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MGTEENRSVLQVGPLMPSLSRRLADDYAARRLPTEPTERAAFLAERGAEIIAVVTSGRTGVDAALMDALP NLAAVINFGVGYDTTDVAAAAARGIGVSNTPDVLTDCVADTAVGLMIDTLRQFSASDRYVRAGRWPVDGM YPLTRQVSKTNVGIIGLGRIGAAIALRLKAFGCTISYHNRHEVPDSPYTYAASPVELAASVDVLVVAAAG GDGTRGLVSSEVLDALGPHGYLINIARGSVVDQDALVSALVERRLAGAGLDVFADEPQVPEELFALDTVV LLPHVASGTVQTRAAMEALTLRNLDEFLATGELVTPVPLPAAAN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1025 | - | - | 100% (324) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
| M. vanbaalenii PYR-1 | Mvan_2128 | - | 6e-32 | 33.56% (295) | D-3-phosphoglycerate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0404 | - | 2e-28 | 35.74% (249) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3020c | serA1 | 2e-31 | 32.99% (288) | D-3-phosphoglycerate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_5240 | - | 1e-141 | 81.61% (310) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv2996c | serA1 | 2e-31 | 32.99% (288) | D-3-phosphoglycerate dehydrogenase |
| M. leprae Br4923 | MLBr_01692 | serA | 1e-31 | 34.68% (248) | D-3-phosphoglycerate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3304c | - | 4e-33 | 35.59% (295) | D-3-phosphoglycerate dehydrogenase |
| M. marinum M | MMAR_0531 | serA3 | 5e-32 | 38.31% (248) | D-3-phosphoglycerate dehydrogenase SerA3 |
| M. avium 104 | MAV_0123 | - | 3e-99 | 61.86% (312) | D-isomer specific 2-hydroxyacid dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_6126 | - | 1e-121 | 70.98% (317) | D-isomer specific 2-hydroxyacid dehydrogenase |
| M. thermoresistible (build 8) | TH_2037 | serA | 1e-33 | 33.73% (249) | PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH) |
| M. ulcerans Agy99 | MUL_1195 | serA3 | 2e-32 | 38.71% (248) | D-3-phosphoglycerate dehydrogenase SerA3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3020c|M.bovis_AF2122/97 ------------MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDR---D
Rv2996c|M.tuberculosis_H37Rv ------------MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDR---D
MLBr_01692|M.leprae_Br4923 ------------MDLPVVLIADKLAQSTVAALGDQVEVRWVDGPDR---T
MAB_3304c|M.abscessus_ATCC_199 -----------------MLIADKLAPSTVEALGDGVEVRWVDGPDR---P
TH_2037|M.thermoresistible__bu ------------VSLPVVLIADKLAESTVAALGDQVEVRWVDGPDR---E
MMAR_0531|M.marinum_M --------MNQPLRVLAHFVPGEKVLEFVAAQRDWLDIRWCAEDDD---S
MUL_1195|M.ulcerans_Agy99 --------MNQPLRVLAHFVPGEKVLEFVAAQRDWLDIRWCAEDDD---S
Mvan_1025|M.vanbaalenii_PYR-1 ---MGTE------ENRSVLQVGPLMPSLSRRLADDYAARRLPTEPTERAA
Mflv_5240|M.gilvum_PYR-GCK ---MSSEGLPECNVGGSVLQVGPLMPSLVRKLADDYDARRLPSDPDERAA
MSMEG_6126|M.smegmatis_MC2_155 MVDVSAQEETG-RGAQGVLQVGPLKPSLNQTLVSTYGAYVLPDGPG-RAA
MAV_0123|M.avium_104 ---MTKLS--------GVFRVGELEPAFGEELAARYDVPRLPDGAA-RDR
: .
