANDIDMLAAAGLGIAFNAKPALREVADASLSHPYLDTV
Mb3068c|M.bovis_AF2122/97 VPMEQTVAVGDGANDIDMLGAAGLGIAFNAKPALREVADASLSHPYLDTV
Rv3042c|M.tuberculosis_H37Rv VPMEQTVAVGDGANDIDMLGAAGLGIAFNAKPALREVADASLSHPYLDTV
MMAR_1652|M.marinum_M VPMEQTVAVGDGANDIDMLAAAGLGVAFNAKPALRAVADASLSHPYLDTV
MUL_1888|M.ulcerans_Agy99 VPMEQTVAVGDGANDIDMLAAAGLGVAFNAKPALRAVADASLSHPYLDTV
MAB_3388c|M.abscessus_ATCC_199 VPLAQTVAVGDGANDIDMLSAAGLGVAFNAKPALRKVADASVSQPYLDVV
**: *************** *****:********* *****:. ****.:
Mvan_2083|M.vanbaalenii_PYR-1 LFILGITRGEIEAADALDGVVRRVEIPD-
Mflv_4276|M.gilvum_PYR-GCK LFILGITRGEIEAADALDGVVRRVDIPD-
MSMEG_2321|M.smegmatis_MC2_155 LFILGITRGEIEAADALDGVVRRVEIPDY
TH_1814|M.thermoresistible__bu LFILGVTRAEIEAADAVDGVLRRVEIPDD
MLBr_01727|M.leprae_Br4923 LFVLGVTRGEIEAADAADGGVRRVEIPPD
MAV_3907|M.avium_104 LFLLGVTRGEIEAADAIDGEVRRVEIPPE
Mb3068c|M.bovis_AF2122/97 LFLLGVTRGEIEAADAGDCGVRRVEIPAD
Rv3042c|M.tuberculosis_H37Rv LFLLGVTRGEIEAADAGDCGVRRVEIPAD
MMAR_1652|M.marinum_M LFLLGVTRGEIEAADNVDGVMRRVEIPED
MUL_1888|M.ulcerans_Agy99 LFLLGVTRGEIEAADNVDGVMRRVEIPED
MAB_3388c|M.abscessus_ATCC_199 LFILGITRAEIEAADAVDGGVRRVDIPDD
**:**:**.****** * :***:**