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M. tuberculosis H37Rv Rv2222c (glnA2)

annotation: PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II)
coordinates: 2492402 - 2493742
length: 446

DRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAIAPAELEGAFEEGIGFDGSSIEGFARVSESDTVAHP
DPSTFQVLPWATSSGHHHSARMFCDITMPDGSPSWADPRHVLRRQLTKAGELGFSCYVHPEIEFFLLKPG
PEDGSVPVPVDNAGYFDQAVHDSALNFRRHAIDALEFMGISVEFSHHEGAPGQQEIDLRFADALSMADNV
MTFRYVIKEVALEEGARASFMPKPFGQHPGSAMHTHMSLFEGDVNAFHSADDPLQLSEVGKSFIAGILEH
ACEISAVTNQWVNSYKRLVQGGEAPTAASWGAANRSALVRVPMYTPHKTSSRRVEVRSPDSACNPYLTFA
VLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERRAMGYRELPSSLDSALRAMEASELVAEALGEHVFDFFL
RNKRTEWANYRSHVTPYELRTYLSL*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv2222cglnA2-100% (446)PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II)
M. tuberculosis H37RvRv2220glnA16e-5330.35% (481) glutamine synthetase GLNA1 (glutamine synthase) (GS-I)
M. tuberculosis H37RvRv2860cglnA44e-3930.24% (453) glutamine synthetase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2246cglnA20.0100.00% (446) glutamine synthetase
M. gilvum PYR-GCKMflv_2909-0.089.24% (446) glutamine synthetase, type I
M. leprae Br4923MLBr_01631glnA20.093.30% (448) glutamine synthase class II
M. abscessus ATCC 19977MAB_1920-0.085.87% (446) glutamine synthetase
M. marinum MMMAR_3294glnA20.093.95% (446) glutamine synthetase GlnA2
M. avium 104MAV_2244glnA0.094.17% (446) glutamine synthetase, type I
M. smegmatis MC2 155MSMEG_4294glnA0.088.79% (446) glutamine synthetase, type I
M. thermoresistible (build 8)TH_3396-0.088.12% (446) PUTATIVE glutamine synthetase, type I
M. ulcerans Agy99MUL_1335glnA20.093.50% (446) glutamine synthetase GlnA2
M. vanbaalenii PYR-1Mvan_3598-0.088.57% (446) glutamine synthetase, type I

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2909|M.gilvum_PYR-GCK          MDRQKEFVLRTLEERDIRFVRLWFTDVLGYLKSVAIAPAELEGAFEEGIG
Mvan_3598|M.vanbaalenii_PYR-1       MDRQMEFVLRTLEERDIRFVRLWFTDVLGYLKSVAIAPAELEGAFEEGIG
MSMEG_4294|M.smegmatis_MC2_155      MDRQKEFVLRTLEERDIRFVRLWFTDVLGYLKSVAIAPAELEGAFEEGIG
TH_3396|M.thermoresistible__bu      MDRQKEFVLRSLEERDIRFVRLWFTDVLGFLKSVAIAPAELEGAFEEGIG
Rv2222c|M.tuberculosis_H37Rv        MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAIAPAELEGAFEEGIG
Mb2246c|M.bovis_AF2122/97           MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAIAPAELEGAFEEGIG
MMAR_3294|M.marinum_M               MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAIAPAELEGAFEEGIG
MUL_1335|M.ulcerans_Agy99           MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAIAPAELEGAFEEGIG
MAV_2244|M.avium_104                MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAIAPAELEGAFEEGIG
MLBr_01631|M.leprae_Br4923          MDRQKEFVLRTLEERDIRFVRLWFTDVLGYLKSVAIAPAELEGAFEEGIG
MAB_1920|M.abscessus_ATCC_1997      MDRQKEFVLRTLEERDIRFVRLWFTDVLGYLKSVSIAPAELEGAFEEGIG
                                    **** *****:******************:****:***************

