For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSSDETKTSPAAVLDQPTEQMWREMLPQLRTFVRRRIADPDRADDLVAEILLRIHQNIGSLDDRERLPNW VFRIARNAIIDEYRRAGRSREQLMASLQEEPAALDEDEPGVVRELSACLRPMLAGLPPDQKAALEMIDLD GMTQADAAQQAGVSLSGMKSRVQRGRRRLAELLSQCCTMTLDGRGVPMDYEPPPGCGCAGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0162 | - | - | 100% (201) | ECF subfamily RNA polymerase sigma-24 factor |
| M. vanbaalenii PYR-1 | Mvan_6065 | - | 3e-12 | 29.70% (165) | Fis family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4496 | - | 8e-12 | 26.54% (162) | RNA polymerase sigma factor SigE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3941 | sigMa | 4e-13 | 30.32% (155) | RNA polymerase sigma factor SigM |
| M. gilvum PYR-GCK | Mflv_2200 | - | 7e-12 | 26.54% (162) | RNA polymerase sigma factor SigE |
| M. tuberculosis H37Rv | Rv1221 | sigE | 5e-13 | 27.81% (169) | RNA polymerase sigma factor SigE |
| M. leprae Br4923 | MLBr_01076 | sigE | 3e-12 | 27.38% (168) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_4938 | - | 8e-15 | 30.32% (155) | alternative RNA polymerase sigma factor SigM |
| M. marinum M | MMAR_5475 | sigM | 5e-15 | 31.61% (155) | alternative RNA polymerase sigma factor SigM |
| M. avium 104 | MAV_5299 | - | 8e-12 | 31.03% (145) | RNA polymerase sigma factor SigM |
| M. smegmatis MC2 155 | MSMEG_5072 | - | 4e-13 | 26.35% (167) | RNA polymerase sigma factor SigE |
| M. thermoresistible (build 8) | TH_0545 | sigE | 1e-12 | 27.65% (170) | ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGE |
| M. ulcerans Agy99 | MUL_5064 | sigM | 1e-13 | 30.13% (156) | RNA polymerase sigma factor SigM |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5072|M.smegmatis_MC2_155 ----MEHDDRRAS---QVRAGNNRVVIRVEQIENN-------------AV
TH_0545|M.thermoresistible__bu --------------------------------------------------
Mflv_2200|M.gilvum_PYR-GCK MTEGARTDTVRTARIDSARSRNENASARVAEHDGSPQGGPHHHLEDPTTT
Rv1221|M.tuberculosis_H37Rv -----------MELLGGPRVGNTESQLCVADGDDL--------------P
MLBr_01076|M.leprae_Br4923 -----MGDGIGMEREGR-WTGNTQCPLRVVPGDES--------------P
Mb3941|M.bovis_AF2122/97 --------------------------------------------------
MAV_5299|M.avium_104 --------------------------------------------------
MMAR_5475|M.marinum_M --------------------------------------------------
MUL_5064|M.ulcerans_Agy99 --------------------------------------------------
MAB_4938|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_0162|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5072|M.smegmatis_MC2_155 HEQEGSTTIASQPVTATHAAPVSMAHLEQFTDSDWVEPSDEPTGTAVFDA
TH_0545|M.thermoresistible__bu -----------------MSVPASMTHFAPPQATEWAEPVEEPTGTAVFDA
Mflv_2200|M.gilvum_PYR-GCK TQAPTSSVSAAAPVAAPVAAPVSMAHREQFTEAEWVEPTDELTGTAVFDA
Rv1221|M.tuberculosis_H37Rv TYCS-ANSEDLNITTITTLSPTSMSHPQQVRDDQWVEPSDQLQGTAVFDA
MLBr_01076|M.leprae_Br4923 TLDGRASPEDLIITNL--LSPTIMSHPPPSRDDDWVEPFDALQGTAVFDA
Mb3941|M.bovis_AF2122/97 -----------------MPPPIGYCPAVGFG-------GRHERSDAELLA
MAV_5299|M.avium_104 ---------------------------MGFGR-----NGNGDRSDAELLA
MMAR_5475|M.marinum_M ---------------------------MAFGGKRQRRDTARQRTDAELLA
MUL_5064|M.ulcerans_Agy99 ---------------------------MAFGGKRQRRNTARQRTDAELLA
MAB_4938|M.abscessus_ATCC_1997 ---------------------------MVQG-----VLTTPQHSDAELLA
Mvan_0162|M.vanbaalenii_PYR-1 ------------------------------------------MSSDETKT
:
MSMEG_5072|M.smegmatis_MC2_155 TGDQAAMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVFRSV
TH_0545|M.thermoresistible__bu TGDKSTMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVFRSL
Mflv_2200|M.gilvum_PYR-GCK TGDKAAMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVFRSV
Rv1221|M.tuberculosis_H37Rv TGDKATMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVFRSV
MLBr_01076|M.leprae_Br4923 TGDKATMPSWEELVRQHAARVYWLAYRLSGNQHDAEDLTQETFIRVFRSV
Mb3941|M.bovis_AF2122/97 AHVAGDRYAFDQLFRRHHRQLHRLARLTSRTSEDADDALQDAMLSAHRGA
MAV_5299|M.avium_104 AHVAGDRYAFGELFVRHQRHLHRLARLTTRSPEDAEDALQDAMLSAHRGA
MMAR_5475|M.marinum_M AFVAGEQLAFEELFRRHHRQLYHLARLTSQTPEDAEDALQEAMISVHNCA
MUL_5064|M.ulcerans_Agy99 AFVAGEQLAFEELFRRHHRQLYHLARLTSQTPEDAEDALQEAMISVHNCA
MAB_4938|M.abscessus_ATCC_1997 AHVAGDPSAFEQLFRRHHRRLYRLARATSRTPEDAADALQEAMLSAHRGA
Mvan_0162|M.vanbaalenii_PYR-1 SPAAVLDQPTEQMWREMLPQLRTFVRRRIADPDRADDLVAEILLRIHQNI
: . :: . :: :. . * * : :: ..
