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IPRVTSTAQTDLTEGADPYGICAADDGALWVTLVHSGAVVRLSADGGRRDYPIGAQARPSVVTVGRDGTA WFTRTGDDRITALDRTGAMTTFELASGSGPFGICVGADGAVWFTESTGDRLGRIDPDATVSYVALPEGCF PAFVAAGADGAVWATLNHADAVVRILPSADPEVIDIPTPGAAPVGITWGGDAVWFVEIATGRIGRIGDDR LVTEFALPDPACRPHAITAGPDGCWFTEWATDRVGHIGRDGTVEEYDLPSSVSEPHGITVAPDGAVWVAA ESGSVVRLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1889 | - | - | 100% (290) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_1720 | - | 1e-10 | 28.11% (185) | YVTN beta-propeller repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1568 | - | 2e-06 | 30.25% (119) | strictosidine synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1006c | PE_PGRS18 | 1e-06 | 26.15% (130) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_1786 | - | 1e-05 | 27.84% (194) | SMP-30/gluconolaconase/LRE domain-containing protein |
| M. tuberculosis H37Rv | Rv0980c | PE_PGRS18 | 1e-06 | 26.15% (130) | PE-PGRS family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0305 | - | 1e-05 | 26.32% (285) | hypothetical protein MMAR_0305 |
| M. avium 104 | MAV_5210 | - | 2e-09 | 25.63% (277) | hypothetical protein MAV_5210 |
| M. smegmatis MC2 155 | MSMEG_4914 | - | 2e-67 | 46.52% (273) | virginiamycin B hydrolase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4817 | - | 6e-06 | 26.32% (285) | hypothetical protein MUL_4817 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1889|M.vanbaalenii_PYR-1 -------------------------MIPRVTSTAQTDLTEGADPYGICAA
MSMEG_4914|M.smegmatis_MC2_155 -----------------------------MSKALKVGLDGG--PYALAAG
Mflv_1786|M.gilvum_PYR-GCK --------------MNARYAAQNPTAAEGWTLRSVTAPSPLFGANGLRTG
MAV_5210|M.avium_104 --------------MPAIDVAP------GWRLDRVTAPSRLFGANGLRTG
MMAR_0305|M.marinum_M MVRAVIPVTRRLQHAGRYPVTRAPNVAEGWTLTRLTAPSRLFGANGLRTG
MUL_4817|M.ulcerans_Agy99 MVRAVIPVTRRLQHAGHYPVTRAPNVAEGWTLTRLTAPSRLFGANGLRTG
Mb1006c|M.bovis_AF2122/97 --------------MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATT
Rv0980c|M.tuberculosis_H37Rv --------------MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATT
. . :
Mvan_1889|M.vanbaalenii_PYR-1 DDGALWVTLVHSGAVVRLSADG---GRRDYPIGAQARPSVVTVGRDGTAW
MSMEG_4914|M.smegmatis_MC2_155 PDGAMWVTLAHSGEIARVTETG---EVAVYPVAPQARPSIIAAGPDGAMW
Mflv_1786|M.gilvum_PYR-GCK PDGRIYIAQVTGSQISALDPATGALETVSAKGGDIIAPDDVAFADDGTLF
MAV_5210|M.avium_104 PDGRIYIAQVTGSQISALDHHTGELETASPKGGDIVAPDDVAFDAAGNLY
MMAR_0305|M.marinum_M PDGRVYIAQVTGSQISALDLSTGRLDTVCPKGGAIIAPDDLAFDQDGNLY
MUL_4817|M.ulcerans_Agy99 PDGRVYIAQVTGSQISALDLSTGRLDTVCPKGGAIIAPDDLAFDQDGNLY
Mb1006c|M.bovis_AF2122/97 QVLAAAQDEVSTAIAALFGSHGQHYQAISAQVAAYQERFVLALSQASSTY
Rv0980c|M.tuberculosis_H37Rv QVLAAAHDEVSTAIAALFGSHGQHYQAISAQVAAYQERFVLALSQASSTY
. . . . :: . :
Mvan_1889|M.vanbaalenii_PYR-1 FTRTGDDRITALDRTG-------------------------------AMT
MSMEG_4914|M.smegmatis_MC2_155 FTRAGDDRIGRITVDG-------------------------------ELA
Mflv_1786|M.gilvum_PYR-GCK ATEVMDGRVSAREPSGRTRVLRDDLPCANGITVDRGRLFVGECRDGGRLM
MAV_5210|M.avium_104 ATEVMDGRVSVRDTGGRTRVLRDDVPSANGITFHRGRLFIGECRERGRLL
MMAR_0305|M.marinum_M ATEVMDGRVSVRAPDGHTRVLRDDIPSANGITFHQGRLFVGECRDGGRLL
MUL_4817|M.ulcerans_Agy99 ATEVMDGRVSVRAPDGHTRVLRDDIPSANGITFHQGRLFVGECRDGGRLL
Mb1006c|M.bovis_AF2122/97 AVAEAASATPLQNVLDAIN-----------------------------AP
Rv0980c|M.tuberculosis_H37Rv AVAEAASATPLQNVLDAIN-----------------------------AP
. . .
