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MTITPLDTHREANAGSPELAAVLSTIAERGVEFVYFQAITVTGRVVGKVAPARHFERLAIRGVQQHQTAI ANLQGTREGVLLAGGVNAPEYTAIPDLETFAVLPWDTSFARVFCRLYEPDHLAERAGAEFACDTRGLLRR MLSGFTDRTGLELRTGCEPEMTWQGDGLEAHFRPGSSPAYHIEHLERNRPIVKKVVEYAQALGLDMIEGD YEDEFQVELNFMYDRADLTADRLTTYRQICKQVARELGIHASFMPKPATGMMGNGCHHNFSLWRDDVNVL AEPGVTELHLSEVGRHALGGLLAHSAGAMLINGSTVNSYKRYWDAGQFAPSRINWGLDNKTCTVRLSAVG RLEYKLPDAAVNPYLSHAVILAACEDGMKNATDPGKPTQGSSYDAPVDGRFPALPLTLGEAISAFRADEV LNQAFGPDLSALLVDYHADEWARFCGHVTEWEREMYWNDTP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1850 | - | - | 100% (461) | glutamate--ammonia ligase |
| M. vanbaalenii PYR-1 | Mvan_3598 | - | 1e-37 | 28.66% (471) | glutamine synthetase, type I |
| M. vanbaalenii PYR-1 | Mvan_5509 | - | 1e-33 | 28.95% (456) | glutamate--ammonia ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2246c | glnA2 | 2e-37 | 29.16% (463) | glutamine synthetase |
| M. gilvum PYR-GCK | Mflv_2909 | - | 5e-37 | 28.82% (465) | glutamine synthetase, type I |
| M. tuberculosis H37Rv | Rv2222c | glnA2 | 2e-37 | 29.16% (463) | glutamine synthetase |
| M. leprae Br4923 | MLBr_01631 | glnA2 | 5e-37 | 28.60% (465) | glutamine synthase class II |
| M. abscessus ATCC 19977 | MAB_1920 | - | 8e-39 | 29.13% (460) | glutamine synthetase |
| M. marinum M | MMAR_3294 | glnA2 | 7e-38 | 28.32% (459) | glutamine synthetase GlnA2 |
| M. avium 104 | MAV_2244 | glnA | 1e-36 | 27.89% (459) | glutamine synthetase, type I |
| M. smegmatis MC2 155 | MSMEG_6693 | - | 0.0 | 92.62% (461) | glutamine synthetase III |
| M. thermoresistible (build 8) | TH_3396 | - | 1e-36 | 27.95% (458) | PUTATIVE glutamine synthetase, type I |
| M. ulcerans Agy99 | MUL_1335 | glnA2 | 3e-38 | 28.54% (459) | glutamine synthetase GlnA2 |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01631|M.leprae_Br4923 --------------MDRQKEFVLRTLEERDIRFVRLWFTDVLGYLKSVAI
MAV_2244|M.avium_104 --------------MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAI
Mb2246c|M.bovis_AF2122/97 --------------MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAI
Rv2222c|M.tuberculosis_H37Rv --------------MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAI
MMAR_3294|M.marinum_M --------------MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAI
MUL_1335|M.ulcerans_Agy99 --------------MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAI
Mflv_2909|M.gilvum_PYR-GCK --------------MDRQKEFVLRTLEERDIRFVRLWFTDVLGYLKSVAI
TH_3396|M.thermoresistible__bu --------------MDRQKEFVLRSLEERDIRFVRLWFTDVLGFLKSVAI
MAB_1920|M.abscessus_ATCC_1997 --------------MDRQKEFVLRTLEERDIRFVRLWFTDVLGYLKSVSI
Mvan_1850|M.vanbaalenii_PYR-1 MTITPLDTHREANAGSPELAAVLSTIAERGVEFVYFQAITVTGRVVGKVA
MSMEG_6693|M.smegmatis_MC2_155 MTITPLDAHRQANATSPDLAAVLETIAERGVEFVYFQAVTITGRVVGKVA
. : ** :: **.:.** : : * : .