MSMEG_5072|M.smegmatis_MC2_155 QNYQPGTFEG-WLHRITTNLFLDMVRRRGRIR---MEALPEDYDRVPAED
TH_0545|M.thermoresistible__bu QNYQPGTFEG-WLHRITTNLFLDMVRRRGRIR---MESLPEDYDRVPGNS
Mflv_2200|M.gilvum_PYR-GCK QNYQPGTFEG-WLHRITTNLFLDMVRRRGRIR---MEALPEDYDRVPADE
Rv1221|M.tuberculosis_H37Rv QNYQPGTFEG-WLHRITTNLFLDMVRRRARIR---MEALPEDYDRVPADE
MLBr_01076|M.leprae_Br4923 QNYQPGTFEG-WLHRITTNLFLDMVRRRARIR---MDALPDDYDRVPADE
Mb3941|M.bovis_AF2122/97 GSFRYDAAVSSWLHRIVVNACLDRLRRAKAHP---TAPLED-VYPVADRT
MAV_5299|M.avium_104 GAFRHDAAVGSWLHRIVVNACLDRLRRTKAHP---TVPLED-IYPVADRT
MMAR_5475|M.marinum_M GSFRQDAAVTSWLHRIVVNACLDRLRRAKSRP---TVPLED-VYPVPDAT
MUL_5064|M.ulcerans_Agy99 GSFRQDAAVTSWLHRIVVNACLERLRRAESRP---TVPLED-VYPVPDAT
MAB_4938|M.abscessus_ATCC_1997 ANFRNDAAVTSWLYRIVVNACLDRMRRNKAHI---PIELEEDVYTLEDPS
Mvan_0162|M.vanbaalenii_PYR-1 GSLDDRERLPNWVFRIARNAIIDEYRRAGRSREQLMASLQEEPAALDEDE
*:.**. * :: ** * : :
MSMEG_5072|M.smegmatis_MC2_155 PNPEQIYHDSRLGADLQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLGV
TH_0545|M.thermoresistible__bu PNPEQIYHDARLGPDLQAALDSLPPDFRAAVVLCDIEGLSYEEIGATLGV
Mflv_2200|M.gilvum_PYR-GCK PNPEQIYHDSRLGADLQAALDSLAPEFRAAVVLCDIEGLSYEEIGATLGV
Rv1221|M.tuberculosis_H37Rv PNPEQIYHDARLGPDLQAALASLPPEFRAAVVLCDIEGLSYEEIGATLGV
MLBr_01076|M.leprae_Br4923 PNPEQIYHDSRLGPDLQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLGV
Mb3941|M.bovis_AF2122/97 -------AQVETAIAVQRALMRLPVEQRAAVVAVDMQGYSIADTSRMLGV
MAV_5299|M.avium_104 -------AQVETTLAVQRALMRLPVEQRAAIVAVDMQGYSVADTARLLGV
MMAR_5475|M.marinum_M -------TRVETAILVRRALMRLPVEQRAAVVAVDMQGYSIADTALLLGV
MUL_5064|M.ulcerans_Agy99 -------TRVETAILVRRALMRLPVEQRAAVVAVDMQRYSIPDTALLLGV
MAB_4938|M.abscessus_ATCC_1997 -------TNVDTSIVIQKALLRLPAEQRAAVIAVDMQGYSVADAAELLGV
Mvan_0162|M.vanbaalenii_PYR-1 PG-----VVRELSACLRPMLAGLPPDQKAALEMIDLDGMTQADAAQQAGV
:: * *. : :**: *:: : : . **
MSMEG_5072|M.smegmatis_MC2_155 KLGTVRSRIHRGRQQLRDY-LAKHS-----SETAQSA-----------
TH_0545|M.thermoresistible__bu KLGTVRSRIHRGRQALRDY-LARHS-----QNSGQSATTS--------
Mflv_2200|M.gilvum_PYR-GCK KLGTVRSRIHRGRQALRDH-LARHSDVGAGRDTAKSA-----------
Rv1221|M.tuberculosis_H37Rv KLGTVRSRIHRGRQALRDY-LAAHPEHGEC--AVHVNPVR--------
MLBr_01076|M.leprae_Br4923 KLGTVRSRIHRGRQALRDYLLTAHPRDGATTDATHVKSA---------
Mb3941|M.bovis_AF2122/97 AEGTVKSRCARARARLARLLGYLNTGVNIRR-----------------
MAV_5299|M.avium_104 AEGTVKSRCARARVRLAELLGYLDAGAHAAAEGAAGQA----------
MMAR_5475|M.marinum_M AQGTVKSRCARGRARLARLLGYLDADINAVDMN---------------
MUL_5064|M.ulcerans_Agy99 AQGTVKSRCARGRARLARLLSYLDADINAVDMN---------------
MAB_4938|M.abscessus_ATCC_1997 PEGTVKSRCARARARLAVALHYLDKAGSVEPETIDY------------
Mvan_0162|M.vanbaalenii_PYR-1 SLSGMKSRVQRGRRRLAELLSQCCTMTLDGRGVPMDYEPPPGCGCAGR
. ::** *.* *