Mb3020c|M.bovis_AF2122/97 KLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAAT
Rv2996c|M.tuberculosis_H37Rv KLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAAT
MLBr_01692|M.leprae_Br4923 KLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAAT
MAB_3304c|M.abscessus_ATCC_199 ALLAAVPEADALLVRSATTVDAEVLAAGTKLKIVARAGVGLDNVDVKAAT
TH_2037|M.thermoresistible__bu KLLAAVADADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVEAAT
MMAR_0531|M.marinum_M GFYRELDHAEVIWH-VLRPLSGADLQRAPRLRLVQKLGAGVNTIDVATAT
MUL_1195|M.ulcerans_Agy99 GFYRELDHAEVIWH-VLRPLSGADLQRAPRLRLVQKLGAGVNTIDVATAT
Mvan_1025|M.vanbaalenii_PYR-1 FLAERGAEIIAVVTSGRTGVDAALMDALPNLAAVINFGVGYDTTDVAAAA
Mflv_5240|M.gilvum_PYR-GCK FLADHGAEFTVAVTSGGVGVDASLMQALPNLGAVVNFGVGYDTTDVEAAH
MSMEG_6126|M.smegmatis_MC2_155 FLAEHGDRVTVAVTSGRTGVDAELMSALPNLGAVVNFGVGYDTTDVDAAA
MAV_0123|M.avium_104 FLAEHAAEVRALLTWGRPGVDAALIAALPNLEVIVNNGAGVDLIDTAAAD
: . :.. : ..* : . *.* : *. :*
Mb3020c|M.bovis_AF2122/97 ARGVLVVNAPTSNIHSAAEHALALLLAASRQIPAADASLR-EHTWKRSSF
Rv2996c|M.tuberculosis_H37Rv ARGVLVVNAPTSNIHSAAEHALALLLAASRQIPAADASLR-EHTWKRSSF
MLBr_01692|M.leprae_Br4923 ARGVLVVNAPTSNIHSAAEHALALLLAASRQIAEADASLR-AHIWKRSSF
MAB_3304c|M.abscessus_ATCC_199 ARGVLVVNAPTSNIHSAAEHAVTLLLATARQIPAADASLK-AHTWKRSSF
TH_2037|M.thermoresistible__bu ARGVLVVNAPTSNIHSAAEHAIALLLAAARQIPAADATLR-QRTWKRSEF
MMAR_0531|M.marinum_M KHGIAVANMPGANAPSVAEGTVLLMLAALRRLPELDAATRQGRGWPTDPQ
MUL_1195|M.ulcerans_Agy99 KHGIAVANMPGANAPSVAEGTVLLMLAALRRLPELDAATRQGRGWPTDPQ
Mvan_1025|M.vanbaalenii_PYR-1 ARGIGVSNTPDVLTDCVADTAVGLMIDTLRQFSASDRYVRAGRWPVDGMY
Mflv_5240|M.gilvum_PYR-GCK ARGIGVSNTPDVLTDCTADTAVGLLIDTMRQLPAADRYVRAGRWPVDGMF
MSMEG_6126|M.smegmatis_MC2_155 ARDIVVSNTPDVLSDCVADTAVGLLIDVMRKFSASDRYVRARRWVTEGNY
MAV_0123|M.avium_104 RRGIGVSNTPDVLSDTVADTALGLILMTLRRLGAADRYVRAGRWAREGPF
:.: * * * .*: :: *:: . *:: * : : .
Mb3020c|M.bovis_AF2122/97 SGTEIFGK---TVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQ
Rv2996c|M.tuberculosis_H37Rv SGTEIFGK---TVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQ
MLBr_01692|M.leprae_Br4923 SGTEIFGK---TVGVVGLGRIGQLVAARIAAFGAHVIAYDPYVAPARAAQ
MAB_3304c|M.abscessus_ATCC_199 NGTEIFGK---TVGVVGLGRIGQLFAQRLAAFGTHIVAYDPYVSAARAAQ
TH_2037|M.thermoresistible__bu SGVEIYDK---TVGVVGLGRIGQLVAQRLAAFGTHLIAYDPYVSPARAAQ
MMAR_0531|M.marinum_M LGESVRDIGSCTVGLIGYGNIAKRVATIVSAMGATVLHTSTRDDGRPGWR
MUL_1195|M.ulcerans_Agy99 LGESVRDIGSCTVGLIGYGNIAKRVATIVSAMGATVLHTSTRDDGRPGWR
Mvan_1025|M.vanbaalenii_PYR-1 PLTRQVSK--TNVGIIGLGRIGAAIALRLKAFGCTISYHNRHEVPDSPYT
Mflv_5240|M.gilvum_PYR-GCK PLTRDVSN--STVGIIGLGRIGTAIAQRLKAFRCSIAYHNRHRVTDCPYP
MSMEG_6126|M.smegmatis_MC2_155 PLAHKVSG--SRVGIIGLGRIGTAIATRLGAFGCTISYHNRREIEGSGYR
MAV_0123|M.avium_104 PYGRDVSG--LQVGILGLGRIGSAIATRLRGFDCAIAYHNRRRIDGSPYR
. **::* *.*. .* : .: : .
