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SGTDTALAELTRPAPILRSAVVPYLTVADARAAIRWYIDVFDAELVGDPVEMDDGRIGHAELALADGVLY LADEYPEMGLKAPSPQAVSVSLMLTVASTDETLRRARDHGAQVQREPYENYGARNAALVDPFGHRWMLTG PVTGAAVPIQHGDVGYVAVWTPDAQRAATFYGHVLGWAVDPATQMVTNTGQRVGIVSAPEQRTLFCCYAV TDLDGARASILAGGGSVGEVVDFGFGAVLRATDPHGVEFGVYRPASGEPRPLLNGGGHGELSYITYQVPD STVFKAFYSGLLFWTYEPGRIDDGWGVVGAHPMSGAAGGNASAVTVPMWTVDDIDAAVSRVRSAGGTVIE EPSQQSYGKSALCTDDQGTRFYLGEL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1292 | - | - | 100% (377) | glyoxalase/bleomycin resistance protein/dioxygenase |
| M. vanbaalenii PYR-1 | Mvan_4455 | - | 9e-14 | 37.50% (128) | glyoxalase/bleomycin resistance protein/dioxygenase |
| M. vanbaalenii PYR-1 | Mvan_5027 | - | 2e-10 | 36.15% (130) | glyoxalase/bleomycin resistance protein/dioxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0708c | - | 3e-14 | 45.35% (86) | hypothetical protein Mb0708c |
| M. gilvum PYR-GCK | Mflv_5064 | - | 1e-171 | 76.60% (376) | glyoxalase/bleomycin resistance protein/dioxygenase |
| M. tuberculosis H37Rv | Rv0689c | - | 4e-14 | 45.35% (86) | hypothetical protein Rv0689c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0931c | - | 2e-15 | 38.06% (134) | putative glyoxalase/bleomycin resistance protein |
| M. marinum M | MMAR_4645 | - | 2e-15 | 40.31% (129) | hypothetical protein MMAR_4645 |
| M. avium 104 | MAV_1014 | - | 4e-14 | 36.36% (132) | glyoxalase family protein |
| M. smegmatis MC2 155 | MSMEG_1417 | - | 1e-143 | 65.53% (380) | glyoxalase family protein |
| M. thermoresistible (build 8) | TH_1897 | - | 2e-85 | 65.81% (234) | glyoxalase family protein |
| M. ulcerans Agy99 | MUL_0263 | - | 1e-15 | 39.84% (128) | hypothetical protein MUL_0263 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1292|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5064|M.gilvum_PYR-GCK -----MTDPMDALRGGDLPVDPDPAFARRLRSRLEAAANLFEQQPDRTKD
Mb0708c|M.bovis_AF2122/97 --------------------------------------------------
Rv0689c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1417|M.smegmatis_MC2_155 -----MNADHDPLTVLHQHDEPPVAPDPEFVARLRARLEAALTLPNRTEG
TH_1897|M.thermoresistible__bu MNQHHSRDPLDVLRGGDRPVQPDPAFAARLRARLESAARFLADRP-HTEG
MMAR_4645|M.marinum_M --------------------------------------------------
MUL_0263|M.ulcerans_Agy99 --------------------------------------------------
MAV_1014|M.avium_104 --------------------------------------------------
MAB_0931c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1292|M.vanbaalenii_PYR-1 --MSGTDTALAELT-------RPAPIL-RSAVVPYLTVADARAAIRWYID
Mflv_5064|M.gilvum_PYR-GCK IIMSGTDTVLAELT-------EPT----SGGLIPYLTVTDARAAIDWYVD
Mb0708c|M.bovis_AF2122/97 --------------------------------------------------
Rv0689c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1417|M.smegmatis_MC2_155 VVMTGTDTAIAELK-------SPSQAAPRPAVISYLTVADARAAIGFYVD
