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AERGAQPPVPRGRRLFLKAVHHLFKPLRPDDYIEMINPLWTTKELRGKVERVEPRGSEAASVLIRPSYEW PGHKPGQYVRLGLVIDGRYHWRAYSLTSDPHPEDGLISVTPKKVDSGVVSPYLVEKIQPGELVRLGEIEG QFTLPEPLPAKMLFISAGSGITPIISMLRSLDHSDDLRDTVVIHSDRTRDHVMFLSVLEDLEDRHDGVRL DIRLTSERGRFSADELDDVCPDWREREAFCSGPGELLDALIEHWEHHGDSERLHYERFQPKIGGGEVQAG EGGTVAFLDSDETVECDGSTPILEAGEQAGLELAFGCRIGICHTCTGTVKSGKVRDLRSGEVSEPTGGDI RICIHAAEGDVEIEL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5247 | - | - | 100% (366) | ferredoxin |
| M. gilvum PYR-GCK | Mflv_4699 | - | 1e-77 | 41.67% (348) | ferredoxin |
| M. gilvum PYR-GCK | Mflv_4815 | - | 3e-39 | 32.13% (361) | oxidoreductase FAD-binding subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3259c | - | 3e-76 | 40.74% (351) | oxidoreductase |
| M. tuberculosis H37Rv | Rv3230c | - | 4e-77 | 41.03% (351) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3549c | - | 6e-68 | 37.60% (383) | putative oxidoreductase |
| M. marinum M | MMAR_1314 | - | 2e-76 | 39.44% (355) | oxidoreductase |
| M. avium 104 | MAV_4193 | - | 5e-78 | 41.88% (351) | 2Fe-2S iron-sulfur cluster binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_1885 | - | 4e-76 | 41.62% (346) | 2Fe-2S iron-sulfur cluster binding domain-containing protein |
| M. thermoresistible (build 8) | TH_2872 | - | 1e-78 | 43.19% (345) | PUTATIVE 2Fe-2S iron-sulfur cluster binding domain protein |
| M. ulcerans Agy99 | MUL_2566 | - | 3e-76 | 39.15% (355) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1767 | - | 3e-83 | 43.44% (343) | ferredoxin |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1885|M.smegmatis_MC2_155 ----MAKNHIKISANVADTVRPTVAGADERPGWHALRRLAARITTPLLPD
Mvan_1767|M.vanbaalenii_PYR-1 ----MAKNTIKNTAKVADTVRPTIAGAKENPGWHLLRTIAGRITTPLLPD
TH_2872|M.thermoresistible__bu ----MAKSEIKYSARVVDTVRPQVAGVENRPVLHRLRRFAERITTPLLPD
Mb3259c|M.bovis_AF2122/97 ----MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLPD
Rv3230c|M.tuberculosis_H37Rv ----MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLPD
MMAR_1314|M.marinum_M ----MVKKNAALSAQIIDTKRPNIVGADKHPGWHALRKIASRITTPLLPD
MUL_2566|M.ulcerans_Agy99 ----MVKKNAALSAQIIDTKRPSIVGADKHPGWHALRKIASRITTPLLPD