Mflv_2909|M.gilvum_PYR-GCK          FDGSSIEGFARVSEADMVARPDPSTFQVLPWADSSGKHHSARMFCDITMP
Mvan_3598|M.vanbaalenii_PYR-1       FDGSSIEGFARVSEADMVARPDPSTFQVLPWTTSAGNHYSARMFCDITMP
MSMEG_4294|M.smegmatis_MC2_155      FDGSSIEGFARVFESDTVARPDPSTFQVLPWKTSDGNHYSARMFCDITMP
TH_3396|M.thermoresistible__bu      FDGSAIEGFARVSEADMVARPDPSTFQVLPWTGDSGKHYSARMFCDITMP
Rv2222c|M.tuberculosis_H37Rv        FDGSSIEGFARVSESDTVAHPDPSTFQVLPWATSSGHHHSARMFCDITMP
Mb2246c|M.bovis_AF2122/97           FDGSSIEGFARVSESDTVAHPDPSTFQVLPWATSSGHHHSARMFCDITMP
MMAR_3294|M.marinum_M               FDGSSIEGFARVSESDTVAHPDPSTFQVLPWVTDAGHHHSARIFCDITMP
MUL_1335|M.ulcerans_Agy99           FDGSSIEGFARVSESDTVAHPDPSTFQVLPWVTDAGHHHSARIFCDITMP
MAV_2244|M.avium_104                FDGSSIEGFSRVSESDTVANPDPSTFQVLPWASPNGHHHSARMFCDITMP
MLBr_01631|M.leprae_Br4923          FDGSSIEGFARVSESDTVAHPDPSTFQILPWATTAGHHHSARMFCDITMP
MAB_1920|M.abscessus_ATCC_1997      FDGSSIEGFARVSESDTVAHPDPSTFQVLPWTTSAGKHHSARMFCDIKLP
                                    ****:****:** *:* **.*******:***    *:*:***:****.:*

Mflv_2909|M.gilvum_PYR-GCK          DGSPSWADSRHVLRRQLSKASDLGFSCYVHPEIEFFLLKPGDNDG--SPP
Mvan_3598|M.vanbaalenii_PYR-1       DGSPSWADSRHVLRRQLSKASDLGFSCYVHPEIEFFLLKPGPDDG--TQP
MSMEG_4294|M.smegmatis_MC2_155      DGSPSWADSRHVLRRQLAKASDLGFTCYVHPEIEFFLLKPGPNDG--TPP
TH_3396|M.thermoresistible__bu      DGSPSWADPRHVLRRQLAKAGDQGFTCYVHPEIEFFLLKPGPHDG--SPP
Rv2222c|M.tuberculosis_H37Rv        DGSPSWADPRHVLRRQLTKAGELGFSCYVHPEIEFFLLKPGPEDG--SVP
Mb2246c|M.bovis_AF2122/97           DGSPSWADPRHVLRRQLTKAGELGFSCYVHPEIEFFLLKPGPEDG--SVP
MMAR_3294|M.marinum_M               DGSPSWADPRHVLRRQLTKANELGFSCYVHPEIEFFLLNPGPEDG--TEP
MUL_1335|M.ulcerans_Agy99           DGSPSWADPRHVLRRQLIKANELGFSCYVHPEIEFFLLNPGPEDG--TEP
MAV_2244|M.avium_104                DGSPSWADPRHVLRRQLQKANDLGFSCYVHPEIEFFLLKPGPDDG--TPP
MLBr_01631|M.leprae_Br4923          DGSSSWADPRHVLRRQLTKANDLGFSCYVHPEIEFFLLKAGPEDGSMPIP
MAB_1920|M.abscessus_ATCC_1997      DGSPSWSDPRHVLRRQLAKASDLGFSCYVHPEIEFFLLKNLPDDG--TAP
                                    ***.**:*.******** **.: **:************:   .**  . *

Mflv_2909|M.gilvum_PYR-GCK          TPADNGGYFDQAVHDSAPNFRRHAIDALEQMGISVEFSHHEGAPGQQEID
Mvan_3598|M.vanbaalenii_PYR-1       IPADNGGYFDQAVHDAAPNFRRHAIDALEQMGISVEFSHHEGAPGQQEID
MSMEG_4294|M.smegmatis_MC2_155      EPADNGGYFDQAVHDAAPNFRRHAIEALEQMGISVEFSHHEGAPGQQEID
TH_3396|M.thermoresistible__bu      VPADTSGYFDQSVHDTAPNFRRHAIEALEQMGISVEFSHHEGAPGQQEID
Rv2222c|M.tuberculosis_H37Rv        VPVDNAGYFDQAVHDSALNFRRHAIDALEFMGISVEFSHHEGAPGQQEID
Mb2246c|M.bovis_AF2122/97           VPVDNAGYFDQAVHDSALNFRRHAIDALEFMGISVEFSHHEGAPGQQEID
MMAR_3294|M.marinum_M               VPIDNAGYFDQAVHVSASKFRRHAIDALEFMGISVEFSHHEGAPGQQEID
MUL_1335|M.ulcerans_Agy99           VPIDNAGYFDQAVHVSASKFRRHVIDALEFMGISVEFSHHEGAPGQQEID
MAV_2244|M.avium_104                VPVDTAGYFDQAIHDSASNFRRHAIEALEFMGISVEFSHHEGAPGQQEID
MLBr_01631|M.leprae_Br4923          VPVDNAGYFDQAVHDSALNFRRHAIEALEFMGISVEFSHHEGAPGQQEID
MAB_1920|M.abscessus_ATCC_1997      IPADDAGYFDQAVHEAAPNFRRHAIDALESMGISVEFSHHEGAPGQQEID
                                     * * .*****::* :* :****.*:*** ********************

