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AFNNRNRSLLSLVHHTERDLHYLLDLSRDLKRAKYSGLGRQSLAGKNIALIFEKTSTRTRCAFEVAAHDE GAHVTYIDPASSQIGHKESMKDTARVLGRMYDAIEYRGASQSTVEELAAYAGVPVFNGLTDEFHPTQMLA DVLTMTEHCPKPLTDIAFAFVGDGRNNVANSLLLVAAKLGMDVRIGAPPDLWPHEDHVSMCEEFAAASGA RLLITDEPAKAVHGVDFIYTDVWVSMGEPVETWGERIDELLPFQVNDTLMAAAGNPRVKFMHCLPAFHNC ETKVGAQIAAQYPHLAGGIEVTDAVFESPANIAFEQAENRMHTIKAVLVSALS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1390 | - | - | 100% (334) | ornithine carbamoyltransferase |
| M. vanbaalenii PYR-1 | Mvan_3310 | - | 1e-52 | 38.11% (307) | ornithine carbamoyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2660 | pyrB | 7e-12 | 30.50% (200) | aspartate carbamoyltransferase catalytic subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1684 | argF | 9e-51 | 37.34% (308) | ornithine carbamoyltransferase |
| M. gilvum PYR-GCK | Mflv_3526 | - | 8e-52 | 37.99% (308) | ornithine carbamoyltransferase |
| M. tuberculosis H37Rv | Rv1656 | argF | 9e-51 | 37.34% (308) | ornithine carbamoyltransferase |
| M. leprae Br4923 | MLBr_01410 | argF | 1e-50 | 36.04% (333) | ornithine carbamoyltransferase |
| M. abscessus ATCC 19977 | MAB_2340 | - | 6e-52 | 37.34% (308) | ornithine carbamoyltransferase |
| M. marinum M | MMAR_2466 | argF | 5e-53 | 38.96% (308) | ornithine carbamoyltransferase, anabolic ArgF |
| M. avium 104 | MAV_3114 | argF | 3e-50 | 36.27% (306) | ornithine carbamoyltransferase |
| M. smegmatis MC2 155 | MSMEG_3772 | argF | 1e-50 | 37.66% (308) | ornithine carbamoyltransferase |
| M. thermoresistible (build 8) | TH_1596 | argF | 1e-50 | 37.13% (307) | Probable Ornithine carbamoyltransferase, anabolic ArgF |
| M. ulcerans Agy99 | MUL_1648 | argF | 3e-53 | 39.29% (308) | ornithine carbamoyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1684|M.bovis_AF2122/97 --------------MIRHFLRDDDLSPAEQAEVLELAAELKKDPVS---R
Rv1656|M.tuberculosis_H37Rv --------------MIRHFLRDDDLSPAEQAEVLELAAELKKDPVS---R
MLBr_01410|M.leprae_Br4923 MGGASRLRGRGAAQLTRHFLRDDDLSPTEQADILALAADLKKAPFS---R
MMAR_2466|M.marinum_M --------------MIRHFLRDDDLSPAEQAEVLQLAAELKREPFS---R
MUL_1648|M.ulcerans_Agy99 --------------MIRHFLRDDDLSPTEQAEVLQLAAELKREPFS---R
Mflv_3526|M.gilvum_PYR-GCK --------------MTRHFLRDDDLTPEEQAEVLALAAALKKDPFS---R
MSMEG_3772|M.smegmatis_MC2_155 --------------MIRHFLRDDDLSPEEQAEVLTLAADLKKTPFS---R
MAB_2340|M.abscessus_ATCC_1997 ---------MIQSKSLRHFLRDDDLSPAEQAEVLTLAAELKKAPFS---R
TH_1596|M.thermoresistible__bu -----------VSTVIRHFLRDDDLTPEEQAEVLALAAELKRDPLS---H
MAV_3114|M.avium_104 -------------MTPRHFLRDDDLSPAEQAEVLALAAELKKDPFS---A
Mvan_1390|M.vanbaalenii_PYR-1 ---------MAFNNRNRSLLSLVHHTERDLHYLLDLSRDLKRAKYSGLGR
* :* . : : :* *: **: *