MAV_4193|M.avium_104 MSNTMSKTTSPITANLGDTKRPVVAGAERHPGWHALRKLAARITTPLLPD
MAB_3549c|M.abscessus_ATCC_199 ----------MKLASWLDASAPGAP-KSRHAAVNILRGLASRITTPLLPD
Mflv_5247|M.gilvum_PYR-GCK ----MAER----------GAQPPVP-----RGRRLFLKAVHHLFKPLRPD
* . : . :: .** **
MSMEG_1885|M.smegmatis_MC2_155 DYLQLANPLWSARELRGRVLEVRRETEDSATLVIKPGWGFSFDYQPGQYI
Mvan_1767|M.vanbaalenii_PYR-1 DYLKLANPLWSARELRGRVLEVRRETEDSATLVIKPGWGFSFDYEPGQYI
TH_2872|M.thermoresistible__bu DYLHLINPLWSARELRGRVEDVRRETEDSATLVIKPGWGFSFDYQPGQYI
Mb3259c|M.bovis_AF2122/97 DYLHLANPLWSARELRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYI
Rv3230c|M.tuberculosis_H37Rv DYLHLANPLWSARELRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYI
MMAR_1314|M.marinum_M DYLQLANPLWSARELRGRILEVRRETEDSATLVIKPGWGFSFDYQPGQYI
MUL_2566|M.ulcerans_Agy99 DYLQLANPLWSARELRGRILEVRRETEDSATLVIKPGWGFSFDYQPGQYI
MAV_4193|M.avium_104 DYLHLANPLWSARELRGRVVDVRRETEDSATLVIKPGWGFNFDYQPGQYI
MAB_3549c|M.abscessus_ATCC_199 DYLSLANPLWSARELRGRVVSVRKETSDSATLEIKPGWGFHFDYHPGQYV
Mflv_5247|M.gilvum_PYR-GCK DYIEMINPLWTTKELRGKVERVEPRGSEAASVLIRPSYEWP-GHKPGQYV
**: : ****:::****:: *. . .::*:: *:*.: : .:.****:
MSMEG_1885|M.smegmatis_MC2_155 GIGVFLDGRWRWRSYSLTSSPVTAHP---------KGRARTITITVKAMP
Mvan_1767|M.vanbaalenii_PYR-1 GIGLLVEGRWRWRSYSLTSSPVTS-----------KG-SRTITITVKAMP
TH_2872|M.thermoresistible__bu GIGLPVDGRWRWRSYSLTSPAVTSG----------RG-GRTITITVKAMP
Mb3259c|M.bovis_AF2122/97 GIGLLVDGCWRWRSYSLTSSPAAS------------GSARMVTVTVKAMP
Rv3230c|M.tuberculosis_H37Rv GIGLLVDGRWRWRSYSLTSSPAAS------------GSARMVTVTVKAMP
MMAR_1314|M.marinum_M GIGLLVDGRWRWRSYSLTSSPVGGKSG--------PGSARTVTITVKAMP
MUL_2566|M.ulcerans_Agy99 GIGLLVDGRWRWRSYSLTSSPVGGKSG--------PGSARTVTITVKAMP
MAV_4193|M.avium_104 GIGLLIDGRWRWRSYSLTSSPATS------------ASARTVTITVKAMP
MAB_3549c|M.abscessus_ATCC_199 GIGVLIDGRWRWRSYSLTSAPAMSGSREERRALHAGGSARTITITVKAMP
Mflv_5247|M.gilvum_PYR-GCK RLGLVIDGRYHWRAYSLTSDPHPE--------------DGLISVTPKKVD
:*: ::* ::**:***** . :::* * :
MSMEG_1885|M.smegmatis_MC2_155 EGFLSTHLVGGLEPGTVVRLAAPQGNFVMPDPAPASVLFLTAGSGITPVM
Mvan_1767|M.vanbaalenii_PYR-1 EGFLSTHLVGGVAPGTIVRLAAPQGNFVMPDPAPASVLFLTAGSGITPVM
TH_2872|M.thermoresistible__bu EGFLSTHLVEGVKPGTIVRLAAPQGNFVMPNPAPPQVLFLTAGSGITPIM
Mb3259c|M.bovis_AF2122/97 EGFLSTHLVAGVKPGTIVRLAAPQGNFVLPDPAPPLILFLTAGSGITPVM