Mflv_2909|M.gilvum_PYR-GCK          LRYADALSMADNVMTFRYLVKEVALGDGVRASFMPKPFAEHPGSAMHTHM
Mvan_3598|M.vanbaalenii_PYR-1       LRYADALSMADNVMTFRYLVKEVALADGVRASFMPKPFAEHPGSAMHTHM
MSMEG_4294|M.smegmatis_MC2_155      LRYADALSMADNVMTFRYLVKEVALADGVRASFMPKPFAEHPGSAMHTHM
TH_3396|M.thermoresistible__bu      LRYADALSMADNVMTFRYVVKQVAISDGVRASFMPKPFAEHPGSAMHTHM
Rv2222c|M.tuberculosis_H37Rv        LRFADALSMADNVMTFRYVIKEVALEEGARASFMPKPFGQHPGSAMHTHM
Mb2246c|M.bovis_AF2122/97           LRFADALSMADNVMTFRYVIKEVALEEGARASFMPKPFGQHPGSAMHTHM
MMAR_3294|M.marinum_M               LRFADALSMADNVMTFRYVIKEVALEEGVRATFMPKPFGQHAGSAMHTHM
MUL_1335|M.ulcerans_Agy99           LRFADALSMADNVMTFRYVIKEVALEEGVRATFMPKPFGQHAGSAMHTHM
MAV_2244|M.avium_104                LRFADALSMADNVMTFRYVIKEVAIENGARASFMPKPFGQHPGSAMHTHM
MLBr_01631|M.leprae_Br4923          LRFADALSMADNVMTFRYVIKEVAIENGARASFMPKPFAQHPGSAMHTHM
MAB_1920|M.abscessus_ATCC_1997      LRYADALSMADNVMTFRNVVKEVAIIDGVHATFMPKPFSDHPGSAMHTHM
                                    **:************** ::*:**: :*.:*:******.:*.********

Mflv_2909|M.gilvum_PYR-GCK          SLFEGDSNAFHSPDDPLQLSAVGKSFIAGILEHANEISAVTNQWVNSYKR
Mvan_3598|M.vanbaalenii_PYR-1       SLFEGDTNAFHSPDDPLQLSDVGKSFIAGILEHANEISAVTNQWVNSYKR
MSMEG_4294|M.smegmatis_MC2_155      SLFEGDTNAFHSPDDPLQLSDVAKSFIAGILEHANEISAVTNQWVNSYKR
TH_3396|M.thermoresistible__bu      SLFEGDTNAFHSPDDPLQLSDVAKSFIAGILEHANEISAVTNQWVNSYKR
Rv2222c|M.tuberculosis_H37Rv        SLFEGDVNAFHSADDPLQLSEVGKSFIAGILEHACEISAVTNQWVNSYKR
Mb2246c|M.bovis_AF2122/97           SLFEGDVNAFHSADDPLQLSEVGKSFIAGILEHACEISAVTNQWVNSYKR
MMAR_3294|M.marinum_M               SLFEGDVNAFHSPDDPLQLSEVGKSFIAGILEHASEISAVTNQWVNSYKR
MUL_1335|M.ulcerans_Agy99           SLFEGDVNAFHSPDDPLQLSEVGKSFIAGILEHASEISAVTNQWVNSYKR
MAV_2244|M.avium_104                SLFEGDVNAFHSPDDPLQLSDVGKSFIAGILEHASEISAVTNQWVNSYKR
MLBr_01631|M.leprae_Br4923          SLFEGDVNAFHSDDDPLQLSDVGKSFIAGILEHASEISAVTNQWVNSYKR
MAB_1920|M.abscessus_ATCC_1997      SLFEGDTNAFHNPDDPLQLSDVGKSFIAGILEHANEISAVTNQWVNSYKR
                                    ****** ****. ******* *.*********** ***************