TH_1897|M.thermoresistible__bu VVMSGTQTALTELTGSTGTAEPAATTPPRPAAVPYLNVADARAAIDWYVE
MMAR_4645|M.marinum_M -------MAIN----------------VEPALSPHLVVHDAAAAIDFYVK
MUL_0263|M.ulcerans_Agy99 -------MAIN----------------VEPALSPHLVVHDAAAAIDFYVK
MAV_1014|M.avium_104 -------MAIN----------------IEPALSPHLVVDNAAAAIDFYVK
MAB_0931c|M.abscessus_ATCC_199 -------MEPSQTS--------PDLPPVQPSVSPYLIVEDSRAAIEFYKN
Mvan_1292|M.vanbaalenii_PYR-1 VFDAELVGDPVEMDDGRIGHAELALADGVLYLADEYPEMG----LKAPSP
Mflv_5064|M.gilvum_PYR-GCK VLGASVVGAPITMDDGRIGHAELTVSGATLYLADEYPEIG----LKAPSS
Mb0708c|M.bovis_AF2122/97 --------------------------------------------------
Rv0689c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1417|M.smegmatis_MC2_155 ALGARVLGDPIVMDDGRIGHAELLLAGGVLYLADEFPEIG----LKAPAP
TH_1897|M.thermoresistible__bu ALGATLSGEPVVMDDGRIGHAELTLAGGVFYLADEYPELG----LRAPAP
MMAR_4645|M.marinum_M AFGAEELG-RVPGPDGRLVHAALRINGSTVMLNDDFPEMCGGKSMTPVSL
MUL_0263|M.ulcerans_Agy99 AFGAEELG-RVPGPDGRLVHAALRINGSTVMLNDDFPEMCGGKSMTPVSL
MAV_1014|M.avium_104 AFGAEELG-RLPRPDGKLAHAAVRINGFMVMLNDDFPEVCGGKSMTPTSL
MAB_0931c|M.abscessus_ATCC_199 AFGAEELG-LLETPDGKVMHAAVKINGTTIMMNDDFPEYNDGKSSTPTAL
Mvan_1292|M.vanbaalenii_PYR-1 QAVSVSLMLTVASTDETLRRARDHGAQVQREPYENYGARNAALVDPFGHR
Mflv_5064|M.gilvum_PYR-GCK QHVSASMMLTVTSVDGTLERARSARAFVQREPYEDHGARTAAIVDPFGHR
Mb0708c|M.bovis_AF2122/97 --------------------------------------------------
Rv0689c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1417|M.smegmatis_MC2_155 NAVSVSLMLSVPDTDAALARAAAHGARVQREPYEDHGTRNATFIDPSGHR
TH_1897|M.thermoresistible__bu EAVSMSLVLPVADTDAALQRARRHGATVQREPYEAHGARSAAIVDPFGHR
MMAR_4645|M.marinum_M GGTPVTIHLTVTDVDAKFQ-------------------------------
MUL_0263|M.ulcerans_Agy99 DGTPVTIHLTVTDVDAKFQ-------------------------------
MAV_1014|M.avium_104 GGTPVTIHLTVPDVDASFQ-------------------------------
MAB_0931c|M.abscessus_ATCC_199 GGTPVTIHLTVPHVDDWFG-------------------------------
Mvan_1292|M.vanbaalenii_PYR-1 WMLTGPVTG--AAVPIQHGDVGYVAVWTPDAQRAATFYGHVLGWAVDPAT
Mflv_5064|M.gilvum_PYR-GCK WMLTGPITG--APVPIRHGDVGYVSVRTPDAQRAAAFYGHVLGWVFDPET
Mb0708c|M.bovis_AF2122/97 --------------------------------------------------
Rv0689c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1417|M.smegmatis_MC2_155 WMLSGPVGVRVPVEAIRHGDVGYVSVWVPDADRAAAFYGHVLGWTYDPAT
TH_1897|M.thermoresistible__bu WMLSGPLTG--ASARIQHGDIGYVALWVPDPQRAAQFYRQVLGWQWDPDS
MMAR_4645|M.marinum_M --------------------------------------------------
MUL_0263|M.ulcerans_Agy99 --------------------------------------------------
MAV_1014|M.avium_104 --------------------------------------------------
MAB_0931c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1292|M.vanbaalenii_PYR-1 QMVTNTGQRVGIVSAPEQRTLFCCYAVTDLDGARASILAGGGSVGEVVDF
Mflv_5064|M.gilvum_PYR-GCK QRVTNTGQRIGITTAPGRHTLFCCYAVTDLDGARDSIVAGGGTVDDVVEF