MLBr_01631|M.leprae_Br4923 APAELEGAFEEGIGFDGSSIEGFARVSE----------SDTVAHPDPSTF
MAV_2244|M.avium_104 APAELEGAFEEGIGFDGSSIEGFSRVSE----------SDTVANPDPSTF
Mb2246c|M.bovis_AF2122/97 APAELEGAFEEGIGFDGSSIEGFARVSE----------SDTVAHPDPSTF
Rv2222c|M.tuberculosis_H37Rv APAELEGAFEEGIGFDGSSIEGFARVSE----------SDTVAHPDPSTF
MMAR_3294|M.marinum_M APAELEGAFEEGIGFDGSSIEGFARVSE----------SDTVAHPDPSTF
MUL_1335|M.ulcerans_Agy99 APAELEGAFEEGIGFDGSSIEGFARVSE----------SDTVAHPDPSTF
Mflv_2909|M.gilvum_PYR-GCK APAELEGAFEEGIGFDGSSIEGFARVSE----------ADMVARPDPSTF
TH_3396|M.thermoresistible__bu APAELEGAFEEGIGFDGSAIEGFARVSE----------ADMVARPDPSTF
MAB_1920|M.abscessus_ATCC_1997 APAELEGAFEEGIGFDGSSIEGFARVSE----------SDTVAHPDPSTF
Mvan_1850|M.vanbaalenii_PYR-1 PARHFERLAIRGVQQHQTAIANLQGTREGVLLAGGVNAPEYTAIPDLETF
MSMEG_6693|M.smegmatis_MC2_155 PAKHFERLAVRGVQQHQTAVANLQGTREGVLLAGGVNAPEYTAIPDLETF
.. .:* .*: . ::: .: . * .: .* ** .**
MLBr_01631|M.leprae_Br4923 QILPWATTAGHHHSARMFCDITMPDGSSSWA------DPRHVLRRQLTKA
MAV_2244|M.avium_104 QVLPWASPNGHHHSARMFCDITMPDGSPSWA------DPRHVLRRQLQKA
Mb2246c|M.bovis_AF2122/97 QVLPWATSSGHHHSARMFCDITMPDGSPSWA------DPRHVLRRQLTKA
Rv2222c|M.tuberculosis_H37Rv QVLPWATSSGHHHSARMFCDITMPDGSPSWA------DPRHVLRRQLTKA
MMAR_3294|M.marinum_M QVLPWVTDAGHHHSARIFCDITMPDGSPSWA------DPRHVLRRQLTKA
MUL_1335|M.ulcerans_Agy99 QVLPWVTDAGHHHSARIFCDITMPDGSPSWA------DPRHVLRRQLIKA
Mflv_2909|M.gilvum_PYR-GCK QVLPWADSSGKHHSARMFCDITMPDGSPSWA------DSRHVLRRQLSKA
TH_3396|M.thermoresistible__bu QVLPWTGDSGKHYSARMFCDITMPDGSPSWA------DPRHVLRRQLAKA
MAB_1920|M.abscessus_ATCC_1997 QVLPWTTSAGKHHSARMFCDIKLPDGSPSWS------DPRHVLRRQLAKA
Mvan_1850|M.vanbaalenii_PYR-1 AVLPWDTS-----FARVFCRLYEPDHLAERAGAEFACDTRGLLRRMLSGF
MSMEG_6693|M.smegmatis_MC2_155 AVLPWDTS-----FARVFCRLYEPDHLAERAGAEFACDSRGLLRRLHAGF
:*** **:** : ** .. : *.* :***
MLBr_01631|M.leprae_Br4923 ND-LGFSCYVHPEIEFFLLKAGPEDGSMPIPVPVDNAGYFDQAVHDSALN
MAV_2244|M.avium_104 ND-LGFSCYVHPEIEFFLLKPGPDDGTP--PVPVDTAGYFDQAIHDSASN