Mb1684|M.bovis_AF2122/97 RPLQGPRGVAVIFDKNSTRTRFSFELGIAQLGGHAVVVDSGSTQLGRDET
Rv1656|M.tuberculosis_H37Rv RPLQGPRGVAVIFDKNSTRTRFSFELGIAQLGGHAVVVDSGSTQLGRDET
MLBr_01410|M.leprae_Br4923 RPLAGPRGVAVIFDKNSTRTRFSFDIGIAQLGGHAVVVDGLSTQLGRDET
MMAR_2466|M.marinum_M RPLDGPRGVAVIFDKNSTRTRFSFEMGIAQLGGHAVVVDGRSTQLGREET
MUL_1648|M.ulcerans_Agy99 RPLDGPRGVAVIFDKNSTRTRFSFEMGIAQLGGHAVVVDGRSTQLGREET
Mflv_3526|M.gilvum_PYR-GCK RPLEGPRGVAVIFEKNSTRTRFSFEMGIAQLGGHAVVVDGRSTQLGREET
MSMEG_3772|M.smegmatis_MC2_155 RPLEGPRGVAVIFEKNSTRTRFSFEMGIAQLGGHAIVVDGRSTQLGREET
MAB_2340|M.abscessus_ATCC_1997 RPLEGPHGVAVIFEKNSTRTRFSFEMGIAQLGGHAVVVDSRTTQLGREET
TH_1596|M.thermoresistible__bu RPLEGPRGVAVIFDKNSTRTRFSFEIGIAQLGGHAVVVDGNTTQLGRDET
MAV_3114|M.avium_104 RPLEGPRGVAVLFDKNSTRTRFSFEVGIAQLGGHAVVVDARSTQLGRDET
Mvan_1390|M.vanbaalenii_PYR-1 QSLAG-KNIALIFEKTSTRTRCAFEVAAHDEGAHVTYIDPASSQIGHKES
:.* * :.:*::*:*.***** :*::. : *.*. :* ::*:*:.*:
Mb1684|M.bovis_AF2122/97 LQDTAKVLSRYVDAIVWRTFGQERLDAMASVATVPVINALSDEFHPCQVL
Rv1656|M.tuberculosis_H37Rv LQDTAKVLSRYVDAIVWRTFGQERLDAMASVATVPVINALSDEFHPCQVL
MLBr_01410|M.leprae_Br4923 LQDTARVLSGYVDAIVWRTFGQHRLDAMAATATVPVVNALSDEFHPCQVL
MMAR_2466|M.marinum_M LPDTAKVLSRFVDAIVWRTFGQDRLQAMASTATVPVVNALSDEFHPCQVL
MUL_1648|M.ulcerans_Agy99 LPDTAKVLSRFVDAIVWRTFGQDRLQAMASTATVPVVNALSDEFHPCQVL
Mflv_3526|M.gilvum_PYR-GCK LEDTGAVLSRYVDAIVWRTFAQERLTAMASGASVPIVNALSDEFHPCQVL
MSMEG_3772|M.smegmatis_MC2_155 LEDTGAVLSRYVDAIVWRTFAQERLTAMASGASVPIVNALSDEFHPCQVL
MAB_2340|M.abscessus_ATCC_1997 LEDTGQVLSRYVEAIVWRTYAQERLTAMASGASVPIVNALSDDFHPCQVL
TH_1596|M.thermoresistible__bu LHDTGKVLSRYVEAIVWRTFGQDRLIEMAAGATVPVVNALSDEFHPCQVL
MAV_3114|M.avium_104 LEDTARVLSRYVEAIVWRTFEQHRLEAMAGAATVPVINALSDEFHPCQVL
Mvan_1390|M.vanbaalenii_PYR-1 MKDTARVLGRMYDAIEYRGASQSTVEELAAYAGVPVFNGLTDEFHPTQML
: **. **. :** :* * : :*. * **:.*.*:*:*** *:*
Mb1684|M.bovis_AF2122/97 ADLQTIAERK-GALRGLRLSYFGDGANNMAHSLLLGGVTAGIHVTVAAPE
Rv1656|M.tuberculosis_H37Rv ADLQTIAERK-GALRGLRLSYFGDGANNMAHSLLLGGVTAGIHVTVAAPE
MLBr_01410|M.leprae_Br4923 ADLQTIAERK-GSLNGLRLSYFGDGANNMAHSLMLGAVTAGVHVTVATPV
MMAR_2466|M.marinum_M ADLQTITERR-GSLKGLRLSYFGDGANNMAHSLMLGGVTAGMHVTVAAPD
MUL_1648|M.ulcerans_Agy99 ADLQTITERR-GSLKGLRLSYFGDGANNMAHSLMLGGVTAGMHVTIAAPD
Mflv_3526|M.gilvum_PYR-GCK ADLQTLIERK-GSLKGLRLAYFGDGANNMAHSLMLGGVTAGVDVTIAAPR
MSMEG_3772|M.smegmatis_MC2_155 ADLQTLAERK-GKLAGLRMTYFGDGANNMAHSLMLGGVTAGVHVTIAAPD
MAB_2340|M.abscessus_ATCC_1997 ADLQTLAERK-GSLDGLRLTYLGDGANNMAHSLMLGGVTAGIHVTIAAPN
TH_1596|M.thermoresistible__bu ADLQTLAERK-GSLAGLRLTYLGDGANNMAHSLLLGGVTAGIHVTIAAPA
MAV_3114|M.avium_104 ADLQAIAEHK-GSLSGLRMCYLGDGANNMAHSLMLGGVTAGIHVTIAAPD
Mvan_1390|M.vanbaalenii_PYR-1 ADVLTMTEHCPKPLTDIAFAFVGDGRNNVANSLLLVAAKLGMDVRIGAPP