Mvan_1889|M.vanbaalenii_PYR-1 TFELASGS---------GPFGICVGADGAVWFTESTGDRLGRIDPDATVS
MSMEG_4914|M.smegmatis_MC2_155 EFELAEGS---------APFGIAAGPDDALWFTAMTSGEVCRISTDGEVT
Mflv_1786|M.gilvum_PYR-GCK ELPLDGGEPRILLENLPSPNAMEVGPDGLLYYPLMTANEIWRIDPSGGEP
MAV_5210|M.avium_104 EFDLAGGPPRVLLDNVPSPNAMEVGPDGLLYFPVMGANEIWRVDPDGGEP
MMAR_0305|M.marinum_M ELDLNGGAPRVLARNLPSPNAMEVGPDGLLYFPVMGANEIWRIDPDGGVP
MUL_4817|M.ulcerans_Agy99 ELDLNGGAPRVLARNLPSPNAMEVGPDGLLYFPVMGANEIWRIDPDGGVP
Mb1006c|M.bovis_AF2122/97 VQSLTGRPLIGDGANGIDGTGQAGGNGGWLWGNGGNGGSGAPGQAGGAGG
Rv0980c|M.tuberculosis_H37Rv VQSLTGRPLIGDGANGIDGTGQAGGNGGWLWGNGGNGGSGAPGQAGGAGG
* . * .. :: .. ....
Mvan_1889|M.vanbaalenii_PYR-1 YVALPEGCFPAFVAAGADGAVWATLNHADAVVRILP--------------
MSMEG_4914|M.smegmatis_MC2_155 SVAVVGG-MPSMITAGPDGAMWFTINQGNAIGRLET--------------
Mflv_1786|M.gilvum_PYR-GCK QRVAADLGVPDAVKFDTDGFIVSTQVASGQVLRIDPRTGEKTVLAQLNPG
MAV_5210|M.avium_104 QCVATGLGVPDSVKFDARGHIVSTQVASGQVLRIDPRSGEQQVLAQLNPG
MMAR_0305|M.marinum_M QCVAGDLGVPDAVKFDPHGHLVSTQVHSGEVLRINPRTGDRTVLAALHPG
MUL_4817|M.ulcerans_Agy99 QCVAGDLRVPDAVKFDPHGHLVSTQVHSGEVLRINPRTGDRTVLAALHPG
Mb1006c|M.bovis_AF2122/97 AAGLIGNGGAGGAGGQGLPFEAGANGGAGGAGGWLFGNGGAGGVGGAGGA
Rv0980c|M.tuberculosis_H37Rv AAGLIGNGGAGGAGGQGLPFEAGANGGAGGAGGWLFGNGGAGGVGGAGGA
. : ..
Mvan_1889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4914|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1786|M.gilvum_PYR-GCK LDNLTFVGDRLFASNFTGEITEIGRDGQTSALLPGGLNWPLDLTVS-DGR
MAV_5210|M.avium_104 LDNCTFVGDRLFVSNFTGEITEISPDGTTRSVLPGGLNWPLDLAVGHDGR
MMAR_0305|M.marinum_M LDNLTFVGERLFVSSFTGEITEILGTGETRTTLPGGLTWPLGLAVDADGD
MUL_4817|M.ulcerans_Agy99 LDNLTFVGERLFVSSFTGEITEILGTGETRTTLPGGLTWPLGLAVAADGD
Mb1006c|M.bovis_AF2122/97 GTTFGVAGGDGGTGGVGGHGGLIGVGGHGGDGGTGG--------------
Rv0980c|M.tuberculosis_H37Rv GTTFGVAGGDGGTGGVGGHGGLIGVGGHGGDGGTGG--------------
Mvan_1889|M.vanbaalenii_PYR-1 --------------SADPEVIDIPTPGAAP--------------------
MSMEG_4914|M.smegmatis_MC2_155 --------------DGTLTVRELPTPAAGP--------------------
Mflv_1786|M.gilvum_PYR-GCK LYVADGTYFYRVGPDGALETVGMLFSPGYPGFLRGVVAVGGDEFVVTTSG
MAV_5210|M.avium_104 LYVADGTYFYAALPDGALHTVGMLFSPGYPGFLRGVAASGPGEFVVTTSG
MMAR_0305|M.marinum_M LYIADGTYFYVLLADGTLRVGGMLFSAGYPGFLRGVAALGSGEFAVTTSN
MUL_4817|M.ulcerans_Agy99 LYIADGTYFYVLLADGTLRVGGMLFSAGYPGFLRGVAALGSGEFAVTTSN
Mb1006c|M.bovis_AF2122/97 -------------TGGAVSLARAGTAGGAGGGPAG---------GIGGTG
Rv0980c|M.tuberculosis_H37Rv -------------TGGAVSLARAGTAGGAGGGPAG---------GIGGAG
.. . .