Mb2246c|M.bovis_AF2122/97 GE-LGFSCYVHPEIEFFLLKPGPEDGSV--PVPVDNAGYFDQAVHDSALN
Rv2222c|M.tuberculosis_H37Rv GE-LGFSCYVHPEIEFFLLKPGPEDGSV--PVPVDNAGYFDQAVHDSALN
MMAR_3294|M.marinum_M NE-LGFSCYVHPEIEFFLLNPGPEDGTE--PVPIDNAGYFDQAVHVSASK
MUL_1335|M.ulcerans_Agy99 NE-LGFSCYVHPEIEFFLLNPGPEDGTE--PVPIDNAGYFDQAVHVSASK
Mflv_2909|M.gilvum_PYR-GCK SD-LGFSCYVHPEIEFFLLKPGDNDGSP--PTPADNGGYFDQAVHDSAPN
TH_3396|M.thermoresistible__bu GD-QGFTCYVHPEIEFFLLKPGPHDGSP--PVPADTSGYFDQSVHDTAPN
MAB_1920|M.abscessus_ATCC_1997 SD-LGFSCYVHPEIEFFLLKNLPDDGTA--PIPADDAGYFDQAVHEAAPN
Mvan_1850|M.vanbaalenii_PYR-1 TDRTGLELRTGCEPEMTWQGDGLEAHFR----PGSSPAYHIEHLERNRP-
MSMEG_6693|M.smegmatis_MC2_155 TDRTGLELRTGCEPEMTWQGEGLEAQFR----PGSSPAYHIEHLERNRP-
: *: . * *: . * . .*. : :.
MLBr_01631|M.leprae_Br4923 FRRHAIEALEFMGISVEFSHHEGAPGQQEIDLRFADALSMADNVMTFRYV
MAV_2244|M.avium_104 FRRHAIEALEFMGISVEFSHHEGAPGQQEIDLRFADALSMADNVMTFRYV
Mb2246c|M.bovis_AF2122/97 FRRHAIDALEFMGISVEFSHHEGAPGQQEIDLRFADALSMADNVMTFRYV
Rv2222c|M.tuberculosis_H37Rv FRRHAIDALEFMGISVEFSHHEGAPGQQEIDLRFADALSMADNVMTFRYV
MMAR_3294|M.marinum_M FRRHAIDALEFMGISVEFSHHEGAPGQQEIDLRFADALSMADNVMTFRYV
MUL_1335|M.ulcerans_Agy99 FRRHVIDALEFMGISVEFSHHEGAPGQQEIDLRFADALSMADNVMTFRYV
Mflv_2909|M.gilvum_PYR-GCK FRRHAIDALEQMGISVEFSHHEGAPGQQEIDLRYADALSMADNVMTFRYL
TH_3396|M.thermoresistible__bu FRRHAIEALEQMGISVEFSHHEGAPGQQEIDLRYADALSMADNVMTFRYV
MAB_1920|M.abscessus_ATCC_1997 FRRHAIDALESMGISVEFSHHEGAPGQQEIDLRYADALSMADNVMTFRNV
Mvan_1850|M.vanbaalenii_PYR-1 IVKKVVEYAQALGLDMIEGDYEDEF-QVELNFMYDRADLTADRLTTYRQI
MSMEG_6693|M.smegmatis_MC2_155 IVKKVVEYAQALGLDMIEGDYEDEF-QVELNFMYDRADLTADRLTTYRQI
: ::.:: : :*:.: ..:*. * *::: : * **.: *:* :
MLBr_01631|M.leprae_Br4923 IKEVAIENGARASFMPKPFAQHPGSAMHTHMSLFEGDVNAFHSD-DDPLQ
MAV_2244|M.avium_104 IKEVAIENGARASFMPKPFGQHPGSAMHTHMSLFEGDVNAFHSP-DDPLQ
Mb2246c|M.bovis_AF2122/97 IKEVALEEGARASFMPKPFGQHPGSAMHTHMSLFEGDVNAFHSA-DDPLQ
Rv2222c|M.tuberculosis_H37Rv IKEVALEEGARASFMPKPFGQHPGSAMHTHMSLFEGDVNAFHSA-DDPLQ
MMAR_3294|M.marinum_M IKEVALEEGVRATFMPKPFGQHAGSAMHTHMSLFEGDVNAFHSP-DDPLQ