Mflv_2909|M.gilvum_PYR-GCK          LVHGGEAPTAASWGAANRSALVRVPMYTPHKVSSRRVEVRSPDSACNPYL
Mvan_3598|M.vanbaalenii_PYR-1       LVHGGEAPTAASWGAANRSALVRVPMYTPHKVSSRRVEVRSPDSACNPYL
MSMEG_4294|M.smegmatis_MC2_155      LVHGGEAPTAASWGAANRSALVRVPMYTPHKVSSRRVEVRSPDSACNPYL
TH_3396|M.thermoresistible__bu      LVHGGEAPTAASWGAANRSALVRVPMYTPHKASSRRVEVRSPDSACNPYL
Rv2222c|M.tuberculosis_H37Rv        LVQGGEAPTAASWGAANRSALVRVPMYTPHKTSSRRVEVRSPDSACNPYL
Mb2246c|M.bovis_AF2122/97           LVQGGEAPTAASWGAANRSALVRVPMYTPHKTSSRRVEVRSPDSACNPYL
MMAR_3294|M.marinum_M               LILGGEAPTAASWGAANRSALVRVPMYTPHKTSSRRIEVRSPDSACNPYL
MUL_1335|M.ulcerans_Agy99           LILGGEAPTAASWGAANRSALVRVPMYTPHKTSSRRIEVRSPDSACNPYL
MAV_2244|M.avium_104                LVGGGEAPTAASWGAANRSALVRVPMYTPHKTSSRRVEVRSPDSACNPYL
MLBr_01631|M.leprae_Br4923          LVVGGEAPTTASWGAANRSALVRVPMYTPHKTSSRRVEVRSPDSACNPYL
MAB_1920|M.abscessus_ATCC_1997      LVQGGEAPTAASWGAANRSALVRVPMYTPNKSSSRRIEVRSPDSACNPYL
                                    *: ******:*******************:* ****:*************

Mflv_2909|M.gilvum_PYR-GCK          TFAVLLAAGLRGIEKNYVLGPEAEDNVWSLTPEERRAMGYKELPGSLGAA
Mvan_3598|M.vanbaalenii_PYR-1       TFAVLLAAGLRGIEKNYVLGPQAEDNVWSLTPEERRAMGYKELPGSLGVA
MSMEG_4294|M.smegmatis_MC2_155      TFAVLLAAGLRGVEKGYVLGPQAEDNVWSLTQEERRAMGYRELPTSLGNA
TH_3396|M.thermoresistible__bu      TFAVLLAAGLRGVEKGYVLGPEAEDNVWTLTPEERRAMGFKELPSSLGQA
Rv2222c|M.tuberculosis_H37Rv        TFAVLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERRAMGYRELPSSLDSA
Mb2246c|M.bovis_AF2122/97           TFAVLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERRAMGYRELPSSLDSA
MMAR_3294|M.marinum_M               AFAVLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERRTMGYRELPTSLDSA
MUL_1335|M.ulcerans_Agy99           AFAVLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERRTMGYRELPTSLDSA
MAV_2244|M.avium_104                TFAVLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERIAMGYRELPTSLDSA
MLBr_01631|M.leprae_Br4923          AFAVLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERLAMGYRELPTSLDSA
MAB_1920|M.abscessus_ATCC_1997      TYAVLLAAGLRGVEQGYTLGPEAEDDVWGLTRAERQAMGYKELPSTLENA
                                    ::**********:*:.*.***:***:** **  ** :**::*** :*  *

Mflv_2909|M.gilvum_PYR-GCK          LADMENSELVAEALGEHVFDFFLRNKRREWENYRSHVTPFELKNYLSL
Mvan_3598|M.vanbaalenii_PYR-1       LTEMENSELVAEALGEHVFDFFLRNKRSEWENYRSHVTPFELKNYLSL
MSMEG_4294|M.smegmatis_MC2_155      LESMENSELVAEALGEHVFDYFLRNKRSEWENYRSHVTPYELKNYLSL
TH_3396|M.thermoresistible__bu      LAEMERSELVAEALGEHVFDFFLRNKRAEWENYRSHVTPYELKNYLSL
Rv2222c|M.tuberculosis_H37Rv        LRAMEASELVAEALGEHVFDFFLRNKRTEWANYRSHVTPYELRTYLSL
Mb2246c|M.bovis_AF2122/97           LRAMEASELVAEALGEHVFDFFLRNKRTEWANYRSHVTPYELRTYLSL
MMAR_3294|M.marinum_M               LRAMESSELVAEALGEHVFDFFLRNKRREWATYRSHVTPYELSTYLSL
MUL_1335|M.ulcerans_Agy99           LRAMESSELVAEALGEHVFDFFLRNKRREWATYRSHVTPYELSTYLSL
MAV_2244|M.avium_104                LRAMESSELVAETLGEHVFDFFLRNKRTEWATYRSHVTPYELRTYLSL
MLBr_01631|M.leprae_Br4923          LGAMEVSEFVAEALGEHVFDFFLRNKRAEWANYRSHVSLYELKTYLSL
MAB_1920|M.abscessus_ATCC_1997      LIAMEGSELVAEALGEHVFDFFLRNKRAEWARYRSNVTPFELRAYLGL
                                    *  ** **:***:*******:****** **  ***:*: :**  **.*