Mb0708c|M.bovis_AF2122/97 --------------------------------------------------
Rv0689c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1417|M.smegmatis_MC2_155 RQVTNTQEHIGIFSVAGAPTMFCCYAVDDLDAARRAITAGGGTPGEVRES
TH_1897|M.thermoresistible__bu NQVTNTTGPIGIHRVPDARTMFCCYAVTDLDAAR----------------
MMAR_4645|M.marinum_M --------------------------------------------------
MUL_0263|M.ulcerans_Agy99 --------------------------------------------------
MAV_1014|M.avium_104 --------------------------------------------------
MAB_0931c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1292|M.vanbaalenii_PYR-1 GFGAVLRATDPHGVEFGVYRPASGEPRPLLNGGGHGELSYITYQVPDSTV
Mflv_5064|M.gilvum_PYR-GCK DFGSVLGATDPAGAEFGVYRPAADEPRPLLNGGGPGELSYITYQVPDSAE
Mb0708c|M.bovis_AF2122/97 --------------------------------------------------
Rv0689c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1417|M.smegmatis_MC2_155 EFGTVLDATDPAGTAFAVFEPVPGTPRPAVNGTGPGSLSYITYNVPDSAA
TH_1897|M.thermoresistible__bu --------------------------------------------------
MMAR_4645|M.marinum_M --------------------------------------------------
MUL_0263|M.ulcerans_Agy99 --------------------------------------------------
MAV_1014|M.avium_104 --------------------------------------------------
MAB_0931c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1292|M.vanbaalenii_PYR-1 FKAFYSGLLFWTYEPGRIDDGWGVVGAHPMSGAAGGNASAVTVPMWTVDD
Mflv_5064|M.gilvum_PYR-GCK FRAFYSRVLFWTYEPGRVDDGWGVVGAHPMSGAAGGHVEAVTVPMWTVAD
Mb0708c|M.bovis_AF2122/97 -------MLGWTVKPGRVADGWQAPGVHLMARCSGPQPASERRADMDGGD
Rv0689c|M.tuberculosis_H37Rv -------MLGWTVKPGRVADGWQAPGVHLMARCSGPQPASERRADMDGGD
MSMEG_1417|M.smegmatis_MC2_155 FKEFYGHVLSWTFEPGRIADGWGVQNCQPMSGMAGGSDRATTVPMWTVAD
TH_1897|M.thermoresistible__bu ---------------QAIIDGGGPPXXX-MVRHLLADPVLPDELLPAG--
MMAR_4645|M.marinum_M ----------------RALDAGATVVAPLDDQFWGDRYGVVADPFGHHWS
MUL_0263|M.ulcerans_Agy99 ----------------RALDAGATVVAPLDDQFWGERYGVVADPFGHHWS
MAV_1014|M.avium_104 ----------------RAVDAGATVVVPLEDQFWGDRYGMVADPFGHHWS
MAB_0931c|M.abscessus_ATCC_199 ----------------RAVDAGATVEMPLEDQFWGDRFGVIKDPFGHLWS
*.
Mvan_1292|M.vanbaalenii_PYR-1 IDAAVSRVRSAGGTVIEEPSQQSYGKSALCTDDQGTRFYLGEL
Mflv_5064|M.gilvum_PYR-GCK IDAAVARVREAGGTVIEEPSQQPYGKSALCTDDQGARFYLGEF
Mb0708c|M.bovis_AF2122/97 IDAAVARVRAAG--ALAEPSRQPDDMSAECADDQGARCHLGQL
Rv0689c|M.tuberculosis_H37Rv IDAAVARVRAAG--ALAEPSRQPDDMSAECADDQGARCHLGQL
MSMEG_1417|M.smegmatis_MC2_155 IDAAVTRVREAGGTVISAPARQPYGLMAECTDDQGARFYLGEF
TH_1897|M.thermoresistible__bu --WPGGAVRDAYRVFAAEMAARRDAGLVEAFD-----------
MMAR_4645|M.marinum_M LGQPVREVSMEEIQAAMSAQASN--------------------
MUL_0263|M.ulcerans_Agy99 LGQPVREVSMEEIQAAMSAQASN--------------------
MAV_1014|M.avium_104 LGQPVREVSPEEMAAAMAAMAAEQGAGQA--------------
MAB_0931c|M.abscessus_ATCC_199 LGQPVKIVNPEDLKKYAAGGSE---------------------
. *