Mb3020c|M.bovis_AF2122/97 LGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAA
Rv2996c|M.tuberculosis_H37Rv LGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAA
MLBr_01692|M.leprae_Br4923 LGIELMSFDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAA
MAB_3304c|M.abscessus_ATCC_199 LGIELLTLDELLGRADFISVHLPKTPETAGLIGKEALAKTKPGVIIVNAA
TH_2037|M.thermoresistible__bu LGIELVDLDELLGRADIISVHLPKTPETAGLIGADALAKVKPGVIIVNAA
MMAR_0531|M.marinum_M P------LPELLATSDIVSLHLPLTPHTDRLLDADALAQMKPNSLLINTS
MUL_1195|M.ulcerans_Agy99 P------LPELLATSDIVSLHLPLTPHTDRLLDADALARMKPNSLLINTS
Mvan_1025|M.vanbaalenii_PYR-1 YAAS---PVELAASVDVLVVAAAGGDGTRGLVSSEVLDALGPHGYLINIA
Mflv_5240|M.gilvum_PYR-GCK YFAS---PVELAASVDVLVVAAAGGDSSRGLVSSEVIEALGPSGYLINIA
MSMEG_6126|M.smegmatis_MC2_155 YVGS---AADLAAQVDVLIIAAAGGAGTRHLVDRAVLDALGPDGYLVNIA
MAV_0123|M.avium_104 YAAS---AVELAELVDVLVVATTGDHQAHKLVDRAVLRALGPEGYLINIA
:* *.: : . : *:. .: * ::* :
Mb3020c|M.bovis_AF2122/97 RGGLVDEAALADAITGGHVRAAGLDVFATEPCT-DSPLFELAQVVVTPHL
Rv2996c|M.tuberculosis_H37Rv RGGLVDEAALADAITGGHVRAAGLDVFATEPCT-DSPLFELAQVVVTPHL
MLBr_01692|M.leprae_Br4923 RGGLVDEVALADAVRSGHVRAAGLDVFATEPCT-DSPLFELSQVVVTPHL
MAB_3304c|M.abscessus_ATCC_199 RGGLIDEAALADAIRSGHVRGAGLDVFSTEPCT-DSPLFELDQVVVTPHL
TH_2037|M.thermoresistible__bu RGGLIDEQALADAIISGRVRAAGIDVFAKEPCT-DSPLFDLPQVVVTPHL
MMAR_0531|M.marinum_M RGAVIDEDALVDALRSGSLAAAGLDVFAVEPVVPENPLLRLDNVVLTPHV
MUL_1195|M.ulcerans_Agy99 RGAVVDEDALVDALRSGSLAAAGLDVFAVEPVVPENPLLRLDNVVLTPHV
Mvan_1025|M.vanbaalenii_PYR-1 RGSVVDQDALVSALVERRLAGAGLDVFADEPQV-PEELFALDTVVLLPHV
Mflv_5240|M.gilvum_PYR-GCK RGSVVDQDALVVALVEKRLAGAGLDVFADEPHV-PEELFALDNVVLLPHV
MSMEG_6126|M.smegmatis_MC2_155 RGSVVDEDALVEALADGRLAGAGLDVFTDEPNV-PEALLGMENVVLLPHV
MAV_0123|M.avium_104 RGSVVDQEALVEMLAGGELAGAGLDVFADEPHV-PAELVGLDNVVLLPHV
**.::*: **. : : .**:***: ** . *. : **: **:
Mb3020c|M.bovis_AF2122/97 GASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVGGGVVNEEVAPWLDLV
Rv2996c|M.tuberculosis_H37Rv GASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVGGGVVNEEVAPWLDLV
MLBr_01692|M.leprae_Br4923 GASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVDGGVVNEEVAPWLDLV
MAB_3304c|M.abscessus_ATCC_199 GASTSEAQDRAGTDVAASVQLALAGEFVPDAVNVGGGVVSEEVAPWLEVV
TH_2037|M.thermoresistible__bu GASTVEAQDRAGTDVAASVKLALAGEFVPDAVNVGAGEVSEEVAPWVDLA
MMAR_0531|M.marinum_M TWYTVDTMRRYLTEAVDNCRRLRDGLSLANVVNCQADC------------
MUL_1195|M.ulcerans_Agy99 TWYTVDTMRRYLTEAVDNCRRLRDGLSLANAVNCQADC------------
Mvan_1025|M.vanbaalenii_PYR-1 ASGTVQTRAAMEALTLRNLDEFLATGELVTPVPLPAAAN-----------
Mflv_5240|M.gilvum_PYR-GCK GSGTVQTRAAMEELTVRNLHSFLTTGALVTPV------------------
MSMEG_6126|M.smegmatis_MC2_155 GSATVETRNAMEALTLANLDAYLKTGELVTPVPMPAAAPAPTPVQ-----
MAV_0123|M.avium_104 GSATARTRRAMASLALRNLDSYLATGQLVTPVLRPRRRIPDRN-------
* : . . : *
Mb3020c|M.bovis_AF2122/97 RKLGVLAGVLSDELPVSLSVQVRGELAAEEVEVLRLSALRGLFSAVIEDA
Rv2996c|M.tuberculosis_H37Rv RKLGVLAGVLSDELPVSLSVQVRGELAAEEVEVLRLSALRGLFSAVIEDA
MLBr_01692|M.leprae_Br4923 CKLGVLVAALSDELPASLSVHVRGELASEDVEILRLSALRGLFSTVIEDA