Rv3230c|M.tuberculosis_H37Rv EGFLSTHLVAGVKPGTIVRLAAPQGNFVLPDPAPPLILFLTAGSGITPVM
MMAR_1314|M.marinum_M EGFLSTHLVAGVAPGTIVRLVAPQGNFVLPDPAPPSMLFLTAGSGITPVM
MUL_2566|M.ulcerans_Agy99 EGFLSTHLVAGVAPGTIVRLVAPQGNFVLPDPAPPSILFLTAGSGITPVM
MAV_4193|M.avium_104 EGFLSSHLVAGVEPGTVVRLAAPQGNFVLPDPAPASILFLTAGSGITPVM
MAB_3549c|M.abscessus_ATCC_199 EGFLSTHLVNGLEPGTIVRLAAPQGNFVLDDPAPPAILFLTAGSGITPIM
Mflv_5247|M.gilvum_PYR-GCK SGVVSPYLVEKIQPGELVRLGEIEGQFTLPEPLPAKMLFISAGSGITPII
.*.:*.:** : ** :*** :*:*.: :* *. :**::*******::
MSMEG_1885|M.smegmatis_MC2_155 SMLRTLVRRDQIT-----DIVHLHSAPTESDVLFGSELTALQGTHPGYRL
Mvan_1767|M.vanbaalenii_PYR-1 SMLRTLVRRGQLG-----DVAHVHSSPTEDDVMFAAELSELADRHEGYRL
TH_2872|M.thermoresistible__bu SMLRTLERRDQIT-----DIVHIHSVPTPSDAMFSGELADLQRRHPSYRF
Mb3259c|M.bovis_AF2122/97 SMLRTLVRRNQIT-----DVVHLHSAPTAADVMFGAELAALAADHPGYRL
Rv3230c|M.tuberculosis_H37Rv SMLRTLVRRNQIT-----DVVHLHSAPTAADVMFGAELAALAADHPGYRL
MMAR_1314|M.marinum_M SMLRTLLRRNQIT-----DITHLHSVPTEADVMFGDELAGVAAQHPGYRL
MUL_2566|M.ulcerans_Agy99 SMLRTLLRRNQIT-----DITHLHSVPTEADVMFGDELAGVAAQHPGYRL
MAV_4193|M.avium_104 SMLRTLVRRNQIG-----DIVHLHSAPTEADVMFRGELAALANEHPGYRL
MAB_3549c|M.abscessus_ATCC_199 SMLRTLVRRSAAAGLPLPDVVHLHSAPTAGDVMFAGELAAFSEAHPSYHY
Mflv_5247|M.gilvum_PYR-GCK SMLRSLDHSDDLR-----DTVVIHSDRTRDHVMFLSVLEDLEDRHDGVRL
****:* : . * . :** * ..:* * . * . :
MSMEG_1885|M.smegmatis_MC2_155 RIRSTRTEGRLDLERIADEVPDWRERQVWACGPEGMLADAERVWKAAGVG
Mvan_1767|M.vanbaalenii_PYR-1 RVRATRTEGRLDLDRLDEVVPDWRERQTWACGPEAMLEAAERTWKAAGIA
TH_2872|M.thermoresistible__bu RLRTTRTEGRLDLSRLDDEVGDWRSRQTWACGPEGLLTAAERVWLGAGIG
Mb3259c|M.bovis_AF2122/97 SVRETRAQGRLDLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGAS
Rv3230c|M.tuberculosis_H37Rv SVRETRAQGRLDLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGAS
MMAR_1314|M.marinum_M SVRATRSQGRLDLSRIGEQVPDWRERQTWACGPESMLNQAEKVWSAAGIG
MUL_2566|M.ulcerans_Agy99 SVRATRSQGRLDLSRIGEQVPDWRERQTWACGPESMLNQAEKVWSAAGIG
MAV_4193|M.avium_104 QLRETRTRGRLDLSLLDREVPDWRERQTWACGPEGMLNAAERVWSAAGIG
MAB_3549c|M.abscessus_ATCC_199 RLRTTKTQGRLDFSSLAAEVPDWARRQTWACGPEGMLDDAQRTWADAGLA
Mflv_5247|M.gilvum_PYR-GCK DIRLTSERGRFSADELDDVCPDWREREAFCSGPGELLDALIEHWEHHGDS
:* * .**:. : ** *:.:..** :* . * * .