Mvan_1889|M.vanbaalenii_PYR-1 -----------------------VGITWG-GDAVWFVEIATGRIGRIGDD
MSMEG_4914|M.smegmatis_MC2_155 -----------------------VGITATHDDAVWFTEIGADQLGRIPLD
Mflv_1786|M.gilvum_PYR-GCK GQVARYRPGAGETDFLATDFDQLYGVDVAGDGSIVFAELGTGRVLRLD-D
MAV_5210|M.avium_104 GQISRYRPQASESEVLADGFDQLYGIAPGPAG-VVVAELGTGRVLSLQRS
MMAR_0305|M.marinum_M GEVARYRPWASESEVVATGLDQLYGVAVAGSGALFVAERGAGRVLSVR-P
MUL_4817|M.ulcerans_Agy99 GEVARYRPWASETEVLATGLDQLYGVAVAGSGALFVAERGAGRVLSVR-P
Mb1006c|M.bovis_AF2122/97 GVGGAGGAAGAVTTITHASFNDPHGVAVNPGGNIYVTNQGSNTVSVIDPV
Rv0980c|M.tuberculosis_H37Rv GVGGAGGAAGAVTTITHASFNDPHGVAVNPGGNIYVTNQGSNTVSVIDPV
*: . : ..: .:. : :
Mvan_1889|M.vanbaalenii_PYR-1 RLVTEFALPDPACRPHAITAGPD-GCWFTEWATDRVGHIG----------
MSMEG_4914|M.smegmatis_MC2_155 EAIQELELPG---KPHAVVADPDDGVWVSLWGADQLARVS----------
Mflv_1786|M.gilvum_PYR-GCK GRVETLASGLR--QPVGVAIDADGAPLVSESGAGRVVRVSS---GAVDTV
MAV_5210|M.avium_104 GAVEVLAAGLR--EPVGVAIGSDGAALVAEAGAGRVVRVDG---SKVDTV
MMAR_0305|M.marinum_M DGVEVMASGLS--DPVGVAVTADGRCVVTEADAGRVRTLG-----DTGTL
MUL_4817|M.ulcerans_Agy99 DGVEVMASGLS--DPVGVAVTADGRCVVTEADAGRVRTLG-----DTGTL
Mb1006c|M.bovis_AF2122/97 TNTVTGSITDGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPNTNTVTGSI
Rv0980c|M.tuberculosis_H37Rv TNTVTGSITDGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPNTNTVTGSI
. . .: :. : :.
Mvan_1889|M.vanbaalenii_PYR-1 ----------------------RDGTVEEYDLPSS---------------
MSMEG_4914|M.smegmatis_MC2_155 ----------------------GDGEVVTIDLPS----------------
Mflv_1786|M.gilvum_PYR-GCK IDGLQRPQGLHVRDNRLYIVDAGAKELVEFDLGTKARSTIATGLPVGPPP
MAV_5210|M.avium_104 MADLQRPQGILLHGGVLYVVDAGAKELIAFDPADKTRRTIASGLPVGPPP
MMAR_0305|M.marinum_M LDGLQCPQGVAICDRQVYVIDSGAKQLVAVDLGSRTRHTIAWDLPVGAPA
MUL_4817|M.ulcerans_Agy99 LDGLQCPQGVAICDRQVYVIDSGAKQLVAVDLGSRTRHTIAWDLPVGAPA
Mb1006c|M.bovis_AF2122/97 PVGTGAYGVAVNPGGNIYVTNQFSNTVSVIDPATNTVTG-----------
Rv0980c|M.tuberculosis_H37Rv PVGTGAYGVAVNPGGNIYVTNQFSNTVSVIDPATNTVTG-----------
: *
Mvan_1889|M.vanbaalenii_PYR-1 ------------VSEPHG----ITVAPDGAVWVAAES-GSVVRLG-----
MSMEG_4914|M.smegmatis_MC2_155 ------------GSEPHG----LAIGPDGAAWVALEC-GFVLRMPN----
Mflv_1786|M.gilvum_PYR-GCK GVEPKPLKGMPPFSGPQGPFAGITSGPDGTLFVSADGDGSVLAVSRG---
MAV_5210|M.avium_104 GVNPKPLKGMPPFSGPQGPFAGITAAADGTLYVSADGEGSVLALRPTRDG
MMAR_0305|M.marinum_M GVTPKPLRGMPPFSGPQGPFAAITAGPDATLYISADADGSVLALRRES--
MUL_4817|M.ulcerans_Agy99 GVTPNPLRGMPPFSGPEGPFAAITPGPDATLYISADADGSVLALRRES--
Mb1006c|M.bovis_AF2122/97 SPIPVGLDPTGVAVNPVTGVVYVTNSLDDTVSVITGEPARSVCSAAI---
Rv0980c|M.tuberculosis_H37Rv SPIPVGLDPTGVAVNPVTGVVYVTNSLDDTVSVITGEPARSVCSAAI---
* :: . * : : . :
Mvan_1889|M.vanbaalenii_PYR-1 -
MSMEG_4914|M.smegmatis_MC2_155 -
Mflv_1786|M.gilvum_PYR-GCK -
MAV_5210|M.avium_104 H
MMAR_0305|M.marinum_M -
MUL_4817|M.ulcerans_Agy99 -
Mb1006c|M.bovis_AF2122/97 -
Rv0980c|M.tuberculosis_H37Rv -