MAB_3304c|M.abscessus_ATCC_199 RKLGVLIGAVSEQLPTSLSVDVRGELASEDVAVLKLSALRGLFSSVIEDQ
TH_2037|M.thermoresistible__bu RKLGLLVGTLSGEPTATLQVRVAGELASEDVEVLRLSALRGLFSTLTDQQ
MMAR_0531|M.marinum_M --------------------------------------------------
MUL_1195|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1025|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5240|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6126|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0123|M.avium_104 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 VTFVNAPALAAERGVTAEICKASESPNHRSVVDVRAVGADGSVVTVSGTL
Rv2996c|M.tuberculosis_H37Rv VTFVNAPALAAERGVTAEICKASESPNHRSVVDVRAVGADGSVVTVSGTL
MLBr_01692|M.leprae_Br4923 VTFVNAPALAAERGVSAEITTGSESPNHRSVVDVRAVASDGSVVNIAGTL
MAB_3304c|M.abscessus_ATCC_199 VTFVNAPSIAEERGVSAEITTATESPNHRSVVDVRAVYADGSVINVAGTL
TH_2037|M.thermoresistible__bu VTYVNAPTLAAERGMQAELEKVSESPNYRSVVDVRAVSTDGTVTNVAGTL
MMAR_0531|M.marinum_M --------------------------------------------------
MUL_1195|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1025|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5240|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6126|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0123|M.avium_104 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 YGPQLSQKIVQINGRHFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVN
Rv2996c|M.tuberculosis_H37Rv YGPQLSQKIVQINGRHFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVN
MLBr_01692|M.leprae_Br4923 SGPQLVQKIVQVNGRNFDLRAQGMNLVIRYVDQPGALGKIGTLLGAAGVN
MAB_3304c|M.abscessus_ATCC_199 SGPQLVQKIVQINGRNFDLRAEGVNLVINYADVPGALGKIGTVLGGAEVN
TH_2037|M.thermoresistible__bu SGPQQVEKIVQINGRNFDLRAEGVNLVMHYVDRPGALGKIGTLLGAADVN
MMAR_0531|M.marinum_M --------------------------------------------------
MUL_1195|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1025|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5240|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6126|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0123|M.avium_104 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 IQAAQLSEDAEGPGATILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
Rv2996c|M.tuberculosis_H37Rv IQAAQLSEDAEGPGATILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
MLBr_01692|M.leprae_Br4923 IQAAQLSEDTEGPGATILLRLDQDVPGDVRSAIVAAVSANKLEVVNLS
MAB_3304c|M.abscessus_ATCC_199 IQAAQLSQDASGAAATIILRIDRTAPDAVLDEIRAAVGATTLELVDLS
TH_2037|M.thermoresistible__bu ILAAQLSQDISGDGATLMLRVNRDVPADVRDAIGAAVGASTLEVVDLS
MMAR_0531|M.marinum_M ------------------------------------------------
MUL_1195|M.ulcerans_Agy99 ------------------------------------------------
Mvan_1025|M.vanbaalenii_PYR-1 ------------------------------------------------
Mflv_5240|M.gilvum_PYR-GCK ------------------------------------------------
MSMEG_6126|M.smegmatis_MC2_155 ------------------------------------------------
MAV_0123|M.avium_104 ------------------------------------------------