**: :: *: * .: : :.*** **:*:**:* ... *:.* :.:*
Mb1684|M.bovis_AF2122/97 GFLPDPSVRAAAERRAQDTGASVTVTADAHAAAAGADVLVTDTWTSMGQE
Rv1656|M.tuberculosis_H37Rv GFLPDPSVRAAAERRAQDTGASVTVTADAHAAAAGADVLVTDTWTSMGQE
MLBr_01410|M.leprae_Br4923 GFTPDPSVLAAAKKRAEATGASVTVTVDADTAAAGADVLVTDTWTSMGQE
MMAR_2466|M.marinum_M GFHPDPSVVGAAEQRAETTGASVRLTADAHVAAAGADVLVTDTWTSMGQE
MUL_1648|M.ulcerans_Agy99 GFHPDPSVVGAAEQRAETTGASVRLTADAHVAAAGADVLVTDTWTSMGQE
Mflv_3526|M.gilvum_PYR-GCK GFEPHPMFIAAAETRAHQTGATVAVIDDPLRAADGADVLVTDTWTSMGQE
MSMEG_3772|M.smegmatis_MC2_155 GFEPDPRFVDAARRRAAETGATVALTKDAKAGADGADVLVTDTWTSMGQE
MAB_2340|M.abscessus_ATCC_1997 GFAPHAKYVAEAEKVAATTGASVSVTADPRSAVARADVLVTDAWTSMGQE
TH_1596|M.thermoresistible__bu GFAPDPEVVAAAEQRARRTGATIAMTDDPRRGAAGADVLVTDTWTSMGQE
MAV_3114|M.avium_104 GFTPAPEFVAAARRRAESTGATVTLTTDARTAARGVDVLVTDTWTSMGQE
Mvan_1390|M.vanbaalenii_PYR-1 DLWPHEDHVSMCEEFAAASGARLLITDEPAKAVHGVDFIYTDVWVSMGEP
.: * .. * :** : : :. .. .*.: **.*.***:
Mb1684|M.bovis_AF2122/97 NDGL-DRVKPFRPFQLNSRLLALA-DSDAIVLHCLPAHR-----------
Rv1656|M.tuberculosis_H37Rv NDGL-DRVKPFRPFQLNSRLLALA-DSDAIVLHCLPAHR-----------
MLBr_01410|M.leprae_Br4923 NDGL-DRVKPFWPFQVNARLVGLA-DSEAIVLHCLPAHR-----------
MMAR_2466|M.marinum_M DDGL-DRVKPFRPFQVNEQLLAAA-DSEAVVLHCLPAHR-----------
MUL_1648|M.ulcerans_Agy99 DDGL-DRVKPFRPFQVNEQLLAAA-DSEVVVLHCLPAHR-----------
Mflv_3526|M.gilvum_PYR-GCK NDGL-DRVRPFRPFQVNADLLGRA-DSEAVVLHCLPAHR-----------
MSMEG_3772|M.smegmatis_MC2_155 NDGL-DRVRPFRPFQVNADLLELA-DPAAVVLHCLPAHR-----------
MAB_2340|M.abscessus_ATCC_1997 NDGL-DRVRPFRAFQVNEDLLALA-DSEAVVLHCLPAHR-----------
TH_1596|M.thermoresistible__bu DDGR-DRVRPFRPFQLNADLLGEA-DPEAVVLHCLPAHR-----------
MAV_3114|M.avium_104 DDGL-DRRTPFWPYQLNADLVSLA-DPEAIVLHCLPAHR-----------
Mvan_1390|M.vanbaalenii_PYR-1 VETWGERIDELLPFQVNDTLMAAAGNPRVKFMHCLPAFHNCETKVGAQIA
: :* : .:*:* *: * :. . .:*****.:
Mb1684|M.bovis_AF2122/97 --------GDEITDAVMDGPASAVWDEAENRLHAQKALLVWLLERS-
Rv1656|M.tuberculosis_H37Rv --------GDEITDAVMDGPASAVWDEAENRLHAQKALLVWLLERS-
MLBr_01410|M.leprae_Br4923 --------GDEITNEVMDGPTSAIWDEAENRLHAQKALLVWLLER--
MMAR_2466|M.marinum_M --------GDEITDQVMDGPASAVWDEAENRLHAQKALLVWLLERGR
MUL_1648|M.ulcerans_Agy99 --------GDEITDQVMDGPASAVWDEAENRLHAQKALLVWLLERGR
Mflv_3526|M.gilvum_PYR-GCK --------GHEITDEVIDGPRSAVWDEAENRLHAQKALLVWLLERS-
MSMEG_3772|M.smegmatis_MC2_155 --------GHEITDEVIDGPQSAVFDEAENRLHAQKALLVWLLEKR-
MAB_2340|M.abscessus_ATCC_1997 --------GHEITDGVIDGPRSAVWDEAENRLHAQKALLVWLLENRR
TH_1596|M.thermoresistible__bu --------GHEITDEVIDGPQSAVWDEAENRLHAQKALLTWLLERRR
MAV_3114|M.avium_104 --------GEEITDEVMDGPSSVVWDEAENRLHAQKALLTWLLERQA
Mvan_1390|M.vanbaalenii_PYR-1 AQYPHLAGGIEVTDAVFESPANIAFEQAENRMHTIKAVLVSALS---
* *:*: *::.* . :::****:*: **:*. *.