MUL_1335|M.ulcerans_Agy99 IKEVALEEGVRATFMPKPFGQHAGSAMHTHMSLFEGDVNAFHSP-DDPLQ
Mflv_2909|M.gilvum_PYR-GCK VKEVALGDGVRASFMPKPFAEHPGSAMHTHMSLFEGDSNAFHSP-DDPLQ
TH_3396|M.thermoresistible__bu VKQVAISDGVRASFMPKPFAEHPGSAMHTHMSLFEGDTNAFHSP-DDPLQ
MAB_1920|M.abscessus_ATCC_1997 VKEVAIIDGVHATFMPKPFSDHPGSAMHTHMSLFEGDTNAFHNP-DDPLQ
Mvan_1850|M.vanbaalenii_PYR-1 CKQVARELGIHASFMPKPATGMMGNGCHHNFSLWRDDVNVLAEPGVTELH
MSMEG_6693|M.smegmatis_MC2_155 CKQVARELGIQASFMPKPATGMMGNGCHHNFSLWRDGVNVLAEPGVTELH
*:** * :*:***** *.. * ::**:... *.: . *:
MLBr_01631|M.leprae_Br4923 LSDVGKSFIAGILEHASEISAVTNQWVNSYKRLVVGGE-APTTASWGAAN
MAV_2244|M.avium_104 LSDVGKSFIAGILEHASEISAVTNQWVNSYKRLVGGGE-APTAASWGAAN
Mb2246c|M.bovis_AF2122/97 LSEVGKSFIAGILEHACEISAVTNQWVNSYKRLVQGGE-APTAASWGAAN
Rv2222c|M.tuberculosis_H37Rv LSEVGKSFIAGILEHACEISAVTNQWVNSYKRLVQGGE-APTAASWGAAN
MMAR_3294|M.marinum_M LSEVGKSFIAGILEHASEISAVTNQWVNSYKRLILGGE-APTAASWGAAN
MUL_1335|M.ulcerans_Agy99 LSEVGKSFIAGILEHASEISAVTNQWVNSYKRLILGGE-APTAASWGAAN
Mflv_2909|M.gilvum_PYR-GCK LSAVGKSFIAGILEHANEISAVTNQWVNSYKRLVHGGE-APTAASWGAAN
TH_3396|M.thermoresistible__bu LSDVAKSFIAGILEHANEISAVTNQWVNSYKRLVHGGE-APTAASWGAAN
MAB_1920|M.abscessus_ATCC_1997 LSDVGKSFIAGILEHANEISAVTNQWVNSYKRLVQGGE-APTAASWGAAN
Mvan_1850|M.vanbaalenii_PYR-1 LSEVGRHALGGLLAHSAGAMLINGSTVNSYKRYWDAGQFAPSRINWGLDN
MSMEG_6693|M.smegmatis_MC2_155 LSELGQHALGGLLAHSAGAMLINGSTVNSYKRYWDAGQFAPSRINWGLDN
** :.: :.*:* *: :... ****** .*: **: .** *
MLBr_01631|M.leprae_Br4923 RSALVRVPMYTPHKTSSRRVEVRSPDSACNPYLAFAVLLAAGLRGVEKGY
MAV_2244|M.avium_104 RSALVRVPMYTPHKTSSRRVEVRSPDSACNPYLTFAVLLAAGLRGVEKGY
Mb2246c|M.bovis_AF2122/97 RSALVRVPMYTPHKTSSRRVEVRSPDSACNPYLTFAVLLAAGLRGVEKGY
Rv2222c|M.tuberculosis_H37Rv RSALVRVPMYTPHKTSSRRVEVRSPDSACNPYLTFAVLLAAGLRGVEKGY
MMAR_3294|M.marinum_M RSALVRVPMYTPHKTSSRRIEVRSPDSACNPYLAFAVLLAAGLRGVEKGY
MUL_1335|M.ulcerans_Agy99 RSALVRVPMYTPHKTSSRRIEVRSPDSACNPYLAFAVLLAAGLRGVEKGY
Mflv_2909|M.gilvum_PYR-GCK RSALVRVPMYTPHKVSSRRVEVRSPDSACNPYLTFAVLLAAGLRGIEKNY