MSMEG_1885|M.smegmatis_MC2_155 ENLHLERFAVKRAAP---HGTGGNVTFERTGKTVHADAAKSLMEAGEEVG
Mvan_1767|M.vanbaalenii_PYR-1 DRLHLERFAVARAA----HGSGGTVEFSRSGKAATVDGATSLMDAGEAAG
TH_2872|M.thermoresistible__bu DRLHLERFAVARVAN---PGGGGTIEFARSGKSTVVDAATSLMDAGEQAG
Mb3259c|M.bovis_AF2122/97 DRLHLERFAVSKTAP---AGAGGTVTFARSGKSVAADAATSLMDAGEGAG
Rv3230c|M.tuberculosis_H37Rv DRLHLERFAVSKTAP---AGAGGTVTFARSGKSVAADAATSLMDAGEGAG
MMAR_1314|M.marinum_M DRLHLERFAVSKAAP---AGAGGTVTFARSGRSVDVDAATSVMDAGERAG
MUL_2566|M.ulcerans_Agy99 DRLHLERFAVSKAAP---AGAGGTVTFARSGRSVDVDAATSVMDAGERAG
MAV_4193|M.avium_104 EQLHLERFAVSKAAP---AGAGGMVTFARSGRSVDADAATSLMDAGEAAG
MAB_3549c|M.abscessus_ATCC_199 ELLHLERFAVSRAAP---HGQGGLVTFARSGKQRAADAATSLMEAGEEAG
Mflv_5247|M.gilvum_PYR-GCK ERLHYERFQPKIGGGEVQAGEGGTVAFLDSDETVECDGSTPILEAGEQAG
: ** *** . * ** : * :.. *.:..:::*** .*
MSMEG_1885|M.smegmatis_MC2_155 IRMPFGCRMGICQSCVVGLVDGHVRDLRTGVEHDA-GSRIQTCVSAASGD
Mvan_1767|M.vanbaalenii_PYR-1 IQMPFGCRMGICQSCVVGLLDGHVRDLRTGVEHEP-GTRVQTCVSAASGD
TH_2872|M.thermoresistible__bu VQMPFGCRMGICQSCVIGLVDGHVRDLRTGEVHDP-GTRVQTCVSAAAGD
Mb3259c|M.bovis_AF2122/97 VQLPFGCRMGICQSCVVDLVEGHVRDLRTGQRHEP-GTRVQTCVSAASGD
Rv3230c|M.tuberculosis_H37Rv VQLPFGCRMGICQSCVVDLVEGHVRDLRTGQRHEP-GTRVQTCVSAASGD
MMAR_1314|M.marinum_M VQMPFGCRMGICQSCVVDLVQGHVRDLRTGQEHDP-GSRVQTCVTAASGD
MUL_2566|M.ulcerans_Agy99 VQMPFGCRMGICQSCVVDLVQGHVRDLRTGQEHDP-GSRVQTCVTAASGD
MAV_4193|M.avium_104 VQMPFGCRMGICQSCVVGLVEGHVRDLRTGAEHEP-GTRVQTCVSAASGD
MAB_3549c|M.abscessus_ATCC_199 VQMPFGCRMGICQTCVVSLVQGHARDLRTGAEYEP-GTRIQTCVSAASGD
Mflv_5247|M.gilvum_PYR-GCK LELAFGCRIGICHTCTGTVKSGKVRDLRSGEVSEPTGGDIRICIHAAEGD
:.:.****:***::*. : .*:.****:* :. * :: *: ** **
MSMEG_1885|M.smegmatis_MC2_155 CVLDV
Mvan_1767|M.vanbaalenii_PYR-1 CVLDV
TH_2872|M.thermoresistible__bu CVLDI
Mb3259c|M.bovis_AF2122/97 CVLDI
Rv3230c|M.tuberculosis_H37Rv CVLDI
MMAR_1314|M.marinum_M CVIDV
MUL_2566|M.ulcerans_Agy99 CAIDV
MAV_4193|M.avium_104 CVLDI
MAB_3549c|M.abscessus_ATCC_199 CVLDV
Mflv_5247|M.gilvum_PYR-GCK VEIEL
:::