TH_3396|M.thermoresistible__bu RSALVRVPMYTPHKASSRRVEVRSPDSACNPYLTFAVLLAAGLRGVEKGY
MAB_1920|M.abscessus_ATCC_1997 RSALVRVPMYTPNKSSSRRIEVRSPDSACNPYLTYAVLLAAGLRGVEQGY
Mvan_1850|M.vanbaalenii_PYR-1 KTCTVRLSAVG-------RLEYKLPDAAVNPYLSHAVILAACEDGMKNAT
MSMEG_6693|M.smegmatis_MC2_155 KTCTVRLSAVG-------RLEYKLPDAAVNPYLSHAVILAACEDGMKNEI
::. **:. *:* : **:* ****:.**:*** *:::
MLBr_01631|M.leprae_Br4923 VLGPQAEDNVWDLTPEERLAMGYRELPTSLDSALGAMEVSEFVAEALGEH
MAV_2244|M.avium_104 VLGPQAEDNVWDLTPEERIAMGYRELPTSLDSALRAMESSELVAETLGEH
Mb2246c|M.bovis_AF2122/97 VLGPQAEDNVWDLTPEERRAMGYRELPSSLDSALRAMEASELVAEALGEH
Rv2222c|M.tuberculosis_H37Rv VLGPQAEDNVWDLTPEERRAMGYRELPSSLDSALRAMEASELVAEALGEH
MMAR_3294|M.marinum_M VLGPQAEDNVWDLTPEERRTMGYRELPTSLDSALRAMESSELVAEALGEH
MUL_1335|M.ulcerans_Agy99 VLGPQAEDNVWDLTPEERRTMGYRELPTSLDSALRAMESSELVAEALGEH
Mflv_2909|M.gilvum_PYR-GCK VLGPEAEDNVWSLTPEERRAMGYKELPGSLGAALADMENSELVAEALGEH
TH_3396|M.thermoresistible__bu VLGPEAEDNVWTLTPEERRAMGFKELPSSLGQALAEMERSELVAEALGEH
MAB_1920|M.abscessus_ATCC_1997 TLGPEAEDDVWGLTRAERQAMGYKELPSTLENALIAMEGSELVAEALGEH
Mvan_1850|M.vanbaalenii_PYR-1 DPGKPTQGSSYDAPVDGR----FPALPLTLGEAISAFRADEVLNQAFGPD
MSMEG_6693|M.smegmatis_MC2_155 DPGAPTQGSSYDAPVDTR----FPALPLTLGEAIEAFRADEVLTQALGPD
* ::.. : . * : ** :* *: :. .*.: :::* .
MLBr_01631|M.leprae_Br4923 VFDFFLRNKRAEWANYRSHVSLYELKTYLSL--
MAV_2244|M.avium_104 VFDFFLRNKRTEWATYRSHVTPYELRTYLSL--
Mb2246c|M.bovis_AF2122/97 VFDFFLRNKRTEWANYRSHVTPYELRTYLSL--
Rv2222c|M.tuberculosis_H37Rv VFDFFLRNKRTEWANYRSHVTPYELRTYLSL--
MMAR_3294|M.marinum_M VFDFFLRNKRREWATYRSHVTPYELSTYLSL--
MUL_1335|M.ulcerans_Agy99 VFDFFLRNKRREWATYRSHVTPYELSTYLSL--
Mflv_2909|M.gilvum_PYR-GCK VFDFFLRNKRREWENYRSHVTPFELKNYLSL--
TH_3396|M.thermoresistible__bu VFDFFLRNKRAEWENYRSHVTPYELKNYLSL--
MAB_1920|M.abscessus_ATCC_1997 VFDFFLRNKRAEWARYRSNVTPFELRAYLGL--
Mvan_1850|M.vanbaalenii_PYR-1 LSALLVDYHADEWARFCGHVTEWEREMYWNDTP
MSMEG_6693|M.smegmatis_MC2_155 LSSLLIDFHADEWARFCGYVTDWEREMYWSDAP
: ::: : ** : . *: :* * .